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公开(公告)号：US20190271670A1
公开(公告)日：2019-09-05
申请号：US16415181
申请日：2019-05-17
Applicant: Waters Technologies Corporation
Inventor： Peter Kirby , Marcos O. Peroza , Steven D. Trudeau , Ryan Hill , Raymond P. Fisk , Jonathan Belanger , Wade P. Leveille
Abstract: A clamp assembly includes a rail configured to receive a first fluidic assembly, and a carriage slidably mounted to the rail and configured to receive a second fluidic assembly. The carriage is operable to establish a first fluid tight seal between the first fluidic assembly and a chromatography column received within the claim assembly, and to establish a second fluid tight seal between the second fluidic assembly and the chromatography column.
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公开(公告)号：US10281416B2
公开(公告)日：2019-05-07
申请号：US14813625
申请日：2015-07-30
Applicant: Waters Technologies Corporation
Inventor： Xiangjin Song , Jonathan Belanger
Abstract: The present disclosure relates to devices and methods for use in SSNMR analysis of solid particulate samples. These devices and methods are configured to contain a solid particulate sample as it undergoes SSNMR analysis while also operating to attenuate peak broadening in the resulting spectrum due to anisotropic dipole coupling interactions and CSA during such analysis by generating a substantially fluidized bed of the solid particulate sample.
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公开(公告)号：US20250114786A1
公开(公告)日：2025-04-10
申请号：US18985183
申请日：2024-12-18
Applicant: Waters Technologies Corporation
Inventor： Mathew H. DeLano , Matthew Lauber , Andrew Wyatt Schmudlach , Daniel P. Walsh , Yeliz Tunc Sarisozen , Jonathan Belanger , Darryl W. Brousmiche , Andrew Bates-Harrison , Nicole L. Lawrence
IPC: B01L3/00 , C09D143/04 , C23C16/56 , G01N30/60
Abstract: The present disclosure is directed to a coating process for chromatographic surfaces. Embodiments of the present disclosure feature a two-step, vapor-liquid phase organosilane deposition method for creating a hydrophilic, non-ionic surface in a chromatographic system.
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公开(公告)号：US12201975B2
公开(公告)日：2025-01-21
申请号：US17502483
申请日：2021-10-15
Applicant: Waters Technologies Corporation
Inventor： Mathew H. DeLano , Matthew Lauber , Andrew Wyatt Schmudlach , Daniel P. Walsh , Yeliz Tunc Sarisozen , Jonathan Belanger , Darryl W. Brousmiche , Andrew Bates-Harrison , Nicole L. Lawrence
IPC: G01N30/56 , B01L3/00 , C09D143/04 , C23C16/56 , G01N30/60
Abstract: The present disclosure is directed to a coating process for chromatographic surfaces. Embodiments of the present disclosure feature a two-step, vapor-liquid phase organosilane deposition method for creating a hydrophilic, non-ionic surface in a chromatographic system.
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Patent Agency Ranking
15.发明公开公开(公告)号：US20230393103A1
公开(公告)日：2023-12-07
申请号：US18206989
申请日：2023-06-07
Applicant: Waters Technologies Corporation
Inventor： Matthew A. Lauber , Mathew H. DeLano , Scott A. McCall , Jonathan Belanger , Theodore A. Dourdeville , Kerri Smith , Paul Rainville , Dimple Shah , Stephen J. Shiner , Catalin Doneanu , Michael Donegan
IPC: G01N30/56 , B01J20/32 , B05D1/00 , B01J20/291 , C23C16/04 , C23C16/30 , C23C14/04 , C23C14/12 , C23C14/24 , G01N30/60
CPC classification number: G01N30/56 , B01J20/3272 , B05D1/60 , B01J20/291 , C23C16/045 , C23C16/30 , C23C14/046 , C23C14/12 , C23C14/24 , G01N30/6052 , B05D2518/10 , G01N30/7266
Abstract: A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I:
R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20, -(C1-C10)[NH(CO)NH(C1-C10)]1-20-, or -(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.-
公开(公告)号：US20210245150A1
公开(公告)日：2021-08-12
申请号：US17166051
申请日：2021-02-03
Applicant: Waters Technologies Corporation
Inventor： Anna K. Boardman , Xiaoxiao Liu , Micah Watt , Jonathan Belanger , Matthew A. Lauber , Michael Lavallee , Wenhao Zhu
Abstract: The present technology relates to a customizable sample preparation device (e.g., liquid sample preparation device, such as a purification, clean-up, or separation device). In particular, the present technology relates to customizable devices formed from modular segments tailored to address one or more of the following: to optimize different sample and elution volumes, to incorporate various connection mechanisms to liquid handlers, to incorporate various liquid dispensing flow conditions, and to fulfill broad applications through the selection of specific resin for sample preparation. Some embodiments are directed to affinity capture devices, such as for example, Protein A affinity capture devices, utilizing a polymethacrylate-based resin. Other resins as well as other materials for processing a liquid sample are described herein.
