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公开(公告)号:US20050245540A1
公开(公告)日:2005-11-03
申请号:US10996589
申请日:2004-11-26
申请人: Nobuaki Takeshita , Takayuki Inoue
发明人: Nobuaki Takeshita , Takayuki Inoue
IPC分类号: A61K31/454 , A61K31/496
CPC分类号: A61K31/454 , A61K31/496
摘要: This invention relates to a method for preventing and/or treating bone diseases which comprises administering a potentiator of TGF-beta activity such as the compound of the formula [I] or pharmaceutically acceptable salts thereof to human being or animals. wherein R1 is hydrogen, etc., R2 is optionally substituted ar(lower)alkyl or optionally substituted heterocyclic(lower)alkyl, etc., R3 is hydrogen, optionally substituted hydroxy, etc., R4 is hydrogen or lower alkyl, and X is CH or N.
摘要翻译: 本发明涉及一种预防和/或治疗骨疾病的方法,其包括向人或动物施用TGF-β活化增强剂,例如式[I]化合物或其药学上可接受的盐。 其中R 1是氢等,R 2是任选取代的芳(低级)烷基或任选取代的杂环(低级)烷基等,R 3 H 2是氢,任选取代的羟基等,R 4是氢或低级烷基,X是CH或N.
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公开(公告)号:US06194396B1
公开(公告)日:2001-02-27
申请号:US09425207
申请日:1999-10-22
申请人: Teruo Oku , Hiroshi Kayakiri , Shigeki Satoh , Yoshito Abe , Yuki Sawada , Takayuki Inoue , Hirokazu Tanaka
发明人: Teruo Oku , Hiroshi Kayakiri , Shigeki Satoh , Yoshito Abe , Yuki Sawada , Takayuki Inoue , Hirokazu Tanaka
IPC分类号: A61K314184
CPC分类号: C07D209/48 , C07D235/06 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/26 , C07D235/28 , C07D235/30 , C07D263/56 , C07D277/64 , C07D307/79 , C07D307/80 , C07D307/84 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07F7/1804
摘要: This invention relates to a heterocyclic compound of the formula wherein a group of the formula: is a group of the formula X is O, S or N-R5, R1 is lower alkyl, etc., R5 is hydrogen, lower alkyl, etc., R2 is hydrogen, halogen, lower alkyl, etc., R3 is halogen, lower alkyl, etc., R4 is amino optionally having suitable substituent(s), and A is lower alkylene, and a salt thereof, to processes for preparation thereof, and to a pharmaceutical composition comprising the same for the prevention and/or the treatment of bradykinin or its analogues mediated diseases in human being or animals.
摘要翻译: 本发明涉及下式的下式的杂环化合物:式X的基团是O,S或N-R 5,R 1是低级烷基等,R 5是氢,低级烷基等,R 2是 氢,卤素,低级烷基等,R 3为卤素,低级烷基等,R 4为任选具有合适取代基的氨基,A为低级亚烷基及其盐,其制备方法为 包含其用于预防和/或治疗缓激肽或其类似物介导的人或动物疾病的药物组合物。
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公开(公告)号:US6083961A
公开(公告)日:2000-07-04
申请号:US776518
申请日:1997-02-03
申请人: Teruo Oku , Hiroshi Kayakiri , Shigeki Satoh , Yoshito Abe , Yuki Sawada , Takayuki Inoue , Hirokazu Tanaka
发明人: Teruo Oku , Hiroshi Kayakiri , Shigeki Satoh , Yoshito Abe , Yuki Sawada , Takayuki Inoue , Hirokazu Tanaka
IPC分类号: C07D209/48 , C07D235/06 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/26 , C07D235/28 , C07D235/30 , C07D263/56 , C07D277/64 , C07D307/79 , C07D307/80 , C07D307/84 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D498/04 , C07F7/18 , A61K31/415 , A61K31/42 , A61K31/44 , A61K31/34 , C07D405/12
CPC分类号: C07D209/48 , C07D235/06 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/26 , C07D235/28 , C07D235/30 , C07D263/56 , C07D277/64 , C07D307/79 , C07D307/80 , C07D307/84 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07F7/1856
摘要: This invention relates to a heterocyclic compound of the formula: ##STR1## wherein a group of the formula: ##STR2## is a group of the formula: ##STR3## etc., X is O, S or N--R.sup.5,R.sup.1 is lower alkyl, etc.,R.sup.5 is hydrogen, lower alkyl, etc.,R.sup.2 is hydrogen, halogen, lower alkyl, etc.,R.sup.3 is halogen, lower alkyl, etc.,R.sup.4 is amino optionally having suitable substituent(s), andA is lower alkylene,and a salt thereof, to processes for preparation thereof, and to a pharmaceutical composition comprising the same for the prevention and/or the treatment of bradykinin or its analogues mediated diseases in human being or animals.
