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191.发明授权公开(公告)号：US10947576B2
公开(公告)日：2021-03-16
申请号：US16633812
申请日：2018-07-25
Inventor： Nongjian Tao , Karan Syal
IPC: G06K9/00 , C12Q1/18 , G01N15/14 , G01N33/543 , G01N15/00
Abstract: A method for rapid antibiotic susceptibility testing by tracking sub-micron scale motion of single bacterial cells including obtaining a biological sample from a subject including live bacteria. Different doses of antibiotic are added to a multi-well glass slide and adding portions of the biological sample to the wells. Bacterial cells are tethered onto the surface. The tethered bacterial cells are imaged and tracked. Bacterial sub-micron motion of tethered cells is measured at the different doses. A processor performs statistical analysis on a population of cells for each antibiotic dose to generate an antibiotic dose curve proportional to the motion changes, where the antibiotic dose curve plots data including a decrease in movement over time indicating a proportional effectiveness of an antibiotic applied to a well.
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公开(公告)号：US10940476B2
公开(公告)日：2021-03-09
申请号：US16095375
申请日：2017-04-21
Inventor： Laimonas Kelbauskas , Honor Glenn , Jeff Houkal , Clifford Anderson , Yanqing Tian , Fengyu Su , Deirdre Meldrum
Abstract: A device for high-throughput multi-parameter functional profiling of the same cells in multicellular settings and in isolation is provided. In certain aspects, an integrated microfluidic device for multi-parameter metabolic and other phenotypic profiling of live biological cells is useable with: 1) multicellular clusters or small biopsy tissue samples, 2) cultures of the constituent cells obtained after cluster/tissue dissociation, and 3) the same constituent single cells in isolation. The approach enables study of the effects of multicellular complexity, such as in response to treatment, pathogens, stress, or other factors concerning disease origination and progression. Measurements may be performed on single cells or multicellular populations or tissues in the same assay at the same time.
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公开(公告)号：US10939857B2
公开(公告)日：2021-03-09
申请号：US16011796
申请日：2018-06-19
Inventor： Jeffrey LaBelle , Anngela Adams , Garrett Repp
IPC: A61B5/1486 , C12Q1/00 , G01N27/327 , G01N33/66 , A61B5/145 , A61B5/15 , A61B5/00 , A61B5/157 , A61B5/1495 , G01N33/49
Abstract: A blood glucose sensing device includes a substrate, multiple three-dimensionally (3D) printed electrode leads comprising graphene arranged on or over the substrate, and glucose monitoring chemistry arranged in or on (e.g., adsorbed in) at least one of the 3D printed electrode leads. An end portion of a counter electrode lead may partially surround an end portion of a working electrode lead, and a reference lead may be further provided, Optionally, the 3D printed electrode leads may include a thermoplastic material, such as an aliphatic polyester. The glucose monitoring chemistry may include an enzyme.
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公开(公告)号：US20210060483A1
公开(公告)日：2021-03-04
申请号：US17010799
申请日：2020-09-02
Inventor： Klaus Lackner
Abstract: A device and method for carbon dioxide capture using circumscribed hollow membranes is disclosed. The device includes a hollow membrane unit having an inner conduit composed of a vapor membrane, and an outer conduit having an inside surface circumscribing the inner conduit forming a lumen. The outer conduit includes a CO2 pump membrane. The device also includes a mechanical pump maintaining a pressure differential between the lumen and the atmosphere, providing a product stream of CO2-rich gas from the lumen. The vapor membrane is sufficiently hydrophobic and porous to contain liquid water while also allowing water vapor formed by evaporation to pass through into the lumen. As water vapor passes from the lumen to the atmosphere through the CO2 pump membrane, a carbon concentration gradient is formed and maintained across the CO2 pump membrane. The carbon concentration gradient actively pumps CO2 out of the atmosphere and into the lumen.
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195.发明申请公开(公告)号：US20210052415A1
公开(公告)日：2021-02-25
申请号：US17090543
申请日：2020-11-05
Inventor： Shengxi CHEN
IPC: A61F6/04 , A61F5/41 , B32B27/04 , C08K3/20 , B32B27/40 , A61K9/00 , A61K9/70 , A61K31/7056 , A61K33/00
Abstract: A method to enhance a male erection or female arousal in a mammal includes topically administering a compound of Formula 1 to the mammal.
