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公开(公告)号：US20090227614A1
公开(公告)日：2009-09-10
申请号：US12224270
申请日：2007-02-22
申请人： Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
发明人： Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
IPC分类号： A61K31/438 , C07D401/02 , A61P25/28
CPC分类号： C07D471/10
摘要： The present invention relates to modulators of muscarnic receptors of formula (I). The present invention also provides impositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
摘要翻译： 本发明涉及式（I）的毒蕈碱受体调节剂。 本发明还提供包含这种调节剂的作用，及其用于治疗毒蕈碱受体介导的疾病的方法。
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12.发明授权公开(公告)号：US07880007B2
公开(公告)日：2011-02-01
申请号：US11288938
申请日：2005-11-29
申请人： Dennis J. Hurley , Daniele M. Bergeron , Ioana Drutu , Miguel Garcia-Guzman Blanco , Lewis R. Makings , Akiko Nakatani , Gabriel Raffai , Alina Silina
发明人： Dennis J. Hurley , Daniele M. Bergeron , Ioana Drutu , Miguel Garcia-Guzman Blanco , Lewis R. Makings , Akiko Nakatani , Gabriel Raffai , Alina Silina
IPC分类号： C07D211/06 , A61K31/445
CPC分类号： C07D211/10 , A61K31/4439 , C07D211/18 , C07D211/32 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/52 , C07D211/64 , C07D401/04 , C07D401/06 , C07D401/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/10 , C07D417/10 , C07D417/12 , C07D451/02 , C07D493/08
摘要： The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
摘要翻译： 本发明涉及毒蕈碱受体的调节剂。 本发明还提供包含这种调节剂的组合物，及其用于治疗毒蕈碱受体介导的疾病的方法。
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公开(公告)号：US20080015179A1
公开(公告)日：2008-01-17
申请号：US11644124
申请日：2006-12-22
申请人： Lewis Makings , Miguel Blanco , Dennis Hurley , Ioana Drutu , Gabriel Raffai , Daniele Bergeron , Akiko Nakatani , Andreas Termin , Alina Silina
发明人： Lewis Makings , Miguel Blanco , Dennis Hurley , Ioana Drutu , Gabriel Raffai , Daniele Bergeron , Akiko Nakatani , Andreas Termin , Alina Silina
IPC分类号： A61K31/438 , A61K31/497 , A61K31/55 , A61P25/00 , C07D487/00 , C07D487/10 , C07D491/107 , C07D495/04
CPC分类号： A61K31/4545 , A61K31/438 , A61K31/46 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , C07D221/20 , C07D401/04 , C07D401/06 , C07D405/04 , C07D417/14 , C07D471/10 , C07D487/08 , C07D491/10
摘要： The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：US20070043023A1
公开(公告)日：2007-02-22
申请号：US11359960
申请日：2006-02-22
申请人： Lewis Makings , Miguel Blanco , Dennis Hurley , Ioana Drutu , Gabriel Raffai , Daniele Bergeron , Akiko Nakatani , Andreas Termin , Alina Silina
发明人： Lewis Makings , Miguel Blanco , Dennis Hurley , Ioana Drutu , Gabriel Raffai , Daniele Bergeron , Akiko Nakatani , Andreas Termin , Alina Silina
IPC分类号： A61K31/55 , A61K31/4747
CPC分类号： A61K31/4747 , A61K31/435 , A61K31/438 , A61K31/55 , C07D221/20 , C07D223/32 , C07D405/06 , C07D451/02 , C07D471/10 , C07D491/10
摘要： The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：US20060079505A1
公开(公告)日：2006-04-13
申请号：US11208386
申请日：2005-08-19
申请人： Lewis Makings , Miguel Blanco , Dennis Hurley , Ioana Drutu , Gabriel Raffai , Daniele Bergeron , Akiko Nakatani , Andreas Termin , Alina Silina
发明人： Lewis Makings , Miguel Blanco , Dennis Hurley , Ioana Drutu , Gabriel Raffai , Daniele Bergeron , Akiko Nakatani , Andreas Termin , Alina Silina
IPC分类号： A61K31/55 , A61K31/4747 , C07D225/04 , C07D223/14
