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公开(公告)号：US20120060230A1
公开(公告)日：2012-03-08
申请号：US13188417
申请日：2011-07-21
申请人： Trevor Collingwood , Laurence J.N. Cooper , Philip D. Gregory , Michael C. Holmes , Jeffrey C. Miller , Edward J. Rebar , Andreas Reik , Fyodor Urnov
发明人： Trevor Collingwood , Laurence J.N. Cooper , Philip D. Gregory , Michael C. Holmes , Jeffrey C. Miller , Edward J. Rebar , Andreas Reik , Fyodor Urnov
IPC分类号： A61K48/00 , C12N15/11 , A61P5/38 , A61P19/00 , A61P37/00 , A61P7/02 , A61P3/00 , A61P31/14 , A61P5/14 , A61P29/00 , A61P17/06 , A61P19/02 , A61P17/00 , A61P19/04 , C12N9/96 , C12N15/63 , C12N1/19 , C12N5/10 , C12N5/071 , C12N5/0775 , C12N5/0735 , C12N5/0797 , A01K67/027 , C07K7/06
CPC分类号： C07K14/70539 , A61K35/17 , C07K2319/81 , C12N15/907 , C12N2800/80
摘要： Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator.
摘要翻译： 本文公开了用于调节HLA基因座表达或选择性删除或操纵HLA基因座或HLA调节子的方法和组合物。
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公开(公告)号：US09834787B2
公开(公告)日：2017-12-05
申请号：US12798749
申请日：2010-04-08
申请人： Philip D. Gregory , Dirk Hockemeyer , Michael C. Holmes , Rudolf Jaenisch , Frank Soldner , Fyodor Urnov , Shuyuan Yao
发明人： Philip D. Gregory , Dirk Hockemeyer , Michael C. Holmes , Rudolf Jaenisch , Frank Soldner , Fyodor Urnov , Shuyuan Yao
CPC分类号： C12N15/86 , C12N9/22 , C12N2710/10343 , C12N2740/15043 , C12N2800/30 , C12N2830/008
摘要： Disclosed herein are methods and compositions for targeted integration of sequences of interest such as lineage-specific or cell fate reporter constructs or protein encoding sequences into stem cells.
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公开(公告)号：US20110136895A1
公开(公告)日：2011-06-09
申请号：US12927557
申请日：2010-11-17
申请人： Philip D. Gregory , Michael C. Holmes , Matthew C. Mendel , Xiangdong Meng , David Paschon , Andreas Reik , Fyodor Urnov
发明人： Philip D. Gregory , Michael C. Holmes , Matthew C. Mendel , Xiangdong Meng , David Paschon , Andreas Reik , Fyodor Urnov
IPC分类号： A61K31/7088 , C07K14/435 , C07H21/00 , C12N5/0783 , A61P35/00 , A61P31/12
CPC分类号： A61K38/1709 , A61K35/17 , A61P31/12 , A61P35/00 , C07K2319/71 , C12N9/22
摘要： Disclosed herein are methods and compositions for modulating expression of a PD1 gene.
摘要翻译： 本文公开了调节PD1基因表达的方法和组合物。
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公开(公告)号：US20110301073A1
公开(公告)日：2011-12-08
申请号：US13068735
申请日：2011-05-17
申请人： Philip D. Gregory , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Siyuan Tan , Fyodor Urnov , Lei Zhang
发明人： Philip D. Gregory , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Siyuan Tan , Fyodor Urnov , Lei Zhang
IPC分类号： A61K38/02 , C07K19/00 , C12N9/16 , C12N5/071 , C12N5/04 , C12N1/21 , C07H21/00 , C12N1/19 , C12N5/10 , C12N1/15 , C12N1/13 , C12N1/11 , C07K14/00 , C12N1/16
CPC分类号： C12N15/907 , A61K38/00 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/52 , C12N15/62 , C12N15/8213 , C12N15/85 , C12Y301/21004
摘要： Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
摘要翻译： 本文公开了编码包含新的DNA结合结构域（包括TALE DNA结合结构域）的多肽，多核苷酸，细胞和生物体。 还公开了使用这些新的DNA结合结构域来调节内源细胞序列的基因表达和/或基因组编辑的方法。
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公开(公告)号：US08586526B2
公开(公告)日：2013-11-19
申请号：US13068735
申请日：2011-05-17
申请人： Philip D. Gregory , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Siyuan Tan , Fyodor Urnov , Lei Zhang
发明人： Philip D. Gregory , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Siyuan Tan , Fyodor Urnov , Lei Zhang
CPC分类号： C12N15/907 , A61K38/00 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/52 , C12N15/62 , C12N15/8213 , C12N15/85 , C12Y301/21004
摘要： Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
摘要翻译： 本文公开了编码包含新的DNA结合结构域（包括TALE DNA结合结构域）的多肽，多核苷酸，细胞和生物体。 还公开了使用这些新的DNA结合结构域来调节内源细胞序列的基因表达和/或基因组编辑的方法。
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公开(公告)号：US07785792B2
公开(公告)日：2010-08-31
申请号：US12217953
申请日：2008-07-10
申请人： Alan P. Wolffe , Elizabeth J. Wolffe, legal representative , Trevor Collingwood , Philip D. Gregory , Andrew Snowden , Fyodor Urnov
CPC分类号： C12N15/1058 , C07K14/4702 , C07K2319/00 , C07K2319/02 , C07K2319/09 , C07K2319/24 , C07K2319/43 , C07K2319/71 , C07K2319/75 , C07K2319/81 , C12N15/102 , C12N15/1034 , C12N15/62 , C12N15/63 , C12N15/66 , C12N15/67 , C12Q1/6811 , G06F19/22 , G06F19/28
摘要： Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences.
