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    Emulsions for in-situ delivery systems
    14.
    发明授权
    Emulsions for in-situ delivery systems 失效
    用于原位输送系统的乳液

    公开(公告)号：US07128927B1

    公开(公告)日：2006-10-31

    申请号：US09060047

    申请日：1998-04-14

    申请人： Richard L. Dunn

    发明人： Richard L. Dunn

    IPC分类号： A61K9/107 ,  A61K47/32 ,  A61K47/34

    CPC分类号： A61K9/0024 ,  Y02A50/465

    摘要： The invention is provides a composition for sustained delivery of a biologically active agent comprising a biologically active mixture and a controlled release formulation. The composition protects the biologically active agent from being destroyed by the controlled release composition. The biologically active mixture includes the biologically active agent and a pharmaceutically acceptable protective carrier. The controlled release formulation includes a pharmaceutically acceptable, biodegradable, matrix forming material that is substantially insoluble in aqueous or body fluids and a pharmaceutically acceptable organic solvent. The biologically active mixture is combined with the controlled release formulation to form an emulsion, the delivery composition, which is then administered to a patient. The protective carrier can be an aqueous substance, a non-aqueous substance or a combination of both. The matrix forming material can be a polymeric material, a non-polymeric material or a combination of both. The organic solvent can have a solubility ranging from a high water solubility to a low water solubility.

    摘要翻译： 本发明提供了用于持续递送包含生物活性混合物和控释制剂的生物活性剂的组合物。 组合物保护生物活性剂免受控释组合物的破坏。 生物活性混合物包括生物活性剂和药学上可接受的保护载体。 控制释放制剂包括药学上可接受的，可生物降解的基质形成材料，其基本上不溶于水性或体液和药学上可接受的有机溶剂。 将生物活性混合物与控制释放制剂组合以形成乳剂，然后将其输送给患者。 保护载体可以是水性物质，非水性物质或两者的组合。 基体形成材料可以是聚合材料，非聚合材料或两者的组合。 有机溶剂可以具有从高水溶性到低水溶性的溶解度。