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101 条记录 (耗时 0.02 秒)

    Hemangioma treatment method
    11.
    发明授权
    Hemangioma treatment method 失效
    血管瘤治疗方法

    公开(公告)号：US5108359A

    公开(公告)日：1992-04-28

    申请号：US628089

    申请日：1990-12-17

    申请人： anatoly M. Granov ,  Vladimir Y. Derkach ,  Vladimir N. Polysalov

    发明人： anatoly M. Granov ,  Vladimir Y. Derkach ,  Vladimir N. Polysalov

    IPC分类号： A61N1/40 ,  A61N2/10

    CPC分类号： A61N1/403 ,  A61N1/40

    摘要： The subject of this invention is in the field of medicine, particularly surgery, and is intended for the treatment of benign tumors and angiomas. A hemangioma is an angioma, or tumor, formed by an anomalous proliferation of vascular endothelium, forming an undesirable mass, which can occur anywhere in the body. The resulting disease is known as hemangiomatosis. The method of this invention is comprised of a reduction of the arterial blood flow to the hemangioma which limits the blood circulation in the tumor mass, thus creating favorable conditions for subsequent ferromagnetic embolization from externally and selectively applied electromagnetic or ultrasound energy and sclerotization of the tumor tissue, preventing the spread of ferromagnetic particles through the vessels and into other organs and systems. At the same time, maintaining the blood flow, though reduced, prevents the development of a total necrosis due to acute impairment of the tumor's blood circulation, which significantly reduces the general toxic effect. The reduced blood stream still leaves the possibility of introducing medication into the tumor, which reduces the possibility of complications during the postembolization period.

    摘要翻译： 本发明的主题是医学领域，特别是手术领域，旨在治疗良性肿瘤和血管瘤。 血管瘤是由血管内皮的异常增殖形成的血管瘤或肿瘤，形成不希望的肿块，这可能发生在身体的任何地方。 所得的疾病称为血管瘤病。 本发明的方法包括减少血管瘤的血流量，限制肿瘤块中的血液循环，从而从外部和选择性施加的电磁或超声能量和肿瘤的结核菌素形成随后的铁磁性栓塞的有利条件 组织，防止铁磁颗粒通过血管和其他器官和系统的扩散。 同时维持血液流通减少，防止由于肿瘤血液循环的急性损伤引起的全部坏死，从而显着降低了一般的毒性作用。 减少的血流仍然有可能将药物引入肿瘤，这降低了在栓塞后期间并发症的可能性。

    Method and apparatus for treating malignant tumors by local hyperpyrexia
    12.
    发明授权
    Method and apparatus for treating malignant tumors by local hyperpyrexia 失效
    通过局部高热治疗恶性肿瘤的方法和装置

    公开(公告)号：US5067952A

    公开(公告)日：1991-11-26

    申请号：US503529

    申请日：1990-04-02

    申请人： Vasily F. Gudov ,  Nikolai E. Yakhontov ,  Vladimir P. Kharchenko ,  Boris K. Dolotov ,  Evgeny L. Belousov ,  Valery B. Vinitsky ,  Alexandr M. Kozlov ,  Mikail G. Akhalaya ,  Alexandr D. Koveshinikov ,  Valery F. Pugachev

    发明人： Vasily F. Gudov ,  Nikolai E. Yakhontov ,  Vladimir P. Kharchenko ,  Boris K. Dolotov ,  Evgeny L. Belousov ,  Valery B. Vinitsky ,  Alexandr M. Kozlov ,  Mikail G. Akhalaya ,  Alexandr D. Koveshinikov ,  Valery F. Pugachev

    IPC分类号： A61F7/00 ,  A61N1/40 ,  A61N2/10

    CPC分类号： A61N1/406 ,  A61F2007/009

    摘要： A method is provided wherein a suspension containing ferromagnetic particles is introduced into a body, and the particles are caused to move towards a tumor and are retained there by a magnetic field. The area of the tumor is exposed to an electromagnetic field to carry out hyperpyrexia of the tumor to a temperature sufficient to kill cancer cells. The contents of the tumor are removed. The condition of a patient's body is monitored during the treatment by determining activity of neutrophils and macrophages. An apparatus is also provided for carrying out the method and comprises an electromagnetic radiation source with emitters, temperature pickups, and a temperature setter connected to inputs of a comparator, a temperature control unit for controlling hyperpyrexia temperature connected to an output of the comparator and forming a signal fed to a control input of the source of radiation. The apparatus is also provided with a magnetic retainer for retaining ferromagnetic particles within the boundaries of a tumor, aa device for removing contents of a tumor, and a device for transferring ferromagnetic particles towards a tumor.