摘要翻译： 提供了在细胞染色质感兴趣的区域内靶向修饰染色质结构的方法和组合物。 这些方法和组合物可用于促进需要外源分子进入染色体DNA序列的过程，例如转录和重组。
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公开(公告)号：US08071370B2
公开(公告)日：2011-12-06
申请号：US12803927
申请日：2010-07-09
申请人： Alan P. Wolffe , Elizabeth J. Wolffe, legal representative , Trevor Collingwood , Philip D. Gregory , Andrew Snowden , Fyodor Urnov
CPC分类号： C12N15/1058 , C07K14/4702 , C07K2319/00 , C07K2319/02 , C07K2319/09 , C07K2319/24 , C07K2319/43 , C07K2319/71 , C07K2319/75 , C07K2319/81 , C12N15/102 , C12N15/1034 , C12N15/62 , C12N15/63 , C12N15/66 , C12N15/67 , C12Q1/6811 , G06F19/22 , G06F19/28
摘要： Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences.
摘要翻译： 提供了在细胞染色质感兴趣的区域内靶向修饰染色质结构的方法和组合物。 这些方法和组合物可用于促进需要外源分子进入染色体DNA序列的过程，例如转录和重组。
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公开(公告)号：US20100323424A1
公开(公告)日：2010-12-23
申请号：US12803927
申请日：2010-07-09
申请人： Alan P. Wolffe , Elizabeth J. Wolffe , Trevor Collingwood , Philip D. Gregory , Andrew Snowden , Fyodor Urnov
发明人： Alan P. Wolffe , Elizabeth J. Wolffe , Trevor Collingwood , Philip D. Gregory , Andrew Snowden , Fyodor Urnov
CPC分类号： C12N15/1058 , C07K14/4702 , C07K2319/00 , C07K2319/02 , C07K2319/09 , C07K2319/24 , C07K2319/43 , C07K2319/71 , C07K2319/75 , C07K2319/81 , C12N15/102 , C12N15/1034 , C12N15/62 , C12N15/63 , C12N15/66 , C12N15/67 , C12Q1/6811 , G06F19/22 , G06F19/28
摘要： Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences.
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公开(公告)号：US08771985B2
公开(公告)日：2014-07-08
申请号：US13066802
申请日：2011-04-25
CPC分类号： C12N9/22 , A01K67/0275 , A01K2207/05 , A01K2217/07 , A01K2227/105 , A01K2267/03 , A61K38/00 , C07K2319/81 , C12N15/102 , C12N15/907
摘要： Disclosed herein are methods and compositions for genome editing of a Rosa locus, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
摘要翻译： 本文公开了使用包含锌指蛋白和切割结构域或裂解半结构域的融合蛋白的罗莎基因座的基因组编辑的方法和组合物。 还提供了编码所述融合蛋白的多核苷酸，以及包含所述多核苷酸和融合蛋白的细胞。
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公开(公告)号：US20110265198A1
公开(公告)日：2011-10-27
申请号：US13066801
申请日：2011-04-25
IPC分类号： C12N15/01 , A61K38/46 , C12N15/85 , A61P43/00 , C12N9/16 , C12N5/073 , C07H21/04 , A61K31/7088
CPC分类号： C12N9/22 , A01K67/0275 , A01K2207/05 , A01K2217/07 , A01K2227/105 , A01K2267/03 , A61K38/00 , C07K2319/81 , C12N15/102 , C12N15/907
摘要： Disclosed herein are methods and compositions for genome editing of a Rosa locus, using fusion proteins comprising a DNA binding domain and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
摘要翻译： 本文公开了使用包含DNA结合结构域和切割结构域或裂解半结构域的融合蛋白的罗莎基因座的基因组编辑的方法和组合物。 还提供了编码所述融合蛋白的多核苷酸，以及包含所述多核苷酸和融合蛋白的细胞。
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