公开(公告)号：US20140157902A1

公开(公告)日：2014-06-12

申请号：US14117050

申请日：2012-06-12

申请人： Makiko Sugiura ,  Hirofumi Higuchi

发明人： Makiko Sugiura ,  Hirofumi Higuchi

IPC分类号： G01S15/50

CPC分类号： G01S15/50 ,  B06B1/0666 ,  G01S7/521

摘要： An ultrasonic sensor device includes a substrate, a piezoelectric vibrator, and a Q-factor adjuster. The piezoelectric vibrator includes a pair of detection electrodes that face each other in a thickness direction of the substrate and a piezoelectric body interposed between the electrodes. The piezoelectric vibrator provides a membrane structure which is formed on a surface of the substrate and has rigidity lower than that of a remaining portion of the substrate. An ultrasonic wave is transmitted by the piezoelectric vibrator, and its reflected wave is received by the same piezoelectric vibrator. The Q-factor adjuster adjusts a Q-factor of the piezoelectric vibrator so that the Q-factor can be larger during a transmission period where the piezoelectric vibrator transmits the ultrasonic wave than during a reception period where the piezoelectric vibrator receives the ultrasonic wave.

摘要翻译： 超声波传感器装置包括基板，压电振动器和Q因子调节器。 压电振子包括在基板的厚度方向上彼此相对的一对检测电极和插在电极之间的压电体。 压电振动器提供形成在基板的表面上的膜结构，其刚性低于基板的剩余部分的刚度。 超声波由压电振子传递，其反射波被同一压电振子接收。 Q因子调节器调节压电振动器的Q因子，使得压电振动器发送超声波的传播期间的Q因子可以比在压电振动器接收超声波的接收时段期间更大。

公开(公告)号：US08603476B2

公开(公告)日：2013-12-10

申请号：US12812341

申请日：2009-01-09

申请人： Kenji Uehara ,  Hirofumi Higuchi ,  Toshihiro Nakashima ,  Daisuke Ishikawa ,  Nobuchika Yamamoto ,  Hirotada Fujita ,  Fumihiko Sakai

发明人： Kenji Uehara ,  Hirofumi Higuchi ,  Toshihiro Nakashima ,  Daisuke Ishikawa ,  Nobuchika Yamamoto ,  Hirotada Fujita ,  Fumihiko Sakai

IPC分类号： A61K39/395

CPC分类号： C07K16/2839 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9, and a means for the prophylaxis or treatment of various diseases involving human α9 integrin in the pathogenesis, which uses the antibody.

摘要翻译： 本发明提供与供体小鼠抗人α9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人α9整联蛋白抗体，即包含重链可变区的人源化抗人α9整联蛋白抗体，其包含 的SEQ ID NO：11所示的氨基酸序列和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，含有重链可变区的人源化抗人α9整联蛋白抗体包含由 由SEQ ID NO：13所示的氨基酸序列和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，含有重链可变区的人源化抗人α9整联蛋白抗体 由SEQ ID NO：15所示的氨基酸序列和由SEQ ID NO：9所示的氨基酸序列组成的轻链可变区，以及预防或治疗涉及 人类α9整联蛋白在发病机制中使用抗体。

公开(公告)号：US20090100931A1

公开(公告)日：2009-04-23

申请号：US12232120

申请日：2008-09-11

申请人： Hirofumi Higuchi

发明人： Hirofumi Higuchi

IPC分类号： G01P15/125

CPC分类号： G01P15/125 ,  G01P15/131

摘要： A physical quantity sensor has a weight mass movable in a detection direction. Auxiliary capacitors are formed at both side ends of the weight mass in a non-detection direction by auxiliary movable electrodes and auxiliary fixed electrodes, respectively. When capacitances of the auxiliary capacitors change due to movement of the weight mass in the non-detection direction, a limiter circuit feedback-controls voltages applied to the auxiliary fixed electrodes to maintain the position of the weight mass unchanged. Thus, the weight mass is limited from moving in the non-detection direction thereby to improve accuracy in detection of the movement in the detection direction.

