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公开(公告)号：US20210171537A1
公开(公告)日：2021-06-10
申请号：US16805895
申请日：2020-03-02
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Jean-Christophe Andrez , David Earl Bogucki , Kristen Nicole Burford , Sultan Chowdhury , Charles Jay Cohen , Shannon Marie Decker , Christoph Martin Dehnhardt , Robert Joseph Devita , James Roy Empfield , Thilo Focken , Michael Edward Grimwood , Syed Abid Hasan , Qi Jia , James Philip Johnson, JR. , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D491/107 , C07D493/10 , C07D237/20 , C07D213/76 , C07D239/69 , C07D261/16 , C07D263/50 , C07D275/03 , C07D277/52 , C07D285/08 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D487/10 , C07D417/14 , C07D451/06
Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.
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公开(公告)号：US10125098B2
公开(公告)日：2018-11-13
申请号：US15988956
申请日：2018-05-24
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe Andrez , Philippe Bergeron , Paul Robert Bichler , Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Wei Gong , Michael Edward Grimwood , Abid Hasan , Ivan William Hemeon , Qi Jia , Brian Safina , Shaoyi Sun , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D207/16 , C07D277/06 , C07D413/14 , C07D413/12 , C07D401/10 , C07D401/12 , C07C235/54 , C07D405/10 , C07D403/14 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US10005724B2
公开(公告)日：2018-06-26
申请号：US15321335
申请日：2015-07-07
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe Andrez , Philippe Bergeron , Paul Robert Bichler , Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Wei Gong , Michael Edward Grimwood , Abid Hasan , Ivan William Hemeon , Qi Jia , Brian Safina , Shaoyi Sun , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07C235/54 , C07D207/16 , C07D405/10 , C07D401/12 , C07D471/08 , C07D403/14 , C07D401/10 , C07D413/12 , C07D413/14 , C07D277/06
CPC classification number: C07D207/16 , C07C235/42 , C07C235/52 , C07C235/54 , C07C2601/02 , C07C2601/04 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/02 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D221/22 , C07D231/06 , C07D263/04 , C07D263/26 , C07D265/30 , C07D277/06 , C07D305/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/10 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/02 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20180162868A1
公开(公告)日：2018-06-14
申请号：US15600612
申请日：2017-05-19
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Jean-Christophe Andrez , David Earl Bogucki , Kristen Nicole Burford , Sultan Chowdhury , Charles Jay Cohen , Shannon Marie Decker , Christoph Martin Dehnhardt , Robert Joseph Devita , James Roy Empfield , Thilo Focken , Michael Edward Grimwood , Syed Abid Hasan , Qi Jia , James Philip Johnson, JR. , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D491/107 , C07D277/52 , C07D417/12 , C07D213/76 , C07D285/08 , C07D401/12 , C07D403/12 , C07D275/03 , C07D239/69 , C07D261/16 , C07D413/12 , C07D263/50 , C07D487/10
Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.
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公开(公告)号：US08952169B2
公开(公告)日：2015-02-10
申请号：US13899526
申请日：2013-05-21
Applicant: Genentech, Inc. , Xenon Pharmaceuticals Inc.