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Patent Agency Ranking
公开(公告)号：US20210041436A1
公开(公告)日：2021-02-11
申请号：US16896117
申请日：2020-06-08
Inventor： Stephen Johnston , Lu Wang
IPC: G01N33/569
Abstract: Assays, arrays, and methods for distinguishing a bacterial infection from a viral infection are disclosed. The antibiotic crisis is in part driven by over prescription of antibiotics. There is a tendency, particular in pediatrics, to give an antibiotic even for viral infections. Thus, embodiments herein are directed to the problem of distinguishing a bacterial infection from a viral infection to reduce unnecessary antibiotic usage.
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197.发明申请公开(公告)号：US20210032634A1
公开(公告)日：2021-02-04
申请号：US16712652
申请日：2019-12-12
Inventor： Michael SIERKS , Lalitha VENKATARAMAN , Wei XIN
Abstract: The present invention provides detection reagents and method for determining risk of traumatic brain injury (TBI) and/or susceptibility to neurodegenerative disease in a subject.
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公开(公告)号：US10909437B2
公开(公告)日：2021-02-02
申请号：US16687875
申请日：2019-11-19
Inventor： Paul B. Johnson , Jose Antonio Bautista-Martinez , Cody A. Friesen , Elise Switzer
IPC: G06K19/07 , G06K19/077 , H01M4/60 , C08G61/12 , H01M4/02
Abstract: The disclosed technology relates generally to apparatus comprising conductive polymers and more particularly to tag and tag devices comprising a redox-active polymer film, and method of using and manufacturing the same. In one aspect, an apparatus includes a substrate and a conductive structure formed on the substrate which includes a layer of redox-active polymer film having mobile ions and electrons. The conductive structure further includes a first terminal and a second terminal configured to receive an electrical signal therebetween, where the layer of redox-active polymer is configured to conduct an electrical current generated by the mobile ions and the electrons in response to the electrical signal. The apparatus additionally includes a detection circuit operatively coupled to the conductive structure and configured to detect the electrical current flowing through the conductive structure.
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公开(公告)号：US20200338337A1
公开(公告)日：2020-10-29
申请号：US16857436
申请日：2020-04-24
Applicant: Stephen Lane , Cami Rowan , Alarmel Sira , Kendra Lenz , ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Inventor： James Abbas , Stephen Lane , Cami Rowan , Alarmel Sira , Kendra Lenz
Abstract: Disclosed herein is a non-invasive intraoral neurostimulation device and method for treating obstructive sleep apnea (OSA) while improving adherence, effectiveness, and outcomes. The intraoral neurostimulation device includes a mouthpiece, at least one electrode pair having a reference electrode and a stimulating electrode supported by the mouthpiece, and a substrate positioned between a tongue of a user and the stimulating electrode. The intraoral neurostimulation device is configured to deliver non-invasive electrical neurostimulation to the motor neurons of at least one genioglossus muscle to induce a muscle contraction of the tongue, thereby eliminating the blockage and returning normal airflow to the user. In certain embodiments, the intraoral neurostimulation device is paired with a respiratory sensor to deliver stimulation synchronized with the respiratory rhythm of the user or deliver stimulation only during apneic episodes, reducing the total amount of stimulation time.
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公开(公告)号：US20200337931A1
公开(公告)日：2020-10-29
申请号：US16856935
申请日：2020-04-23
Inventor： Benjamin Shuch , Chaitanya Kulkarni , Sudhanshu Katarey , Harshit Dangaich , Saivimal Sridar , Pham Huy Nguyen , Thomas Sugar
Abstract: An orthosis for increasing a range of motion of an ankle is disclosed. In various embodiments, the orthosis includes a frame including a ball shell and a heel shell; a first actuator disposed on the ball shell and configured to apply a first force against a ball region of a foot, resulting in a moment being applied at the ankle; and a first rod connecting the heel shell and the ball shell, the first rod being slidably connected to at least one of the heel shell or the ball shell. In various embodiments, a second actuator is disposed on the heel shell and configured to apply a second force against a heel region of the foot. In various embodiments, a calf shell is configured to support a calf region of a leg that is connected to the ankle.
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