摘要翻译: PCT No.PCT / JP95 / 01478 Sec。 371日期1997年2月3日 102(e)日期1997年2月3日PCT提交1995年7月25日PCT公布。 公开号WO96 / 04251 日本特开1996年2月15日本发明涉及下式的杂环化合物:其中式为下式的基团:X为O,S或N-R 5,R 1为低级烷基等。 R 5为氢,低级烷基等,R 2为氢,卤素,低级烷基等,R 3为卤素,低级烷基等,R 4为任选具有适当取代基的氨基,A为低级亚烷基, 及其盐,其制备方法,以及包含其的药物组合物,用于预防和/或治疗人类或动物中缓激肽或其类似物介导的疾病。
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公开(公告)号:US5932737A
公开(公告)日:1999-08-03
申请号:US849076
申请日:1997-05-30
申请人: Yoshikuni Itoh , Toshiro Iwamoto , Takumi Yatabe , Hitoshi Hamashima , Takayuki Inoue , Seiji Hashimoto , Teruo Oku
发明人: Yoshikuni Itoh , Toshiro Iwamoto , Takumi Yatabe , Hitoshi Hamashima , Takayuki Inoue , Seiji Hashimoto , Teruo Oku
IPC分类号: A61K38/00 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/00 , A61P27/02 , A61P29/00 , A61P43/00 , C07K5/06 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/078 , A61K31/44 , C07D407/14
CPC分类号: C07K5/06078 , C07K5/06043 , C07K5/0606 , C07K5/06086 , C07K5/06095 , C07K5/06104 , C07K5/06113 , C07K5/06139 , C07K5/06147 , A61K38/00
摘要: New peptide compounds of the formula:1. A compound of the formula: ##STR1##
摘要翻译: PCT No.PCT / JP95 / 02428 Sec。 371日期1997年5月30日 102(e)日期1997年5月30日PCT 1995年11月29日PCT PCT。 第WO96 / 16981号公报 日期1996年6月6日新的下式的肽化合物:1.下式的化合物:
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公开(公告)号:US5930864A
公开(公告)日:1999-08-03
申请号:US8635
申请日:1998-01-16
申请人: Takayuki Inoue , Masami Fukumoto , Izumi Yamaura
发明人: Takayuki Inoue , Masami Fukumoto , Izumi Yamaura
摘要: An upright vacuum cleaner includes a main body, a floor nozzle unit, and a float plate or float unit. The main body has a motor fan for generating a suction force and a dust-collection chamber for collecting dust. The motor fan provides the suction force to the dust collection chamber. The floor nozzle unit is disposed under the main body. The floor nozzle unit has an inlet port connected to the dust-collection chamber for attracting dust on a floor into the dust-collection chamber by the suction force of said motor fan. The float plate or float unit is disposed on a lower face of the floor nozzle unit. The float plate or float unit includes a floor opposing face where an outlet port is formed for spouting discharge air to the floor from the motor fan. The float face is located around the outlet port to receive a lifting force produced by pressure of the discharge air between the float face and the floor to be cleaned. The float unit has an elastic portion arranged on a lower portion of the float unit to contact a floor. Also, a pressure-regulating valve is provided for controlling the pressure of the discharge air so as to maintain the discharge air pressure under a predetermined safe pressure.
