公开(公告)号：US10086010B2

公开(公告)日：2018-10-02

申请号：US15126777

申请日：2015-03-17

Applicant: STC.UNM ,  Hiroshi Ide

Inventor： Yoshihiro Matsumoto ,  Alan Edward Tomkinson ,  Hiroshi Ide

IPC: A01N43/04 ,  A61K31/70 ,  A61K31/7072 ,  A61K31/513 ,  A61P35/00 ,  A61K45/06 ,  A61K31/7064 ,  A61K31/706 ,  A61K31/7068

Abstract: In one embodiment, the invention provides a method of treating a subject who suffers from a neoplasm (including a cancer such as a radiotherapeutic-resistant cancer) by administering to the subject a therapeutically effective amount of (a) 5-formyl-2′-deoxyuridine (fdU or foUdR) or a 5-formyl-2′-deoxyuridine derivative, optionally in combination with 5-hydroxy-2′-deoxyuridine (hUdR); and (b) at least one composition selected from the group consisting of either 5-fluorouracil (5-FU), a 5-FU prodrug (e.g. 5-fluoro-2′-deoxyuridine (FdU)) or 5-FU metabolite. In a preferred embodiment, a subject who suffers from colorectal cancer (CRC) or metastatic colorectal cancer (mCRC) is treated with a therapeutically-effective amount of fdU and either 5-FU or the 5-FU prodrug 5-fluoro-2′-deoxyuridine (FdU). Related pharmaceutical compositions are also provided.

公开(公告)号：US20180264220A1

公开(公告)日：2018-09-20

申请号：US15753887

申请日：2016-08-22

Applicant: STC.UNM

Inventor： Hans Fredrick Hurt

IPC: A61M16/06 ,  A61M39/08

CPC classification number: A61M16/0605 ,  A61J15/0003 ,  A61J15/0061 ,  A61M16/00 ,  A61M16/06 ,  A61M16/0672 ,  A61M16/0683 ,  A61M16/0688 ,  A61M39/08 ,  A61M2202/0208 ,  A61M2210/0618

Abstract: A medical device sealing system for use with a positive pressure ventilation mask and a nasal cannula. The system includes a plurality of sealing elements. The sealing elements include an opening sized to receive a nasal cannula. The sealing elements are spaced apart a distance sufficient to cause the sealing elements to engage the edges of a mask and to form a seal between the edges of a mask and a patient.

公开(公告)号：US20180236024A1

公开(公告)日：2018-08-23

申请号：US15553786

申请日：2016-02-25

Applicant: STC.UNM

Inventor： Vojo P. Deretic ,  Tomonori Kimura

IPC: A61K38/05 ,  A61K45/06 ,  A61K38/17 ,  A61K31/713 ,  A61P1/00 ,  A61P29/00

CPC classification number: A61K38/05 ,  A61K31/713 ,  A61K38/17 ,  A61K45/06 ,  A61P1/00 ,  A61P29/00 ,  A61K2300/00

Abstract: The present invention relates to the discovery that IRGM, encoded by a uniquely human gene which confers risk for inflammatory diseases, affects autoophagy through a hitherto unknown mechanism. The present invention shows that IRGM controls autophagy and that IRGM modulators, in particular, double-stranded RNA, including poly I:C, poly-UG (polyUGUGU) and polyl-CLC and muramyldipeptide and related analogs of same, including N-acetyl muramyl-L-alanyl-D-isoglutamine (DMP) and numerous other compounds as identified herein, which may be used alone, in combination, or in combination with alternative autophagy modulators and additional bioactive agents to provide effective therapies for a number of diseases, including cancer, bacterial infections and inflammatory diseases, especially including tuberculosis infections and Crohn's disease, among others. The present invention is also directed to compositions and methods for treating inflammatory or autophagy-related diseases including diseases which cause excessive inflammation in patients.

公开(公告)号：US10049469B2

公开(公告)日：2018-08-14

申请号：US15103977

申请日：2014-12-15

Applicant: STC.UNM

Inventor： Cesar Carranza ,  Marios Stephanou Pattichis ,  Daniel Llamocca Obregon

IPC: G06T11/00 ,  G06F17/14 ,  G06K9/00

Abstract: A fast and a scalable approach for computing the forward and inverse DPRT that uses: (i) a parallel array of fixed-point adder trees to compute the additions, (ii) circular shift registers to remove the need for accessing external memory components, (iii) an image block-based approach to DPRT computation that can fit the proposed architecture to available resources, and (iv) fast transpositions that are computed in one or a few clock cycles that do not depend on the size of the input image.

公开(公告)号：US20180190841A1

公开(公告)日：2018-07-05

申请号：US15904296

申请日：2018-02-23

Applicant: STC.UNM

Inventor： Sang Eon Han ,  Brittany R. Hoard ,  Sang M. Han ,  Swapnadip Ghosh

IPC: H01L31/0236 ,  G02B1/00 ,  H01L31/20 ,  H01L31/18 ,  H03H9/145 ,  H03H9/25 ,  H03H9/10 ,  H01L31/0747

CPC classification number: H01L31/02363 ,  G02B1/005 ,  H01L31/0747 ,  H01L31/1804 ,  H01L31/202 ,  H01L31/208 ,  H03H9/10 ,  H03H9/145 ,  H03H9/25 ,  Y02E10/547 ,  Y02P70/521

Abstract: Provided is a method for fabricating a nano-patterned surface. The method includes forming a mask on a substrate, patterning the substrate to include a plurality of symmetry-breaking surface corrugations, and removing the mask. The mask includes a pattern defined by mask material portions that cover first surface portions of the substrate and a plurality of mask space portions that expose second surface portions of the substrate, wherein the plurality of mask space portions are arranged in a lattice arrangement having a row and column, and the row is not oriented parallel to a [110] direction of the substrate. The patterning the substrate includes anisotropically removing portions of the substrate exposed by the plurality of spaces.