Inventor： Jean-Christophe Andrez , Sultan Chowdhury , Shannon Marie Decker , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Qi Jia , Jun Li , Daniel F. Ortwine , Brian Safina , Tao Sheng , Shaoyi Sun , Daniel P. Sutherlin , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07C311/51 , C07D403/12 , C07D213/82 , C07D213/64 , C07D205/04 , C07D311/58 , A61K31/445 , A61K31/44 , A61K31/18 , C07D265/30 , C07D233/84 , C07D257/04 , C07C307/06 , C07D295/26 , C07D207/48 , C07D311/70 , C07D413/12 , C07D451/02 , C07D307/12 , C07D309/08 , C07D311/72 , C07D405/12 , C07D491/107 , C07D211/22 , C07D295/192 , C07D211/96 , C07D307/18
CPC classification number: C07D491/107 , A61K31/18 , A61K31/397 , A61K31/40 , A61K31/41 , A61K31/4164 , A61K31/44 , A61K31/5375 , C07B2200/05 , C07C307/06 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07C2602/18 , C07C2602/20 , C07C2602/42 , C07C2602/44 , C07C2602/50 , C07C2603/66 , C07C2603/68 , C07C2603/74 , C07D205/04 , C07D207/46 , C07D207/48 , C07D209/52 , C07D211/22 , C07D211/96 , C07D213/64 , C07D213/82 , C07D233/84 , C07D257/04 , C07D265/30 , C07D295/192 , C07D295/26 , C07D307/12 , C07D307/18 , C07D309/08 , C07D311/58 , C07D311/70 , C07D311/72 , C07D403/12 , C07D405/12 , C07D413/12 , C07D451/02 , C07D471/08
Abstract: The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, B, R1, R2, R3, R4, R5 and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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Patent Agency Ranking
公开(公告)号：US11174268B2
公开(公告)日：2021-11-16
申请号：US16805895
申请日：2020-03-02
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Jean-Christophe Andrez , David Earl Bogucki , Kristen Nicole Burford , Sultan Chowdhury , Charles Jay Cohen , Shannon Marie Decker , Christoph Martin Dehnhardt , Robert Joseph Devita , James Roy Empfield , Thilo Focken , Michael Edward Grimwood , Syed Abid Hasan , Qi Jia , James Philip Johnson, Jr. , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D491/107 , C07D493/10 , C07D237/20 , C07D213/76 , C07D239/69 , C07D261/16 , C07D263/50 , C07D275/03 , C07D277/52 , C07D285/08 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D487/10 , C07D417/14 , C07D451/06 , A61K31/395 , A61K31/427
Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.
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公开(公告)号：US11149002B2
公开(公告)日：2021-10-19
申请号：US16702286
申请日：2019-12-03
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe Andrez , Philippe Bergeron , Paul Robert Bichler , Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Wei Gong , Michael Edward Grimwood , Abid Hasan , Ivan William Hemeon , Qi Jia , Brian Salvatore Safina , Shaoyi Sun , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D207/16 , C07D403/12 , C07D413/14 , C07D221/22 , C07D401/12 , C07D413/12 , C07C235/52 , C07D205/04 , C07D277/06 , C07D209/02 , C07D305/08 , C07D401/14 , C07D231/06 , C07D403/04 , C07D403/14 , C07D409/06 , C07D417/12 , C07D451/02 , C07D263/04 , C07D263/26 , C07C235/42 , C07C235/54 , C07D265/30 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D401/10 , C07D405/10 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US10981905B2
公开(公告)日：2021-04-20
申请号：US16556055
申请日：2019-08-29
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Jean-Christophe Andrez , Kristen Nicole Burford , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Qi Jia , Verner Alexander Lofstrand , Shaoyi Sun , Steven Sigmund Wesolowski , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D471/04 , A61K31/437 , C07D417/14 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/08
Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.
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公开(公告)号：US10526285B2
公开(公告)日：2020-01-07
申请号：US16150070
申请日：2018-10-02
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe Andrez , Philippe Bergeron , Paul Robert Bichler , Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Wei Gong , Michael Edward Grimwood , Abid Hasan , Ivan William Hemeon , Qi Jia , Brian Salvatore Safina , Shaoyi Sun , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D207/16 , C07D403/12 , C07D413/14 , C07D221/22 , C07D401/12 , C07D413/12 , C07C235/52 , C07D205/04 , C07D277/06 , C07D209/02 , C07D305/08 , C07D401/14 , C07D231/06 , C07D403/04 , C07D403/14 , C07D409/06 , C07D417/12 , C07D451/02 , C07D263/04 , C07D263/26 , C07C235/42 , C07C235/54 , C07D265/30 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D401/10 , C07D405/10 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20190194184A1
公开(公告)日：2019-06-27
申请号：US16289212
申请日：2019-02-28
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Jean-Christophe Andrez , Kristen Nicole Burford , Sultan Chowdhury , Charles Jay Cohen , Christoph Martin Dehnhardt , Robert Joseph Devita , James Roy Empfield , Thilo Focken , Michael Edward Grimwood , Syed Abid Hasan , James Philip Johnson, JR. , Alla Yurevna Zenova
IPC: C07D451/06 , C07D285/08 , C07D277/52 , C07D493/10 , C07D261/16 , C07D417/12 , C07D401/12 , C07D239/69 , C07D237/20 , C07D213/76 , C07D403/12 , C07D417/14 , C07D413/12
Abstract: This invention is directed to methods of preparing benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.
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