公开(公告)号：US20240044852A1

公开(公告)日：2024-02-08

申请号：US18491132

申请日：2023-10-20

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Joseph D. Michienzi ,  Joseph D. Antocci ,  Jeffrey Musacchio

IPC: G01N30/60

CPC classification number: G01N30/6026 ,  G01N30/6047

Abstract: A clamp assembly includes a rail extending along the length and configured to receive a first fluidic assembly, and a carriage movably attachable to the rail such that the carriage moves along the rail, the carriage configured to receive a second fluidic assembly, the carriage including an actuator and a stop mechanism. The stop mechanism is configured to selectively prevent and allow movement of the carriage relative to the rail. The stop mechanism is configured to be independently operable from the actuator assembly, and the actuator is configured: to move a chromatography column received by the clamp assembly relative to the rail to create a first fluid tight seal between the chromatography column and the first fluidic assembly, and move the second fluidic assembly relative to the carriage body to create a second fluid tight seal between the second fluidic assembly and the chromatography column.

公开(公告)号：US11796516B2

公开(公告)日：2023-10-24

申请号：US17239813

申请日：2021-04-26

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Joseph D. Michienzi ,  Joseph D. Antocci ,  Jeffrey Musacchio

IPC: G01N30/60

CPC classification number: G01N30/6026 ,  G01N30/6047

Abstract: A clamp assembly includes a rail extending along the length and configured to receive a first fluidic assembly, and a carriage movably attachable to the rail such that the carriage moves along the rail, the carriage configured to receive a second fluidic assembly, the carriage including an actuator and a stop mechanism. The stop mechanism is configured to selectively prevent and allow movement of the carriage relative to the rail. The stop mechanism is configured to be independently operable from the actuator assembly, and the actuator is configured: to move a chromatography column received by the clamp assembly relative to the rail to create a first fluid tight seal between the chromatography column and the first fluidic assembly, and move the second fluidic assembly relative to the carriage body to create a second fluid tight seal between the second fluidic assembly and the chromatography column.

公开(公告)号：US11794200B2

公开(公告)日：2023-10-24

申请号：US17155462

申请日：2021-01-22

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Emrys Jones ,  Steven Derek Pringle ,  Stephen Hattan ,  Gregory T. Roman

IPC: B05B5/03 ,  B05B12/32

CPC classification number: B05B5/03 ,  B05B12/32

Abstract: A sprayer assembly for an ion source is disclosed. The sprayer includes a capillary having an outlet, a sheath for the capillary, and an elastic member. The sheath can move relative to the capillary between a first position in which the sheath covers the outlet of the capillary and a second position in which the outlet of the capillary is exposed. When the sheath moves from the first position to or towards the second position, the elastic member provides a restoring force that acts to restore the position of the sheath to or towards the first position.

公开(公告)号：US20220128527A1

公开(公告)日：2022-04-28

申请号：US17512864

申请日：2021-10-28

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Michael O. Fogwill

IPC: G01N30/60

Abstract: The exemplary embodiments provide chromatography column positioning assemblies that can ensure that the distance between face seals or other sealing surfaces/mechanisms at the respective ends of a liquid chromatography column is a desired distance (i.e., the length of the liquid chromatography column). The exemplary embodiments can adjust the separation between the face seals to accommodate different length liquid chromatography columns. For example, a chromatography column positioning assembly of an exemplary embodiment can set the distance between face seals to accommodate a 25 mm column, a 50 mm column or a 100 mm column.

公开(公告)号：US20210199624A1

公开(公告)日：2021-07-01

申请号：US17057361

申请日：2019-05-20

Applicant: Waters Technologies Corporation

Inventor： Martin Gilar ,  Thomas S. McDonald ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Rachel Mumma ,  Keith Fadgen ,  Geoff C. Gerhardt

IPC: G01N30/06 ,  G01N1/40 ,  G01N30/54 ,  G01N30/60 ,  B01J20/24 ,  B01J20/28 ,  B01J20/288 ,  B01J20/32 ,  B01D15/38 ,  B01D15/22 ,  B01D15/16

Abstract: Sample preparation and separation can be performed using a sample cartridge (201). The cartridge includes a barrel (204) with a first and second end, a column segment (209) connected to the second end of the barrel, and a column (205) containing a sorbent material. The sorbent material includes particles that have antibodies attached to them to selectively retain analytes, proteins attached to them to retain certain classes of antibodies, or enzymes attached to them to perform specific modifications to certain classes of molecules. The column segment can be in thermal communication with a temperature control device in order to control the temperature of the column.

