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    Drug Delivery Device with Brake Mechanism
    12.
    发明申请
    Drug Delivery Device with Brake Mechanism 审中-公开
    带制动机构的药物输送装置

    公开(公告)号：US20160235924A1

    公开(公告)日：2016-08-18

    申请号：US15028867

    申请日：2014-10-14

    申请人： NOVO NORDISK A/S

    发明人： Morten Soerensen ,  Bo Kvolsbjerg ,  Kalle H. Madsen ,  Christian Plambech

    IPC分类号： A61M5/315 ,  A61M5/24

    CPC分类号： A61M5/31563 ,  A61M5/20 ,  A61M5/2033 ,  A61M5/24 ,  A61M5/31501 ,  A61M5/31528 ,  A61M5/31551 ,  A61M5/31553 ,  A61M5/31583 ,  A61M2005/2411 ,  A61M2005/3143

    摘要： A drug delivery device (1) comprises a housing and an expelling assembly adapted to expel a dose of drug from a cartridge (380). The expelling assembly comprises a drive spring (135) which in an energized state is adapted to drive the expelling assembly, a rotating component (550,650) adapted to rotate relative to an axis of rotation during expelling of a dose of drug, and user actuated release means (191, 190) for releasing the drive spring to thereby expel a dose of drug. The device is provided with a brake element (575, 675) being moveable in a plane generally perpendicular to the axis of rotation, the brake element being adapted to engage the rotating component such that during rotation thereof the brake element is moved back and forth, whereby the brake element provides a braking action on the rotating component.

    摘要翻译： 药物输送装置（1）包括壳体和适于从药筒（380）排出一定剂量的药物的排出组件。 排出组件包括驱动弹簧（135），其在通电状态下适于驱动排出组件，旋转部件（550,650）适于在药物剂量排出期间相对于旋转轴线旋转，并且用户致动释放 用于释放驱动弹簧以释放一剂药物的装置（191,190）。 该装置设置有可在大致垂直于旋转轴线的平面中移动的制动元件（575,675），制动元件适于接合旋转部件，使得在其旋转期间制动元件前后移动， 由此制动元件对旋转部件提供制动作用。

    AUTOMATIC DRUG INJECTION DEVICE WITH SOPHISTICATED DRIVE MECHANISM
    14.
    发明申请
    AUTOMATIC DRUG INJECTION DEVICE WITH SOPHISTICATED DRIVE MECHANISM 审中-公开
    具有放射性驱动机构的自动注射装置

    公开(公告)号：US20160067417A1

    公开(公告)日：2016-03-10

    申请号：US14782705

    申请日：2014-04-08

    申请人： SANOFI

    发明人： Stefan Bayer ,  Daniel Berning ,  Philippe Blank ,  Wolfgang Pelzer ,  Björn Wilden

    IPC分类号： A61M5/315

    CPC分类号： A61M5/31548 ,  A61M5/2033 ,  A61M5/31541 ,  A61M5/31553 ,  A61M5/31558 ,  A61M5/31563 ,  A61M5/3157 ,  A61M5/31575 ,  A61M5/3158 ,  A61M5/31583 ,  A61M5/31585 ,  A61M5/31591 ,  A61M5/31593 ,  A61M2005/202 ,  A61M2005/2086 ,  A61M2005/3126 ,  A61M2005/314 ,  A61M2005/3143 ,  A61M2005/31508 ,  A61M2005/3152 ,  A61M2005/3154 ,  A61M2205/581

    摘要： Handheld drug injection device (10) for setting and dispensing of a dose of a medicament, having a housing (20) extending in an axial direction (1, 2) and a dose setting and drive mechanism (3) comprising: —a rotatable dose setting member (50) in a sidewall of the housing and engaging two dose indicating wheels (54,56), —a drive member (70) axially displaceable relative to a drive spindle (80) and the housing against the action of a spring element (78) during dose setting and having a sleeve-shaped part (72) being threadedly engaged with the drive spindle (80) to form a spindle gear, and having a rack portion (71) engaged with a gear wheel (58) of the dose setting member, —the drive spindle (80) being linked on its proximal end to a ratchet mechanism (140,150) which is releasable via an axially shiftable trigger button (40) for dose dispensing, and on its distal end via a pinion (86) to a —drive sleeve (90), the latter being axially shiftable to form a clutch for engagement with —a threaded piston rod (120), which engages a piston (14) of a cartridge (12) to displace the piston (14) in a distal axial direction (1), the trigger button (40) releasing the ratchet holding the drive spindle (80) to free it for rotation, and closing the clutch between drive sleeve (90) and piston rod (120), such that the drive spring (78) can push the drive member (70) forward, thereby rotating the spindle (80), which in turn rotates the drive sleeve (90), which in turn produces spiral forward movement of the piston rod (120). A dose limiter element (130) is also included between piston rod and coaxial drive sleeve.