    摘要翻译： 提供了一种方法，其中将含有铁磁颗粒的悬浮液引入体内，并使颗粒朝向肿瘤移动，并通过磁场保持在那里。 肿瘤的面积暴露于电磁场，以使肿瘤的高热度达到足以杀死癌细胞的温度。 去除肿瘤的内容物。 通过测定嗜中性粒细胞和巨噬细胞的活性，在治疗期间监测患者身体的状况。 还提供了一种用于执行该方法的装置，并且包括具有发射器，温度拾取器和连接到比较器的输入的温度设定器的电磁辐射源，温度控制单元，用于控制连接到比较器的输出的高热温度并形成 信号馈送到辐射源的控制输入端。 该装置还设置有用于将铁磁颗粒保持在肿瘤边界内的磁性保持器，用于去除肿瘤内容物的装置和用于将铁磁性颗粒转移到肿瘤的装置。

    Inductive heating process for use in causing necrosis of neoplasms at selective frequencies
    13.
    发明授权
    Inductive heating process for use in causing necrosis of neoplasms at selective frequencies 失效
    用于引起选择性频率的赘生物坏死的感应加热过程

    公开(公告)号：US4983159A

    公开(公告)日：1991-01-08

    申请号：US908190

    申请日：1986-09-17

    申请人： Robert W. Rand

    发明人： Robert W. Rand

    IPC分类号： A61K41/00 ,  A61N1/40 ,  A61N2/10

    CPC分类号： A61N1/406 ,  A61K41/0052

    摘要： A process of effecting necrosis of neoplasms in warm blooded animals as a result of hyperthermia of the neoplasm includes injecting particles into the warm blooded animals in proximity of the neoplasm. The particles are capable of exhibiting hysteresis heating when subjected to an alternating magnetic field. Further, the particles are of a size of at least two microns, or greater, so as to be incapable of being intracellularly absorbed within the cells of either the viable tissue of the animal or the neoplastic tissue. After interjecting the particles in association with the neoplasm, the area of the neoplasm is then subjected to an alternating magnetic field. This field is of a frequency greater than that sufficient to cause any appreciable neuromuscular response to the alternating magnetic field, and is less than that capable of causing any detrimental eddy current heating and/or dielectric heating of viable healthy tissue of the warm blooded animal. The neoplasm is maintained within the field for a time sufficient to heat the particles and the neoplasm, with which the particles are associated, to a temperature of at least 42.degree. C. to cause necrosing of the neoplasm.

    摘要翻译： 由于肿瘤的热疗导致温血动物中的肿瘤坏死的过程包括将颗粒注射到肿瘤附近的温血动物中。 当经受交变磁场时，颗粒能够显示滞后加热。 此外，颗粒的尺寸至少为两微米或更大，从而不能在动物的活组织或肿瘤组织的细胞内被细胞内吸收。 在与肿瘤相关联的颗粒插入后，肿瘤的面积然后经受交变磁场。 该场的频率大于对交变磁场造成任何明显的神经肌肉响应的频率，并且小于能够对温血动物的活的健康组织造成任何不利的涡流加热和/或电介质加热的频率。 将肿瘤保持在田地内一段足以将颗粒和与颗粒结合的肿瘤加热至至少42℃的温度以引起赘生物的坏死的时间。

    Process for applying a localized magnetic or electric field
    14.
    发明授权
    Process for applying a localized magnetic or electric field 失效
    施加局部磁场或电场的方法

