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11.Capturing sequences adjacent to type-IIS restriction sites for genomic library mapping 有权
标题翻译: 捕获与基因组文库映射的类型-Ill限制位点相邻的序列公开(公告)号:US07662559B2
公开(公告)日:2010-02-16
申请号:US10942479
申请日:2004-09-16
IPC分类号: C12Q1/68
CPC分类号: C12Q1/683 , C12Q1/6806 , C12Q1/6809 , C12Q1/6827 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2565/501 , C12Q2600/156 , C12Q2525/191 , C12Q2521/313 , C12Q2525/179 , C12Q2525/161 , C12Q2525/155 , C12Q2525/143 , C12Q2525/131
摘要: The present invention relates to novel methods for sequencing and mapping genetic markers in polynucleotide sequences using Type-IIs restriction endonucleases. The methods herein described result in the “capturing” and determination of specific oligonucleotide sequences located adjacent to Type-IIs restriction sites. The resulting sequences are useful as effective markers for use in genetic mapping, screening and manipulation.
摘要翻译: 本发明涉及使用II型限制性内切核酸酶对多核苷酸序列中的遗传标记进行测序和鉴定的新方法。 本文描述的方法导致“捕获”和确定与II型限制性位点相邻的特定寡核苷酸序列。 所得序列可用作用于遗传图谱,筛选和操纵的有效标记。
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12.Capturing sequences adjacent to type-IIs restriction sites for genomic library mapping 失效
标题翻译: 捕获与II型限制性位点相邻的基因组文库作图的序列公开(公告)号:US07985547B2
公开(公告)日:2011-07-26
申请号:US12272680
申请日:2008-11-17
IPC分类号: C12Q1/68
CPC分类号: C12Q1/683 , C12Q1/6806 , C12Q1/6809 , C12Q1/6827 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2565/501 , C12Q2600/156 , C12Q2525/191 , C12Q2521/313 , C12Q2525/179 , C12Q2525/161 , C12Q2525/155 , C12Q2525/143 , C12Q2525/131
摘要: The present invention relates to novel methods for sequencing and mapping genetic markers in polynucleotide sequences using Type-IIs restriction endonucleases. The methods herein described result in the “capturing” and determination of specific oligonucleotide sequences located adjacent to Type-IIs restriction sites. The resulting sequences are useful as effective markers for use in genetic mapping, screening and manipulation.
摘要翻译: 本发明涉及使用II型限制性内切核酸酶对多核苷酸序列中的遗传标记进行测序和鉴定的新方法。 本文描述的方法导致“捕获”和确定与II型限制性位点相邻的特定寡核苷酸序列。 所得序列可用作用于遗传图谱,筛选和操纵的有效标记。
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13.Capturing sequences adjacent to Type-IIs restriction sites for genomic library mapping 失效
标题翻译: 捕获与II型限制性位点相邻的序列用于基因组文库绘制公开(公告)号:US5710000A
公开(公告)日:1998-01-20
申请号:US485606
申请日:1995-06-07
CPC分类号: C12Q1/683 , C12Q1/6806 , C12Q1/6809 , C12Q1/6827 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2565/501 , C12Q2600/156
摘要: The present invention relates to novel methods for sequencing and mapping genetic markers in polynucleotide sequences using Type-IIs restriction endonucleases. The methods herein described result in the "capturing" and determination of specific oligonucleotide sequences located adjacent to Type-IIs restriction sites. The resulting sequences are useful as effective markers for use in genetic mapping, screening and manipulation.
摘要翻译: 本发明涉及使用II型限制性内切核酸酶对多核苷酸序列中的遗传标记进行测序和鉴定的新方法。 本文描述的方法导致“捕获”和确定与II型限制性位点相邻的特定寡核苷酸序列。 所得序列可用作用于遗传图谱,筛选和操纵的有效标记。
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14.
公开(公告)号:US20120329677A9
公开(公告)日:2012-12-27
申请号:US11506176
申请日:2006-08-18
申请人: Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P.A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
发明人: Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P.A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
CPC分类号: C12Q1/6874 , C12Q1/6886
摘要: The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the CFTR gene.
摘要翻译: 本发明提供了固定化探针的阵列,以及采用阵列的方法,用于检测CFTR基因中的突变。
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15.
公开(公告)号:US07399584B2
公开(公告)日:2008-07-15
申请号:US09510378
申请日:2000-02-22
申请人: Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P. A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
发明人: Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P. A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
CPC分类号: C07H21/00 , B01J19/0046 , B01J2219/00432 , B01J2219/00529 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C07B2200/11 , C12Q1/6827 , C12Q1/6837 , C12Q1/6869 , C12Q1/6874 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C40B40/06 , C40B60/14 , C12Q2565/513
摘要: The invention provides methods of comparing a target nucleic acid with a reference nucleic acid using nucleic acid arrays.
