公开(公告)号：US08853281B2

公开(公告)日：2014-10-07

申请号：US13139962

申请日：2009-12-18

申请人： Susana Ayesa ,  Anna Karin Belfrage ,  Bjorn Classon ,  Urszula Grabowska ,  Ellen Hewitt ,  Vladimir Ivanov ,  Daniel Jönsson ,  Pia Kahnberg ,  Peter Lind ,  Magnus Nilsson ,  Lourdes Odén ,  Mikael Pelcman ,  Horst Wähling

发明人： Susana Ayesa ,  Anna Karin Belfrage ,  Bjorn Classon ,  Urszula Grabowska ,  Ellen Hewitt ,  Vladimir Ivanov ,  Daniel Jönsson ,  Pia Kahnberg ,  Peter Lind ,  Magnus Nilsson ,  Lourdes Odén ,  Mikael Pelcman ,  Horst Wähling

IPC分类号： A01N33/02 ,  A61K31/13 ,  A01N37/00 ,  A61K31/21 ,  A01N33/00 ,  A61K31/16 ,  A01N37/18 ,  A61K31/165 ,  A01N35/00 ,  A61K31/12 ,  A01N33/18 ,  A01N33/24 ,  A61K31/04 ,  A01N29/00 ,  A61K31/02 ,  A01N29/02 ,  C07D231/00 ,  C07D413/00 ,  C07D295/22 ,  C07D307/02 ,  C07C303/00 ,  C07C307/00 ,  C07C309/00 ,  C07C311/00 ,  C07C233/00 ,  C07C235/00 ,  C07C237/00 ,  C07C239/00 ,  C07C261/00 ,  C07C269/00 ,  C07C271/00 ,  C07D405/12 ,  C07D403/12 ,  C07C271/24 ,  C07D417/12 ,  C07C311/21 ,  C07D241/24 ,  C07D401/12 ,  C07D277/36 ,  C07D307/85 ,  C07D307/68 ,  C07D277/56 ,  C07D295/215 ,  C07C237/24 ,  C07D231/40 ,  C07D207/34 ,  C07D213/71 ,  C07D231/14 ,  C07D239/80 ,  C07D213/40

CPC分类号： C07C311/21 ,  C07C237/24 ,  C07C271/24 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/06 ,  C07C2601/08 ,  C07D207/34 ,  C07D213/40 ,  C07D213/71 ,  C07D231/14 ,  C07D231/40 ,  C07D239/80 ,  C07D241/24 ,  C07D277/36 ,  C07D277/56 ,  C07D295/215 ,  C07D307/68 ,  C07D307/85 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

摘要： Compounds of the formula I wherein R1a is H; and R1b is C1-C6 alkyl, Carbocyclyl or Het; or R1a and R1b together define a saturated cyclic amine with 3-6 ring atoms; R2a and R2b are H, halo, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy; or R2a and R2b together with the carbon atom to which they are attached form a C3-C6cycloalkyl; R3 is a branched C5-C10alkyl chain, C2-C4haloalkyl or C3-C7cycloalkylmethyl, R4 is Het, Carbocyclyl, optionally substituted as defined in the specification and pharmaceutically acceptable salts, hydrates and N-oxides thereof; are inhibitors of cathepsin S and have utility in the treatment of psoriasis, autoimmune disorders and other disorders such as asthma, arteriosclerosis, COPD and chronic pain.

摘要翻译： 式Ⅰ化合物，其中R1a是H; 并且R 1b是C 1 -C 6烷基，碳环或Het; 或R 1a和R 1b一起限定具有3-6个环原子的饱和环胺; R2a和R2b是H，卤素，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基; 或R 2a和R 2b与它们所连接的碳原子一起形成C 3 -C 6环烷基; R3是支链C 5 -C 10烷基链，C 2 -C 4卤代烷基或C 3 -C 7环烷基甲基，R 4是Het，碳环基，如说明书中所定义的任选取代，以及其药学上可接受的盐，水合物和N-氧化物; 是组织蛋白酶S的抑制剂，并且可用于治疗牛皮癣，自身免疫性疾病和其它疾病如哮喘，动脉硬化，COPD和慢性疼痛。

公开(公告)号：US20140025579A1

公开(公告)日：2014-01-23

申请号：US13882597

申请日：2012-03-13

申请人： Magnus Nilsson

发明人： Magnus Nilsson

IPC分类号： G06Q20/40

CPC分类号： G06Q20/4012 ,  G06F21/35 ,  G06Q20/20 ,  G06Q20/325 ,  G06Q20/341 ,  G06Q20/4037 ,  G06Q20/425 ,  G07F7/088 ,  G07F7/1016 ,  G07F7/1066 ,  G07F7/1075 ,  G07F7/1091

摘要： A method for conducting PIN authorized EMV payments using an ordinary mobile phone. The credit card payment is conducted using a merchant's device comprising a card reader and a mobile phone a payment server and a buyer's mobile phone. A PIN entry request is sent from the merchant's device to the buyer's device via the payment server. A secure application in the buyer's device is executed and a PIN code may be entered securely. The entered PIN code is either verified, via the payment server, against the credit card in said merchant's device or against a bank server. Thus, secure credit card payments can be performed using an ordinary unsecure mobile device's.

