公开(公告)号：US10155029B2

公开(公告)日：2018-12-18

申请号：US15429532

申请日：2017-02-10

Applicant: ModernaTX, Inc.

Inventor： Tirtha Chakraborty ,  Stephane Bancel ,  Stephen G. Hoge ,  Atanu Roy ,  Antonin De Fougerolles ,  Noubar B. Afeyan

IPC: A61K39/00 ,  C12N15/67

Abstract: The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.

公开(公告)号：US10849920B2

公开(公告)日：2020-12-01

申请号：US15761220

申请日：2016-10-05

Applicant: ModernaTX, Inc.

Inventor： Stephen Hoge ,  Tirtha Chakraborty ,  Gilles Besin ,  Ruchi Jain

IPC: A61K48/00 ,  C07H21/04 ,  A61K31/7115 ,  C12N15/67 ,  A61K9/00 ,  A61K9/127 ,  C12N15/113

Abstract: The disclosure features methods of reducing or inhibiting an anti-drug antibody response in a subject, as well as methods of reducing or inhibiting unwanted immune cell activation in a subject to be treated with a messenger RNA (mRNA), comprising administering to the subject a mRNA, e.g., a chemically modified messenger RNA (mmRNA), encoding a polypeptide of interest, wherein the mRNA comprises at least one microRNA (miR) binding site for a miR expressed in immune cells, such as miR-126 binding site and/or miR-142 binding site, such that an anti-drug antibody response to the polypeptide or interest, or unwanted immune cell activation (e.g., B cell activation, cytokine secretion), is reduced or inhibited in the subject. The disclosure further provides therapeutic treatment regimens designed to reduce or inhibit AD A or unwanted immune cell activation (e.g., B cell activation, cytokine secretion) in a subject being treated with mRNA-based therapeutics.

公开(公告)号：US20190185529A1

公开(公告)日：2019-06-20

申请号：US16036170

申请日：2018-07-16

Applicant: ModernaTX, Inc.

Inventor： Stephen G. Hoge ,  Tirtha Chakraborty ,  Joshua P. Frederick ,  Matthias John ,  Antonin De Fougerolles

IPC: C07K14/47 ,  A61K31/711 ,  C12N15/85 ,  C12N15/113 ,  A61K48/00 ,  A61K31/7105

CPC classification number: C07K14/47 ,  A61K31/7105 ,  A61K31/711 ,  A61K38/00 ,  A61K48/0058 ,  C12N15/113 ,  C12N15/85 ,  C12N2310/141

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of signal-sensor polynucleotides, primary transcripts and mmRNA molecules.

公开(公告)号：US20180291335A1

公开(公告)日：2018-10-11

申请号：US15815020

申请日：2017-11-16

Applicant: ModernaTX, Inc.

Inventor： Stephane Bancel ,  Antonin de Fougerolles ,  Susan Whoriskey ,  Tirtha Chakraborty ,  Eric Yi-Chun Huang

IPC: C12N5/071 ,  C12N15/67 ,  C12N9/02 ,  C12P21/00 ,  C07K14/535

Abstract: The present invention relates to compositions, methods and kits using cell phenotype altering polynucleotides, cell phenotype altering primary transcripts and cell phenotype altering mmRNA molecules.

公开(公告)号：US20170348436A1

公开(公告)日：2017-12-07

申请号：US15403517

申请日：2017-01-11

Applicant: ModernaTX, Inc.

Inventor： Stephane Bancel ,  Tirtha Chakraborty ,  Antonin de Fougerolles ,  Sayda M. Elbashir ,  Matthias John ,  Atanu Roy ,  Susan Whoriskey ,  Kristy M. Wood ,  Paul Hatala ,  Jason P. Schrum ,  Kenechi Ejebe ,  Jeff Lynn Ellsworth ,  Justin Guild

IPC: A61K48/00 ,  A61K9/127 ,  C12P21/00 ,  C12P13/04 ,  C12N15/87 ,  C12N15/85 ,  C12N15/52 ,  C12N15/11 ,  C12N9/00 ,  C12N9/88 ,  C12N9/64 ,  C12N9/42 ,  C12N9/24 ,  C12N9/16 ,  C12N9/10 ,  C07K16/00 ,  C07K14/705 ,  C07K14/62 ,  C07K14/56 ,  C07K14/535 ,  C07K14/525 ,  C07K14/515 ,  C07K14/505 ,  A61K47/54 ,  C07K14/47 ,  C07K14/435 ,  C07K14/005 ,  A61K38/48 ,  A61K38/45 ,  A61K38/21 ,  A61K38/19 ,  A61K38/18 ,  A61K38/17 ,  A61K31/7115 ,  A61K9/51 ,  A61K9/14 ,  C07K14/485 ,  A61K38/00