    摘要翻译： 用于设置和分配药物剂量的手持药物注射装置（10），其具有沿轴向方向（1,2）延伸的壳体（20）和剂量设定和驱动机构（3），包括： - 可旋转剂量 设置构件（50）在壳体的侧壁中并且接合两个剂量指示轮（54,56）， - 驱动构件（70）可相对于驱动轴（80）轴向移位，并且抵抗弹簧元件 （78），并且具有与所述驱动主轴（80）螺纹接合的套筒形部件（72）以形成主轴齿轮，并且具有与所述驱动轴（80）的齿轮（58）接合的齿条部分（71） 驱动轴（80）在其近端处连接到棘爪机构（140,150），该棘轮机构可通过用于剂量分配的可轴向移动的触发按钮（40）可释放，并且其远端经由小齿轮（86 ）到驱动套筒（90），后者可轴向移动以形成用于接合的离合器 h螺纹活塞杆（120），其与筒（12）的活塞（14）接合以沿远端轴向方向（1）移动活塞（14），触发按钮（40）释放保持 驱动主轴（80）以使其旋转，并且关闭驱动套筒（90）和活塞杆（120）之间的离合器，使得驱动弹簧（78）可以向前推动驱动构件（70），从而使主轴 （80），其又使驱动套筒（90）旋转，其又产生活塞杆（120）的螺旋向前运动。 活塞杆和同轴驱动套筒之间还包括剂量限制器元件（130）。

    INJECTION DEVICE WITH DOSING CONTROL MEANS
    16.
    发明申请
    INJECTION DEVICE WITH DOSING CONTROL MEANS 审中-公开
    具有剂量控制装置的注射装置

    公开(公告)号：US20150250950A1

    公开(公告)日：2015-09-10

    申请号：US14664536

    申请日：2015-03-20

    申请人： TecPharma Licensing AG

    发明人： Ulrich Moser ,  Jürg Hirschel ,  Markus Tschirren ,  Philipp Wälchli ,  Peter Stettler ,  Patrick Sackermann ,  Christian Schrul ,  Martin Berger ,  Nicolas Binggeli

    IPC分类号： A61M5/315 ,  A61M5/50 ,  A61M5/32

    CPC分类号： A61M5/31536 ,  A61M5/28 ,  A61M5/3146 ,  A61M5/3155 ,  A61M5/3202 ,  A61M5/3204 ,  A61M5/502 ,  A61M2005/3142 ,  A61M2005/3143 ,  Y10T29/49826

    摘要： An injection device provides a casing which accommodates or forms a reservoir for a liquid drug; a plunger rod which can move relative to the casing in an axially forward direction to deliver the drug; a dosing means which can move in the forward direction relative to the casing to prime the reservoir and which can rotate relative to the casing for selecting a dose to be injected, wherein rotation of the dosing means relative to the casing is prevented until a priming operation for priming the reservoir is completed; d) wherein the dosing means comprises a dosing control means which is configured to enable rotation of the dosing means at the end of the priming stroke for selecting the dose and to prevent a rotation of the dosing means back into the position which the dosing means had at the end of the priming stroke relative to the casing.

    摘要翻译： 注射装置提供容纳或形成用于液体药物的储存器的壳体; 柱塞杆，其能够沿着轴向向前的方向相对于壳体移动以输送药物; 一个可相对于壳体在向前方向上移动以便引导储存器并且可相对于壳体旋转以便选择要注射的剂量的计量装置，其中防止计量装置相对于壳体的旋转，直到起动操作 用于启动水库完成; d）其中所述计量装置包括计量控制装置，所述计量控制装置构造成能够在所述起动冲程结束时使所述计量装置旋转以选择所述剂量并防止所述计量装置旋转到所述计量装置具有的位置 在启动冲程结束时相对于外壳。

    AUTOMATIC INJECTION DEVICE WITH TRIGGER ASSEMBLY
    17.
    发明申请
    AUTOMATIC INJECTION DEVICE WITH TRIGGER ASSEMBLY 有权
    具有触发器组件的自动注入装置

    公开(公告)号：US20150246181A1

    公开(公告)日：2015-09-03

    申请号：US14435765

    申请日：2013-10-11

    申请人： ELI LILLY AND COMPANY

    发明人： Jesse Arnold Fourt ,  Jennifer Ellen Davis-Wilson ,  Bradley Simpson ,  James R. Yurchenco

    IPC分类号： A61M5/315 ,  A61M5/32

    CPC分类号： A61M5/31566 ,  A61M5/2033 ,  A61M5/3158 ,  A61M5/3202 ,  A61M5/326 ,  A61M2005/206 ,  A61M2005/2073 ,  A61M2005/3143 ,  A61M2205/583

    摘要： Automatic injection device with trigger assembly. The trigger assembly includes a button (25), and a single prong (160) extending from a biased element of the device toward the button. A button-engaging surface (167) of the prong and a support surface of the device define a radially extending opening in which an actuating element (52) of the button fits for a radially outward face of the actuating element to be backed up by the support surface. For release of the biased element, when the button is pressed to shift the actuating element to cause a latching surface of the prong to disengage from a latch surface of the device, motion of the actuating element in a direction away from the prong is limited by the radially outward face of the actuating element abutting the support surface.

