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11.发明申请METHOD TO PERFORM A MEASUREMENT OF AN ANALYTE IN A SAMPLE USING AN AUTOMATIC ANALYZER 审中-公开使用自动分析仪在样品中进行分析仪测量的方法公开(公告)号：US20160216289A1
公开(公告)日：2016-07-28
申请号：US15092806
申请日：2016-04-07
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Manfred Augstein , Nadine Losleben , Thorsten Brueckner , Christoph Boehm , Juergen Spinke
CPC classification number: G01N35/1002 , B01L3/021 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2200/04 , B01L2300/02 , B01L2300/042 , B01L2300/0609 , B01L2300/0663 , B01L2300/123 , B01L2400/0481 , G01F11/082 , G01F11/086 , G01F11/088 , G01N35/00871 , G01N2035/1034
Abstract: A method of performing a measurement of an analyte in a sample using an automatic analyzer is provided. The automatic analyzer comprises: a cartridge for dispensing a fluid, a measurement unit for performing the measurement, a sample holder for receiving the sample, and a pump for pumping the fluid out of the cartridge and into the sample holder. The cartridge comprises: a rigid portion, a flexible bladder, and an outlet. The rigid portion comprises an opening, which is connected to an inner cavity. The flexible bladder seals the opening to form a fluid chamber from the inner cavity. The fluid chamber is at least partially filled with the fluid. The pump is connected to the outlet. The method comprises: placing the sample into the sample holder, controlling the pumping of the fluid from the cartridge into the sample holder, and performing the measurement of the analyte using the measurement unit.
Abstract translation: 提供了使用自动分析仪对样品中的分析物进行测量的方法。 自动分析仪包括：用于分配流体的盒，用于执行测量的测量单元，用于接收样品的样品保持器和用于将流体从盒中抽出并进入样品架的泵。 盒包括：刚性部分，柔性囊和出口。 刚性部分包括连接到内腔的开口。 柔性气囊密封开口以从内腔形成流体室。 流体室至少部分地被流体填充。 泵连接到出口。 该方法包括：将样品放入样品架中，控制将流体从料筒泵送到样品架中，并使用测量单元进行分析物的测量。
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公开(公告)号：US12194466B2
公开(公告)日：2025-01-14
申请号：US17229086
申请日：2021-04-13
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Thorsten Brueckner , Thomas Fischer , Eloisa Lopez-Calle , Sascha Lutz , Josef Roedl , Juergen Spinke , Pamela Espindola , Thomas Manuel Keller , Thomas Dolbinow , Sabrina Adler , Erik Beiersdorf , Domenik Wensorra
Abstract: A medical system for determining an analyte quantity in a blood sample via a cartridge that spins around a rotational axis. The cartridge may include: a separation chamber that separates blood plasma from the sample; a processing chamber containing a reagent with a specific binding partner which binds to the analyte to form an analyte specific binding partner complex; a first valve structure connecting the separation chamber to the processing chamber; a measurement structure to measure the quantity of the analyte, wherein the measurement structure includes a chromatographic membrane with an immobilized binding partner for direct or indirect binding of the analyte or the analyte specific binding partner complex, and an absorbent structure that is nearer to the axis than the membrane; a second valve structure connecting the processing chamber to the measurement structure; and a fluid chamber filled with a washing buffer and fluidically connected to the measurement structure.
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公开(公告)号：US11000848B2
公开(公告)日：2021-05-11
申请号：US15982009
申请日：2018-05-17
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Thomas Dolbinow , Sabrina Adler , Erik Beiersdorf , Domenik Wensorra , Thorsten Brueckner , Thomas Fischer , Eloisa Lopez-Calle , Sascha Lutz , Josef Roedl , Juergen Spinke , Pamela Espindola , Thomas Manuel Keller
Abstract: A medical system for determining an analyte quantity in a blood sample via a cartridge that spins around a rotational axis. The cartridge may include: a separation chamber that separates blood plasma from the sample; a processing chamber containing a reagent with a specific binding partner which binds to the analyte to form an analyte specific binding partner complex; a first valve structure connecting the separation chamber to the processing chamber; a measurement structure to measure the quantity of the analyte, wherein the measurement structure includes a chromatographic membrane with an immobilized binding partner for direct or indirect binding of the analyte or the analyte specific binding partner complex, and an absorbent structure that is nearer to the axis than the membrane; a second valve structure connecting the processing chamber to the measurement structure; and a fluid chamber filled with a washing buffer and fluidically connected to the measurement structure.