CPC classification number: A61K48/0066 ,  A61K9/1271 ,  A61K9/145 ,  A61K9/5123 ,  A61K9/5146 ,  A61K9/5153 ,  A61K31/7115 ,  A61K38/00 ,  A61K38/17 ,  A61K38/177 ,  A61K38/1816 ,  A61K38/1891 ,  A61K38/191 ,  A61K38/193 ,  A61K38/212 ,  A61K38/45 ,  A61K38/4846 ,  A61K47/543 ,  A61K48/0033 ,  A61K48/005 ,  A61K48/0075 ,  C07H21/02 ,  C07K14/005 ,  C07K14/435 ,  C07K14/43595 ,  C07K14/47 ,  C07K14/4705 ,  C07K14/4713 ,  C07K14/4723 ,  C07K14/4746 ,  C07K14/475 ,  C07K14/485 ,  C07K14/495 ,  C07K14/505 ,  C07K14/515 ,  C07K14/525 ,  C07K14/535 ,  C07K14/5418 ,  C07K14/56 ,  C07K14/61 ,  C07K14/62 ,  C07K14/705 ,  C07K14/745 ,  C07K16/00 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/40 ,  C12N9/0069 ,  C12N9/0091 ,  C12N9/1051 ,  C12N9/1241 ,  C12N9/16 ,  C12N9/2402 ,  C12N9/2445 ,  C12N9/6435 ,  C12N9/6437 ,  C12N9/644 ,  C12N9/6443 ,  C12N9/6451 ,  C12N9/88 ,  C12N9/93 ,  C12N15/11 ,  C12N15/52 ,  C12N15/85 ,  C12N15/87 ,  C12P13/04 ,  C12P21/00 ,  C12P21/005 ,  C12Y113/12007 ,  C12Y116/03001 ,  C12Y207/07012 ,  C12Y304/21007 ,  C12Y304/21022 ,  C12Y304/21027 ,  C12Y403/02001 ,  C12Y603/02019 ,  Y02A50/401 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/423 ,  Y02A50/463 ,  Y02A50/491

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

公开(公告)号：US09814760B2

公开(公告)日：2017-11-14

申请号：US14878400

申请日：2015-10-08

Applicant: ModernaTX, Inc.

Inventor： Stephane Bancel ,  Tirtha Chakraborty ,  Antonin de Fougerolles ,  Sayda M. Elbashir ,  Matthias John ,  Atanu Roy ,  Susan Whoriskey ,  Kristy M. Wood ,  Paul Hatala ,  Jason P. Schrum ,  Kenechi Ejebe ,  Jeff Lynn Ellsworth ,  Justin Guild

IPC: C07H21/02 ,  C12N15/85 ,  A61K38/17 ,  C07K14/47 ,  C07K14/62 ,  A61K48/00 ,  A61K31/7115 ,  C12N9/88 ,  A61K9/127 ,  C12N15/11 ,  C07K14/705 ,  C07K14/505 ,  C07K14/535 ,  C12N9/64 ,  C12N9/10 ,  C12N9/00 ,  C12N9/42 ,  C12N15/87 ,  C12P13/04 ,  A61K38/45 ,  C07K14/005 ,  C12N9/16 ,  C12N9/24 ,  C12N15/52 ,  C07K14/435 ,  C12P21/00 ,  C07K14/485 ,  C07K14/475 ,  C07K14/495 ,  C07K14/525 ,  C07K14/54 ,  C07K14/56 ,  C07K14/61 ,  C07K14/745 ,  C07K16/28 ,  C07K16/40 ,  C12N9/02 ,  C12N9/12 ,  C12N9/68 ,  A61K38/00

CPC classification number: A61K48/0066 ,  A61K9/1271 ,  A61K9/145 ,  A61K9/5123 ,  A61K9/5146 ,  A61K9/5153 ,  A61K31/7115 ,  A61K38/00 ,  A61K38/17 ,  A61K38/177 ,  A61K38/1816 ,  A61K38/1891 ,  A61K38/191 ,  A61K38/193 ,  A61K38/212 ,  A61K38/45 ,  A61K38/4846 ,  A61K47/543 ,  A61K48/0033 ,  A61K48/005 ,  A61K48/0075 ,  C07H21/02 ,  C07K14/005 ,  C07K14/435 ,  C07K14/43595 ,  C07K14/47 ,  C07K14/4705 ,  C07K14/4713 ,  C07K14/4723 ,  C07K14/4746 ,  C07K14/475 ,  C07K14/485 ,  C07K14/495 ,  C07K14/505 ,  C07K14/515 ,  C07K14/525 ,  C07K14/535 ,  C07K14/5418 ,  C07K14/56 ,  C07K14/61 ,  C07K14/62 ,  C07K14/705 ,  C07K14/745 ,  C07K16/00 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/40 ,  C12N9/0069 ,  C12N9/0091 ,  C12N9/1051 ,  C12N9/1241 ,  C12N9/16 ,  C12N9/2402 ,  C12N9/2445 ,  C12N9/6435 ,  C12N9/6437 ,  C12N9/644 ,  C12N9/6443 ,  C12N9/6451 ,  C12N9/88 ,  C12N9/93 ,  C12N15/11 ,  C12N15/52 ,  C12N15/85 ,  C12N15/87 ,  C12P13/04 ,  C12P21/00 ,  C12P21/005 ,  C12Y113/12007 ,  C12Y116/03001 ,  C12Y207/07012 ,  C12Y304/21007 ,  C12Y304/21022 ,  C12Y304/21027 ,  C12Y403/02001 ,  C12Y603/02019 ,  Y02A50/401 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/423 ,  Y02A50/463 ,  Y02A50/491

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

公开(公告)号：US09597380B2

公开(公告)日：2017-03-21

申请号：US14043927

申请日：2013-10-02

Applicant: ModernaTX, Inc.

Inventor： Tirtha Chakraborty ,  Stephane Bancel ,  Stephen G. Hoge ,  Atanu Roy ,  Antonin de Fougerolles ,  Noubar B. Afeyan

IPC: A61K39/00 ,  A61K48/00 ,  C07H21/04 ,  C12N15/67

CPC classification number: A61K39/00 ,  C12N15/67

Abstract: The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.