NOVEL MACROLIDE DERIVATIVE
    12.
    发明申请
    NOVEL MACROLIDE DERIVATIVE 审中-公开
    新的魔法衍生物

    公开(公告)号:US20140011757A1

    公开(公告)日:2014-01-09

    申请号:US13982397

    申请日:2012-01-31

    IPC分类号: C07H17/08

    CPC分类号: C07H17/08 A61K31/7048

    摘要: The inventors of the present invention have succeeded in acquiring a compound having excellent antibacterial activities against pathogens of respiratory tract infections in animals through the use of josamycin as a lead scaffold.

    摘要翻译: 本发明的发明人通过使用约沙霉素作为引脚支架,成功地获得了对动物呼吸道感染病原体具有优异抗菌活性的化合物。

    METHOD OF MANUFACTURING FILM AND METHOD OF MANUFACTURING DISPLAY
    13.
    发明申请
    METHOD OF MANUFACTURING FILM AND METHOD OF MANUFACTURING DISPLAY 审中-公开
    制造薄膜的方法和制造显示方法

    公开(公告)号:US20120322334A1

    公开(公告)日:2012-12-20

    申请号:US13487731

    申请日:2012-06-04

    IPC分类号: H01J9/20 B41M1/10

    摘要: There are provided a method of manufacturing a film, suitable for forming a film having a plurality of minute through holes, and a method of manufacturing a display using the method of manufacturing a film. The method of manufacturing a film, includes: transferring a film of a first pattern onto a base material with use of an intaglio plate including the first pattern and a second pattern; and forming a film including through holes on the base material by transferring a film of the second pattern of the intaglio plate onto the film of the first pattern.

    摘要翻译: 提供一种适于形成具有多个微通孔的膜的膜的制造方法以及使用该膜的制造方法制造显示器的方法。 制造薄膜的方法包括:使用包括第一图案和第二图案的凹版印刷将第一图案的薄膜转印到基材上; 以及通过将所述凹版的所述第二图案的膜转印到所述第一图案的膜上,在所述基材上形成包括通孔的膜。

    Tetrahydronaphthofuranone derivatives and process for producing the same
    15.
    发明授权
    Tetrahydronaphthofuranone derivatives and process for producing the same 失效
    四氢萘并呋喃酮衍生物及其制备方法

    公开(公告)号:US06255339B1

    公开(公告)日:2001-07-03

    申请号:US09117070

    申请日:1998-07-21

    IPC分类号: A61K3134

    摘要: Compounds represented by the following formula (I) and pharmaceutically acceptable salts thereof are disclosed. The compounds have progesterone receptor binding inhibitory activity and, hence, can be used as therapeutic and prophylactic agents for progesterone-related diseases. Specifically, they are useful as abortifacients, oral contraceptive pills, carcinostatic agents for breast cancer and ovarian cancer, therapeutic agents for endometriosis, meningioma, and myeloma, and therapeutic and prophylactic agents for osteoporosis and climacteric disturbance. wherein R1 and R2 represent a hydroxyl group, alkyloxy, alkenyloxy, alkynyloxy, cycloalkyloxy, alkoxyalkyloxy, cycloalkyloxy containig one oxygen atom, aralkyloxy, alkylcarbonyloxy, alkenylcarbonyloxy, alkynylcarbonyloxy, cycloalkylcarbonyloxy, alkoxycarbonyloxy, aryloxy carbonyloxy, aralkylcarbonyloxy, aromatic acyloxy, heteroaromatic acyloxy, saturated heterocyclic carbonyloxy, alkylsulfonyloxy, aromatic sulfonyloxy, alkylcarbamoyloxy, aromatic carbamoyloxy, alkylcarbonylamino, or aromatic acylamino, provided that R1 may further represent a hydrogen atom, alkyl, alkenyl, or alkynyl; and R3, R4, and R5 each independently represent a hydrogen atom, alkyl or alkenyl.

    摘要翻译: 公开了由下式(I)表示的化合物及其药学上可接受的盐。 所述化合物具有孕酮受体结合抑制活性,因此可用作孕酮相关疾病的治疗和预防剂。 具体地说,它们可用作流产者,口服避孕药,乳腺癌和卵巢癌的制癌剂,子宫内膜异位症的治疗剂,脑膜瘤和骨髓瘤,以及骨质疏松症和更年期障碍的治疗和预防剂。其中R1和R2表示羟基, 烷氧基,链烯氧基,炔氧基,环烷氧基,烷氧基烷氧基,含有一个氧原子的环烷氧基,芳烷氧基,烷基羰基氧基,链烯基羰基氧基,炔基羰氧基,环烷基羰基氧基,烷氧基羰基氧基,芳氧基羰基氧基,芳烷基羰基氧基,芳香酰氧基,杂芳基酰氧基,饱和杂环羰氧基,烷基磺酰氧基,芳香磺酰氧基,烷基氨基甲酰氧基, 芳族氨基甲酰氧基,烷基羰基氨基或芳族酰氨基,条件是R 1可以进一步代表氢原子,烷基,烯基或炔基; 并且R 3,R 4和R 5各自独立地表示氢原子,烷基或链烯基。