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公开(公告)号：US09573131B2
公开(公告)日：2017-02-21
申请号：US14530857
申请日：2014-11-03
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Thorsten Brueckner , Peter Koltay , Norbert Oranth , Juergen Spinke , Laurent Tanguy
CPC classification number: B01L3/52 , B01L1/00 , B01L3/523 , B01L5/00 , B01L2200/0684 , B01L2200/141 , B01L2300/048 , B01L2300/0681 , B01L2400/086 , G01N35/1002 , Y10T436/11
Abstract: A cartridge for dispensing a fluid is presented. The cartridge comprises a reservoir chamber for receiving the fluid and for receiving a ventilation gas. The reservoir chamber comprises an inlet for receiving the ventilation gas and an outlet for dispensing the fluid. At least a portion of the reservoir chamber is filled with the ventilation gas when in an operating position. The inlet is located in the portion being filled with the ventilation gas. The fluid comprises a reagent. The cartridge further comprises a baffle for restricting gas diffusion through the inlet. The reservoir chamber receives the ventilation gas via the baffle. The inlet is maintains a constant gas pressure within the portion of the reservoir chamber that is being filled with the ventilation gas.
Abstract translation: 呈现用于分配流体的盒。 墨盒包括用于接收流体并用于接收通气气体的储存室。 储存室包括用于接收通气气体的入口和用于分配流体的出口。 当处于操作位置时，储存室的至少一部分填充有通气气体。 入口位于填充有通气气体的部分中。 流体包含试剂。 墨盒还包括用于限制通过入口的气体扩散的挡板。 储存室通过挡板接收通气气体。 入口在储存室的被填充有通风气体的部分内保持恒定的气体压力。
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15.发明授权Microfluidic dispenser, cartridge and analysis system for analyzing a biological sample 有权用于分析生物样品的微流量分配器，盒和分析系统公开(公告)号：US09469464B2
公开(公告)日：2016-10-18
申请号：US14530861
申请日：2014-11-03
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Timo Klein , Peter Koltay , Nadine Losleben , Juergen Spinke , Chris Steinert
CPC classification number: B65D83/14 , B01L3/0265 , B01L3/502738 , B01L3/505 , B01L3/523 , B01L3/527 , B01L2300/123 , B01L2400/0611 , G01N35/1016
Abstract: A dispenser for dispensing a fluid is presented. The dispenser comprises a compressible elastomeric fluid conduit having a first end and a second end for flowing the fluid from the first end to the second end, a first check valve and a second check valve distanced in the conduit for forming a fluid chamber, and an actor for compressing the fluid chamber for dispensing a portion of the fluid. At least the second check valve is a duckbill valve. The second check valve is located at the second end of the conduit. The second check valve has sealing lips that extend beyond the second end of the conduit.
Abstract translation: 呈现用于分配流体的分配器。 分配器包括可压缩弹性体流体导管，其具有第一端和用于使流体从第一端流到第二端的第二端，在导管中间隔开形成流体室的第一止回阀和第二止回阀，以及 演员，用于压缩流体室以分配一部分流体。 至少第二止回阀是鸭嘴阀。 第二止回阀位于导管的第二端。 第二止回阀具有延伸超出导管第二端的密封唇。
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Patent Agency Ranking
公开(公告)号：US20150050186A1
公开(公告)日：2015-02-19
申请号：US14530858
申请日：2014-11-03
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Stefan Borja Bammesberger , Sabrina Kartmann , Peter Koltay , Klaus Mutschler , Juergen Spinke , Laurent Tanguy
CPC classification number: B01L3/567 , B01L3/0265 , B01L3/52 , B01L2300/0838 , B01L2400/0666 , F16K99/0005 , F16K99/0042 , F16K2099/0084 , G01N35/0099 , G01N35/1002 , G01N35/1016 , G01N2035/1034
Abstract: A valve for dispensing a fluid comprising a dry portion and a wet portion is presented. Only the wet portion is contacted by the fluid. The wet portion comprises a fluid dispenser unit having a inlet opening, a capillary nozzle providing a fluid outlet, a cavity, the capillary nozzle having an end within the cavity, and a plunger. The plunger moves within the cavity into an opening position allowing an inflow of the fluid through the inlet opening through the cavity and an outflow of the fluid through the capillary nozzle. The plunger has a sealing surface directed towards the end of the capillary nozzle. The plunger moves into a closing position for sealing the end of the capillary nozzle with the sealing surface. The dry portion comprises a closing component for exercising a magnetic closing force onto the plunger for attracting the plunger into the closing position.