    摘要翻译： 自动注射装置带扳机组件。 触发器组件包括按钮（25）和从设备的偏置元件朝向按钮延伸的单个插脚（160）。 叉子的按钮接合表面（167）和装置的支撑表面限定径向延伸的开口，其中按钮的致动元件（52）适合于致动元件的径向向外的表面， 支撑面。 为了释放偏置的元件，当按钮按压以移动致动元件以使插脚的闩锁表面与装置的闩锁表面脱离时，致动元件在远离插脚的方向上的运动受到 致动元件的径向向外的表面邻接支撑表面。

    Flush syringe assembly with controlled pulsatile flushing
    18.
    发明授权
    Flush syringe assembly with controlled pulsatile flushing 有权
    用控制的脉冲冲洗冲洗注射器组件

    公开(公告)号：US09084851B2

    公开(公告)日：2015-07-21

    申请号：US13871682

    申请日：2013-04-26

    申请人： Becton, Dickinson and Company

    发明人： Anthony J. Kosinski ,  Girum Yemane Tekeste ,  Nichola Charles

    IPC分类号： A61M5/315 ,  A61M25/00

    CPC分类号： A61M5/31505 ,  A61M5/3129 ,  A61M5/31501 ,  A61M5/31511 ,  A61M5/31595 ,  A61M2005/3143 ,  A61M2005/31508 ,  A61M2005/3151 ,  A61M2025/0019 ,  A61M2206/10

    摘要： Flush syringe assemblies capable of creating pulsatile movement of the plunger rod as it moves in the distal direction within a syringe barrel, while preventing overpressurization of the catheter are provided. An exemplary flush syringe assembly includes a syringe barrel with a first pulsing element and a chamber with flush solution, a plunger rod with a stopper and a second pulsing element that interacts with the first pulsing element to provide an engagement force that causes pulsatile movement of the plunger rod and a thumb press slidably attached to the plunger rod with a pulse control element. The pulse control element is compressible to create a compression force that is greater than the engagement force of the first pulsing element and the second pulsing element.

    摘要翻译： 冲洗注射器组件，其能够在柱塞杆在注射器筒内在远端方向移动时产生脉动运动，同时防止导管的过压。 示例性的冲洗注射器组件包括具有第一脉冲元件的注射器筒和具有冲洗溶液的腔室，具有塞子的柱塞杆和与第一脉冲元件相互作用的第二脉冲元件，以提供接合力， 柱塞杆和拇指按压器，其用脉冲控制元件可滑动地附接到柱塞杆。 脉冲控制元件是可压缩的，以产生大于第一脉冲元件和第二脉冲元件的接合力的压缩力。

    Automatic injection device with delay mechanism including dual functioning biasing member
    19.
    发明授权
    Automatic injection device with delay mechanism including dual functioning biasing member 有权
    具有延迟机构的自动注射装置，包括双功能偏压构件

    公开(公告)号：US08734394B2

    公开(公告)日：2014-05-27

    申请号：US13581057

    申请日：2011-02-24

    申请人： Matthew Robert Adams ,  Jesse Arnold Fourt ,  Jonathan I. Kaplan ,  Paul Joseph Silberschatz ,  James R. Yurchenco

    发明人： Matthew Robert Adams ,  Jesse Arnold Fourt ,  Jonathan I. Kaplan ,  Paul Joseph Silberschatz ,  James R. Yurchenco

    IPC分类号： A61M5/315 ,  A61M5/20

    CPC分类号： A61M5/2033 ,  A61M5/3204 ,  A61M5/326 ,  A61M2005/206 ,  A61M2005/2073 ,  A61M2005/3143 ,  A61M2005/3247 ,  A61M2205/583

    摘要： An automatic injection apparatus including a delay mechanism for properly delivering medication prior to the needled syringe of the apparatus being retracted. In one form, the delay mechanism includes a shuttle (170) for the syringe, a follower (250), a locking member, a damping compound between the follower and a supporting surface (308) to dampen rotation of the follower relative to the shuttle, and a dual functioning biasing member (290) acting between the shuttle and the follower. When the locking member moves to a release position during an injection, the dual functioning biasing member first provides a torsional force to force the follower to rotate relative to the shuttle from a latching position to an unlatching position, and then the dual functioning biasing member provides an axial force to force the shuttle axially relative to the follower to move the shuttle for retracting the syringe needle into the housing of the apparatus after injection.

    摘要翻译： 一种自动注射装置，包括用于在被缩回的装置的针刺注射器之前适当递送药物的延迟机构。 在一种形式中，延迟机构包括用于注射器的梭（170），一个跟随器（250），一锁定件，所述从动件和一支撑表面（308），以抑制相对于所述从动旋转至梭之间的阻尼化合物 以及作用在梭子和跟随器之间的双功能偏压构件（290）。 当在注射过程中，锁定部件移动到释放位置时，双功能偏置构件首先提供一个扭转力以迫使从动件相对于所述梭从闩锁位置旋转到解锁位置，然后将双重功能偏置构件提供 的轴向力，迫使沿轴向相对于所述从动往复移动的梭子用于缩回注射器针头插入装置中的注射后壳体。