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公开(公告)号：US09169934B2
公开(公告)日：2015-10-27
申请号：US14114330
申请日：2012-04-24
申请人： Bernard Bunner , Joseph Michienzi , Keith Fadgen
发明人： Bernard Bunner , Joseph Michienzi , Keith Fadgen
CPC分类号： F16K3/10 , F16K3/18 , F16K31/041 , G01N35/1097 , G01N2030/202 , Y10T137/0318
摘要： A method for switching a high pressure fluid includes applying a fixed force between a planar surface of a rotor and a planar surface of a stator. The planar surface of the rotor includes a fluidic channel and the planar surface of the stator has a pair of ports to receive and provide the fluid. A control signal is applied to a linear actuator coupled to the rotor to generate a controllable force between the planar surfaces of the rotor and stator. The control signal is responsive to a rotational state of the rotor. The total force between the planar surfaces of the rotor and the stator is substantially equal to a sum of the fixed force and the controllable force. The method reduces the wear and extends the lifetime of components in a rotary shear seal valve.
摘要翻译： 用于切换高压流体的方法包括在转子的平坦表面和定子的平坦表面之间施加固定的力。 转子的平面表面包括流体通道，并且定子的平坦表面具有一对接口并提供流体的端口。 控制信号被施加到耦合到转子的线性致动器，以在转子和定子的平面之间产生可控的力。 控制信号响应转子的旋转状态。 转子和定子的平面之间的总的力基本上等于固定力和可控力之和。 该方法减少了磨损并延长了旋转剪切密封阀中部件的使用寿命。
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公开(公告)号：US20140053910A1
公开(公告)日：2014-02-27
申请号：US14114330
申请日：2012-04-24
申请人： Bernard Bunner , Joseph Michienzi , Keith Fadgen
发明人： Bernard Bunner , Joseph Michienzi , Keith Fadgen
CPC分类号： F16K3/10 , F16K3/18 , F16K31/041 , G01N35/1097 , G01N2030/202 , Y10T137/0318
摘要： Described are a rotary shear seal valve and a method for switching a high pressure fluid. The method includes applying a fixed force between a planar surface of a rotor and a planar surface of a stator. The planar surface of the rotor includes a fluidic channel and the planar surface of the stator has a pair of ports to receive and provide the fluid. A control signal is applied to a linear actuator coupled to the rotor to generate a controllable force between the planar surfaces of the rotor and stator. The control signal is responsive to a rotational state of the rotor. The total force between the planar surfaces of the rotor and the stator is substantially equal to a sum of the fixed force and the controllable force. The method reduces the wear and extends the lifetime of components in a rotary shear seal valve.
摘要翻译： 描述了一种旋转剪切密封阀和一种用于切换高压流体的方法。 该方法包括在转子的平坦表面和定子的平坦表面之间施加固定的力。 转子的平面表面包括流体通道，并且定子的平坦表面具有一对接口并提供流体的端口。 控制信号被施加到耦合到转子的线性致动器，以在转子和定子的平面之间产生可控的力。 控制信号响应转子的旋转状态。 转子和定子的平面之间的总的力基本上等于固定力和可控力之和。 该方法减少了磨损并延长了旋转剪切密封阀中部件的使用寿命。
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公开(公告)号：US20060285983A1
公开(公告)日：2006-12-21
申请号：US11362411
申请日：2006-02-23
申请人： Bernard Bunner , Manish Deshpande , Sebastian Bohm , Richard Day , John Gilbert
发明人： Bernard Bunner , Manish Deshpande , Sebastian Bohm , Richard Day , John Gilbert
IPC分类号： F04B17/00
CPC分类号： F04B43/025 , F04B43/04 , F04B43/043 , Y10S977/963
摘要： An electromagnetic micropump for pumping small volumes of liquids and gases comprises a magnetic actuator assembly, a flexible membrane and a housing defining a chamber and a plurality of valves. The magnetic actuator assembly comprises a coil and a permanent magnet for deflecting the membrane to effect pumping of the fluid. A plurality of micropumps may be stacked together to increase pumping capacity.