摘要翻译： 使用普通移动电话进行PIN授权EMV支付的方法。 使用包括读卡器和移动电话的商家装置支付服务器和买方移动电话进行信用卡支付。 通过付款服务器将PIN输入请求从商家的设备发送到买方的设备。 执行买方设备中的安全应用程序，并且可以安全地输入PIN码。 所输入的PIN码通过支付服务器对所述商家的设备中的信用卡或银行服务器进行验证。 因此，可以使用普通的不安全的移动设备来执行安全的信用卡付款。

公开(公告)号：US08466158B2

公开(公告)日：2013-06-18

申请号：US13468787

申请日：2012-05-10

申请人： Magnus Nilsson ,  Lourdes Salvador Odén ,  Pia Kahnberg ,  Urszula Grabowska

发明人： Magnus Nilsson ,  Lourdes Salvador Odén ,  Pia Kahnberg ,  Urszula Grabowska

IPC分类号： A61K31/496

CPC分类号： C07D491/048

摘要： Compounds of the formula II: wherein R2 is the side chain of leucine, isoleucine, cyclohexylglycine, O-methyl threonine, 4-fluoroleucine or 3-methoxyvaline; R3 is H, methyl or F; Rq is trifluoromethyl and Rq′ is H or Rq and Rq′ define keto; Q is a p-(C1-C6alkylsulphonyl)phenyl- or an optionally substituted 4-(C1-C6alkyl)piperazin-1-yl-thiazol-4-yl-moiety have utility in the treatment of disorders characterized by inappropriate expression or activation of cathepsin K, such as osteoporosis, osteoarthritis, rheumatoid arthritis or bone metastases.

摘要翻译： 式II化合物：其中R2是亮氨酸的侧链，异亮氨酸，环己基甘氨酸，O-甲基苏氨酸，4-氟亮氨酸或3-甲氧基缬氨酸; R3是H，甲基或F; Rq是三氟甲基，Rq'是H或Rq，Rq'定义酮基; Q是对 - （C 1 -C 6烷基磺酰基）苯基 - 或任选取代的4-（C 1 -C 6烷基）哌嗪-1-基 - 噻唑-4-基 - 部分可用于治疗以不适当表达或活化为特征的疾病 组织蛋白酶K，例如骨质疏松症，骨关节炎，类风湿性关节炎或骨转移。

公开(公告)号：US20120186196A1

公开(公告)日：2012-07-26

申请号：US13295703

申请日：2011-11-14

申请人： Magnus Nilsson

发明人： Magnus Nilsson

IPC分类号： B65B55/02

CPC分类号： B08B9/20 ,  B08B9/30 ,  B08B9/423 ,  B67B3/22 ,  B67B7/00 ,  B67B7/14

摘要： A method and means for handling of laboratory animal drinking bottles (17) provided with nipples (17) in an automatic bottle wash-up line, wherein the nipples (16) of all the bottles (17), arranged in a basket, are removed from the bottles with the aid of compressed air in a nipple removal means (2) and are washed and dried together with the drinking bottles and are subsequently put back onto filled bottles in a nipple reassembly means (4), which operates with similar tools (6) as the nipple removal means (2).

摘要翻译： 一种用于处理在自动洗瓶系统中设置有乳头（17）的实验室动物饮水瓶（17）的方法和装置，其中布置在篮子中的所有瓶子（17）的乳头（16）被去除 从瓶中借助于压缩空气在乳头去除装置（2）中，并与饮料瓶一起洗涤和干燥，并随后将其放回到用类似工具操作的乳头重新组装装置（4）中的填充瓶子上 6）作为乳头去除装置（2）。