    Tetrahydrobenzindolone derivatives
    18.
    发明授权
    Tetrahydrobenzindolone derivatives 有权
    四氢苯并吲哚酮衍生物

    公开(公告)号:US6077840A

    公开(公告)日:2000-06-20

    申请号:US331294

    申请日:1999-06-18

    摘要: Compounds represented by the following formula (I) or pharmaceutically acceptable salts thereof and a process for producing the same are disclosed. The compounds have progesterone receptor binding inhibitory activity and, hence, can be used as therapeutic and prophylactic agents for progesterone-related diseases. Specifically, they are useful as carcinostatic agents for breast cancer and ovarian cancer, therapeutic agents for hysteromyoma, endometriosis, meningioma, and myeloma, abortifacients, oral contraceptive pills, and therapeutic and prophylactic agents for osteoporosis and climacteric disturbance. ##STR1## wherein R.sup.1 represents alkyl or aralkyl; R.sup.2 represents a hydrogen atom, alkylcarbonyl, cycloalkylcarbonyl, aromatic acyl, heteroaromatic acyl, saturated heterocyclic acyl, alkyl, alkenyl, aralkyl, carbamoyl, alkylcarbamoyl, aromatic carbamoyl, aralkylcarbamoyl, alkylaminocarbonyl, cycloalkylcarbamoyl, alkoxycarbonyl, aryloxycarbonyl, heteroaromatic thiocarbonyl, saturated heterocyclic thiocarbonyl, or alkyl-thiocarbamoyl: and R.sup.3 represents a hydrogen atom, a hydroxyl group, alkyloxy, alkylcarbonyloxy, alkylthio, or arylthio.

    摘要翻译: PCT No.PCT / JP97 / 04683 Sec。 371日期:1999年6月18日 102(e)1999年6月18日PCT 1997年12月18日PCT公布。 第WO98 / 27059号公报 日期:1998年6月25日公开了由下式(I)表示的化合物或其药学上可接受的盐及其制备方法。 所述化合物具有孕酮受体结合抑制活性,因此可用作孕酮相关疾病的治疗和预防剂。 具体地说,它们可用作乳腺癌和卵巢癌的制癌剂,子宫肌瘤,子宫内膜异位症,脑膜瘤和骨髓瘤的治疗剂,流产者,口服避孕药以及用于骨质疏松和更年期障碍的治疗和预防剂。 其中R1表示烷基或芳烷基; R 2表示氢原子,烷基羰基,环烷基羰基,芳香族酰基,杂芳基酰基,饱和杂环酰基,烷基,烯基,芳烷基,氨基甲酰基,烷基氨基甲酰基,芳香族氨基甲酰基,芳烷基氨基甲酰基,烷基氨基羰基,环烷基氨基甲酰基,烷氧基羰基,芳氧基羰基,杂芳硫基羰基,饱和杂环硫代羰基, 或烷基 - 硫代氨基甲酰基:和R3表示氢原子,羟基,烷氧基,烷基羰氧基,烷硫基或芳硫基。

    Lead frame having cut-out wing leads
    19.
    发明授权
    Lead frame having cut-out wing leads 失效
    引线框架具有切割机翼引线

    公开(公告)号:US5623162A

    公开(公告)日:1997-04-22

    申请号:US549529

    申请日:1995-10-27

    申请人: Kenichi Kurihara

    发明人: Kenichi Kurihara

    摘要: In a remote tie-bar lead frame 10 rising an island 4 for bearing a semiconductor chip, one pair of hanger pins 1 for supporting the island 4, a number of outwardly extending leads 2 located to surround the island 4 separately from the island 4, and a pair of tie-bars 6 for mutually tying the leads so as to prevent a flow-out of a resin when a resin packaging is carried out, one pair of wing leads 3A outwardly extend from a pair of opposite sides of the island 4 orthogonal to the pair of opposite sides from which the hanger pins 1 extends. Each of the wing leads 3A extends between a pair of adjacent leads, but terminates to slightly outwardly project from a mold line 5.

    摘要翻译: 在用于支撑半导体芯片的一个用于支撑岛屿4的一对悬挂销1的远程连杆引线架10上升,用于支撑岛4的一对悬挂销1,与岛4分开地围绕岛4定位的多个向外延伸的引线2, 以及一对连接杆6,用于相互捆扎引线,以便在进行树脂封装时防止树脂流出,一对机翼引线3A从岛4的一对相对侧向外延伸 与吊架销1延伸的一对相对侧正交。 翼导体3A中的每一个在一对相邻引线之间延伸,但是从模具线5端部略微向外突出。