利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

41 条记录 (耗时 0.022 秒)

    Prostaglandin derivatives of the .DELTA.2,4-11-deoxy-PEG series
    12.
    发明授权
    Prostaglandin derivatives of the .DELTA.2,4-11-deoxy-PEG series 失效
    DELTA 2,4-11-脱氧-PEG系列前列腺素衍生物

    公开(公告)号：US4258057A

    公开(公告)日：1981-03-24

    申请号：US054874

    申请日：1979-07-05

    申请人： Wilhelm Bartmann ,  Gerhard Beck ,  Ulrich Lerch ,  Martin Bickel

    发明人： Wilhelm Bartmann ,  Gerhard Beck ,  Ulrich Lerch ,  Martin Bickel

    IPC分类号： C07D317/72 ,  A61K31/557 ,  A61K31/5575 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07F9/535 ,  C07F9/54 ,  A01N37/00 ,  C07C69/74

    CPC分类号： C07F9/5428 ,  C07C405/00 ,  C07F9/535

    摘要： The present invention relates to novel prostaglandin derivatives of the formula I ##STR1## which are structurally related to the naturally occurring prostaglandins and in which R.sup.1 denotes (a) hydrogen or a straight-chain or branched, saturated or unsaturated aliphatic or cycloaliphatic hydrocarbon radical having up to ten carbon atoms or (b) a physiologically acceptable metal or NH.sub.4 ion or an ammonium ion which is derived from a primary, secondary or tertiary amine and R.sup.2 denotes a straight-chain, aliphatic hydrocarbon radical having up to six carbon atoms and to a process for their manufacture.The compounds of the invention are distinguished in particular by gastric acid secretion-inhibiting and ulcer-protective properties.

    摘要翻译： 本发明涉及结构上与天然存在的前列腺素相关的式I的新型前列腺素衍生物，其中R1表示（a）氢或直链或支链，饱和或不饱和的脂族或脂环族烃基 具有至多10个碳原子或（b）生理上可接受的金属或NH 4离子或衍生自伯，仲或叔胺的铵离子，R 2表示具有至多6个碳原子的直链脂族烃基， 到他们的制造过程。 本发明的化合物特别区别于胃酸分泌抑制和溃疡保护性质。

    Novel prostaglandin derivatives
    14.
    发明授权
    Novel prostaglandin derivatives 失效
    新型前列腺素衍生物

    公开(公告)号：US4182773A

    公开(公告)日：1980-01-08

    申请号：US816207

    申请日：1977-07-15

    申请人： Wilhelm Bartmann ,  Ulrich Lerch ,  Hermann Teufel ,  Bernward Scholkens ,  Gerhard Beck

    发明人： Wilhelm Bartmann ,  Ulrich Lerch ,  Hermann Teufel ,  Bernward Scholkens ,  Gerhard Beck

    IPC分类号： C07D339/08 ,  A61K31/19 ,  A61K31/215 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D317/72 ,  C07D339/06 ,  C07C177/00

    CPC分类号： C07D317/72 ,  C07C405/00 ,  C07D339/06

    摘要： What is disclosed are prostaglandin-analogous cyclopentane derivatives of the formula I ##STR1## wherein R.sup.1 is hydrogen or a linear or branched, saturated or unsaturated aliphatic or cycloaliphatic radical having from 1 to 8 carbon atoms, or an araliphatic radical having from 7 to 9 carbon atoms, or a physiologically tolerable metal, NH.sub.4 or substituted ammonium ion derived from a primary, secondary or tertiary amine;R.sup.2 is a linear or branched, saturated or unsaturated aliphatic hydrocarbon radical having from 1 to 8 carbon atoms;R.sup.3 is hydrogen or a R.sup.4 CO group wherein R.sup.4 is a hydrogen atom or a linear or branched alkyl group having up to 10 carbon atoms;A is a saturated, linear or branched alkylene group having from 2 to 5 carbon atoms, and a process for the manufacture thereof.

    摘要翻译： 公开的是具有式I的前列腺素类似环戊烷衍生物，其中R 1是氢或具有1至8个碳原子的直链或支链，饱和或不饱和的脂族或脂环族基团，或具有7至9个 碳原子或生理上可耐受的金属，NH 4或衍生自伯，仲或叔胺的取代的铵离子; R2是具有1至8个碳原子的直链或支链饱和或不饱和的脂族烃基; R3是氢或R4CO基，其中R4是氢原子或具有至多10个碳原子的直链或支链烷基; A是具有2至5个碳原子的饱和直链或支链亚烷基及其制备方法。