摘要翻译： 物理量传感器具有在检测方向上可移动的重量。 辅助电容器分别通过辅助可动电极和辅助固定电极在非检测方向上形成在重量块的两侧。 当辅助电容器的电容由于重量质量在非检测方向的移动而变化时，限制器电路对施加到辅助固定电极的电压进行反馈控制，以保持重量质量的位置不变。 因此，重量质量被限制为在非检测方向上移动，从而提高检测方向上的运动的检测精度。

公开(公告)号：US20090053212A1

公开(公告)日：2009-02-26

申请号：US11755671

申请日：2007-05-30

申请人： Nobuchika Yamamoto ,  Fumihiko Sakai ,  Hirofumi Higuchi ,  Masaharu Torikai ,  Toshihiro Nakashima

发明人： Nobuchika Yamamoto ,  Fumihiko Sakai ,  Hirofumi Higuchi ,  Masaharu Torikai ,  Toshihiro Nakashima

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07H21/04 ,  C12N15/64 ,  A61P37/06 ,  C12N1/21 ,  C12P21/00

CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56

摘要： The present invention provides a humanized anti-human osteopontin antibody having better activities (antigen binding activity, leukocyte migration inhibitory activity and the like) and/or stability (resistance to heat, low-pH conditions, denaturants and the like) than those of conventional anti-human osteopontin antibodies.

摘要翻译： 本发明提供具有比常规的更好的活性（抗原结合活性，白细胞迁移抑制活性等）和/或稳定性（耐热，低pH条件，变性剂等）的人源化抗人骨桥蛋白抗体 抗人骨桥蛋白抗体。

公开(公告)号：US20050199063A1

公开(公告)日：2005-09-15

申请号：US11075708

申请日：2005-03-10

申请人： Hirofumi Higuchi

发明人： Hirofumi Higuchi

IPC分类号： B81B5/00 ,  G01C19/5762 ,  G01P15/08

CPC分类号： G01C19/5762

摘要： An oscillator is oscillatable in a predetermined direction. First and second driving electrodes are secured to the base and apply an electrostatic force to the oscillator to make drive oscillation of the oscillator in the predetermined direction. At the time of the drive oscillation of the oscillator, a predetermined electric charge is accumulated in the oscillator, and electric charges of opposite polarities are alternately and periodically accumulated in the first and second driving electrodes, respectively, to exert an attractive force between the oscillator and a corresponding one of the first and second driving electrodes and also to exert a repulsive force between the oscillator and the other one of the first and second driving electrodes, and vice versa.

摘要翻译： 振荡器可在预定方向上振荡。 第一驱动电极和第二驱动电极固定到基座并向振荡器施加静电力，以使振荡器在预定方向上的驱动振荡。 在振荡器的驱动振荡时，在振荡器中累积预定的电荷，相反极性的电荷分别交替地周期地累积在第一和第二驱动电极中，以在振荡器之间施加吸引力 以及第一和第二驱动电极中的相应一个，并且还在振荡器和第一和第二驱动电极中的另一个之间施加排斥力，反之亦然。

公开(公告)号：US5087750A

公开(公告)日：1992-02-11

申请号：US586802

申请日：1990-09-24

申请人： Akitomo Uda ,  Shuji Ebata ,  Hirofumi Higuchi

发明人： Akitomo Uda ,  Shuji Ebata ,  Hirofumi Higuchi

IPC分类号： B01J23/34 ,  C07B61/00 ,  C07C231/06 ,  C07C235/06

CPC分类号： C07C231/065

摘要： A process for producing .alpha.-hydroisobutyric acid amide by a hydration reaction of acetonecyanohydrin in the presence of a catalyst containing manganese dioxide as a main component, and also in the presence of an oxidizing agent. In accordance with the process, the service life of the catalyst is increased, and the .alpha.-hydroxyisobutyric acid amide is produced in a high yield.

公开(公告)号：US5061675A

公开(公告)日：1991-10-29

申请号：US542835

申请日：1990-06-25

申请人： Shuji Ebata ,  Hiroyuki Hirayama ,  Hirofumi Higuchi ,  Koichi Kida

发明人： Shuji Ebata ,  Hiroyuki Hirayama ,  Hirofumi Higuchi ,  Koichi Kida

IPC分类号： B01J23/34 ,  C07B43/06 ,  C07C231/06

CPC分类号： B01J23/34 ,  C07C231/065

摘要： A process for producing a denatured manganese dioxide for the hydration reaction of cyanohydrins comprising reacting an aqueous permanganate salt solution and an aqueous manganese (II) compound in an acidic aqueous solution at a temperature of 70.degree. C. to 130.degree. C. is disclosed. The manganese dioxide catalyst obtained by the process exhibits a high activity over a long period in the preparation of an amide by the hydration of the corresponding cyanohydrin.

公开(公告)号：US20140214209A1

公开(公告)日：2014-07-31

申请号：US14343526

申请日：2012-08-28

申请人： Makiko Sugiura ,  Hirofumi Higuchi

发明人： Makiko Sugiura ,  Hirofumi Higuchi

IPC分类号： B25J9/16 ,  G01L1/16 ,  B06B1/06

CPC分类号： B25J9/1612 ,  B06B1/0674 ,  B25J13/082 ,  G01B17/00 ,  G01L1/16 ,  G01L1/162 ,  G01L1/255 ,  G01L5/226

摘要： A complex device includes: a substrate having a thick portion, a cavity and a membrane for bridging the cavity; and multiple piezoelectric elements having a lower electrode, a piezoelectric film and an upper electrode. A part of the piezoelectric elements has a projecting portion arranged on the upper electrode. The part of piezoelectric elements (30) provides a vertical pressure detection element. The piezoelectric elements further have an ultrasonic element other than the vertical pressure detection element. The ultrasonic element is arranged over at least the cavity of the substrate in a horizontal direction.