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公开(公告)号：US07134639B2
公开(公告)日：2006-11-14
申请号：US11099014
申请日：2005-04-04
IPC分类号： F16K31/02
CPC分类号： F16K99/0001 , F15C5/00 , F16K99/0005 , F16K99/0007 , F16K99/0009 , F16K99/0015 , F16K99/0046 , F16K99/0048 , F16K2099/0069 , F16K2099/0071 , F16K2099/0074 , F16K2099/0076 , F16K2099/008 , F16K2099/0084 , G05D7/0694 , Y10T29/49412 , Y10T137/87314
摘要： A latching microregulator for regulating liquid flow on micro-scale levels comprises a substrate having an inlet port and an outlet port, a valve element defining a valve chamber for opening and closing the inlet port, and an actuator assembly for actuating the valve element. The valve chamber is configured to contain a volume of fluid, and the inlet port and the outlet port are in fluid communication with the valve chamber to provide a liquid flow path through the chamber. The actuator assembly comprises a cantilever beam for moving the valve element between an open position and a closed position, an actuator, such as a piezoelectric element, for moving the cantilever beam, and a latch, such as a permanent magnet, for securing the cantilever beam in the closed position. A flow regulation system comprises a plurality of fluid channels of varied flow conductance and a plurality of latching microregulators for selectively blocking or allowing flow through each of the fluid channels.
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公开(公告)号：US07033148B2
公开(公告)日：2006-04-25
申请号：US10329013
申请日：2002-12-23
IPC分类号： F04B17/00
CPC分类号： F04B43/025 , F04B43/04 , F04B43/043 , Y10S977/963
摘要： An electromagnetic micropump for pumping small volumes of liquids and gases comprises a magnetic actuator assembly, a flexible membrane and a housing defining a chamber and a plurality of valves. The magnetic actuator assembly comprises a coil and a permanent magnet for deflecting the membrane to effect pumping of the fluid. A plurality of micropumps may be stacked together to increase pumping capacity.
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公开(公告)号：US09496125B2
公开(公告)日：2016-11-15
申请号：US12919570
申请日：2009-03-03
CPC分类号： H01J49/167 , B01L3/0268 , B01L3/502792 , B01L2200/026 , B01L2300/0819 , B01L2300/089 , B01L2400/0427 , B03C5/024 , B03C2201/26 , G01N30/06 , G01N30/20 , G01N2030/201
摘要： Described are techniques for use in connection with analyzing a droplet. One or more droplets of a sample are formed on a surface of a digital microfluidic device. The droplets are manipulated to perform processing using said one or more droplets generating one or more resulting droplets. The one or more resulting droplets may be transferred from the microfluidic device to another device for analysis. The one or more droplets may also be provided to the digital microfluidic device from yet another device or analysis instrument.
摘要翻译： 描述了与分析液滴有关的技术。 在数字微流体装置的表面上形成一个或多个样品液滴。 操纵液滴以使用所述一个或多个液滴产生一个或多个所产生的液滴进行处理。 所产生的一个或多个液滴可以从微流体装置转移到另一装置用于分析。 一个或多个液滴也可以从另一个装置或分析仪器提供给数字微流体装置。
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7.发明申请CHROMATOGRAPHY APPARATUS HAVING DIFFUSION-BONDED AND SURFACE-MODIFIED COMPONENTS 有权具有扩散键合和表面改性成分的色谱装置公开(公告)号：US20130014567A1
公开(公告)日：2013-01-17
申请号：US13637273
申请日：2011-03-25
CPC分类号： G01N30/7266 , B01L3/502707 , B01L3/502753 , B01L2200/0689 , B01L2300/0816 , B01L2300/0887 , B01L2400/0487 , B23B35/00 , B23H9/12 , B23H9/14 , B23K20/023 , B23K20/233 , B23K26/382 , B23K2101/18 , B23K2103/14 , C23C16/44 , C23C26/00 , C23F1/14 , G01N30/6095 , H01J49/0018 , H01J49/167
摘要： A microfluidic device for separating a sample by chromatography includes diffusion bonded metallic sheets joined together to create a hermetically sealed interface between each adjacent metallic sheet without the introduction of a secondary material. Enclosed within the diffusion bonded sheets is a separation channel accessible by at least one of an inlet or an outlet. The separation channel is packed with micrometer-sized particles serving as a stationary phase in a chromatographic separation. Wetted surfaces of the separation channel include a coating of an organic material at least one monolayer thick.