公开(公告)号：US20210033629A1

公开(公告)日：2021-02-04

申请号：US16939509

申请日：2020-07-27

Applicant: Waters Technologies Corporation

Inventor： Jeffrey Musacchio ,  Scott Kelley

IPC: G01N35/00 ,  G01N35/04

Abstract: Described is an interface module for robotic loading and unloading of a liquid chromatography sample manager. The module includes a transfer drawer receiving apparatus having a device track and a drawer drive system configured to transport a transfer drawer along the device track into and out from a sample tray of a sample manager. The transfer drawer receives a sample-vial carrier that holds samples to be analyzed. The module further includes a window apparatus that has a window controllable to be in an open state or a closed state. When in the open state, transport of the transfer drawer through the window into or out from the sample manager permits loading of the sample-vial carrier into the sample tray and unloading of the sample-vial carrier from the sample tray. In the closed state, the window apparatus substantially seals the internal environment of the sample manager from the ambient environment.

公开(公告)号：US20190383277A1

公开(公告)日：2019-12-19

申请号：US16444180

申请日：2019-06-18

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Jacob N. Fairchild ,  Jeffrey Musacchio ,  Joseph D. Michienzi

IPC: F04B25/00 ,  F16K15/03

Abstract: Described is a multi-stage pump having at least two stages. The multi-stage pump includes a first pump stage and a second pump stage each having a chamber of different diameter and volume. The multi-stage pump also includes a plunger having first and second plunger sections. The first plunger section has a first plunger diameter, a first end configured for coupling to a drive mechanism, and a second end opposite to the first end. The second plunger section has a second plunger diameter that is less than the first plunger diameter, a third end in contact with the second end of the first plunger, and a fourth end opposite the third end. Movement of the plunger produces a displacement volume for the first chamber that is different than a displacement volume produced for the second chamber. The multi-stage pump can be configured in different operational modes to provide different flow rates.

公开(公告)号：US11994500B2

公开(公告)日：2024-05-28

申请号：US17084998

申请日：2020-10-30

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Mark J. Basile ,  Jeffrey Musacchio ,  Michael O. Fogwill ,  Sebastien Besner ,  Joseph D. Michienzi ,  Wade P. Leveille

IPC: G01N30/74 ,  G01N30/30 ,  G01N30/02

CPC classification number: G01N30/74 ,  G01N30/30 ,  G01N2030/027 ,  G01N2030/3038 ,  G01N2030/746

Abstract: Techniques and apparatus for thermally controlled interfaces for separation devices and optical flow cell devices with minimized post-column volumes are described. In one embodiment, for example, a column-optical cell assembly may include an insulating device, a chromatography column arranged within the insulating device, and an optical flow cell in fluid communication with the chromatography column, the chromatography column arranged within a minimum distance of the optical flow cell.

公开(公告)号：US11986751B2

公开(公告)日：2024-05-21

申请号：US17241480

申请日：2021-04-27

Applicant: Waters Technologies Corporation

Inventor： Jonathan L. Belanger ,  Wade P. Leveille, Sr. ,  Michael O. Fogwill ,  Joseph D. Michienzi ,  Jeffrey Musacchio

IPC: B01D15/22 ,  B01D15/10 ,  F16J15/34 ,  G01N30/60

CPC classification number: B01D15/22 ,  B01D15/10 ,  F16J15/34 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026

Abstract: Described are apparatuses, devices, and systems implementing seals for separation devices. An apparatus for a separation device may include an end nut shaped to be positioned on one of an inlet side and an outlet side of the separation device. The end nut may be further shaped to mate with a connecting fitting. The apparatus may further include a face seal having a device side and a fitting side. The face seal may be positioned, at least in part, in the end nut on the device side of the face seal. The face seal may be positioned to interface with the connecting fitting on the fitting side of the face seal upon the end nut being mated with the connecting fitting. The apparatus may also include a face seal bore of the face seal being axially alignable with at least one of an inlet and an outlet of the separation device.

公开(公告)号：US20220128526A1

公开(公告)日：2022-04-28

申请号：US17513003

申请日：2021-10-28

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Sylvain G. Cormier ,  Michael O. Fogwill ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Joseph D. Antocci

IPC: G01N30/60 ,  B01D15/22

Abstract: Exemplary embodiments integrate a tee or valve into an outlet end fitting of a liquid chromatography column. The tee or valve is suitable for providing additional fluidic flow paths to ports of the end fitting and eliminates the need for post-column fluidic conduits connecting to tees or valves to insert fluidic inputs or divert flow to outputs. This integration decreases the distance that eluent from the liquid chromatography column has to travel to reach a detector relative to systems that use external tees or valves while providing tee/valve functionality and reducing the fluidic volume post-column. As a result, the exemplary embodiments help decrease sample dispersion.