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公开(公告)号：US20180140678A1
公开(公告)日：2018-05-24
申请号：US15640063
申请日：2017-06-30
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： James Yoo , Sang Jin Lee , Anthony Atala , Mark Van Dyke
CPC classification number: A61K38/39 , A61K9/0024 , A61K38/4886 , A61L27/24 , A61L27/52 , A61L27/54 , A61L2300/41 , A61L2300/434 , A61L2400/06 , A61L2430/26 , A61K2300/00
Abstract: The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic resources and environmental conditions can be used for in situ tissue regeneration and thereby reduce or eliminate the need for donor cell procurement and ex vivo manipulation of such donor cells. Methods are disclosed for recruitment of a subject's own stem cells to a target region by inducing a sustained positive pressure at a target site, such as the kidney, thereby increasing the number of pluripotent cells capable of differentiating to regenerate the target tissue.
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公开(公告)号：US20170368743A1
公开(公告)日：2017-12-28
申请号：US15672885
申请日：2017-08-09
Applicant: Wake Forest University Health Sciences
Inventor： Hyun-Wook Kang , Sang Jin Lee , Anthony Atala , James J. Yoo
IPC: B29C64/112 , A61L27/26 , A61L27/38 , B29C64/393 , A61L27/52 , A61L27/20 , A61L27/22 , B33Y80/00 , B33Y70/00 , B33Y30/00 , A61K35/12 , B29K105/00 , B29L31/00 , C12M3/00 , B33Y10/00 , C12M1/26 , C12M1/00
CPC classification number: B29C64/112 , A61K35/12 , A61L27/20 , A61L27/222 , A61L27/225 , A61L27/26 , A61L27/38 , A61L27/52 , B29C64/124 , B29C64/386 , B29C64/393 , B29K2105/0005 , B29K2267/04 , B29L2031/7532 , B33Y10/00 , B33Y30/00 , B33Y70/00 , B33Y80/00 , C12M21/08 , C12M23/50 , C12M33/00 , C08L5/08
Abstract: A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.
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公开(公告)号：US09764516B2
公开(公告)日：2017-09-19
申请号：US14476359
申请日：2014-09-03
Applicant: Wake Forest University Health Sciences
Inventor： Hyun-Wook Kang , Sang Jin Lee , Anthony Atala , James J. Yoo
IPC: C12N5/00 , C12N5/02 , A61F13/00 , B29C67/00 , A61L27/20 , A61L27/22 , A61L27/38 , A61L27/52 , A61L27/26 , A61K35/12 , B33Y10/00 , B33Y30/00 , B33Y70/00 , B33Y80/00 , B29K105/00 , B29L31/00 , C12M3/00 , C12M1/00 , C12M1/26
CPC classification number: B29C64/112 , A61K35/12 , A61L27/20 , A61L27/222 , A61L27/225 , A61L27/26 , A61L27/38 , A61L27/52 , B29C64/124 , B29C64/386 , B29C64/393 , B29K2105/0005 , B29K2267/04 , B29L2031/7532 , B33Y10/00 , B33Y30/00 , B33Y70/00 , B33Y80/00 , C12M21/08 , C12M23/50 , C12M33/00 , C08L5/08
Abstract: A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.
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公开(公告)号：US09713501B2
公开(公告)日：2017-07-25
申请号：US14325908
申请日：2014-07-08
Inventor： Rohan A. Shirwaiker , Caroline Elise Webster , John D. Jackson , Richard A. Wysk , Sang Jin Lee , Ola L. A. Harrysson , James J. Yoo , Anthony Atala , Paul H. Cohen , Yuan-Shin Lee , Peter M. Prim , Molly F. Purser , Katie L. Basinger
IPC: A61B17/322 , A61B19/00 , A61B90/00
CPC classification number: A61B90/02 , A61B17/322 , A61B2017/3225
Abstract: Provided herein is a tissue stretching device configured for orbicular expansion of a tissue placed therein. Methods of use of the device to stretch a tissue as well as for culturing organized tissues are also provided. Stretched and/or cultured tissues produced by these processes are also provided, as well as methods making use of the same.