公开(公告)号：US20060146193A1

公开(公告)日：2006-07-06

申请号：US11027339

申请日：2004-12-30

申请人： Chaminda Weerasinghe ,  Magnus Nilsson ,  Yu Shi

发明人： Chaminda Weerasinghe ,  Magnus Nilsson ,  Yu Shi

IPC分类号： H04N9/74 ,  H04N11/06 ,  H04N7/01 ,  H04N11/20

CPC分类号： H04N9/68 ,  H04N9/67

摘要： A low complexity apparatus (100) and method (200) for variable color saturation, performed in combination with RGB to YUV color space conversion, is used to direct input signal noise away from a luminance channel, to which the human eye is highly sensitive, and into chrominance channels. The apparatus (100) is adapted to perform color conversion and variable color saturation of input primary color signals red, green and blue to produce variable chrominance signals and luminance invariance. The apparatus includes a luminance composition module (105) dependent on non-varying luminance composition coefficients. A first chrominance composition module (110) is dependent on the non-varying luminance composition coefficients and includes a first variable saturation coefficient that is multiplied by the difference between low pass filtered red and green primary color signals. A second chrominance composition module (115) is also dependent on the non-varying luminance composition coefficients and includes a second variable saturation coefficient that is multiplied by the difference between low pass filtered blue and green primary color signals.

摘要翻译： 使用与RGB至YUV色彩空间转换结合执行的用于可变色彩饱和度的低复杂度装置（100）和方法（200）来将输入信号噪声引导离开人眼高度敏感的亮度通道， 并进入色度通道。 该装置（100）适于对输入的原色信号红色，绿色和蓝色进行颜色转换和可变色饱和度，以产生可变色度信号和亮度不变性。 该装置包括依赖于不变亮度组成系数的亮度组合模块（105）。 第一色度组合模块（110）取决于非变化亮度组成系数，并且包括乘以低通滤波的红色和绿色原色信号之间的差的第一可变饱和度系数。 第二色度组合模块（115）还取决于不变亮度组合系数，并且包括乘以低通滤波的蓝色和绿色原色信号之间的差的第二可变饱和系数。

公开(公告)号：US06952138B2

公开(公告)日：2005-10-04

申请号：US09949845

申请日：2001-09-12

申请人： Hans Hagberg ,  Magnus Nilsson

发明人： Hans Hagberg ,  Magnus Nilsson

IPC分类号： H03L7/00 ,  H03L7/081 ,  H03L7/085 ,  H03L7/089 ,  H03L7/091 ,  H03L7/197 ,  H04B1/06 ,  H04B15/04

CPC分类号： H03L7/081 ,  H03L7/0891 ,  H03L7/1976 ,  H04B15/04

摘要： The present invention helps to mitigate and reduce the amount of interfering signals (e.g. RF leakage) that enter the phase detector of a phase locked loop by acting as a less than perfect sampler. This is accomplished by introducing a time jitter to the signal edges that enter the phase detector input. A phase detector can also be made to act as a less than perfect sampler by intentionally introducing an interfering signal. For example, a small interfering analog signal can be introduced with a different frequency from the reference frequency already present in the PLL. The interfering signal will cause the stable internal signal to vary slightly in time at the rate of the interfering signal frequency. It is this signal variation and jitter introduced on the signal edges entering the phase detector input that induces the phase detector to act as a less than perfect sampler.

摘要翻译： 本发明有助于通过充当不太完美的采样器来减轻和减少进入锁相环的相位检测器的干扰信号（例如RF泄漏）的量。 这是通过将时间抖动引入到进入相位检测器输入的信号边缘来实现的。 也可以通过有意引入干扰信号，使相位检测器作为不太完美的采样器。 例如，可以引入与PLL中已经存在的参考频率不同的频率的小干扰模拟信号。 干扰信号会导致稳定的内部信号以干扰信号频率的速率在时间上略有变化。 在信号边缘上引入的信号变化和抖动是进入相位检测器输入的，这引起相位检测器作为不太完美的采样器。

公开(公告)号：US06892057B2

公开(公告)日：2005-05-10

申请号：US10215127

申请日：2002-08-08

申请人： Magnus Nilsson

发明人： Magnus Nilsson

IPC分类号： H03C3/09 ,  H03C5/00 ,  H04B1/04 ,  H04G3/20

CPC分类号： H03C3/0933 ,  H03C3/0925 ,  H03C5/00

摘要： An output-power threshold is selected such that one or more signal requirements is not outside a pre-determined range when output power of a polar transmitter is less than the output-power threshold. A determination is made whether the output power is less than the threshold. In response to a determination that the output power is less than the threshold, amplitude modulation of a polar signal transmitted by the polar transmitter is disabled. When the output power meets or exceeds the output-power threshold, the polar signal transmitted by the polar transmitter is both amplitude and phase modulated.