公开(公告)号：US10000787B2

公开(公告)日：2018-06-19

申请号：US14434509

申请日：2013-10-08

Applicant: STC.UNM ,  LOS ALAMOS NATIONAL SECURITY, LLC

Inventor： Graham Timmins ,  Louis Pete Silks

IPC: C12Q1/04 ,  C12Q1/02 ,  A61B5/083 ,  G01N33/497 ,  G01N33/569 ,  G01N33/60 ,  G21H5/02 ,  A61B5/08 ,  A61B5/145 ,  A61B5/20

CPC classification number: C12Q1/04 ,  A61B5/082 ,  A61B5/0836 ,  A61B5/14507 ,  A61B5/14546 ,  A61B5/207 ,  C12Q1/02 ,  G01N33/497 ,  G01N33/56911 ,  G01N33/60 ,  G01N2333/33 ,  G21H5/02

Abstract: The present invention is directed to methods of determining the presence or absence of a bacterial infection in a patient using isotopically-labeled tyrosine and/or isotopically-labeled p-hydroxyphenylacetic acid.

公开(公告)号：US09982296B2

公开(公告)日：2018-05-29

申请号：US14870513

申请日：2015-09-30

Applicant: STC.UNM

Inventor： Jeremy Edwards

IPC: C12Q1/68

CPC classification number: C12Q1/6874 ,  C12Q1/6869 ,  C12Q2525/155 ,  C12Q2521/313 ,  C12Q2565/518 ,  C12Q2563/131 ,  C12Q2525/191

Abstract: We describe ultra-high throughput polony genome sequencing that can permit, for example, generating raw data to re-sequencing the human genome in about one week (including library prep and sequencing) at a reasonable cost. The methods described herein include one or more of the following: (1) increasing polony sequencing read length, (2) improving library construction and emulsions protocols, (3) increasing bead density and/or moving to alternative clonal amplication strategies (other than emulsion PCR or ePCR), (4) extending software capabilities to allow SNP calls from our new sequencing raw data, (5) Dual Primer Emulsion PCR, and (6) diagnostic method exploiting one or more of the foregoing.

公开(公告)号：US20180143278A1

公开(公告)日：2018-05-24

申请号：US15574431

申请日：2016-05-13

Applicant: STC.UNM

Inventor： Laurel Sillerud

IPC: G01R33/56 ,  B82Y15/00 ,  G01R33/465 ,  G06T7/00

CPC classification number: G01R33/5602 ,  B82Y15/00 ,  G01R33/465 ,  G01R33/5601 ,  G01R33/5608 ,  G06K2209/05 ,  G06T7/0016 ,  G06T2207/10088 ,  G06T2207/30004

Abstract: A method of measuring the concentration of a magnetic material in an object using magnetic resonance imaging comprising administering magnetic material to the object; obtaining a set of T1-weighted and T2-weighted images of the object in order to determine a background magnetic resonance imaging signal intensity and measurements of the background nuclear magnetic relaxation times (T1, T2) of the object without magnetic material; and obtaining a set of T1-weighted and T2-weighted magnetic resonance images of the object with magnetic materials added; measuring effect of magnetic material on the relaxation times; and converting the T1-weighted and T2-weighted images into a set of contrast images which are subtracted from each other to yield a contrast difference image proportional to the concentration of the magnetic material.

公开(公告)号：US09970000B2

公开(公告)日：2018-05-15

申请号：US14996048

申请日：2016-01-14

Applicant: National Technology & Engineering Solutions of Sandia, LLC ,  STC.UNM

Inventor： Bryan J. Kaehr ,  C. Jeffrey Brinker ,  Jason L. Townson

IPC: C12N11/14 ,  C08K3/36

CPC classification number: G01N1/2806 ,  C08K3/36 ,  C12N11/14 ,  G01N1/2853

Abstract: The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable.

公开(公告)号：US20180111006A1

公开(公告)日：2018-04-26

申请号：US15843706

申请日：2017-12-15

Applicant: STC.UNM

Inventor： Shuang Luan ,  Daniel Andres Riofrio Almeida

IPC: A61N5/10 ,  G06N3/00

CPC classification number: A61N5/1031 ,  A61N5/10 ,  A61N5/1001 ,  A61N5/1007 ,  A61N5/103 ,  A61N5/1084 ,  A61N2005/101 ,  A61N2005/1024 ,  A61N2005/1034 ,  G06F19/325 ,  G06N3/006 ,  G16H20/40

Abstract: An optimization technique for use with radiation therapy planning that combines stochastic optimization techniques such as Particle Swarm Optimization (PSO) with deterministic techniques to solve for optimal and reliable locations for delivery of radiation doses to a targeted tumor while minimizing the radiation dose experienced by the surrounding critical structures such as normal tissues and organs.