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    Method of Producing Human IgG Antibodies with Enhanced Effector Functions
    12.
    发明申请
    Method of Producing Human IgG Antibodies with Enhanced Effector Functions 审中-公开
    用增强效应功能生产人IgG抗体的方法

    公开(公告)号：US20090215639A1

    公开(公告)日：2009-08-27

    申请号：US11912568

    申请日：2006-04-26

    申请人： Roberto Crea ,  Arvind Rajpal ,  Guido Cappuccilli ,  Toshihiko Takeuchi ,  Ramesh Bhatt ,  Randy Shen

    发明人： Roberto Crea ,  Arvind Rajpal ,  Guido Cappuccilli ,  Toshihiko Takeuchi ,  Ramesh Bhatt ,  Randy Shen

    IPC分类号： C40B30/04 ,  C40B30/00 ,  C12P19/34

    CPC分类号： C07K16/00 ,  C07K2317/72 ,  C07K2319/30 ,  C07K2319/33 ,  C12N15/1051 ,  C12N15/1086

    摘要： A method for generating human IgG1 antibodies with enhanced Fc effector function is disclosed. In practicing the method, an IgG1 Fc look-through mutagenesis (LTM) coding library directed at four receptor-contact regions of the Fc CH2 portion of in human IgG1 Fc is expressed in a system in which the mutated Fc fragments are displayed on the surfaces of the expression cells. The fragments are then screened for altered binding affinity to a selected Fc receptor or other Fc-binding protein. The selected mutations may be used, in turn, to guide the selection of multiple substitutions in the construction of a walk-through mutation (WTM) library, for generating additional Fc fragment mutations with desired binding properties. The antibodies so produced have a variety of therapeutic and diagnostic applications.

    摘要翻译： 公开了产生具有增强的Fc效应子功能的人IgG1抗体的方法。 在实施该方法中，针对人IgG1 Fc中的Fc CH2部分的四个受体 - 接触区域的IgG1 Fc直通诱变（LTM）编码文库在其中突变的Fc片段显示在表面上的系统中表达 的表达细胞。 然后筛选片段以改变与选定的Fc受体或其它Fc结合蛋白的结合亲和力。 可以使用选定的突变来指导在构建穿越突变（WTM）文库中的多个取代的选择，以产生具有期望的结合性质的另外的Fc片段突变。 所产生的抗体具有多种治疗和诊断应用。

    Bicycle handlebar clamp assembly
    17.
    发明授权
    Bicycle handlebar clamp assembly 有权
    自行车把手夹具总成

    公开(公告)号：US09550544B2

    公开(公告)日：2017-01-24

    申请号：US13558862

    申请日：2012-07-26

    申请人： Toshihiko Takeuchi ,  Yoshimitsu Miki ,  Shinya Hirotomi

    发明人： Toshihiko Takeuchi ,  Yoshimitsu Miki ,  Shinya Hirotomi

    IPC分类号： F16B7/04 ,  B62K23/06 ,  B62K21/12 ,  F16B33/00 ,  F16M13/02

    CPC分类号： B62K23/06 ,  B62K21/12 ,  F16B7/04 ,  F16B33/00 ,  F16M13/02 ,  Y10T74/20256 ,  Y10T74/20822

    摘要： A bicycle handlebar clamp assembly has a handlebar clamp, a fixing nut, and a fixing bolt. The fixing nut includes a threaded bore having a bolt entrance opening and a bolt exit opening. The fixing nut defines a bolt shaft receiving space disposed adjacent the bolt exit opening. The fixing bolt includes a head and a shaft extending from the head. The shaft has a non-threaded portion disposed between two threaded portions. One of threaded portions is disposed closer to the head of the fixing bolt than the other threaded portion. The threaded portions are dimensioned to threadedly engage the threaded bore of the fixing nut. The non-threaded portion has a axial length that is greater than the axial length of the threaded bore of the fixing nut.

    摘要翻译： 自行车车把夹具组件具有车把夹，固定螺母和固定螺栓。 固定螺母包括具有螺栓入口和螺栓出口的螺纹孔。 固定螺母限定了一个邻近螺栓出口开口设置的螺栓轴接纳空间。 固定螺栓包括头部和从头部延伸的轴。 轴具有设置在两个螺纹部分之间的非螺纹部分。 一个螺纹部分设置成比另一个螺纹部分更靠近固定螺栓的头部。 螺纹部分的尺寸设计成螺纹接合固定螺母的螺纹孔。 非螺纹部分的轴向长度大于固定螺母的螺纹孔的轴向长度。

    Power storage device and method for manufacturing the same
    18.
    发明授权
    Power storage device and method for manufacturing the same 有权
    蓄电装置及其制造方法

    公开(公告)号：US08709654B2

    公开(公告)日：2014-04-29

    申请号：US13596163

    申请日：2012-08-28

    申请人： Toshihiko Takeuchi ,  Minoru Takahashi ,  Takeshi Osada ,  Teppei Oguni ,  Takuya Hirohashi ,  Hiroyuki Tomisu

    发明人： Toshihiko Takeuchi ,  Minoru Takahashi ,  Takeshi Osada ,  Teppei Oguni ,  Takuya Hirohashi ,  Hiroyuki Tomisu