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15.发明授权公开(公告)号：US10751447B2
公开(公告)日：2020-08-25
申请号：US16128273
申请日：2018-09-11
Applicant: Wake Forest University Health Sciences
Inventor： Hyunhee Ahn , Young Min Ju , Anthony Atala , Sang Jin Lee
Abstract: Vascular scaffolds and methods of fabricating the same are disclosed for tissue engineering of vascular constructs. By combining electrospun matrices with cell sheet technologies, vascular constructs with more mature cell layers can be obtained for reconstruction of blood vessels, heart valves and the like. A engineered smooth muscle cell sheet, wrapped around an electrospun vascular scaffold, is able to provide a mature SMC layer that expresses strong cell-to-cell junction markers and contractile proteins. In addition, preconditioning of the cell sheet covered vascular scaffold maintained cell viability and infiltration into the scaffold.
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Patent Agency Ranking
16.发明申请公开(公告)号：US20150119994A1
公开(公告)日：2015-04-30
申请号：US14476359
申请日：2014-09-03
Applicant: Wake Forest University Health Sciences
Inventor： Hyun-Wook Kang , Sang Jin Lee , Anthony Atala , James J. Yoo
CPC classification number: B29C64/112 , A61K35/12 , A61L27/20 , A61L27/222 , A61L27/225 , A61L27/26 , A61L27/38 , A61L27/52 , B29C64/124 , B29C64/386 , B29C64/393 , B29K2105/0005 , B29K2267/04 , B29L2031/7532 , B33Y10/00 , B33Y30/00 , B33Y70/00 , B33Y80/00 , C12M21/08 , C12M23/50 , C12M33/00 , C08L5/08
Abstract: A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.
Abstract translation: 一种制造器官或组织的方法包括：（a）提供含有结构支持聚合物的第一分配器和包含含活细胞组合物的第二分配器; （b）从所述第一和第二分配器在所述支撑件上沉积一层，所述层包括结构支撑聚合物和所述含细胞的组合物; 然后（c）重复地重复所述沉积步骤多次以形成多个层，其中每个所述层中的单独和离散区域包括所述支撑聚合物或所述含细胞组合物中的一种或另一种， 从而产生提供包含结构支持区域和含细胞区域的复合三维结构。 还描述了用于实施由该方法生产的方法和复合产品的装置。
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17.发明申请Laminous Vascular Constructs Combining Cell Sheet Engineering And Electrospinning Technologies 审中-公开结合细胞板工程和静电纺丝技术的层状血管构造公开(公告)号：US20150112419A1
公开(公告)日：2015-04-23
申请号：US14518352
申请日：2014-10-20
Applicant: Wake Forest University Health Sciences
Inventor： Hyunhee Ahn , Young Min Ju , Anthony Atala , Sang Jin Lee
CPC classification number: A61L27/507 , A61F2/06 , A61F2/062 , A61F2/07 , A61F2210/0076 , A61F2240/001 , A61L27/26 , A61L27/3808 , A61L27/3826 , C12N5/0691 , C12N2533/40 , C12N2533/54 , D01D5/0007 , C08L67/04 , C08L89/06
Abstract: Vascular scaffolds and methods of fabricating the same are disclosed for tissue engineering of vascular constructs. By combining electrospun matrices with cell sheet technologies, vascular constructs with more mature cell layers can be obtained for reconstruction of blood vessels, heart valves and the like. A engineered smooth muscle cell sheet, wrapped around an electrospun vascular scaffold, is able to provide a mature SMC layer that expresses strong cell-to-cell junction markers and contractile proteins. In addition, preconditioning of the cell sheet covered vascular scaffold maintained cell viability and infiltration into the scaffold.