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公开(公告)号：US20160033599A1
公开(公告)日：2016-02-04
申请号：US14813625
申请日：2015-07-30
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： Xiangjin Song , Jonathan Belanger
CPC classification number: G01N24/08 , G01R33/30 , G01R33/307
Abstract: The present disclosure relates to devices and methods for use in SSNMR analysis of solid particulate samples. These devices and methods are configured to contain a solid particulate sample as it undergoes SSNMR analysis while also operating to attenuate peak broadening in the resulting spectrum due to anisotropic dipole coupling interactions and CSA during such analysis by generating a substantially fluidized bed of the solid particulate sample.
Abstract translation: 本公开涉及在固体颗粒样品的SSNMR分析中使用的装置和方法。 这些装置和方法被配置为在经历SSNMR分析时含有固体颗粒样品，同时在这种分析过程中由于各向异性偶极耦合相互作用和CSA而在所得光谱中衰减峰值变宽，从而产生固体颗粒样品的基本流化床 。
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公开(公告)号：US20150323509A1
公开(公告)日：2015-11-12
申请号：US14367245
申请日：2012-12-10
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： Peter Kirby , Marcos O. Peroza , Steven D. Trudeau , Ryan Hill , Raymond P. Fisk , Jonathan Belanger , Wade P. Leveille
CPC classification number: G01N30/6026 , B01D15/10 , F16L19/00 , G01N30/02 , G01N30/30 , G01N30/6039 , G01N30/6047 , G01N2030/3061 , Y10T29/53917 , Y10T29/53952
Abstract: A clamp assembly includes a rail configured to receive a first fluidic assembly, and a carriage slidably mounted to the rail and configured to receive a second fluidic assembly. The carriage is operable to establish a first fluid tight seal between the first fluidic assembly and a chromatography column received within the clamp assembly, and to establish a second fluid tight seal between the second fluidic assembly and the chromatography column.
Abstract translation: 夹具组件包括构造成容纳第一流体组件的导轨和可滑动地安装到导轨并被构造成容纳第二流体组件的托架。 托架可操作以在第一流体组件和容纳在夹具组件内的色谱柱之间建立第一流体密封，并且在第二流体组件和色谱柱之间建立第二流体密封。
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公开(公告)号：US20130256231A1
公开(公告)日：2013-10-03
申请号：US13901848
申请日：2013-05-24
Applicant: Waters Technologies Corporation
Inventor： Jonathan Belanger , Micah Inglis Watt , Stephen J. Shiner
IPC: B01D15/22
CPC classification number: B01D15/22 , B01D15/12 , G01N30/08 , G01N30/6004 , G01N30/6026 , G01N30/603 , G01N2030/085 , Y10T29/49826 , G01N30/6039
Abstract: Embodiment of the present invention feature a device having a body, a separation media and a frit element. The exterior surface of the body has a first attachment means positioned radially about at least one of the media chamber and the frit section to form a compact assembly.
Abstract translation: 本发明的实施例的特征在于具有主体，分离介质和玻璃料元件的装置。 主体的外表面具有围绕介质室和玻璃料部分中的至少一个径向放置的第一附接装置，以形成紧凑的组件。
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