摘要翻译： 复杂装置包括：具有厚部分的基底，用于桥接空腔的空腔和膜; 以及具有下电极，压电膜和上电极的多个压电元件。 压电元件的一部分具有布置在上电极上的突出部分。 压电元件（30）的一部分提供垂直压力检测元件。 压电元件还具有除垂直压力检测元件之外的超声波元件。 超声波元件在水平方向上至少布置在基板的空腔上。

公开(公告)号：US08715655B2

公开(公告)日：2014-05-06

申请号：US12810939

申请日：2008-12-26

申请人： Masaharu Torikai ,  Daisuke Ishikawa ,  Toshihiro Nakashima ,  Hirofumi Higuchi ,  Fumihiko Sakai ,  Nobuchika Yamamoto ,  Hirotada Fujita ,  Katsunari Taguchi

发明人： Masaharu Torikai ,  Daisuke Ishikawa ,  Toshihiro Nakashima ,  Hirofumi Higuchi ,  Fumihiko Sakai ,  Nobuchika Yamamoto ,  Hirotada Fujita ,  Katsunari Taguchi

IPC分类号： A61K39/395 ,  C07K16/00 ,  C07K16/46 ,  C07K16/28 ,  G01N33/53

CPC分类号： C07K16/2839 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/00

摘要： The present invention provides a human anti-α9 integrin antibody or an antibody fragment which specifically recognize human α9 integrin and mouse α9 integrin, inhibit interaction with their ligands, particularly, the antibody or antibody fragment which recognize loop regions of human and mouse α9 integrins, a gene encoding the antibody or antibody fragment, a recombinant expression vector containing the gene, a transformant harboring the gene, production method of human anti-α9 integrin antibody or antibody fragment using the transformant, and an agent for the prophylaxis or treatment of rheumatoid arthritis which contains the antibody or antibody fragment.

摘要翻译： 本发明提供一种人抗α9整联蛋白抗体或特异性识别人α9整联蛋白和小鼠α9整联蛋白的抗体片段，抑制与其配体的相互作用，特别是识别人和小鼠α9整联蛋白环区的抗体或抗体片段， 编码抗体或抗体片段的基因，含有该基因的重组表达载体，携带该基因的转化体，使用该转化体的人抗-α9整联蛋白抗体的制备方法或抗体片段，以及预防或治疗类风湿性关节炎 其含有抗体或抗体片段。

公开(公告)号：US08413507B2

公开(公告)日：2013-04-09

申请号：US12801405

申请日：2010-06-08

申请人： Tetsuo Fujii ,  Hisanori Yokura ,  Hirofumi Higuchi

发明人： Tetsuo Fujii ,  Hisanori Yokura ,  Hirofumi Higuchi

IPC分类号： G01C19/56 ,  G01P15/125

CPC分类号： H01L27/1203 ,  B81B2201/025 ,  B81B2201/0257 ,  B81B2201/0285 ,  B81B2201/047 ,  B81C1/00182 ,  G01C19/5755 ,  G01P15/0802 ,  G01P15/125 ,  G01P2015/0814 ,  H01L21/84

摘要： A semiconductor dynamic quantity sensor has a substrate including a semiconductor substrate, an insulation layer on a main surface of the semiconductor substrate, and a semiconductor layer on the insulation layer. The main surface has a projection that is trapezoidal or triangular in cross section. The semiconductor layer is divided by a through hole into a movable portion. A tip of the projection is located directly below the movable portion and spaced from the movable portion by a predetermined distance in a thickness direction of the substrate. A width of the tip of the projection is less than a width of the movable portion in a planar direction of the substrate. The distance between the tip of the projection and the movable portion is equal to a thickness of the insulation layer.

摘要翻译： 半导体动态量传感器具有包括半导体衬底，半导体衬底的主表面上的绝缘层和绝缘层上的半导体层的衬底。 主表面具有横截面为梯形或三角形的突起。 半导体层由通孔分割成可动部。 突出部的尖端位于可动部的正下方，与基板的厚度方向与可动部隔开预定的距离。 突起的尖端的宽度小于基板的平面方向上的可动部的宽度。 突起的尖端和可动部之间的距离等于绝缘层的厚度。