CPC分类号： C07D401/06 , A61K31/435 , A61K31/438 , A61K31/4747 , A61K31/55 , C07D221/20 , C07D223/32 , C07D405/04 , C07D405/06 , C07D405/12 , C07D451/02 , C07D451/04 , C07D471/10 , C07D491/10
摘要： The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：US20060287303A1
公开(公告)日：2006-12-21
申请号：US11288938
申请日：2005-11-29
申请人： Dennis Hurley , Daniele Bergeron , Ioana Drutu , Miguel Blanco , Lewis Makings , Akiko Nakatani , Gabriel Raffai , Alina Silina
发明人： Dennis Hurley , Daniele Bergeron , Ioana Drutu , Miguel Blanco , Lewis Makings , Akiko Nakatani , Gabriel Raffai , Alina Silina
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/453 , A61K31/452 , C07D417/02 , C07D403/02 , C07D413/02
CPC分类号： C07D211/10 , A61K31/4439 , C07D211/18 , C07D211/32 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/52 , C07D211/64 , C07D401/04 , C07D401/06 , C07D401/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/10 , C07D417/10 , C07D417/12 , C07D451/02 , C07D493/08
摘要： The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：US20170196862A2
公开(公告)日：2017-07-13
申请号：US14876525
申请日：2015-10-06
申请人： Mark Thomas Miller , Corey Anderson , Vijayalaksmi Arumugam , Brian Richard Bear , Hayley Marie Binch , Jeremy J. Ciemens , Thomas Cleveland , Erica Conroy , Timothy Richard Coon , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Sara Sabina Hadida-Ruah , Haripada Khatuya , Pramod Virupax Joshi , Paul John Krenitsky , Chun-Chieh Lin , Gulin Erdogan Marelius , Vito Melillo , Jason McCartney , Georgia McGaughey Nicholls , Fabrice Jean Denis Pierre , Alina Silina , Andreas P. Termin , Johnny Uy , Jinglan Zhou
发明人： Mark Thomas Miller , Corey Anderson , Vijayalaksmi Arumugam , Brian Richard Bear , Hayley Marie Binch , Jeremy J. Ciemens , Thomas Cleveland , Erica Conroy , Timothy Richard Coon , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Sara Sabina Hadida-Ruah , Haripada Khatuya , Pramod Virupax Joshi , Paul John Krenitsky , Chun-Chieh Lin , Gulin Erdogan Marelius , Vito Melillo , Jason McCartney , Georgia McGaughey Nicholls , Fabrice Jean Denis Pierre , Alina Silina , Andreas P. Termin , Johnny Uy , Jinglan Zhou
IPC分类号： A61K31/506 , A61K31/4418 , A61K31/444 , A61K31/44 , C07D213/84 , C07D231/14 , A61K31/415 , C07D209/42 , A61K31/404 , C07D401/12 , A61K31/4439 , C07D401/14 , C07D231/12 , A61K31/497 , C07D417/12 , C07D405/14 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4525 , A61J1/03 , C07D213/82
CPC分类号： A61K31/506 , A61J1/035 , A61K31/404 , A61K31/415 , A61K31/44 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4525 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , C07D209/18 , C07D209/42 , C07D209/49 , C07D213/64 , C07D213/73 , C07D213/82 , C07D213/84 , C07D231/12 , C07D231/14 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/14 , C07D407/12 , C07D413/14 , C07D417/12
摘要： The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
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18.发明授权公开(公告)号：US08828996B2
公开(公告)日：2014-09-09
申请号：US13418737
申请日：2012-03-13
申请人： Sara Sabina Hadida-Ruah , Hayley Marie Binch , Michael Paul DeNinno , Lev Tyler Dewey Fanning , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Nicole Hilgraf , Pramod Joshi , Edward Adam Kallel , Mark Thomas Miller , Joseph Pontillo , Alina Silina , Urvi Jagdishbhai Sheth , Dennis James Hurley , Vijayalaksmi Arumugam