    公开(公告)号：US4923437A

    公开(公告)日：1990-05-08

    申请号：US250821

    申请日：1988-09-27

    申请人： Robert T. Gordon

    发明人： Robert T. Gordon

    IPC分类号： A61K41/00 ,  A61N2/00 ,  A61N2/10 ,  G01N33/532 ,  G01N33/553

    CPC分类号： A61N2/00 ,  A61K41/0019 ,  G01N33/532 ,  G01N33/553

    摘要： The process includes applying a localized static, magnetic or electric field to neurological or neuromuscular tissue to aid in the intracellular uptake and energy absorption of electric or magnetic dipoles present in the tissue and the cells. Before the applying step dipoles can be introduced in the tissues or cells. Also, after or during the applying step, an alternating, oscillating or pulsed electromagnetic field can be applied to the tissue to enhance the intracellular uptake of energy, and the energy absorption responsiveness in the tissue and/or the energy absorption of the dipoles in the tissue. The process can utilize a constant magnetic field through the interaction with the intracellular dipoles in the tissue. Further, an external electromagnetic field can be applied to the tissue to excite the particles and raise the energy level of the tissue to destroy the cells and modify their behavior to decrease the degenerative process. Additionally, particles can be introduced into the extracellular environment of the tissue to alter membrane events and potentiate energy delivery to the diseased inflammatory or reactive cells or reduce energy delivery to the normal cells.

    摘要翻译： 该方法包括将局部静态，磁场或电场施加到神经或神经肌肉组织，以帮助存在于组织和细胞中的电或磁偶极子的细胞内吸收和能量吸收。 在施用步骤之前，可将偶极子引入组织或细胞中。 此外，在施加步骤之后或期间，可以将交替的，振荡的或脉冲的电磁场施加到组织以增强细胞内的能量摄取，并且组织中的能量吸收反应性和/或偶极子的能量吸收在 组织。 该过程可以通过与组织中细胞内偶极子的相互作用来利用恒定的磁场。 此外，可以对组织施加外部电磁场以激发颗粒并提高组织的能量水平以破坏细胞并改变其行为以减少退行过程。 另外，颗粒可以被引入到组织的细胞外环境中以改变膜事件并且增强能量递送到患病的炎症或反应性细胞或减少向正常细胞的能量递送。

    Induction heating apparatus for use in causing necrosis of neoplasm
    15.
    发明授权
    Induction heating apparatus for use in causing necrosis of neoplasm 失效
    用于引起肿瘤坏死的感应加热装置

    公开(公告)号：US4392040A

    公开(公告)日：1983-07-05

    申请号：US223727

    申请日：1981-01-09

    申请人： Robert W. Rand ,  Harold D. Snow ,  David G. Elliott ,  Glenn M. Haskins

    发明人： Robert W. Rand ,  Harold D. Snow ,  David G. Elliott ,  Glenn M. Haskins

    IPC分类号： A61N2/08 ,  A61K9/50 ,  A61K41/00 ,  A61N1/40 ,  A61N2/10 ,  H05B6/44

    CPC分类号： A61K9/5094 ,  A61K41/0052 ,  A61N1/406

    摘要： Induction heating can be utilized to cause necrosis of neoplasm as a result of hyperthermia by a process involving the injection of particles having hysteresis heating characteristics into tissue either within or in close proximity to the neoplasm and then subjecting these particles to an alternating magnetic field sufficient to cause hysteresis heating. The frequency of the field is preferably sufficiently low so as to minimize eddy current and dielectric heating. The particles used are preferably initially located within a biologically inert liquid carrier which will facilitate the insertion of the particles within the body and which will automatically become non-liquid within the body so as to hold the particles in place. The actual heating is preferably carried out by positioning either the entire patient or the affected portion of the patient's body through a series of axially aligned, parallel, liquid cooled coils. Only one of these coils is connected to a power supply.

    摘要翻译： 感应加热可以由于通过涉及将具有滞后加热特性的颗粒注入到在肿瘤内或紧邻肿瘤内的组织中的方法由于高热引起的肿瘤坏死，然后使这些颗粒经受足够的交变磁场 造成滞后加热。 场的频率优选足够低，以便使涡电流和电介质加热最小化。 所使用的颗粒优选地初始位于生物惰性液体载体内，其将有助于颗粒在体内的插入，并且其将在体内自动变成非液体，以将颗粒保持在适当位置。 实际加热优选通过将患者身体的整个患者或受影响的部分定位通过一系列轴向对准的平行的液体冷却的线圈来进行。 这些线圈中只有一个连接到电源。