摘要翻译: 立式吸尘器包括主体,地板喷嘴单元和浮板或浮子单元。 主体具有用于产生吸力的电机风扇和用于收集灰尘的集尘室。 电机风扇为吸尘室提供吸力。 地板喷嘴单元设置在主体下方。 地板喷嘴单元具有连接到集尘室的入口,用于通过所述电动机风扇的吸力将地板上的灰尘吸入集尘室。 浮板或浮子单元设置在地板喷嘴单元的下表面上。 浮子板或浮动单元包括一个地面相对的面,其中形成一个出口,用于从电机风扇喷出空气到地板上。 浮动面位于出口周围,以接收由浮动面和待清洁的地板之间的排出空气的压力产生的提升力。 浮子单元具有布置在浮子单元的下部以与地板接触的弹性部分。 此外,设置有用于控制排出空气的压力以便将排出空气压力保持在预定安全压力的压力调节阀。
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公开(公告)号:US5175875A
公开(公告)日:1992-12-29
申请号:US502680
申请日:1990-04-02
申请人: Satoshi Yokoya , Takayuki Inoue , Nobutaka Takao , Noboru Someno
发明人: Satoshi Yokoya , Takayuki Inoue , Nobutaka Takao , Noboru Someno
IPC分类号: H04B7/26
CPC分类号: H04B7/26
摘要: A radio communication apparatus comprising a modulating portion for modulating a carrier with a signal to transmit so as to produce a transmissible signal; a signal transmitting portion for transmitting the transmissible signal; a level adjusting portion for adjusting a level of the signal to transmit or a level of a control signal used for controlling the transmissible signal in accordance with digital control data supplied to the level adjusting portions; a memory for storing digital adjusting data; and a control unit for reading the digital adjusting data from the memory and supplying the level adjusting portion with the digital adjusting data read from the memory or modified digital adjusting data obtained based on the digital adjusting data read from the memory as the digital control data.
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公开(公告)号:US4985880A
公开(公告)日:1991-01-15
申请号:US247355
申请日:1988-09-21
申请人: Yoshio Yoshida , Nobuo Ogata , Mitsuo Ishii , Yukio Kurata , Yasuo Nakata , Takayuki Inoue , Kazuko Inoue
发明人: Yoshio Yoshida , Nobuo Ogata , Mitsuo Ishii , Yukio Kurata , Yasuo Nakata , Takayuki Inoue , Kazuko Inoue
IPC分类号: G11B11/10 , G11B11/105 , G11B27/36
CPC分类号: G11B11/10595 , G11B11/10504 , G11B11/10515 , G11B27/36
摘要: An improved optical information recording and reproducing apparatus which is capable of detecting recording errors simultaneously with recording function for reduction of recording time, without requiring particular high accuracy for an optical system, and avoiding complication in the construction and consequent large size of the optical system.
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公开(公告)号:US4347651A
公开(公告)日:1982-09-07
申请号:US168242
申请日:1980-07-10
申请人: Takayuki Inoue , Tatsuya Iwasa
发明人: Takayuki Inoue , Tatsuya Iwasa
IPC分类号: H01R43/055 , H01R43/04 , H01R43/28 , H01R43/00
CPC分类号: H01R43/28 , H01R43/04 , Y10T29/5138 , Y10T29/5142 , Y10T29/5193 , Y10T29/53187 , Y10T29/53213
摘要: A connection wire manufacturing system is provided in which a number of pairs of press-connecting terminals are formed in a hoop material, each being coupled at the heads with each other, and the hoop material with the pairs of press-connecting terminals is transferred to a press-connecting step where those pairs of terminals are separated into individual pairs of terminals and those individual ones are press-connected to connection wires with given lengths properly prepared into a continuous connection wire line which is allowed to be taken up by a take-up drum.
