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公开(公告)号：US20130171185A1
公开(公告)日：2013-07-04
申请号：US13808157
申请日：2011-07-05
IPC分类号： C07K14/08 , A61K39/295
CPC分类号： C07K14/005 , A61K39/12 , A61K39/295 , C07K14/08 , C07K2319/00 , C12N7/00 , C12N2770/16022 , C12N2770/16023
摘要： The invention relates to chimeric norovirus VP1 proteins containing the S-domain of VP1 of a first norovirus strain and a P-domain that contains at least a portion of the P-domain of VP1 of a second norovirus strain. The invention also relates to nucleic acids that encode the chimeric VP1 proteins, virus-like particles that contain a chimeric norovirus VP1 protein, and to immunogenic compositions.
摘要翻译： 本发明涉及含有第一诺如病毒株的VP1的S-结构域和含有第二诺如病毒株的VP1的至少一部分的P结构域的嵌合诺如病毒VP1蛋白质。 本发明还涉及编码嵌合VP1蛋白的核酸，含有嵌合诺如病毒VP1蛋白的病毒样颗粒和免疫原性组合物。
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公开(公告)号：US20110104192A1
公开(公告)日：2011-05-05
申请号：US12965344
申请日：2010-12-10
IPC分类号： A61K39/125 , C12P21/02 , C07K14/08 , A61P31/14 , A61P37/04
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译： 描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。 特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法 以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。 还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。 本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。
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公开(公告)号：US07491808B2
公开(公告)日：2009-02-17
申请号：US11213326
申请日：2005-08-26
申请人： David Chien , Doris Coit , Celine Hu , Sansan Lin , Angelica Medina-Selby
发明人： David Chien , Doris Coit , Celine Hu , Sansan Lin , Angelica Medina-Selby
IPC分类号： C07H21/04
CPC分类号： G01N33/5767 , C07K14/005 , C12N2770/24222
摘要： Modified HCV non-structural proteins are described. The proteins include modified NS3 domains such that proteolytic activity of the NS3 molecule is inhibited. The modified proteins retain conformational epitopes. HCV immunoassays including the modified NS3 molecules are also described.
摘要翻译： 描述了修饰的HCV非结构蛋白。 蛋白质包括修饰的NS3结构域，使得NS3分子的蛋白水解活性被抑制。 修饰的蛋白质保留构象表位。 还描述了包括经修饰的NS3分子的HCV免疫测定。
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公开(公告)号：US07449566B2
公开(公告)日：2008-11-11
申请号：US11195009
申请日：2005-08-02
CPC分类号： C07K14/005 , A61K39/00 , A61K47/593 , A61K47/62 , A61K2039/53 , A61K2039/57 , C12N2770/24222
摘要： Polypeptides comprising a mutant non-structural Hepatitis C virus useful in diagnostic and/or immunogenic compositions are disclosed, in which the mutant is an N-terminal mutation that functionally disrupts the catalytic domain of NS3. Polynucleotides encoding these polypeptides, host cells transformed with polynucleotides and methods of using the polypeptides and polynucleotides are also disclosed.
摘要翻译： 公开了包含可用于诊断和/或免疫原性组合物的突变非结构性丙型肝炎病毒的多肽，其中所述突变体是功能性破坏NS3的催化结构域的N-末端突变。 还公开了编码这些多肽的多核苷酸，用多核苷酸转化的宿主细胞和使用多肽和多核苷酸的方法。
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公开(公告)号：US20070207526A1
公开(公告)日：2007-09-06
申请号：US11603913
申请日：2006-11-22
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译： 描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。 特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法 以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。 还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。 本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。
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公开(公告)号：US07241879B2
公开(公告)日：2007-07-10
申请号：US10899715
申请日：2004-07-26
申请人： David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
发明人： David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
IPC分类号： C07H21/04
CPC分类号： C07K14/005 , C07K2319/00 , C12N2770/24222 , G01N33/5767 , G01N2333/18 , G01N2469/10 , G01N2469/20
摘要： HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.
