公开(公告)号：US20240228591A1

公开(公告)日：2024-07-11

申请号：US18403419

申请日：2024-01-03

Applicant: ACADEMIA SINICA

Inventor： Kuo-I LIN ,  Che MA ,  Chi-Huey WONG ,  Szu-Wen WANG ,  Yi-Hsuan CHANG ,  Xiaorui CHEN ,  Han-Yi HUANG

IPC: C07K16/10 ,  A61K39/00 ,  A61K39/42

CPC classification number: C07K16/10 ,  A61K39/42 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure relates to an antibody or antigen-binding fragment thereof that specifically binds to a spike protein of SARS-COV-2. The present disclosure also relates to a pharmaceutical composition, a method for treating and/or preventing diseases and/or disorders caused by a coronavirus in a subject in need thereof, and a method for detecting a coronavirus in a sample.

公开(公告)号：US20240207814A1

公开(公告)日：2024-06-27

申请号：US18427379

申请日：2024-01-30

Applicant: Academia Sinica

Inventor： Jia-Hui WANG ,  Hao-Ju CHOU ,  Po-Wen CHUNG

IPC: B01J20/20 ,  B01D53/02 ,  B01J20/28 ,  B01J20/30 ,  B01J27/02 ,  B01J31/04 ,  B01J37/20 ,  C01B32/318 ,  C01B32/354

CPC classification number: B01J20/20 ,  B01D53/02 ,  B01J20/28059 ,  B01J20/3071 ,  B01J20/3078 ,  B01J20/3085 ,  B01J27/02 ,  B01J31/04 ,  B01J37/20 ,  C01B32/318 ,  C01B32/354 ,  B01D2253/102 ,  C01P2002/72 ,  C01P2002/76 ,  C01P2002/78 ,  C01P2002/82 ,  C01P2002/85

Abstract: Disclosed is a modified carbonaceous material, which includes hexagonal carbon networks in a layered stacking structure and acidic functional groups bonded to the hexagonal carbon networks and mainly existing at edges of the layered carbonaceous structure. Accordingly, the close proximity of acid moiety at the edges can resemble the center of hydrolysis enzymes, resulting in enhancement of hydrolytic efficiency. Additionally, the acid-functionalized carbonaceous material can also be applied in the capture and storage of carbon dioxide due to its unexpectedly higher capacity for CO2 molecular.

公开(公告)号：US11981846B2

公开(公告)日：2024-05-14

申请号：US17611896

申请日：2020-07-29

Applicant: Academia Sinica

Inventor： Michael Hsiao ,  Ming-Hsien Chan ,  Subbiramaniyan Kubendhiran ,  Ming-Che Hsieh ,  Zhen Bao ,  An-Bang Wang ,  Ru-Shi Liu

IPC: C09K11/02 ,  C09K11/56 ,  C09K11/70 ,  C09K11/77 ,  C09K11/88 ,  G01N33/58 ,  B82Y20/00 ,  B82Y40/00

CPC classification number: C09K11/025 ,  C09K11/565 ,  C09K11/70 ,  C09K11/7773 ,  C09K11/883 ,  G01N33/587 ,  G01N33/588 ,  B82Y20/00 ,  B82Y40/00 ,  G01N2458/00

Abstract: Disclosed herein is a nanocomposite comprising a core-shell nanoparticle and a core-shell quantum dot. The core-shell nanoparticle comprises a phosphor core, a shell layer, and a cleavable peptide. The core-shell quantum dot comprises a center core, an intermediate layer, an outer layer, a silica layer, and an arginylglycylaspartic acid (RGD) peptide. The core-shell nanoparticle and the core-shell quantum dot are linked to each other via forming a peptide bond between the cleavable peptide and the RGD peptide. Also disclosed are the uses of the nanocomposite in making a diagnosis of tumors.

公开(公告)号：US20240110139A1

公开(公告)日：2024-04-04

申请号：US18267996

申请日：2021-12-30

Applicant: ACADEMIA SINICA

Inventor： YING-CHIH CHANG

IPC: C12M1/00 ,  C12M1/32

CPC classification number: C12M23/20 ,  C12M23/12 ,  C12N2513/00 ,  C12N2533/40 ,  C12N2537/10

Abstract: A surface coating comprising a hydrophilic polymer and polyelectrolyte multilayers. Also, a cell culture system including a cell culture article having a surface coated with the surface coating. Also, methods of preparing the surface coatings and systems.

公开(公告)号：US11918641B2

公开(公告)日：2024-03-05

申请号：US17998208

申请日：2021-05-07

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey Wong ,  Hsin-Yu Liao ,  Shih-Chi Wang ,  Yi-An Ko ,  Kuo-I Lin ,  Che Ma ,  Ting-Jen Cheng

IPC: A61K39/145 ,  A61K35/76 ,  A61K39/00 ,  A61K39/12 ,  A61P31/16 ,  C07K14/005 ,  C07K14/11

CPC classification number: A61K39/145 ,  A61P31/16 ,  C07K14/005 ,  A61K2039/575

Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).