发明人： Sara Sabina Hadida-Ruah , Hayley Marie Binch , Michael Paul DeNinno , Lev Tyler Dewey Fanning , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Nicole Hilgraf , Pramod Joshi , Edward Adam Kallel , Mark Thomas Miller , Joseph Pontillo , Alina Silina , Urvi Jagdishbhai Sheth , Dennis James Hurley , Vijayalaksmi Arumugam
IPC分类号： C07D498/10 , A61K31/537
CPC分类号： C07D498/10
摘要： The invention relates to morpholine spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的吗啉螺环哌啶酰胺化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20120040020A1
公开(公告)日：2012-02-16
申请号：US13104291
申请日：2011-10-27
申请人： Jean-Damien Charrier , Steven John Durrant , David Kay , Michael O'Donnell , Ronald Marcellus Alphonsus Knegtel , Somhairle MacCormick , Joanne Pinder , Stephen Clinton Young , Haley Marie Binch , Thomas Cleveland , Lev Tyler Dewey Fanning , Dennis James Hurley , Pramod Joshi , Urvi Jagdishbhai Sheth , Alina Silina , Philip Michael Reaper , Anisa Nizarali Virani
发明人： Jean-Damien Charrier , Steven John Durrant , David Kay , Michael O'Donnell , Ronald Marcellus Alphonsus Knegtel , Somhairle MacCormick , Joanne Pinder , Stephen Clinton Young , Haley Marie Binch , Thomas Cleveland , Lev Tyler Dewey Fanning , Dennis James Hurley , Pramod Joshi , Urvi Jagdishbhai Sheth , Alina Silina , Philip Michael Reaper , Anisa Nizarali Virani
IPC分类号： A61K33/24 , C07D401/14 , C07D413/14 , A61K31/551 , A61K31/497 , A61K31/5377 , C07D417/14 , A61K31/541 , C07D405/14 , C07D471/04 , C07D491/113 , A61K31/506 , C07D513/04 , C07D409/14 , C07D487/04 , A61K31/4985 , C07D487/10 , A61K38/16 , A61K31/704 , A61K31/675 , A61K31/7068 , A61K31/7072 , A61K31/706 , A61K38/12 , A61P17/06 , A61P35/00 , A61P31/18 , A61P1/16 , A61P31/20 , C07D403/14
CPC分类号： C07D403/14 , A61K31/497 , A61K31/541 , A61K31/551 , A61K45/06 , C07D241/28 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/113
摘要： The present disclosure relates to pyrazine compounds of formula I: wherein L, n, R1, and R2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure; methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure; processes for preparing the compounds of the disclosure; intermediates for the preparation of the compounds of the disclosure; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
摘要翻译： 本公开涉及式I的吡嗪化合物：其中L，n，R 1和R 2如说明书中所述。 这些化合物可用作ATR蛋白激酶的抑制剂。 本公开还涉及包含本公开内容的化合物的药学上可接受的组合物; 使用本公开的化合物治疗各种疾病，病症和病症的方法; 制备本公开的化合物的方法; 用于制备本公开的化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。
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公开(公告)号：US08598205B2
公开(公告)日：2013-12-03
申请号：US13439379
申请日：2012-04-04
申请人： Hayley Binch , Lev T. D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D. J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
发明人： Hayley Binch , Lev T. D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D. J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
IPC分类号： C07D215/38 , A61K31/04
CPC分类号： A61K31/4709 , A61K45/06 , C07D215/56 , C07D221/22 , C07D451/02 , C07D471/06 , C07D471/08 , C07D487/04 , C07D487/08 , C07F7/1804 , G01N33/5041 , G01N33/6872 , G01N2800/382
摘要： The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.
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