摘要翻译： 用于通过色谱分离样品的微流体装置包括连接在一起的扩散接合的金属片，以在每个相邻的金属片之间形成气密密封的界面，而不引入次级材料。 封隔在扩散接合片内的是可由入口或出口中的至少一个接近的分离通道。 分离通道用色谱分离中用作固定相的微米级颗粒填充。 分离通道的接液表面包括至少一层单层厚的有机材料的涂层。
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公开(公告)号：US06981518B2
公开(公告)日：2006-01-03
申请号：US10179537
申请日：2002-06-24
CPC分类号： F16K99/0001 , F15C5/00 , F16K99/0005 , F16K99/0007 , F16K99/0009 , F16K99/0015 , F16K99/0046 , F16K99/0048 , F16K2099/0069 , F16K2099/0071 , F16K2099/0074 , F16K2099/0076 , F16K2099/008 , F16K2099/0084 , G05D7/0694 , Y10T29/49412 , Y10T137/87314
摘要： A latching microregulator for regulating liquid flow on micro-scale levels comprises a substrate having an inlet port and an outlet port, a valve element defining a valve chamber for opening and closing the inlet port, and an actuator assembly for actuating the valve element. The valve chamber is configured to contain a volume of fluid, and the inlet port and the outlet port are in fluid communication with the valve chamber to provide a liquid flow path through the chamber. The actuator assembly comprises a cantilever beam for moving the valve element between an open position and a closed position, an actuator, such as a piezoelectric element, for moving the cantilever beam, and a latch, such as a permanent magnet, for securing the cantilever beam in the closed position. A flow regulation system comprises a plurality of fluid channels of varied flow conductance and a plurality of latching microregulators for selectively blocking or allowing flow through each of the fluid channels.
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公开(公告)号：US20120009025A1
公开(公告)日：2012-01-12
申请号：US13179084
申请日：2011-07-08
IPC分类号： B65G53/16
CPC分类号： B65G51/08 , B01F13/0062 , B01F13/0064 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00891 , B01L3/502776 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0487 , B65G51/00 , G01N15/1404 , G01N15/1484 , G01N2015/1409
摘要： A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.
摘要翻译： 用于产生鞘流的微细鞘层流动结构包括用于输送护套流体的初级鞘流动通道，用于将样品注入主鞘流道中的鞘液中的样品入口，用于将样品聚焦在 护套流体和辅助聚焦区域，用于提供样品在护套液体内的附加聚焦。 次要聚焦区域可以由与主鞘流道相交的流动通道形成，以从选定的方向将另外的鞘流体注入主鞘流动通道。 护套流动系统可以包括在微流体芯片上并行操作的多个护套流动结构。
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公开(公告)号：US20100111616A1
公开(公告)日：2010-05-06
申请号：US12610753
申请日：2009-11-02
CPC分类号： B65G51/08 , B01F13/0062 , B01F13/0064 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00891 , B01L3/502776 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0487 , B65G51/00 , G01N15/1404 , G01N15/1484 , G01N2015/1409
摘要： A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.
摘要翻译： 用于产生鞘流的微细鞘层流动结构包括用于输送护套流体的初级鞘流动通道，用于将样品注入主鞘流道中的鞘液中的样品入口，用于将样品聚焦在 护套流体和辅助聚焦区域，用于提供样品在护套液体内的附加聚焦。 次要聚焦区域可以由与主鞘流道相交的流动通道形成，以从选定的方向将另外的鞘流体注入主鞘流动通道。 护套流动系统可以包括在微流体芯片上并行操作的多个护套流动结构。
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