Abstract translation: 血管支架及其制造方法被公开用于血管构造的组织工程。 通过将静电纺丝基质与细胞片技术相结合，可以获得具有更成熟细胞层的血管构造物用于重建血管，心脏瓣膜等。 围绕电纺丝血管支架的工程化平滑肌细胞片能够提供表达强的细胞 - 细胞连接标记物和收缩蛋白质的成熟的SMC层。 此外，细胞膜覆盖的血管支架的预处理保持细胞活力并渗入支架。
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公开(公告)号：US20140371869A1
公开(公告)日：2014-12-18
申请号：US14256643
申请日：2014-04-18
Applicant: Wake Forest University Health Sciences
Inventor： Anthony Atala , James J. Yoo , Grace Lim , Sang Jin Lee
CPC classification number: A61F2/28 , A61K35/32 , A61K35/34 , A61K38/18 , A61L27/3604 , A61L27/3817 , A61L27/3821 , A61L27/3826 , A61L27/383 , A61L27/3891 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2430/02
Abstract: The invention pertains to methods of producing artificial composite tissue constructs that permit coordinated motion. Biocompatable structural matrices having sufficient rigidity to provide structural support for cartilage-forming cells and bone-forming cells are used. Biocompatable flexible matrices seeded with muscle cells are joined to the structural matrices to produce artificial composite tissue constructs that are capable of coordinated motion.
Abstract translation: 本发明涉及生产允许协调运动的人造复合组织结构的方法。 使用具有足够刚性以提供软骨形成细胞和骨形成细胞的结构支持的生物相容性结构基质。 用肌肉细胞接种的生物相容的柔性基质连接到结构基质上以产生能够协调运动的人造复合组织构建体。
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公开(公告)号：US11801327B2
公开(公告)日：2023-10-31
申请号：US17237116
申请日：2021-04-22
Applicant: Wake Forest University Health Sciences
Inventor： Hyun-Wook Kang , Sang Jin Lee , Anthony Atala , James J. Yoo
IPC: A61L27/20 , A61L27/22 , A61L27/26 , A61L27/38 , A61L27/52 , B29C64/112 , B29C64/124 , B29C64/393 , B33Y70/00 , C12M3/00 , C12M1/00 , C12M1/26 , A61K35/12 , B33Y10/00 , B33Y30/00 , B33Y80/00 , B29K105/00 , B29K267/00 , B29L31/00
CPC classification number: A61L27/20 , A61L27/222 , A61L27/225 , A61L27/26 , A61L27/38 , A61L27/52 , B29C64/112 , B29C64/124 , B29C64/393 , B33Y70/00 , A61K35/12 , B29K2105/0005 , B29K2267/04 , B29L2031/7532 , B33Y10/00 , B33Y30/00 , B33Y80/00 , C12M21/08 , C12M23/50 , C12M33/00
Abstract: A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.
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公开(公告)号：US11786581B2
公开(公告)日：2023-10-17
申请号：US17105156
申请日：2020-11-25
Applicant: Wake Forest University Health Sciences
Inventor： James Yoo , Sang Jin Lee , Anthony Atala , Mark Van Dyke
CPC classification number: A61K38/39 , A61K9/0024 , A61K38/4886 , A61L27/24 , A61L27/52 , A61L27/54 , A61L2300/41 , A61L2300/434 , A61L2400/06 , A61L2430/26 , A61K38/39 , A61K2300/00 , A61K38/4886 , A61K2300/00
Abstract: The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic resources and environmental conditions can be used for in situ tissue regeneration and thereby reduce or eliminate the need for donor cell procurement and ex vivo manipulation of such donor cells. Methods are disclosed for recruitment of a subject's own stem cells to a target region by inducing a sustained positive pressure at a target site, such as the kidney, thereby increasing the number of pluripotent cells capable of differentiating to regenerate the target tissue.
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