公开(公告)号：US11933700B2

公开(公告)日：2024-03-19

申请号：US17067760

申请日：2020-10-12

申请人： Xiyuan Sun

发明人： Xiyuan Sun

IPC分类号： B01L3/00 ,  B01L3/02 ,  G01N1/14 ,  G01N33/558 ,  G01N33/574 ,  G01N1/00

CPC分类号： G01N1/14 ,  B01L3/0293 ,  B01L3/502 ,  B01L3/563 ,  B01L3/565 ,  G01N33/558 ,  G01N33/57419 ,  B01L2300/042 ,  B01L2300/0636 ,  B01L2300/069 ,  B01L2300/0848 ,  G01N2001/002 ,  G01N2001/1463

摘要： The present invention provides an analytical system comprising a sample management module. A pressure delivery assembly is configured to compress and deform a mixing chamber containing a sample preparation, and simultaneously open a plug of the mixing chamber to release the sample preparation. The system can be manufactured as a sample box combinable to a detector box, and is particularly convenient for patients to use at home, for example, screening colorectal cancer with their fecal sample.

公开(公告)号：US20240085441A1

公开(公告)日：2024-03-14

申请号：US18453116

申请日：2023-08-21

申请人： UNIVERSITY OF NOTRE DAME DU LAC

发明人： Rachel Marie ROLLER ,  Marya LIEBERMAN

IPC分类号： G01N33/94 ,  B01L3/00

CPC分类号： G01N33/94 ,  B01L3/5023 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/0681 ,  B01L2300/069

摘要： A paper analytical device for detecting an analyte in a sample, and methods of fabricating and using the same. A paper analytical device may include laminated strips of a porous hydrophilic substrate and an adhesive layer. The laminated strips may be disposed on a hydrophobic backing with an air gap barrier between each laminated strip that is about 1 mm to about 5 mm in width and extends along the entire length of the laminated strip. A paper analytical device also may include one or more assay regions having one or more reagents for detecting an analyte, and sample deposition areas for receiving a test sample.

公开(公告)号：US20240082842A1

公开(公告)日：2024-03-14

申请号：US18260899

申请日：2022-01-12

申请人： PARIS SCIENCES ET LETTRES ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  MICROFACTORY SAS

发明人： Hubert GEISLER ,  Patrick TABELING ,  Andrew GRIFFITHS ,  Stéphane CHIRON ,  Fabrice MONTI ,  Gaël BLIVET-BAILLY ,  Marjan ABDORAHIM ,  Yvette TRAN-AMARELIS ,  Phillipe NGHE

IPC分类号： B01L3/00

CPC分类号： B01L3/502761 ,  B01L3/502707 ,  B01L2200/0647 ,  B01L2200/12 ,  B01L2300/069 ,  B01L2300/12

摘要： A microfluidic device comprising: —a first wall comprising a first substrate on which a plurality of closed patterns is grafted, —a second wall, facing the first wall, comprising a second substrate, —a plurality of nucleic acids grafted either on the first substrate or on the second substrate, wherein each nucleic acid comprises a barcode that encodes the position of the nucleic acid on said first or second substrate, wherein at least the plurality of closed patterns or the second substrate is made of an actuatable hydrogel which is swellable between a retracted state and a swollen state in which the closed patterns and the second substrate come into contact.

公开(公告)号：US20240058809A1

公开(公告)日：2024-02-22

申请号：US18450188

申请日：2023-08-15

申请人： Nicole Shamayev

发明人： Nicole Shamayev ,  David Otto Madrigal

IPC分类号： B01L3/00

CPC分类号： B01L3/5023 ,  B01L2300/044 ,  B01L2300/069 ,  B01L2300/0825

摘要： A portable, self-contained drug test kit for testing for the presence or absence of a drug has a housing having a hollow portion with a liquid solvent accessible from outside to enable introduction of a test solute therein. A lateral flow test strip is in user-selective fluid communication with the liquid solvent in the hollow portion. The lateral flow test strip is selectively moveable from a first position in which the lateral flow test strip is not in fluid communication with the liquid solvent in the hollow portion to a second position in which it is in fluid communication with the liquid solvent. When the lateral flow test strip is moved into the second position and the test solute is introduced into the hollow portion, the liquid solvent mixes with the test solute to form a test solution and thereby activate the lateral flow test strip.

公开(公告)号：US20240042449A1

公开(公告)日：2024-02-08

申请号：US18382747

申请日：2023-10-23

申请人： Solios Diagnostics GmbH

发明人： Dieter Hassberg

IPC分类号： B01L3/00

CPC分类号： B01L3/523 ,  B01L2300/042 ,  B01L2300/069 ,  B01L2300/0832

摘要： The present invention relates to a test device and a test method for carrying out a test directed to the detection of an organic structure. The test device comprises a housing wherein a receiving area for receiving a sample collection stick, a liquid reservoir forming a separated area within the housing and filled with a reaction solution, and an analysis area are received. Preferably, the reaction solution is received in a cartridge sealed at both ends by a separation layer.

公开(公告)号：US20240033733A1

公开(公告)日：2024-02-01

申请号：US18338392

申请日：2023-06-21

申请人： Mesa Biotech, Inc.

