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11.发明申请公开(公告)号：US20230020195A1
公开(公告)日：2023-01-19
申请号：US17948434
申请日：2022-09-20
Applicant: The Trustees of Dartmouth College
Inventor： Stephen Chad Kanick , Brian William Pogue , Keith D. Paulsen , Jonathan T. Elliott , David M. McClatchy, III , Venkataramanan Krishnaswamy
IPC: A61B5/00
Abstract: A method for determining sub-diffuse scattering parameters of a material includes illuminating the material with structured light and imaging remission by the material of the structured light. The method further includes determining, from captured remission images, sub-diffuse scattering parameters of the material. A structured-light imaging system for determining sub-diffuse scattering parameters of a material includes a structured-light illuminator, for illuminating the material with structured light of periodic spatial structure, and a camera for capturing images of the remission of the structured light by the material. The structured-light imaging system further includes an analysis module for processing the images to quantitatively determine the sub-diffuse scattering parameters. A software product includes machine-readable instructions for analyzing images of remission of structured light by a material to determine sub-diffuse scattering parameters of the material.
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公开(公告)号：US10667870B2
公开(公告)日：2020-06-02
申请号：US15735907
申请日：2016-06-10
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Venkataramanan Krishnaswamy , Richard J. Barth, Jr. , Keith D. Paulsen
Abstract: A method for guiding resection of local tissue from a patient includes generating at least one image of the patient, automatically determining a plurality of surgical guidance cues indicating three-dimensional spatial properties associated with the local tissue, and generating a visualization of the surgical guidance cues relative to the surface. A system for generating surgical guidance cues for resection of a local tissue from a patient includes a location module for processing at least one image of the patient to determine three-dimensional spatial properties of the local tissue, and a surgical cue generator for generating the surgical guidance cues based upon the three-dimensional spatial properties. A patient-specific locator form for guiding resection of local tissue from a patient includes a locator form surface matching surface of the patient, and a plurality of features indicating a plurality of surgical guidance cues, respectively.
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13.发明授权公开(公告)号：US09792411B2
公开(公告)日：2017-10-17
申请号：US13831160
申请日：2013-03-14
Applicant: The Trustees of Dartmouth College
Inventor： Adam J. Pattison , Matthew D J McGarry , Keith D. Paulsen , John B. Weaver
CPC classification number: G06F19/3437 , A61B5/0051 , A61B5/055 , A61B5/1128 , A61B5/4064 , A61B5/6868 , G01N3/32 , G01N2203/0005 , G01N2203/0069 , G01N2203/0073 , G01N2203/0094 , G01N2203/0218 , G01R33/56358 , G06F19/00 , G06F19/3481 , G16H50/50
Abstract: A system for determining parameters of porous media or material, which in an embodiment is biological tissue, includes an actuator and a displacement monitor. The actuator is adapted to apply a displacement to tissue at a particular frequency selected from a range of frequencies, and the force monitor adapted to monitor a mechanical response of tissue. The system also has a processor coupled to drive the actuator and to read the mechanical response, the processor coupled to execute from memory a poroelastic model of mechanical properties of the material, and a convergence procedure for determining parameters for the poroelastic model such that the model predicts mechanical response of the tissue to within limits.
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公开(公告)号：US20170164836A1
公开(公告)日：2017-06-15
申请号：US15116808
申请日：2015-02-04
Applicant: The Trustees of Dartmouth College
Inventor： Venkataramanan Krishnaswamy , Brian W. Pogue , Keith D. Paulsen , Jonathan T. Elliott , David M. McClatchy, III
CPC classification number: A61B5/0059 , A61B5/0075 , A61B5/4869 , A61B2505/05 , G01B11/2513
Abstract: A structured-light imaging system includes a structured light projector for illuminating a surface and an electronic camera configured to image the surface. An image processor receives the images and has structured light scatteroscopy (SLS) firmware with machine readable instructions that illuminate the surface with structured light having a spatial frequency of at least 0.5 mm″1, and process the images to determine a map of scattering parameters at the surface independent of absorption properties. In an embodiment, the system also has cameras configured to obtain a stereo pair of images of the surface, the image processor having 3D firmware for extracting a three dimensional model of the surface from the stereo pair of images and compensating the map for non-flat surfaces.
