公开(公告)号：US20050284800A1

公开(公告)日：2005-12-29

申请号：US11165249

申请日：2005-06-24

Applicant: Yoichiro Handa ,  Yasuyuki Numajiri

Inventor： Yoichiro Handa ,  Yasuyuki Numajiri

IPC: B03C1/32 ,  B07C5/02

CPC classification number: B03C1/32 ,  B03C2201/18

Abstract: An apparatus for sorting particles of multiple kinds having different properties in a fluid includes a flow channel for conveying the fluid containing the particles, multiple sorting regions provided in the flow channel for sorting the particles according to their properties, and sorting means provided in each of the sorting regions. The sorting means is capable of sorting particles having the same property by utilizing a difference in attraction force caused by a difference in property between particles.

Abstract translation: 一种用于分选流体中具有不同性质的多种颗粒的设备包括用于输送含有颗粒的流体的流动通道，设置在流动通道中的多个分选区域，用于根据其性质对颗粒进行分选，以及分类装置 分拣区域。 分选装置能够通过利用由颗粒之间的特性差引起的吸引力差异来分选具有相同性质的颗粒。

公开(公告)号：US20050274650A1

公开(公告)日：2005-12-15

申请号：US11143522

申请日：2005-06-02

Applicant: A. Frazier ,  Ki Han

Inventor： A. Frazier ,  Ki Han

IPC: B03C1/00 ,  B03C1/30

CPC classification number: B03C1/30 ,  B03C1/002 ,  B03C1/0332 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26

Abstract: Single stage and cascaded stage magnetophoretic microseparators are disclosed that efficiently separate blood cells from whole blood based on their native magnetic properties using a high gradient magnetic field without the use of additives such as magnetic tagging or fluorescent dyes. The microseparators are fabricated using microfabrication methods, enabling integration of micro-scale magnetic flux concentrators in an aqueous microenvironment, providing strong magnetic forces, and fast separations.

Abstract translation: 公开了单级和级联级磁电泳微分离器，其使用高梯度磁场，而不使用诸如磁性标记或荧光染料的添加剂，基于其天然磁性能，有效地将血细胞与全血分离。 微分离器使用微细加工方法制造，使得微尺度磁通量聚集器能够在水性微环境中集成，提供强大的磁力和快速分离。

公开(公告)号：US20050126976A1

公开(公告)日：2005-06-16

申请号：US11008193

申请日：2004-12-10

Applicant: Hiroaki Yoda ,  Satoshi Yumoto ,  Minoru Morita

Inventor： Hiroaki Yoda ,  Satoshi Yumoto ,  Minoru Morita

IPC: C02F1/52 ,  B03C1/00 ,  B03C1/027 ,  B03C1/029 ,  B03C1/03 ,  B03C1/032 ,  C02F1/48 ,  C02F1/56 ,  C02F1/66 ,  C02F11/14

CPC classification number: C02F1/488 ,  B03C1/01 ,  B03C1/032 ,  B03C1/0337 ,  B03C1/034 ,  B03C2201/18 ,  C02F1/001 ,  C02F1/5236 ,  C02F1/56 ,  C02F1/66 ,  C02F11/14 ,  C02F2301/046

Abstract: A magnetic separation unit can prevent any magnetic flocs deposited on an inner wall of a water passing pipe from closing a water channel for stabilizing a magnetic separation performance and reduce cost by a small-diameter portion of the water passing pipe. The magnetic separation unit has an air-core solenoid type magnet provided around the water passing pipe guiding, from a lower side, treated water including magnetic flocs in which contaminants and magnetic particles are flocculated, a rotating disc type magnetic filter case provided above the air-core solenoid type magnet for attracting the magnetic flocs in the treated water supplied from the water passing pipe and flushing means for flushing the matrixes to which the magnetic flocs are attracted. The water passing pipe has a small-diameter pipe positioned in the air-core solenoid type magnet, and an enlarged pipe enlarged from the small-diameter pipe toward a water passing part of the rotating disc type magnetic filter case.

Abstract translation: 磁分离单元可以防止沉积在水通过管的内壁上的任何磁性絮凝物关闭水通道以稳定磁分离性能，并且通过水通过管的小直径部分降低成本。 磁分离单元具有设置在水通过管周围的空心螺线管型磁体，从下侧引导包括污染物和磁性颗粒絮凝的磁性絮凝物的处理水，设置在空气上方的旋转盘型磁性过滤器壳体 用于吸引从通水管供给的处理水中的磁絮凝物的芯螺线管型磁体和用于冲洗磁絮凝物所吸收的基体的冲洗装置。 通水管具有位于空心螺线管型磁体中的小直径管，并且从小直径管朝向旋转盘型磁性过滤器壳体的水通过部分扩大的管。