Abstract translation: 提出了一种用于分配包括干燥部分和湿部分的流体的阀。 只有湿部分被流体接触。 湿部分包括具有入口开口的流体分配器单元，提供流体出口的毛细管嘴，空腔，毛细管喷嘴在腔内具有一端，以及柱塞。 柱塞在空腔内移动到打开位置，允许流体通过入口通过空腔流入，流体通过毛细管喷嘴流出。 柱塞具有指向毛细管喷嘴端部的密封表面。 柱塞移动到关闭位置，以用密封表面密封毛细管嘴的端部。 所述干燥部分包括关闭部件，用于对所述柱塞施加磁力关闭力，以将所述柱塞吸引到所述关闭位置。
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公开(公告)号：US20210229098A1
公开(公告)日：2021-07-29
申请号：US17229086
申请日：2021-04-13
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Thorsten Brueckner , Thomas Fischer , Eloisa Lopez-Calle , Sascha Lutz , Josef Roedl , Juergen Spinke , Pamela Espindola , Thomas Manuel Keller , Thomas Dolbinow , Sabrina Adler , Erik Beiersdorf , Domenik Wensorra
Abstract: A medical system for determining an analyte quantity in a blood sample via a cartridge that spins around a rotational axis. The cartridge may include: a separation chamber that separates blood plasma from the sample; a processing chamber containing a reagent with a specific binding partner which binds to the analyte to form an analyte specific binding partner complex; a first valve structure connecting the separation chamber to the processing chamber; a measurement structure to measure the quantity of the analyte, wherein the measurement structure includes a chromatographic membrane with an immobilized binding partner for direct or indirect binding of the analyte or the analyte specific binding partner complex, and an absorbent structure that is nearer to the axis than the membrane; a second valve structure connecting the processing chamber to the measurement structure; and a fluid chamber filled with a washing buffer and fluidically connected to the measurement structure.
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公开(公告)号：US10330693B2
公开(公告)日：2019-06-25
申请号：US15132915
申请日：2016-04-19
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Peter Kupser , Norbert Oranth , Juergen Spinke , Thorsten Brueckner , Timo Klein
Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.
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公开(公告)号：US10307757B2
公开(公告)日：2019-06-04
申请号：US15833476
申请日：2017-12-06
Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
Inventor： Christoph Boehm , Sascha Lutz , Juergen Spinke
Abstract: An automatic analyzer cartridge, spinnable around a rotational axis, has aliquoting and metering chambers, a connecting duct there between, and a vent connected to the metering chamber and nearer to the rotational axis than the metering chamber. The metering chamber has side walls that taper away from a central region. Capillary action next to the side walls is greater than in the central region. A circular arc about the rotational axis passes through a duct entrance in the aliquoting chamber and a duct exit in the metering chamber. The cartridge has a downstream fluidic element which is part of a fluidic structure for processing a biological sample into the processed biological sample. A valve connects the metering chamber to the fluidic element, which is fluidically connected to the fluidic structure. The fluidic structure receives the biological sample and has a measurement structure for enabling measurement of the processed biological sample.
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公开(公告)号：US10252273B2
公开(公告)日：2019-04-09
申请号：US14530858
申请日：2014-11-03
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Stefan Borja Bammesberger , Sabrina Kartmann , Peter Koltay , Klaus Mutschler , Juergen Spinke , Laurent Tanguy
Abstract: A valve for dispensing a fluid comprising a dry portion and a wet portion is presented. Only the wet portion is contacted by the fluid. The wet portion comprises a fluid dispenser unit having a inlet opening, a capillary nozzle providing a fluid outlet, a cavity, the capillary nozzle having an end within the cavity, and a plunger. The plunger moves within the cavity into an opening position allowing an inflow of the fluid through the inlet opening through the cavity and an outflow of the fluid through the capillary nozzle. The plunger has a sealing surface directed towards the end of the capillary nozzle. The plunger moves into a closing position for sealing the end of the capillary nozzle with the sealing surface. The dry portion comprises a closing component for exercising a magnetic closing force onto the plunger for attracting the plunger into the closing position.
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