摘要翻译： 提供包含NS3 / 4a构象表位和多表位融合抗原的HCV免疫测定，以及用于免疫测定的免疫测定固体支持物。
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公开(公告)号：US08475808B2
公开(公告)日：2013-07-02
申请号：US10557427
申请日：2004-05-21
申请人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes , Yiu-Lian Fong
发明人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes , Yiu-Lian Fong
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/545 , A61K2039/55566 , C07K2319/02 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N33/6854 , G01N2333/18 , G01N2469/20 , Y02A50/394
摘要： Recombinant production of immunogenic West Nile Virus (WNV) proteins is described. These proteins, heterodimers comprising the proteins, fusions thereof, polynucleotides encoding the proteins, and combinations thereof, as well as antibodies produced therefrom, can be used in immunogenic compositions for preventing, treating and diagnosing WNV infection. Also described are highly sensitive ELISA and strip immunoassay methods for detecting the presence of WNV in biological samples.
摘要翻译： 描述了免疫原性西尼罗病毒（WNV）蛋白的重组产生。 包含蛋白质的这些蛋白质，其融合物，编码蛋白质的多核苷酸及其组合以及由其产生的抗体可用于预防，治疗和诊断WNV感染的免疫原性组合物中。 还描述了用于检测生物样品中WNV存在的高灵敏度ELISA和条带免疫测定方法。
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公开(公告)号：US08124104B2
公开(公告)日：2012-02-28
申请号：US12383420
申请日：2009-03-24
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译： 描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。 特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法 以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。 还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。 本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。
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公开(公告)号：US20090087447A1
公开(公告)日：2009-04-02
申请号：US12287006
申请日：2008-10-03
CPC分类号： C07K14/005 , A61K39/00 , A61K47/593 , A61K47/62 , A61K2039/53 , A61K2039/57 , C12N2770/24222
摘要： Polypeptides comprising a mutant non-structural Hepatitis C virus useful in diagnostic and/or immunogenic compositions are disclosed, in which the mutant is an N-terminal mutation that functionally disrupts the catalytic domain of NS3. Polynucleotides encoding these polypeptides, host cells transformed with polynucleotides and methods of using the polypeptides and polynucleotides are also disclosed.
摘要翻译： 公开了包含可用于诊断和/或免疫原性组合物的突变非结构性丙型肝炎病毒的多肽，其中所述突变体是功能性破坏NS3的催化结构域的N-末端突变。 还公开了编码这些多肽的多核苷酸，用多核苷酸转化的宿主细胞和使用多肽和多核苷酸的方法。
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20.发明申请Hcv Multiple Epitope Fusion Antigens With Modified Proteolytic Cleavage Sites And Uses Thereof 有权Hcv多重表位融合抗原与修饰的蛋白水解切割位点及其用途公开(公告)号：US20080299544A1
公开(公告)日：2008-12-04
申请号：US11661577
申请日：2005-08-26
申请人： David Y Chien , Doris Coit , Carlos George-Nascimento , Sansan Lin , Angelica Medina-Selby , Laura Tandeske
发明人： David Y Chien , Doris Coit , Carlos George-Nascimento , Sansan Lin , Angelica Medina-Selby , Laura Tandeske
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , G01N33/5767 , G01N2469/20
摘要： Modified HCV multiple epitope fusion antigens (MEFAs) are described. The proteins include modified sequences such that proteolytic cleavage of the MEFAs by HCV NS3 protease is inhibited. HCV immunoassays including the modified MEFAs are also described.
摘要翻译： 描述了修饰的HCV多表位融合抗原（MEFA）。 蛋白质包括修饰的序列，使得HCV NS3蛋白酶对MEFAs的蛋白水解切割被抑制。 还描述了包括修饰的MEFAs的HCV免疫测定。
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