公开(公告)号：US06896801B2

公开(公告)日：2005-05-24

申请号：US10654551

申请日：2003-09-03

Applicant: Raymond L. Anderson ,  Jason L. Sisler

Inventor： Raymond L. Anderson ,  Jason L. Sisler

IPC: B01D35/06 ,  B03C1/02 ,  B03C1/20 ,  B03C1/28 ,  C02F1/48

CPC classification number: C02F1/488 ,  B03C1/20 ,  B03C1/286 ,  B03C2201/18 ,  C02F1/481 ,  C02F2101/20 ,  C02F2103/16 ,  C02F2103/34

Abstract: The magnetic separator has a tank with a pair of dual conveyor chains, spaced apart, at opposite sides of the tank. A plurality of frames with spaced apart magnetic rods are suspended from the conveyor chains in a manner allowing the frames to swivel and always hang vertically as the chains traverse their endless path. The liquid in the tank flows through the frames and ferrous particles are attracted to the magnetic rods. The rods are cleaned and the ferrous particles removed at a wiping station. Each frame has a scraping edge which contacts the bottom of the tank and drags out the non-magnetic particulate which has separated from the liquid.

Abstract translation: 磁力分离器具有在罐的相对侧具有间隔开的一对双输送链的罐。 具有间隔开的磁棒的多个框架以这样的方式悬挂在输送链上，即当链条横过其无尽路径时，框架能够垂直地旋转并且始终垂直悬挂。 罐中的液体流过框架，铁质颗粒被吸引到磁棒上。 清洁棒，并在擦拭站移除亚铁颗粒。 每个框架具有接触罐的底部的刮削边缘并且拖出与液体分离的非磁性颗粒。

公开(公告)号：US20050079591A1

公开(公告)日：2005-04-14

申请号：US10885275

申请日：2004-07-06

Applicant: Daniel Reich ,  Monica Tanase ,  Christopher Chen

Inventor： Daniel Reich ,  Monica Tanase ,  Christopher Chen

IPC: B01L3/00 ,  B03C1/01 ,  B03C1/28 ,  C12M1/26 ,  C12M3/00 ,  C12N13/00

CPC classification number: B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0877 ,  B01L2300/0896 ,  B01L2400/043 ,  B01L2400/0487 ,  B03C1/01 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  B82Y30/00 ,  C12M47/04 ,  C12N13/00

Abstract: In accordance with the invention, a surface is provided with a plurality of microscale magnets (“micromagnets”) disposed on a surface in a pattern to form a desired distribution of magnetic field strength. Cells and magnetic nanowires are attached, immersed in fluid, and flowed over the pattern. The nanowires and their bound cells are attracted to and bound to regions of the pattern as controlled by the geometry and magnetic properties of the pattern, the strength and direction of the fluid flow, and the strength and direction of an applied magnetic field.

Abstract translation: 根据本发明，表面设置有以图案设置在表面上以形成期望的磁场强度分布的多个微细磁体（“微型磁体”）。 将细胞和磁性纳米线连接，浸入流体中，并流过图案。 由图案的几何形状和磁特性，流体流动的强度和方向以及施加的磁场的强度和方向来控制纳米线及其结合的细胞被吸引并结合到图案的区域。

公开(公告)号：US06833069B1

公开(公告)日：2004-12-21

申请号：US10193883

申请日：2002-07-12

Applicant: Gunther E. Asterlin

Inventor： Gunther E. Asterlin

IPC: B01D3506

CPC classification number: B03C1/284 ,  B03C1/0332 ,  B03C1/286 ,  B03C2201/18

Abstract: A magnetic filter removes magnetic particles from fluid communicated through the filter. The filter includes elongated, circumferentially spaced magnetic elements which capture magnetic particles entrained in the turbulent passing fluid. The magnetic elements must be cleaned periodically to remove the particles from the elements by moving a scraper plate from one end of the housing to the other. At the end of travel of the scraper plate, the particles are scraped upon non-magnetic end portions (which may contain residual magnetism) of the magnetic elements, from which they are flushed by fluid communicated through the inlet port out through other ports provided on the housing.