摘要翻译: 本发明提供了使用核酸阵列比较靶核酸与参考核酸的方法。
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公开(公告)号:US20080261832A1
公开(公告)日:2008-10-23
申请号:US11506176
申请日:2006-08-18
申请人: Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P.A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
发明人: Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P.A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
CPC分类号: C12Q1/6874 , C12Q1/6886
摘要: The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the CFTR gene.
摘要翻译: 本发明提供了固定化探针的阵列,以及采用阵列的方法,用于检测CFTR基因中的突变。
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公开(公告)号:US5837832A
公开(公告)日:1998-11-17
申请号:US441887
申请日:1995-05-16
申请人: Mark Chee , Maureen T. Cronin , Stephen P. A. Fodor , Xiaohua X. Huang , Earl A. Hubbell , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
发明人: Mark Chee , Maureen T. Cronin , Stephen P. A. Fodor , Xiaohua X. Huang , Earl A. Hubbell , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
CPC分类号: C07H21/00 , B01J19/0046 , B82Y30/00 , B01J2219/00432 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00689 , B01J2219/00711 , B01J2219/00722 , C07B2200/11 , C40B40/06 , C40B60/14
摘要: DNA chips containing arrays of oligonucleotide probes can be used to determine whether a target nucleic acid has a nucleotide sequence identical to or different from a specific reference sequence. The array of probes comprises probes exactly complementary to the reference sequence, as well as probes that differ by one or more bases from the exactly complementary probes.
摘要翻译: 可以使用含有寡核苷酸探针阵列的DNA芯片来确定靶核酸是否具有与特定参考序列相同或不同的核苷酸序列。 探针阵列包括与参考序列完全互补的探针,以及与精确互补探针不同的一个或多个碱基的探针。
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公开(公告)号:US06468744B1
公开(公告)日:2002-10-22
申请号:US09341399
申请日:1999-11-17
申请人: Maureen T. Cronin , Edward L. Sheldon , Charles G. Miyada , Earl A. Hubbell , Mark Chee , Stephen P. A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris
发明人: Maureen T. Cronin , Edward L. Sheldon , Charles G. Miyada , Earl A. Hubbell , Mark Chee , Stephen P. A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris
IPC分类号: C12Q168
CPC分类号: B01J19/0046 , B01J2219/00432 , B01J2219/00529 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00644 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C07B2200/11 , C07H21/00 , C12Q1/6827 , C12Q1/6837 , C12Q1/6874 , C12Q1/6876 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C40B40/06 , C40B60/14 , C12Q2565/513
摘要: The invention provides methods for detecting variations in polymorphic sites and/or variations in gene copy number. The methods are particularly useful for analysis of biotransformation genes, such as cytochromes P450.
摘要翻译: 本发明提供了用于检测多态位点变异和/或基因拷贝数变异的方法。 该方法对生物转化基因如细胞色素P450的分析特别有用。
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19.Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis 失效
标题翻译: 核酸探针阵列及其用于检测囊性纤维化的方法公开(公告)号:US6027880A
公开(公告)日:2000-02-22
申请号:US544381
申请日:1995-10-10
申请人: Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P. A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , Macdonald S. Morris , Edward L. Sheldon
发明人: Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P. A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , Macdonald S. Morris , Edward L. Sheldon
CPC分类号: C07H21/00 , B01J19/0046 , B82Y30/00 , C12Q1/6827 , C12Q1/6837 , C12Q1/6869 , C12Q1/6874 , C12Q1/6883 , B01J2219/00432 , B01J2219/00529 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , C07B2200/11 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C40B40/06 , C40B60/14
摘要: The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the CFTR gene.
摘要翻译: 本发明提供了固定化探针的阵列,以及采用阵列的方法,用于检测CFTR基因中的突变。
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20.Computer-aided engineering system for design of sequence arrays and lithographic masks 失效
标题翻译: 用于设计序列阵列和光刻掩模的计算机辅助工程系统公开(公告)号:US5593839A
公开(公告)日:1997-01-14
申请号:US460411
申请日:1995-06-02
IPC分类号: B01J19/00 , C07B61/00 , C07K1/04 , C40B40/06 , C40B60/14 , G03F1/00 , C12Q1/68 , C07H21/04 , G03F9/00
CPC分类号: B82Y30/00 , B01J19/0046 , C07K1/04 , C07K1/045 , B01J2219/00432 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00693 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要: An improved set of computer tools for forming arrays. According to one aspect of the invention, a computer system is used to select probes and design the layout of an array of DNA or other polymers with certain beneficial characteristics. According to another aspect of the invention, a computer system uses chip design files to design and/or generate lithographic masks.
摘要翻译: 一组改进的用于形成阵列的计算机工具。 根据本发明的一个方面,计算机系统用于选择探针并设计具有某些有益特征的DNA或其它聚合物阵列的布局。 根据本发明的另一方面,计算机系统使用芯片设计文件来设计和/或生成光刻掩模。
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