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公开(公告)号:US20110020278A1
公开(公告)日:2011-01-27
申请号:US12838684
申请日:2010-07-19
申请人: Eda Canales , Lee S. Chong , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael Mertzman , Philip A. Morganelli , William J. Watkins , Hong Ye
发明人: Eda Canales , Lee S. Chong , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael Mertzman , Philip A. Morganelli , William J. Watkins , Hong Ye
IPC分类号: A61K31/381 , C07D409/12 , A61K31/4436 , A61K31/497 , A61K31/501 , A61K31/506 , C07D413/14 , A61K31/5377 , A61K31/41 , C07D417/14 , A61K31/427 , A61P31/14 , A61K38/21 , A61K31/7056
CPC分类号: A61K31/513 , A61K31/427 , A61K31/4436 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K45/06 , C07D333/68 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D493/04
摘要: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
摘要翻译: 提供式I的化合物及其药学上可接受的盐和酯。 所提供的化合物,组合物和方法可用于治疗黄病毒科感染,特别是丙型肝炎感染。
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公开(公告)号:US20100310512A1
公开(公告)日:2010-12-09
申请号:US12779023
申请日:2010-05-12
申请人: Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard L. Mackman , Hyung-Jun Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu
发明人: Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard L. Mackman , Hyung-Jun Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu
IPC分类号: A61K31/4178 , C07D403/14 , C07D401/14 , C07D417/14 , A61K31/435 , A61K31/55 , A61K31/438 , A61K31/496 , A61K31/5415 , A61K38/21 , A61K31/708 , A61K31/7052 , A61P31/14
CPC分类号: C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
摘要: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明涉及抗病毒化合物,含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号:US20090275535A1
公开(公告)日:2009-11-05
申请号:US12166076
申请日:2008-07-01
申请人: Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Haolun Jin , Ralph F. Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
发明人: Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Haolun Jin , Ralph F. Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
IPC分类号: A61K31/675 , C07F9/6561 , A61P31/12
CPC分类号: C07F9/65616 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/4075 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/65031 , C07F9/650905 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561 , C07H15/00 , C07H17/00 , C07H19/056 , C07H19/10 , C07H19/20 , C07H21/00 , Y02A50/393 , Y02A50/465
摘要: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明涉及具有抗病毒活性的磷取代的化合物,含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号:US20090247488A1
公开(公告)日:2009-10-01
申请号:US12145611
申请日:2008-06-25
申请人: Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Craig Gibbs , Ralp F. Hirschmann , Thorsten Kirschberg , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , Peter H. Nelson , David A. Oare , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
发明人: Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Craig Gibbs , Ralp F. Hirschmann , Thorsten Kirschberg , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , Peter H. Nelson , David A. Oare , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
IPC分类号: A61K31/675 , C07F9/28 , A61P29/00
CPC分类号: C07F9/65616 , A61K31/675 , A61K47/54 , C07D237/14 , C07F9/4006 , C07F9/572 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/65031 , C07F9/65038 , C07F9/6512 , C07F9/6524 , C07F9/653 , C07F9/65515 , C07F9/65517 , C07F9/65586 , C07F9/6561
摘要: The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明涉及磷取代的抗炎化合物,含有这些化合物的组合物,以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号:US07541701B2
公开(公告)日:2009-06-02
申请号:US11759730
申请日:2007-06-07
申请人: Chih M. Lin , William J. Watkins , Oscar Romero , Janice Fitzgerald , John R. Belko , Ming Kuo
发明人: Chih M. Lin , William J. Watkins , Oscar Romero , Janice Fitzgerald , John R. Belko , Ming Kuo
IPC分类号: H02K9/00
摘要: A motor assembly comprises a first end frame, a second end frame including at least one air outlet aperture, an air shroud surrounding a stator between the first end frame and the second end frame, the air shroud cooperating with the stator to form at least one air passage, and cooperating with the first end frame to form at least one air inlet aperture. The motor assembly also comprises a fan mounted on the rotating shaft, the fan operable to generate an air flow of ambient air through the at least one air inlet aperture, the at least one air passage and the at least one air outlet aperture.