Abstract translation: 磁性过滤器从通过过滤器的流体中除去磁性颗粒。 过滤器包括细长的周向间隔开的磁性元件，其捕获夹带在湍流通过流体中的磁性颗粒。 必须定期清洁磁性元件，以便通过将刮板从外壳的一端移动到另一端，以将元件从元件上移除。 在刮板行进结束时，将颗粒刮在磁性元件的非磁性端部（可能含有剩余磁性）上，这些磁性元件由通过入口端口通过设置在其上的其它端口流出​​的流体冲洗掉 住房。

公开(公告)号：US06805840B1

公开(公告)日：2004-10-19

申请号：US09646653

申请日：2000-09-18

Applicant: Hideji Tajima

Inventor： Hideji Tajima

IPC: B01L302

CPC classification number: B01L3/50853 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/0029 ,  B01J2219/00292 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00313 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/00369 ,  B01J2219/00459 ,  B01J2219/00466 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00686 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/0074 ,  B01L3/0231 ,  B01L3/5025 ,  B01L2300/0829 ,  B03C1/025 ,  B03C1/033 ,  B03C1/035 ,  B03C1/284 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  C40B40/06 ,  C40B60/14 ,  G01N35/0098 ,  G01N35/028 ,  G01N35/1065 ,  G01N35/1074 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: The present invention relates to an apparatus for an integrated process of magnetic particles and a method of controlling the same, for executing a process for magnetic particles incorporated in a fluid in an integrated state. The present invention aims to provide an apparatus for an integrated process of magnetic particles and a method of controlling the same, that can promptly and efficiently process all together in high precision, with the process of magnetic particles integrated. The apparatus for an integrated process of magnetic particles comprises a reservoir body provided with plural pit-like reservoirs for storing a drawn liquid arranged in a matrix, a sliding body with jutting plural sliding projections sliding through the reservoirs and capable of moving vertically to and from the reservoir body, plural nozzles attached to the lower parts of the reservoirs and capable of passing the liquid therethrough, a magnetic force device capable of magnetization and demagnetization having plural through sections in which is inserted each nozzle and having a wall part in contact with or near the outer side surface of the nozzle, with the nozzles inserted thereinto, wherein each wall part has two divided wall parts being apart from one another in such a manner that the divided wall parts have opposite polarities by magnetization, respectively.

Abstract translation: 本发明涉及一种用于磁性颗粒的集成过程的装置及其控制方法，用于执行以一体化状态结合在流体中的磁性颗粒的过程。 本发明的目的在于提供一种用于磁性颗粒的集成处理的装置及其控制方法，其可以以高精度快速有效地处理所有的磁性颗粒的集成过程。 磁性粒子包括：储存器体，设置有多个用于储存以矩阵形式排列的抽取液体的凹坑状储存器;滑动体，具有突出的多个滑动突起，其滑动通过储存器并且能够垂直地移动到储存器主体和从储存器本体移动;多个喷嘴 到达储存器的下部并且能够使液体通过其中的磁力装置，其能够进行磁化和去磁，其具有多个贯穿部分的贯穿部分，其中每个喷嘴插入每个喷嘴并具有壁部分与外部表面接触或接近 喷嘴，其中插入有喷嘴，其中每个壁部分具有两个分开的壁p 艺术彼此分开，使得分隔壁部分分别具有相对于磁化的极性。

公开(公告)号：US06758969B2

公开(公告)日：2004-07-06

申请号：US10267451

申请日：2002-10-09

Applicant: Joseph C. Caiozza

Inventor： Joseph C. Caiozza

IPC: B01D3506

CPC classification number: B01D29/114 ,  B01D29/902 ,  B01D29/925 ,  B01D35/06 ,  B01D35/147 ,  B01D2201/4084 ,  B03C1/288 ,  B03C2201/18 ,  Y10S210/17

Abstract: Generally, a magnetically enhanced oil filter apparatus includes a cartridge housing which includes an oil input channel and an outlet channel. The cartridge housing defines a cartridge interior space. A magnet unit is affixed to an outside portion of the cartridge housing, whereby a magnetic field from the magnet unit extends into the cartridge interior space providing an interior magnetic field zone. A hollow annular (e.g. cylindrical) filter element is employed. Filter positioning means are provided for supporting and positioning the hollow cylindrical filter element. Oil flow control means are positioned so that portions thereof enter the interior magnetic field zone, for directing oil flow to and from the hollow cylindrical filter element. In this respect, the oil flow control means are positioned with respect to the hollow cylindrical filter element and the interior magnetic field zone to divide the interior magnetic field zone into a pre-filtration magnetic treatment zone and a post-filtration magnetic treatment zone.

Abstract translation: 通常，磁力增强型油过滤器装置包括一个包括油输入通道和出口通道的盒壳体。 盒壳体限定盒的内部空间。 磁体单元被固定到盒壳体的外部部分，由此来自磁体单元的磁场延伸到提供内部磁场区域的盒内部空间中。 使用中空的环形（例如圆柱形）过滤元件。 提供过滤器定位装置用于支撑和定位中空圆柱形过滤元件。 油流控制装置被定位成使得其部分进入内部磁场区，用于引导油流到中空圆柱形过滤器元件和从中空圆柱形过滤器元件流出。 在这方面，油流量控制装置相对于中空圆柱形过滤元件和内部磁场区域定位，以将内部磁场区域分成预过滤磁性处理区域和后过滤磁性处理区域。