    IPC分类号： H01M4/36 ,  H01M4/64

    CPC分类号： C23C26/00 ,  B82Y30/00 ,  C23C28/04 ,  H01M4/134 ,  H01M4/1395 ,  H01M4/364 ,  H01M4/366 ,  H01M4/386 ,  H01M4/483 ,  H01M4/62 ,  H01M4/625 ,  H01M2004/021

    摘要： A power storage device including a negative electrode having high cycle performance in which little deterioration due to charge and discharge occurs is manufactured. A power storage device including a positive electrode, a negative electrode, and an electrolyte provided between the positive electrode and the negative electrode is manufactured, in which the negative electrode includes a negative electrode current collector and a negative electrode active material layer, and the negative electrode active material layer includes an uneven silicon layer formed over the negative electrode current collector, a silicon oxide layer or a mixed layer which includes silicon oxide and a silicate compound and is in contact with the silicon layer, and graphene in contact with the silicon oxide layer or the mixed layer including the silicon oxide and the silicate compound.

    摘要翻译： 一种蓄电装置，其特征在于，包括具有高周期性能的负极，其中由于充放电引起的劣化很小。 制造包括正极，负极和设置在正极和负极之间的电解质的蓄电装置，其中负极包括负极集电体和负极活性物质层，负极 电极活性物质层包括在负极集电体上形成的不均匀硅层，氧化硅层或包含氧化硅和硅酸盐化合物并与硅层接触的混合层，以及与氧化硅接触的石墨烯 层或包含氧化硅和硅酸盐化合物的混合层。

    Manufacturing method of group of whiskers
    19.
    发明授权
    Manufacturing method of group of whiskers 有权
    晶须组的制造方法

    公开(公告)号：US08658246B2

    公开(公告)日：2014-02-25

    申请号：US13248675

    申请日：2011-09-29

    申请人： Toshihiko Takeuchi ,  Makoto Ishikawa ,  Yuki Murakami

    发明人： Toshihiko Takeuchi ,  Makoto Ishikawa ,  Yuki Murakami

    IPC分类号： C23C16/00 ,  H01L31/18

    CPC分类号： H01L31/035209 ,  H01L21/0242 ,  H01L21/02422 ,  H01L21/02532 ,  H01L21/02603 ,  H01L21/0262 ,  H01L21/02645

    摘要： A seed substrate is placed to face a formation substrate, and then a gas containing silicon is introduced and chemical vapor deposition is performed. There is no particular limitation on a kind of a material used for the formation substrate as long as the material can withstand the temperature at which the reduced pressure chemical vapor deposition is performed. A group of silicon whiskers which does not include a seed atom can be grown directly on and in contact with the formation substrate. Further, the substrate provided with the group of whiskers can be applied to a solar cell, a lithium ion secondary battery, and the like, by utilizing surface characteristics of the group of whiskers.

    摘要翻译： 将种子基板放置成面对形成衬底，然后引入含有硅的气体并进行化学气相沉积。 只要材料能够承受进行减压化学气相沉积的温度，对形成基板的材料的种类没有特别限制。 不包括种子原子的一组硅晶须可以直接在地层衬底上生长并与其接触。 此外，通过利用晶须组的表面特性，可以将具有一组晶须的基板施加到太阳能电池，锂离子二次电池等。

    POWER STORAGE DEVICE, ELECTRODE THEREOF, AND METHOD FOR MANUFACTURING POWER STORAGE DEVICE
    20.
    发明申请
    POWER STORAGE DEVICE, ELECTRODE THEREOF, AND METHOD FOR MANUFACTURING POWER STORAGE DEVICE 有权
    蓄电装置及其电极及制造蓄电装置的方法

    公开(公告)号：US20120328962A1

    公开(公告)日：2012-12-27

    申请号：US13491647

    申请日：2012-06-08

    申请人： Toshihiko Takeuchi ,  Teppei Oguni ,  Takeshi Osada

    发明人： Toshihiko Takeuchi ,  Teppei Oguni ,  Takeshi Osada

    IPC分类号： H01M4/64 ,  H01M4/66 ,  H01M4/04 ,  H01M8/22

    CPC分类号： H01M4/134 ,  H01M4/0428 ,  H01M4/1395 ,  H01M4/661 ,  H01M4/667 ,  Y02P70/54

    摘要： To provide a power storage device having excellent charge/discharge cycle characteristics and a high charge/discharge capacity. The following electrode is used as an electrode of a power storage device: an electrode including a current collector and an active material layer provided over the current collector. The active material layer includes a plurality of whisker-like active material bodies. Each of the plurality of whisker-like active material bodies includes at least a core and an outer shell provided to cover the core. The outer shell is amorphous, and a portion between the current collector and the core of the active material bodies is amorphous. Note that a metal layer may be provided instead of the current collector, the active material bodies do not necessarily have to include the core, and a mixed layer may be provided between the current collector and the active material layer.

    摘要翻译： 提供具有优异的充放电循环特性和高充电/放电容量的蓄电装置。 作为蓄电装置的电极，使用以下电极：设置在集电体上的集电体和活性物质层的电极。 活性物质层包括多个晶须状活性物质体。 多个晶须状活性物质体中的每一个至少包括芯部和设置成覆盖芯部的外壳。 外壳是无定形的，并且集电体和活性材料体的芯之间的部分是无定形的。 注意，可以提供金属层而不是集电体，活性材料体不一定必须包括芯，并且可以在集电体和活性材料层之间设置混合层。