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15.发明申请METHOD AND APPARATUS FOR QUANTITATIVE AND DEPTH RESOLVED HYPERSPECTRAL FLUORESCENCE AND REFLECTANCE IMAGING FOR SURGICAL GUIDANCE 审中-公开定量和深度分析手术指导的超视距荧光和反射成像的方法和装置公开(公告)号：US20160278678A1
公开(公告)日：2016-09-29
申请号：US15044097
申请日：2016-02-15
Applicant: The Trustees of Dartmouth College
Inventor： Pablo Valdes , Frederic Leblone , Keith D. Paulsen , Brian Campbell Wilson , David W. Roberts , Michael Jermyn
IPC: A61B5/1455 , A61B5/00 , A61B1/04 , A61B5/055 , A61B5/1495 , A61B1/06 , A61B1/00 , A61B5/1459 , A61B5/145
CPC classification number: A61B5/14556 , A61B1/00009 , A61B1/00165 , A61B1/00193 , A61B1/042 , A61B1/043 , A61B1/05 , A61B1/0646 , A61B1/0669 , A61B1/0684 , A61B1/07 , A61B1/3132 , A61B5/0071 , A61B5/0077 , A61B5/055 , A61B5/14546 , A61B5/14553 , A61B5/1459 , A61B5/1495 , A61B5/4836 , A61B5/7264 , G01J3/0229 , G01J3/1256 , G01J3/2823 , G01J2003/1269 , G01J2003/2826
Abstract: An imaging system, such as a surgical microscope, laparoscope, or endoscope or integrated with these devices, includes an illuminator providing patterned white light and/or fluorescent stimulus light. The system receives and images light hyperspectrally, in embodiments using a hyperspectral imaging array, and/or using narrowband tunable filters for passing filtered received light to an imager. Embodiments may construct a 3-D surface model from stereo images, and will estimate optical properties of the target using images taken in patterned light or using other approximations obtained from white light exposures. Hyperspectral images taken under stimulus light are displayed as fluorescent images, and corrected for optical properties of tissue to provide quantitative maps of fluorophore concentration. Spectral information from hyperspectral images is processed to provide depth of fluorophore below the tissue surface. Quantitative images of fluorescence at depth are also prepared. The images are displayed to a surgeon for use in surgery.
Abstract translation: 诸如手术显微镜，腹腔镜或内窥镜或与这些装置集成的成像系统包括提供图案化的白光和/或荧光激发光的照明器。 在使用高光谱成像阵列的实施例中，系统接收并高光图像光，并且/或使用窄带可调滤波器将滤波的接收光传递到成像器。 实施例可以从立体图像构造3-D表面模型，并且将使用在图案化光线中拍摄的图像或使用从白光曝光获得的其它近似来估计目标的光学性质。 在激发光下拍摄的高光谱图像显示为荧光图像，并对组织的光学性质进行校正，以提供荧光团浓度的定量图谱。 处理来自高光谱图像的光谱信息，以提供组织表面下方的荧光团的深度。 还准备了深度荧光的定量图像。 图像显示给外科医生用于手术。
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Patent Agency Ranking
公开(公告)号：US12285277B2
公开(公告)日：2025-04-29
申请号：US18614944
申请日：2024-03-25
Applicant: The Trustees of Dartmouth College
Inventor： Kenneth Tichauer , Robert W. Holt , Frederic Leblond , Pablo Valdes , Brian W. Pogue , Keith D. Paulsen , David W. Roberts
Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.