摘要翻译: 提供一种连接线制造系统,其中多个压接端子形成在环形材料中,每对连接端子彼此在头部处连接,并且具有一对压接端子的环形材料被转移到 压接连接步骤,其中这些端子对被分离成单独的端子对,并且这些端子被连接到具有给定长度的连接线,连接线被适当地制备成连续的连接线, 鼓鼓。
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公开(公告)号:US4058647A
公开(公告)日:1977-11-15
申请号:US661413
申请日:1976-02-25
CPC分类号: B32B27/32 , Y10T428/31746 , Y10T428/31786 , Y10T428/31797 , Y10T428/31826 , Y10T428/31855 , Y10T428/31928 , Y10T428/31931 , Y10T428/31935
摘要: In a process for preparing a laminated resin product by melt-laminating (1) a modified polyolefin composition with (2) a polyester, a polyamide or a hydrolyzed copolymer of ethylenevinylacetate, the improvement comprising using as the modified polyolefin a modified polyolefin composition which comprises a mixture of 60 - 97 wt.% of a polyolefin which polyolefin comprises from 0.1 to 100 wt.% of a polyolefin modified with an unsaturated acid or anhydride content is from 0.01 to 10 wt.% of the total polyolefin content and wherein an unmodified polyolefin comprises from 99.9 to 0 wt.% of the total polyolefin content with 40 - 3 wt.% of a rubber component having 40 - 140 of Mooney viscosity 50 ML.sub.1 + .sub.4 (100.degree. C) and the product so produced.
摘要翻译: 在(2)聚乙烯乙酸乙烯酯的聚酯,聚酰胺或水解共聚物的熔融层压(1)改性聚烯烃组合物的制备方法中,改进包括使用改性聚烯烃组合物,其包含 60-97重量%聚烯烃的混合物,其中聚烯烃包含0.1-100重量%的用不饱和酸或酸酐含量改性的聚烯烃,占总聚烯烃含量的0.01〜10重量%,其中未改性 聚烯烃占总聚烯烃含量的99.9至0重量%,40至3重量%的橡胶组分具有40-140门尼粘度为50ML1 + 4(100℃)和如此制备的产品。
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公开(公告)号:US08871565B2
公开(公告)日:2014-10-28
申请号:US13222513
申请日:2011-08-31
申请人: Shunpei Yamazaki , Yusuke Nonaka , Takayuki Inoue , Masashi Tsubuku , Kengo Akimoto , Akiharu Miyanaga
发明人: Shunpei Yamazaki , Yusuke Nonaka , Takayuki Inoue , Masashi Tsubuku , Kengo Akimoto , Akiharu Miyanaga
IPC分类号: H01L21/44 , H01L29/786
CPC分类号: H01L29/78606 , H01L23/552 , H01L23/564 , H01L29/04 , H01L29/66969 , H01L29/7869 , H01L29/78696 , H01L2924/0002 , H01L2924/00
摘要: An object is to manufacture a semiconductor device including an oxide semiconductor film, which has stable electric characteristics and high reliability. A crystalline oxide semiconductor film is formed, without performing a plurality of steps, as follows: by utilizing a difference in atomic weight of plural kinds of atoms included in an oxide semiconductor target, zinc with low atomic weight is preferentially deposited on an oxide insulating film to form a seed crystal including zinc; and tin, indium, or the like with high atomic weight is deposited on the seed crystal while causing crystal growth. Further, a crystalline oxide semiconductor film is formed by causing crystal growth using a seed crystal with a hexagonal crystal structure including zinc as a nucleus, whereby a single crystal oxide semiconductor film or a substantially single crystal oxide semiconductor film is formed.
摘要翻译: 本发明的目的是制造具有稳定的电特性和高可靠性的氧化物半导体膜的半导体装置。 通过利用包含在氧化物半导体靶中的多种原子的原子量的差异,形成结晶氧化物半导体膜,而不进行多个步骤,优选将低原子量的锌沉积在氧化物绝缘膜上 形成包含锌的晶种; 并且具有高原子量的锡,铟等沉积在晶种上同时引起晶体生长。 此外,通过使用具有包含锌作为核的六方晶系结构的晶种进行晶体生长来形成结晶氧化物半导体膜,从而形成单晶氧化物半导体膜或大致单晶氧化物半导体膜。
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