-
公开(公告)号：US09474787B2
公开(公告)日：2016-10-25
申请号：US14556281
申请日：2014-12-01
Inventor： Avinoam Kadouri , Avihay Bar-Ilan , Eldad Melamed , Daniel Offen , Ofer Sadan , Merav Bahat-Stromza
CPC classification number: A61K38/185 , A61K35/12 , A61K35/28 , C12N5/0618 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0669 , C12N2500/84 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2506/1353
Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.
Abstract translation: 公开了一种分离的人细胞，其包含至少一种间充质干细胞表型和分泌性脑源性神经营养因子（BDNF），其中BDNF的基础分泌比间充质干细胞中BDNF的基础分泌高至少五倍 。 还公开了生产方法及其用途。
-
公开(公告)号：US20150290298A1
公开(公告)日：2015-10-15
申请号：US14442731
申请日：2013-11-14
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Henn Benkler , Daniel Offen
CPC classification number: A61K38/44 , A01K2227/105 , A01K2267/0318 , A61K38/1709 , A61K38/43 , A61K45/06 , A61K48/00 , A61K48/005 , C12N2740/15043 , C12Y104/01003
Abstract: A method of treating a disease selected from the group consisting of emphysema, sepsis, septic shock, ischemic injury, cerebral ischemia, a neurodegenerative disorder, meningitis, encephalitis, hemorrhage, cerebral ischemia, heart ischemia and a cognitive deficit in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of a combination of at least two agents, wherein a first of said two agents upregulates an activity and/or expression of Nrf2 and a second of said two agents is a glutamatergic modulator, thereby treating the disease.
Abstract translation: 一种在有需要的受试者中治疗选自肺气肿，败血症，败血症休克，缺血性损伤，脑缺血，神经变性疾病，脑膜炎，脑炎，出血，脑缺血，心脏缺血和认知缺陷的疾病的方法 被提供。 所述方法包括向受试者施用治疗有效量的至少两种试剂的组合，其中所述两种试剂中的第一种上调Nrf2的活性和/或表达，所述两种试剂中的第二种是谷氨酸能调节剂，由此处理 这种病。
-
公开(公告)号：US08900574B2
公开(公告)日：2014-12-02
申请号：US14164286
申请日：2014-01-27
Inventor： Avinoam Kadouri , Avihay Bar-Ilan , Eldad Melamed , Daniel Offen , Ofer Sadan , Merav Bahat-Stromza
CPC classification number: A61K38/185 , A61K35/12 , A61K35/28 , C12N5/0618 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0669 , C12N2500/84 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2506/1353
Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.
Abstract translation: 公开了一种分离的人细胞，其包含至少一种间充质干细胞表型和分泌性脑源性神经营养因子（BDNF），其中BDNF的基础分泌比间充质干细胞中BDNF的基础分泌高至少五倍 。 还公开了生产方法及其用途。
-
14.发明申请METHODS, NUCLEIC ACID CONSTRUCTS AND CELLS FOR TREATING NEURODEGENERATIVE DISORDERS 审中-公开方法，用于治疗神经损伤性疾病的核酸结构和细胞公开(公告)号：US20130236964A1
公开(公告)日：2013-09-12
申请号：US13783607
申请日：2013-03-04
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Eldad MELAMED , Daniel Offen , Yosef Levy , Pnina Green
IPC: C12N5/0793
CPC classification number: C12N5/0619 , A01K67/027 , A01K2227/105 , A01K2267/0306 , A61K48/0058 , C12N15/635 , C12N15/85 , C12N2830/008 , C12N2830/205 , C12N2840/203
Abstract: A method of treating a neurodegenerative disorder is provided. The method is effected by administering to an individual in need thereof cells capable of exogenously regulatable neurotransmitter synthesis thereby treating the neurodegenerative disorder.
Abstract translation: 提供治疗神经变性疾病的方法。 该方法通过向有需要的个体施用能够外源可调节的神经递质合成的细胞来实现，从而治疗神经变性疾病。
-
公开(公告)号：US20230330130A1
公开(公告)日：2023-10-19
申请号：US18194163
申请日：2023-03-31
Inventor： Shulamit Levenberg , Shaowei Guo , Daniel Offen , Nisim Perets
IPC: A61K31/713 , A61K35/28 , A61K38/51 , C12N15/113 , A61K9/50 , C12N15/11
CPC classification number: A61K31/713 , A61K35/28 , A61K38/51 , C12N15/1137 , A61K9/5068 , C12N15/111 , C12N15/113 , A61K9/127
Abstract: The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.