发明人： Donald J. Thomas ,  Hong Cai ,  Robert B Cary

IPC分类号： B01L3/00 ,  C12Q1/6825 ,  C12Q1/6806 ,  C12Q1/6809 ,  G01N33/543 ,  B01L7/00

CPC分类号： B01L3/502723 ,  C12Q1/6825 ,  C12Q1/6806 ,  C12Q1/6809 ,  G01N33/54366 ,  B01L3/502761 ,  B01L7/52 ,  B01L2300/048 ,  B01L2300/0809 ,  B01L2300/0861 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2400/0481 ,  B01L2200/026 ,  B01L2200/0636 ,  B01L2200/142 ,  B01L2300/047 ,  B01L2300/0825 ,  B01L2400/0644 ,  B01L2300/069 ,  B01L2300/1827 ,  B01L2200/0689 ,  B01L2300/123 ,  B01L2200/04 ,  B01L2300/043 ,  B01L2400/0478 ,  B01L2300/0887 ,  B01L2400/0683

摘要： A disposable cassette for detecting nucleic acids or performing other assays. The cassette can be inserted into a base station during use. The cassette has numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. The vent pockets have protrusions to help prevent accidental resealing. The cassette also can have a gasket to ensure free air movement between open vent pockets. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with the vent pockets and the chambers. Recesses in the cassette channels or chambers can have structures such as ridges or grooves to direct fluid flow to enhance rehydration of lyophilized reagents disposed in the recess. Flow diverters in the chambers can reduce the flow velocity of the sample fluid and increase the effective fluid flow path length, enabling more accurate control of fluid flow in the cassette. The roof of each chamber can have a projection that prevents capillary fluid flow across the top of the chamber, thus reducing or preventing sequestration of newly resuspended reagent from the bulk of the reaction solution volume.

公开(公告)号：US20240032900A1

公开(公告)日：2024-02-01

申请号：US17754492

申请日：2019-10-03

申请人： NOVANDSAT

发明人： Philippe DAURENJOU

IPC分类号： A61B10/00 ,  A01K1/01 ,  B01L3/00 ,  G01N33/52

CPC分类号： A61B10/007 ,  A01K1/0107 ,  B01L3/5023 ,  G01N33/528 ,  B01L2200/16 ,  B01L2300/0825 ,  B01L2400/0633 ,  B01L2300/069 ,  A61B2503/40

摘要： The casing for capturing and analysing animal urine comprises a first urine receptacle (188) and a second urine receptacle (191) which is provided with a support (187) for a strip (195) which carries test specimens comprising reagents, the receptacles being separated by a partition wall (156) which is provided with a passage (157), and at least one support which forms a tilting axis between:



a first configuration in which, when the passage is open, the urine flows as a result of gravity into the first receptacle and
a second configuration in which, when the passage is open, the urine flows as a result of gravity into the second receptacle.

公开(公告)号：US20240024875A1

公开(公告)日：2024-01-25

申请号：US18254817

申请日：2021-11-26

申请人： FUJIMORI KOGYO CO., LTD.

发明人： Masato ABE ,  Takao SATO ,  Tomoko WADA ,  Tomoka NAGASATO ,  Kazuya HOSOKAWA

IPC分类号： B01L3/00

CPC分类号： B01L3/502761 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/069 ,  B01L2300/0663

摘要： A method for manufacturing a microchip for a blood coagulation test includes preparing a substrate which has, in the surface thereof, a groove serving as a flow channel, and has a first through-hole serving as an inlet and provided on one end side of the groove. A film having a surface coated with collagen and/or tissue thromboplastin is prepared so as to cover a region of a portion on the flow channel when the film is bonded to the surface, of the substrate, having the groove therein overlaps the surface, of the film, coated with the collagen and/or tissue thromboplastin.

公开(公告)号：US20240024872A1

公开(公告)日：2024-01-25

申请号：US18211778

申请日：2023-06-20

申请人： GattaCo Inc.

发明人： Michael Ryan McNeely

IPC分类号： B01L3/00 ,  B01D61/14 ,  B01D63/08 ,  G01N33/49 ,  A61M1/36

CPC分类号： B01L3/502753 ,  B01D61/14 ,  B01L3/5023 ,  B01D63/087 ,  G01N33/491 ,  A61M1/36 ,  B01L2200/16 ,  B01L2300/0681 ,  B01L2400/0406 ,  B01L2400/0457 ,  B01L2300/069 ,  B01L2300/0861 ,  B01L2200/026 ,  B01L2200/0605 ,  A61M2205/33

摘要： A new method is disclosed for extracting plasma from whose blood and metering the amount of plasma to an exact volume for dispensing into a diagnostic test, in a fully automatic and self-contained device. The device can be used in resource limited settings by unskilled users to facilitate sophisticated medical diagnostic testing outside of a hospital, clinic or laboratory.

公开(公告)号：US20230390775A1

公开(公告)日：2023-12-07

申请号：US17803958

申请日：2023-02-06

申请人： Jonathan N. Roth

发明人： Jonathan N. Roth

IPC分类号： B01L3/00 ,  C12Q1/04 ,  C12M1/12

CPC分类号： B01L3/5085 ,  C12Q1/04 ,  C12M23/04 ,  B01L3/5023 ,  B01L2300/0816 ,  B01L2200/16 ,  B01L2300/069

摘要： A test card is provided for separately but simultaneously or sequentially detecting the existence and/or identity of different samples of microorganisms, having three layers which allow total separation, growth, and testing of different test samples which require chemically different growth media or replicative simultaneous testing.