摘要翻译： 选择输出功率阈值使得当极性发射机的输出功率小于输出功率阈值时，一个或多个信号要求不在预定范围之外。 确定输出功率是否小于阈值。 响应于输出功率小于阈值的确定，由极性发射器发送的极坐标信号的幅度调制被禁用。 当输出功率满足或超过输出功率阈值时，由极性发射器发送的极坐标信号都是幅度和相位调制的。

公开(公告)号：US06389266B1

公开(公告)日：2002-05-14

申请号：US09656114

申请日：2000-09-06

申请人： Magnus Nilsson

发明人： Magnus Nilsson

IPC分类号： H04Q720

CPC分类号： H03L7/18 ,  H04B1/00 ,  H04B1/406

摘要： A radio ASIC including a VCO (30) connected to both a homodyne receiver (60, 80, 90, 110, 120, 140, 150) for downconting the frequency of a received signal, when said radio ASIC is in a receiving mode (110, 120, A), and to a radio transmitter (70, 100, 110, 120) for transmitting another signal, when said radio ASIC is in a transmitting mode (110, 120, B). A divider (50) with a dividing factor of two is arranged between the VCO (30) and a mixer (80, 140) of the homodyne receiver in order to divide the signal from the VCO with a factor of two. The VCO is run on double GSM-RX-frequency implying that it covers both PCS-TX (radio ASIC in transmission mode) and GSM-RX (radio ASIC in receiving mode).

摘要翻译： 一种无线电ASIC，包括连接到零差接收器（60,80,90,110,120,140,​​150）的VCO（30），用于降低接收信号的频率，当所述无线电ASIC处于接收模式时（110 ，120A），以及当所述无线电ASIC处于发送模式（110,120，B）时用于发送另一信号的无线电发射机（70,100,110,120）。 在VCO（30）和零差接收机的混频器（80,140）之间布置有分频因子为2的分频器（50），以便将来自VCO的信号以因子2分频。 VCO在双GSM-RX频率上运行，这意味着它涵盖PCS-TX（传输模式下的无线电ASIC）和GSM-RX（接收模式下的无线电ASIC）。

公开(公告)号：US09746253B2

公开(公告)日：2017-08-29

申请号：US13131309

申请日：2009-11-25

申请人： Fredrik Blomgren ,  Magnus Nilsson

发明人： Fredrik Blomgren ,  Magnus Nilsson

IPC分类号： F28F3/08 ,  F28F3/14 ,  F28F11/06

CPC分类号： F28F3/083 ,  F28F2280/04

摘要： A heat exchanger plate, where the plate is provided with a heat transfer surface having a corrugated pattern with a plurality of ridges and valleys, and where the heat exchanger plate is provided with a plurality of guiding sections, and where each guiding section has a first guiding surface and a second guiding surface, where the first and second guiding surfaces are perpendicular to each other. A heat exchanger having a plurality of heat exchanger plates is also disclosed. The advantage of this heat exchanger plate is that it allows for an improved alignment of the heat exchanger plates.

公开(公告)号：US08779863B2

公开(公告)日：2014-07-15

申请号：US13508414

申请日：2010-11-19

申请人： Magnus Nilsson

发明人： Magnus Nilsson

IPC分类号： H03L7/06

CPC分类号： H03L7/099 ,  H03L7/1976

摘要： A method of generating a first oscillator signal having a desired frequency in a first frequency range comprises generating in a voltage controlled oscillator unit a second oscillator signal having a frequency in a second frequency range of at least one octave. The method further comprises selecting said second continuous frequency range to have a lower endpoint in said first frequency range and an upper endpoint above said range; and selectively using the oscillator signal unchanged or dividing it by a division ratio selected from integer powers of the number 2 to obtain said first oscillator signal. By centering the VCO higher than otherwise required and using an additional divider, so that the VCO signal can selectively be used unchanged or divided, a sufficient margin below as well as above the desired range for e.g. drift and tolerances of the VCO is achieved. It also simplifies the VCO design.

摘要翻译： 在第一频率范围内产生具有期望频率的第一振荡器信号的方法包括在压控振荡器单元中产生具有至少一个八度的第二频率范围内的频率的第二振荡器信号。 所述方法还包括选择所述第二连续频率范围以在所述第一频率范围内具有较低端点，并且在所述范围之上具有上端点; 并且选择性地使用振荡器信号或将其除以从数字2的整数倍数中选择的分频比来获得所述第一振荡器信号。 通过使VCO高于其他要求并使用附加的分压器，使得VCO信号可以选择性地不变地或不分割地使用，低于以上以及高于例如范围的期望范围的足够余量。 实现VCO的漂移和公差。 它也简化了VCO设计。