摘要翻译: 电动机组件包括第一端框架,第二端框架,其包括至少一个空气出口孔,围绕第一端框架和第二端框架之间的定子的空气护罩,空气罩与定子配合以形成至少一个 空气通道,并且与第一端框配合以形成至少一个空气入口孔。 所述马达组件还包括安装在所述旋转轴上的风扇,所述风扇可操作以产生通过所述至少一个空气入口孔,所述至少一个空气通道和所述至少一个空气出口孔的环境空气的空气流。
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公开(公告)号:US07470724B2
公开(公告)日:2008-12-30
申请号:US10833295
申请日:2004-04-26
申请人: Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Alan X. Huang , Thorsten Kirschberg , Christopher P. Lee , Richard L. Mackman , Peter H. Nelson , Hyung-Jung Pyun , Adrian S. Ray , William J. Watkins , Jennifer R. Zhang , Sundaramoorthi Swaminathan
发明人: Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Alan X. Huang , Thorsten Kirschberg , Christopher P. Lee , Richard L. Mackman , Peter H. Nelson , Hyung-Jung Pyun , Adrian S. Ray , William J. Watkins , Jennifer R. Zhang , Sundaramoorthi Swaminathan
IPC分类号: A61K31/27
CPC分类号: A61K47/548 , A61K47/542
摘要: The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明涉及具有免疫调节活性的膦酸酯取代的化合物,含有这些化合物的组合物,以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号:US07427624B2
公开(公告)日:2008-09-23
申请号:US10832816
申请日:2004-04-26
申请人: James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Thorsten Kirschberg , Adrian S. Ray , Sundaramoorthi Swaminathan , William J. Watkins
发明人: James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Thorsten Kirschberg , Adrian S. Ray , Sundaramoorthi Swaminathan , William J. Watkins
IPC分类号: A61K31/517 , C07D487/00
CPC分类号: A61K31/519 , A61K31/662 , A61K31/675 , A61K47/54 , A61K47/548
摘要: The invention is related to phosphorus substituted purine nucleoside phosphorylase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明涉及磷取代的嘌呤核苷磷酸化酶抑制化合物,含有这些化合物的组合物,以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号:US08267640B1
公开(公告)日:2012-09-18
申请号:US12472794
申请日:2009-05-27
申请人: Chih Lin , William J. Watkins
发明人: Chih Lin , William J. Watkins
IPC分类号: F04D1/00
CPC分类号: F04D13/08 , F04D5/002 , F04D29/0416
摘要: A turbine pump that permits an impeller to stay compliant with a raceway by the use of a preloaded floating raceway that operates by utilizing fluid floating on both side of the raceway within the pump. Exemplary embodiments of the pump include a mounting frame that is adapted to engage the pump to a drive source; an end frame that is adapted to attach to the mounting frame and includes an inlet section and an outlet section that facilitate fluid flow entering and exiting the pump; a motor shaft enclosed within the mounting frame; a floating raceway that is situated within the end frame and positioned around the distal end of the motor shaft, and includes an inlet passage, an outlet passage and a bypass hole fixed relative to the position of the inlet passage and the outlet passage; a spring located at the top of the floating raceway and at least partially contained within a corresponding cavity located in the end frame that is preloaded to help maintain a desired clearance between the floating raceway and the impeller; and an impeller secured to an distal end of the motor shaft.
摘要翻译: 一种涡轮泵,其允许叶轮通过使用通过利用在泵内的滚道两侧浮动的流体操作的预加载的浮动滚道来保持与滚道的顺应性。 泵的示例性实施例包括适于将泵接合到驱动源的安装框架; 端框架,其适于附接到所述安装框架并且包括促进流体流入和流出泵的入口部分和出口部分; 封闭在安装框架内的电动机轴; 位于端框架内且围绕电动机轴的远端定位的浮动轨道,并且包括相对于入口通道和出口通道的位置固定的入口通道,出口通道和旁通孔; 位于浮动滚道顶部的至少部分地容纳在位于端框架中的相应空腔内的弹簧,其被预加载以帮助在浮动滚道和叶轮之间保持期望的间隙; 以及固定到电动机轴的远端的叶轮。
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公开(公告)号:US20110178129A1
公开(公告)日:2011-07-21
申请号:US13007150
申请日:2011-01-14
申请人: Eda Canales , Michael O' Neil Hanrahan Clarke , Scott E. Lazerwith , Willard Lew , Philip Anthony Morganelli , William J. Watkins
发明人: Eda Canales , Michael O' Neil Hanrahan Clarke , Scott E. Lazerwith , Willard Lew , Philip Anthony Morganelli , William J. Watkins
IPC分类号: A61K31/381 , C07D409/12 , A61K31/4436 , A61P31/14 , C07D333/36
CPC分类号: C07D409/12 , A61K31/381 , A61K31/4436 , A61K45/06
摘要: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
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公开(公告)号:US20110071101A1
公开(公告)日:2011-03-24
申请号:US12100314
申请日:2008-04-09
申请人: Constantine G. Boojamra , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , David A. Oare , Vidya K. Prasad , Adrian S. Ray , Sundaramoorthi Swaminathan , William J. Watkins
发明人: Constantine G. Boojamra , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , David A. Oare , Vidya K. Prasad , Adrian S. Ray , Sundaramoorthi Swaminathan , William J. Watkins
IPC分类号: A61K31/7068 , C07H19/06
CPC分类号: C07F9/65616 , C07F9/65586 , C07F9/6561 , C07H7/04 , C07H19/056 , C07H19/06 , C07H19/14 , C07H19/173
摘要: The invention is related to phosphorus substituted nucleoside compounds and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明涉及磷取代的核苷化合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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