摘要:
An occupant presence sensor apparatus disposed in a seat includes first and second substantially non-compliant force translation plates generally parallel to the seating surface of the seat, an elastomeric mat disposed between the first and second force translation plates, and a switch mechanism disposed between the first and second force translation plates within an opening formed in the elastomeric mat. The elastomeric mat includes a distributed array of hollow protuberances that extend toward and contact the force translation plates, and the mat has a stiffness that normally provides a clearance between the switch mechanism and one of the force translation plates. When an occupant of specified or higher weight sits on the seating surface, the protuberances collapse and the force translation plates activate the switch mechanism.
摘要:
Disclosed is a method for delivering decision-supported patient data to a clinician to aid the clinician with the diagnosis and treatment of a medical condition. The method including presenting a patient with questions generated by a decision-support module and gathering patient data indicative of the responses to the questions. Each question presented to the patient is based upon the prior questions presented to and the patient data gathered from the patient. Upon receiving the patient data from the client module, evaluating the patient data at the module to generate decision-supported patient data, this supported patient data includes medical condition diagnoses, pertinent medical parameters for the medical condition, and medical care recommendations for the medical condition. At the client module or a clinician's client module, presenting the clinician with this patient data in either a standardized format associated with a progress note or a format selected by the clinician.
摘要:
The present invention provides methods for designing a filtration systems for capturing viable tumor cells, such as circulating tumor cells at high efficiency and high viability. The methods involve development of a set of “key engineering design parameters” that are crucial to achieve high tumor cell viability. These important design parameters include the filter geometry design, fluid delivery method, transfilter pressure and total filtration time.
摘要:
Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 μm to 5 μm thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The thin regions of parylene are semipermeable to allow for proteins in serum to pass through, and the thick regions give mechanical support for handling by a surgeon. The smooth front side allows for monolayer cell growth, and the rough back side helps prevents cells from attaching there.
摘要:
The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC), for example, a viable CTC, from a sample using a parylene microfilter device comprising a membrane filter having or consisting of a parylene substrate, which has an array of holes with a predetermined shape and size; and detecting and quantifying telomerase activity in blood circulating tumor cells. The invention further provides methods of using cells live-captured in various applications.
摘要:
A microfiltration apparatus and method for separating cells, such as circulating tumor cells, from a sample using a microfiltration device having a top porous membrane and a bottom porous membrane. The porous membranes are formed from parylene and assembled using microfabrication techniques. The porous membranes are arranged so that the pores in the top membrane are offset from the pores in the bottom membrane.
摘要:
The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC), for example, a viable CTC, from a sample using a parylene microfilter device comprising a membrane filter having or consisting of a parylene substrate, which has an array of holes with a predetermined shape and size; and detecting and quantifying telomerase activity in blood circulating tumor cells. The invention further provides methods of using cells live-captured in various applications.
摘要:
An occupant presence sensor apparatus disposed in a seat includes first and second substantially non-compliant force translation plates generally parallel to the seating surface of the seat, an elastomeric mat disposed between the first and second force translation plates, and a switch mechanism disposed between the first and second force translation plates within an opening formed in the elastomeric mat. The elastomeric mat includes a distributed array of hollow protuberances that extend toward and contact the force translation plates, and the mat has a stiffness that normally provides a clearance between the switch mechanism and one of the force translation plates. When an occupant of specified or higher weight sits on the seating surface, the protuberances collapse and the force translation plates activate the switch mechanism.
摘要:
An over-molded electronic module (2) includes a frame (10), an electronic assembly (20), and a polymeric body (32). The frame (10) includes a sidewall (14) that defines an opening (12) to provide a position for the electronic assembly (20), and includes an upper face (16) and a lower face (18) opposite the upper face (16) to act as sealing surfaces during over-molding. The polymeric body (32) is formed of a polymeric composition encapsulating both sides of the electronic assembly (20) and a portion of the frame (10).
摘要:
A decision-support system for providing a clinician with real-time patient data specific to each patient that the clinician is to examine in a defined time period. The system including a decision-support module that is configured to generate decision-supported patient data that is specific to each patient that a clinician is to examine in a defined time period. The decision-support module including an inference engine that communicates with a knowledge module and a patient module to generate the decision-supported patient data. In real-time communication with the decision-support module is a user module that is adapted to present the decision-supported patient data in real-time to the clinician in a configuration that assists the clinician in treating each patient. The user module further allowing the clinician to changes elements of the decision-supported patient data and receive new recommendations and medical care suggestions in real-time from the decision-support module.