利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

97 条记录 (耗时 0.052 秒)

    PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2
    14.
    发明申请
    PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 有权
    用于治疗由CRTH2介导的疾病的吡咯烷衍生物

    公开(公告)号：US20100322980A1

    公开(公告)日：2010-12-23

    申请号：US12868663

    申请日：2010-08-25

    申请人： Tai-wei Ly ,  Yuji Koriyama ,  Takashi Yoshino ,  Hiroki Sato ,  Kazuho Tanaka ,  Hiromi Sugimoto ,  Yoshihisa Manabe ,  Kevin Bacon ,  Klaus Urbahns ,  Masanori Seki ,  Takuya Shintani

    发明人： Tai-wei Ly ,  Yuji Koriyama ,  Takashi Yoshino ,  Hiroki Sato ,  Kazuho Tanaka ,  Hiromi Sugimoto ,  Yoshihisa Manabe ,  Kevin Bacon ,  Klaus Urbahns ,  Masanori Seki ,  Takuya Shintani

    IPC分类号： A61K9/00 ,  A61K31/505 ,  A61K31/5377 ,  A61K31/506

    CPC分类号： C07D239/42 ,  C07D239/30 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12

    摘要： The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.

    摘要翻译： 本发明涉及式（I）的嘧啶衍生物及其盐，其可用作药物制剂的活性成分。 本发明的嘧啶衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病，特别是用于治疗过敏性疾病 ，如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。

    Imidazo[1,2-C]pyrimidinylacetic acid derivatives
    17.
    发明授权
    Imidazo[1,2-C]pyrimidinylacetic acid derivatives 有权
    咪唑并[1,2-C]嘧啶基乙酸衍生物

    公开(公告)号：US07750014B2

    公开(公告)日：2010-07-06

    申请号：US10585429

    申请日：2005-01-19

    申请人： Tai-Wei Ly ,  Takashi Yoshino ,  Yuki Takekawa ,  Takuya Shintani ,  Hiromi Sugimoto ,  Kevin Bacon ,  Klaus Urbahns

    发明人： Tai-Wei Ly ,  Takashi Yoshino ,  Yuki Takekawa ,  Takuya Shintani ,  Hiromi Sugimoto ,  Kevin Bacon ,  Klaus Urbahns

    IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D487/00

    CPC分类号： C07D487/04

    摘要： The present invention relates to an imidazo[1,2-c]pyrimidinylacetic acid derivative and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The imidazo[1,2-c]pyrimidinylacetic acid derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.

    摘要翻译： 本发明涉及可用作药物制剂活性成分的咪唑并[1,2-c]嘧啶基乙酸衍生物及其盐。 本发明的咪唑并[1,2-c]嘧啶基乙酸衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病 特别是用于治疗过敏性疾病如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。

    Imidazo[1,2-C]Pyrimidinylacetic Acid Derivatives
    18.
    发明申请
    Imidazo[1,2-C]Pyrimidinylacetic Acid Derivatives 有权
    咪唑并[1,2-C]嘧啶基乙酸衍生物

    公开(公告)号：US20090012102A1

    公开(公告)日：2009-01-08

    申请号：US10585429

    申请日：2005-01-19

    申请人： Tai-wei Ly ,  Takashi Yoshino ,  Yuki Takekawa ,  Takuya Shintani ,  Hiromi Sugimoto ,  Kevin Bacon ,  Klaus Urbahns

    发明人： Tai-wei Ly ,  Takashi Yoshino ,  Yuki Takekawa ,  Takuya Shintani ,  Hiromi Sugimoto ,  Kevin Bacon ,  Klaus Urbahns

    IPC分类号： A61K31/519 ,  C07D487/04 ,  A61P11/06 ,  A61P37/08 ,  A61P35/00

    CPC分类号： C07D487/04

    摘要： The present invention relates to an imidazo[1,2-c]pyrimidinylacetic acid derivative and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The imidazo[1,2-c]pyrimidinylacetic acid derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.

    摘要翻译： 本发明涉及可用作药物制剂活性成分的咪唑并[1,2-c]嘧啶基乙酸衍生物及其盐。 本发明的咪唑并[1,2-c]嘧啶基乙酸衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病 特别是用于治疗过敏性疾病如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。

    Data converting apparatus, method, and computer product
    20.
    发明授权
    Data converting apparatus, method, and computer product 有权
    数据转换装置，方法和计算机产品

    公开(公告)号：US08326850B2

    公开(公告)日：2012-12-04

    申请号：US12837801

    申请日：2010-07-16

    申请人： Kazuo Mineno ,  Takashi Yoshino

    发明人： Kazuo Mineno ,  Takashi Yoshino

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30569 ,  G06F17/30914

    摘要： A data converting apparatus includes a storage unit that stores encoded meta-definition information, a data converting function, a conversion rule table, and a conversion rule; an input unit that receives input of data to be converted; a detecting unit that uses the encoded meta-definition information to detect metadata codes for a conversion source and a conversion destination for which the conversion rule code matches; a determining unit that determines whether the detected metadata codes match; a specifying unit that, by referring to a conversion rule and based on the determination result at the determining unit, specifies the data converting function, according to the combination of the metadata codes for the conversion source and for the conversion destination; and a converting unit that uses the specified data converting function to convert the data of the conversion source to have a property prescribed by metadata for the conversion destination.

    摘要翻译： 数据转换装置包括存储编码的元定义信息的存储单元，数据转换功能，转换规则表和转换规则; 接收要转换的数据的输入的输入单元; 检测单元，其使用编码的元定义信息来检测转换源和转换规则码匹配的转换目的地的元数据代码; 确定单元，确定检测到的元数据代码是否匹配; 指定单元，通过参照转换规则并且基于确定单元的确定结果，根据转换源和转换目的地的元数据代码的组合来指定数据转换功能; 以及转换单元，其使用指定的数据转换功能将转换源的数据转换为具有用于转换目的地的元数据规定的属性。