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公开(公告)号：US20250111632A1
公开(公告)日：2025-04-03
申请号：US18840030
申请日：2023-02-21
Applicant: The Trustees of Dartmouth College
Inventor： Keith D. Paulsen , Xiaoyao FAN , William R. WARNER
Abstract: An intraoperative stereovision system has a stereo imager configured to provide stereo images at first and second time (iSV0, iSV(n)) to an image processor configured with a computerized mechanical model of a spinal column, the computerized mechanical model configured to model vertebrae as rigid, displaceable, bodies. The image processor is configured to extract an iSV0 surface model from iSV0 and an iSV(n) surface model from the iSV(n); to register these surfaces, and identify differences therefrom. The image processor is configured to adjust the computerized mechanical model according to the identified differences thereby causing the adjusted computerized mechanical model to track the iSV(n) surface model at each of multiple timepoints.
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公开(公告)号：US20240260909A1
公开(公告)日：2024-08-08
申请号：US18614944
申请日：2024-03-25
Applicant: The Trustees of Dartmouth College
Inventor： Kenneth Tichauer , Robert W. Holt , Frederic Leblond , Pablo Valdes , Brian W. Pogue , Keith D. Paulsen , David W. Roberts
CPC classification number: A61B5/7278 , A61B5/0071 , A61K49/0058 , A61B5/0035 , A61B5/0062 , A61B2576/00
Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.
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19.发明授权公开(公告)号：US11751767B2
公开(公告)日：2023-09-12
申请号：US16673165
申请日：2019-11-04
Applicant: The Trustees of Dartmouth College
Inventor： Stephen Chad Kanick , Brian William Pogue , Keith D. Paulsen , Jonathan T. Elliott , David M. McClatchy, III , Venkataramanan Krishnaswamy
IPC: A61B5/00
CPC classification number: A61B5/0075 , A61B2576/00
Abstract: A method for determining sub-diffuse scattering parameters of a material includes illuminating the material with structured light and imaging remission by the material of the structured light. The method further includes determining, from captured remission images, sub-diffuse scattering parameters of the material. A structured-light imaging system for determining sub-diffuse scattering parameters of a material includes a structured-light illuminator, for illuminating the material with structured light of periodic spatial structure, and a camera for capturing images of the remission of the structured light by the material. The structured-light imaging system further includes an analysis module for processing the images to quantitatively determine the sub-diffuse scattering parameters. A software product includes machine-readable instructions for analyzing images of remission of structured light by a material to determine sub-diffuse scattering parameters of the material.
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公开(公告)号：US20230075997A1
公开(公告)日：2023-03-09
申请号：US17961480
申请日：2022-10-06
Applicant: The Trustees of Dartmouth College
Inventor： Pablo Valdes , Frederic Leblond , Keith D. Paulsen , Brian Campbell Wilson , David W. Roberts , Michael Jermyn
IPC: A61B5/1455 , A61B5/1459 , A61B1/04 , A61B5/145 , A61B5/00 , A61B5/1495 , A61B1/06 , A61B5/055 , G01J3/28 , A61B1/05 , G01J3/12 , G01J3/02 , A61B1/00 , A61B1/07
Abstract: An imaging system, such as a surgical microscope, laparoscope, or endoscope or integrated with these devices, includes an illuminator providing patterned white light and/or fluorescent stimulus light. The system receives and images light hyperspectrally, in embodiments using a hyperspectral imaging array, and/or using narrowband tunable filters for passing filtered received light to an imager. Embodiments may construct a 3-D surface model from stereo images, and will estimate optical properties of the target using images taken in patterned light or using other approximations obtained from white light exposures. Hyperspectral images taken under stimulus light are displayed as fluorescent images, and corrected for optical properties of tissue to provide quantitative maps of fluorophore concentration. Spectral information from hyperspectral images is processed to provide depth of fluorophore below the tissue surface. Quantitative images of fluorescence at depth are also prepared. The images are displayed to a surgeon for use in surgery.
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