-
Patent Agency Ranking
公开(公告)号：US10052363B2
公开(公告)日：2018-08-21
申请号：US15261959
申请日：2016-09-11
Inventor： Avinoam Kadouri , Avihay Bar-Ilan , Eldad Melamed , Daniel Offen , Ofer Sadan , Merav Bahat-Stromza
CPC classification number: A61K38/185 , A61K35/12 , A61K35/28 , C12N5/0618 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0669 , C12N2500/84 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2506/1353
Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.
-
公开(公告)号：US10040836B2
公开(公告)日：2018-08-07
申请号：US15404378
申请日：2017-01-12
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Daniel Offen , Israel Aharony
Abstract: An isolated peptide comprising a Huntingtin (Htt) amino acid sequence being no longer than 15 amino acids, wherein said Htt amino acid sequence comprises the sequence X1X2X3X4 X5, wherein X1 is a hydrophobic amino acid or threonine, X2 is a hydrophobic amino acid, X3 is a hydrophobic amino acid, X4 is an acidic amino acid and X5 is selected from the group consisting of glycine, serine and alanine, the peptide capable of specifically inhibiting the activity of caspase 6.
-
公开(公告)号：US09598478B2
公开(公告)日：2017-03-21
申请号：US14433047
申请日：2013-03-05
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Daniel Offen , Israel Aharony
CPC classification number: C07K14/47 , A61K38/00 , C07K14/4703 , C07K14/8139 , C07K2319/10
Abstract: An isolated peptide comprising a Huntingtin (Htt) amino acid sequence being no longer than 15 amino acids, wherein said Htt amino acid sequence comprises the sequence X1X2X3X4 X5, wherein X1 is a hydrophobic amino acid or threonine, X2 is a hydrophobic amino acid, X3 is a hydrophobic amino acid, X4 is an acidic amino acid and X5 is selected from the group consisting of glycine, serine and alanine, the peptide capable of specifically inhibiting the activity of caspase 6.
-
19.发明申请公开(公告)号：US20140335059A1
公开(公告)日：2014-11-13
申请号：US14359623
申请日：2012-11-21
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Sandu Pitaru , Javier Ganz , Daniel Offen , Eldad Melamed
CPC classification number: A61K35/30 , A61K2035/124 , C12N5/0619 , C12N5/0622 , C12N2500/38 , C12N2500/90 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/13 , C12N2501/135 , C12N2501/41 , C12N2501/415 , C12N2501/999 , C12N2506/097
Abstract: The present invention provides methods and uses of neural cells differentiated from adult stem cells of the oral mucosa for cell therapy of neurological and psychiatric diseases and disorders. Methods for direction of differentiation of oral mucosal stem cells into neuronal or neuron supporting cells are also provided.
Abstract translation: 本发明提供了从口腔粘膜的成体干细胞分化的神经细胞用于神经和精神疾病和病症的细胞治疗的方法和用途。 还提供了将口腔粘膜干细胞分化为神经元或神经元支持细胞的方向的方法。
-
20.发明申请公开(公告)号：US20130123187A1
公开(公告)日：2013-05-16
申请号：US13662697
申请日：2012-10-29
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Nirit LEV , Daniel Offen , Eldad Melamed
CPC classification number: C07K7/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/162 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1019 , C07K5/1021 , C07K5/1024 , C07K7/08 , C07K14/47 , C12Q1/025 , C12Q1/6897 , G01N33/5058
Abstract: A method of selecting an agent comprising a neuroprotecting activity is disclosed. The method comprises: (a) introducing a plurality of agents into a plurality of cells; and (b) analyzing Vesicular Monoamine Transporter 2 (VMAT2) transcription in the cells; and (c) identifying an agent of the plurality of agents capable of up-regulating DJ-1-dependent VMAT2 transcription in the cells, thereby selecting the agent comprising the neuroprotecting activity.
Abstract translation: 公开了选择包含神经保护活性的试剂的方法。 该方法包括：（a）将多个试剂引入多个单元中; 和（b）分析细胞中的Vesicular Monoamine Transporter 2（VMAT2）转录; 和（c）鉴定能够在细胞中上调DJ-1依赖性VMAT2转录的多种试剂的试剂，从而选择包含神经保护活性的试剂。
-
-
-
-
-
-
-
-
-
Search Results
20
records
(took 0.032 seconds)