公开(公告)号：US20040009614A1

公开(公告)日：2004-01-15

申请号：US10276099

申请日：2003-08-04

Inventor： Chong H Ahn ,  Hyoung J Cho ,  Jin-Woo Choi

IPC: G01N033/553

CPC classification number: B01F13/0076 ,  B01F3/08 ,  B01F5/0403 ,  B01F13/0001 ,  B01F13/0005 ,  B01F13/0077 ,  B01F2215/0037 ,  B01J19/0046 ,  B01J2219/00459 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/0054 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00655 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01L3/502707 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2400/0415 ,  B01L2400/0487 ,  B03C1/00 ,  B03C1/0332 ,  B03C1/034 ,  B03C1/28 ,  B03C2201/18 ,  B03C2201/26 ,  C40B40/06 ,  C40B40/10 ,  C40B70/00 ,  G01N30/6095 ,  G01N35/0098 ,  G01N2030/347 ,  H01F10/16 ,  H01F41/16 ,  H01F41/26 ,  H01F41/34 ,  G01N2030/0035

Abstract: The present invention relates to magnetic particle separators using micromachined magnetic arrays and more particularly, to magnetic particle separators or manipulators using controlled magnetization on micromachined magnetic arrays for the separation of cells and other biological materials. The present invention also pertains to using such devices for the separation and analysis of biological materials for immunoassays, DNA sequencing, protein analysis, and biochemical detection applications. The present invention can also be viewed as a novel method for fabricating fully integrated permanent magnet components within any microelectromechanical system (nullMEMSnull) structures. The present invention also provides a magnetic particle separation and manipulation system for rapid separation and accurate manipulation of magnetic particles in two-dimensional electromagnetic arrays, which utilize high throughput biological analyses. A disposable cartridge can be produced in low cost using a low cost substrate such as plastic or other polymer, glass, or metal. Magnetic flux is generated by conventional or micromachined electromagnets a platform system consisting of magnetic flux sources, magnetic flux guidance, and a microprocessor control interface. By controlling direction of electric currents into inductors on the platform system, arbitrary magnetic poles can be generated on Permalloy structures of the cartridge to separate and manipulate magnetic particles. The magnetic particle separator and manipulator in the present invention can be easily combined with automated detection systems such as a fluorescent monitoring system.

Abstract translation: 本发明涉及使用微加工磁阵列的磁性颗粒分离器，更具体地说，涉及使用微加工磁阵列上的受控磁化的磁性颗粒分离器或操纵器来分离细胞和其它生物材料。 本发明还涉及使用这种装置来分离和分析用于免疫测定，DNA测序，蛋白质分析和生物化学检测应用的生物材料。 本发明还可以被看作是在任何微机电系统（“MEMS”）结构内制造完全集成的永磁体部件的新方法。 本发明还提供一种用于快速分离和精确操作二维电磁阵列中的磁性粒子的磁性粒子分离和操纵系统，其利用高通量生物分析。 可以使用低成本的基材例如塑料或其它聚合物，玻璃或金属，可以低成本地生产一次性盒。 磁通由常规或微机电电磁铁产生，由磁通源，磁通引导和微处理器控制接口组成的平台系统。 通过控制平台系统中电感器的电流方向，可以在墨盒的坡莫合金结构上产生任意磁极，以分离和操纵磁性颗粒。 本发明的磁粉分离器和机械手可以容易地与诸如荧光监视系统的自动检测系统组合。

公开(公告)号：US20030183580A1

公开(公告)日：2003-10-02

申请号：US10113658

申请日：2002-03-29

Inventor： William R. Schaaf ,  Ray R. Arel

IPC: B01D035/06

CPC classification number: B03C1/286 ,  B03C2201/18

Abstract: A tank nullAnull has a fluid inlet, a fluid outlet, and a closure nullBnull wherein the tank may be positioned in line as a pressure vessel. A magnetic core assembly includes elongated permanent magnets nullCnull and magnet covers or tubes nullDnull constructed of non-magnetic material for collecting magnetic particles from a liquid. The core assembly is carried in the tank and is removable after the separate closure is removed from the tank. The method contemplates separating the magnets from the tubes for removal of the magnetic particles from the magnetic core assembly externally of the tank and independently of the closure.

Abstract translation: 罐[A]具有流体入口，流体出口和封闭件[B]，其中罐可以作为压力容器排成直线。 磁芯组件包括由用于从液体收集磁性颗粒的非磁性材料构成的细长永磁体[C]和磁体盖或管[D]。 芯组件被装载在罐中，并且在从罐中移除单独的封闭件之后是可拆卸的。 该方法考虑将磁体与管分离，以从磁体外部的磁芯组件除去磁性颗粒并且独立于闭合件。