公开(公告)号：US11884739B2

公开(公告)日：2024-01-30

申请号：US17211619

申请日：2021-03-24

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey Wong ,  Chung-Yi Wu ,  Ming-Hung Tsai

IPC: C07K16/28 ,  C12P21/00 ,  A61K39/00

CPC classification number: C07K16/2887 ,  C07K16/283 ,  C12P21/005 ,  C12Y302/01 ,  C12Y302/01051 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92

Abstract: The present disclosure relates to a novel class of anti-CD20 monoclonal antibodies comprising a homogeneous population of anti-CD20 IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-CD20 monoclonal antibodies by Fc glycoengineering. Importantly, the antibodies of the invention have improved therapeutic values with increased ADCC activity and increased Fc receptor binding affinity compared to the corresponding monoclonal antibodies that have not been glycoengineered.

公开(公告)号：US11872260B2

公开(公告)日：2024-01-16

申请号：US16585984

申请日：2019-09-27

Applicant: ACADEMIA SINICA

Inventor： Lie-Fen Shyur ,  Chih-Ting Chang ,  Yuhsin Chen

IPC: A61K36/534 ,  A61K31/015 ,  A61P35/00 ,  A61K31/122 ,  A61K9/00

CPC classification number: A61K36/534 ,  A61K31/015 ,  A61K31/122 ,  A61P35/00 ,  A61K9/0014

Abstract: This disclosure is directed to essential oils, and methods of their use in treating skin conditions. The skin conditions include those involving HRASQ61L mutant keratinocyte activity, wherein the essential oil inhibits said activity to treat and/or prevent skin cancer. Particularly, the present invention denotes to and composition for inhibiting and prevent skin carcinogenesis or BRAF inhibitor, a type of anti-cancer drug induced cutaneous side effect.

公开(公告)号：US20240009259A1

公开(公告)日：2024-01-11

申请号：US18253662

申请日：2021-11-19

Applicant: ACADEMIA SINICA

Inventor： Lie-Fen SHYUR ,  Yu-Chuan LIANG ,  Yu-Hsin CHEN ,  Chuan-Ju LIN ,  Meng-Ting CHANG ,  Chung-Chih YANG

IPC: A61K36/28 ,  A61K31/7028 ,  A61P21/00 ,  A61P25/24

CPC classification number: A61K36/28 ,  A61K31/7028 ,  A61P21/00 ,  A61P25/24

Abstract: The present disclosure provides a method for preventing and/or treating fatigue and/or depression in a subject in need of such prevention and/or treatment, comprising administering to said subject an effective amount of Crassocephalum rabens plant or extract and optionally a pharmaceutically acceptable carrier or excipient. The present disclosure also provides a method for increasing skeletal muscle lactate dehydrogenase and/or malate dehydrogenase.

公开(公告)号：US20230381761A1

公开(公告)日：2023-11-30

申请号：US18030773

申请日：2021-10-07

Applicant: Academia Sinica

Inventor： Shang-Cheng HUNG ,  Chi-Huey WONG ,  Veeranjaneyulu GANNEDI ,  Bharath Kumar VILLURI ,  Nimmakayala Sivakumar REDDY ,  Chiao-Chu KU

IPC: B01J31/02 ,  C07H1/02 ,  C07H7/06

CPC classification number: B01J31/0245 ,  C07H1/02 ,  C07H7/06

Abstract: Disclosed herein are novel catalysts for producing remdesivir in one-pot manner, in which a diastereomerically enriched form of an intermediate, which following acidic hydrolysis would give rise to the desired remdesivir, was produced with the aid of the disclosed novel catalysts. Also disclosed herein is an improved process for the preparation of remdesivir without the need to separate one of the enantiomers while minimizing the formation of undesired isomers, thus offers economic advantages for operation on a commercial scale.

公开(公告)号：US20230366879A1

公开(公告)日：2023-11-16

申请号：US18308531

申请日：2023-04-27

Applicant: Academia Sinica

Inventor： Ying-Chih Chang ,  Han-Chung Wu ,  Po-Yuan Tseng ,  Jen-Chia Wu

IPC: G01N33/543 ,  C07K16/30 ,  G01N33/574 ,  C07K17/14 ,  G01N1/40

CPC classification number: G01N33/54393 ,  C07K16/30 ,  C07K17/14 ,  G01N1/405 ,  G01N33/54386 ,  G01N33/57492

Abstract: This invention relates to a surface coating for capture circulating rare cells, comprising a nonfouling composition to prevent the binding of non-specific cells and adsorption of serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the nonfouling and bioactive compositions. The invention also provide a surface coating for capture and purification of a biological substance, comprising a releasable composition to release the non-specific cells and other serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the releasable and bioactive compositions. The present invention also discloses a novel microfluidic chip, with specific patterned microstructures to create a flow disturbance and increase the capture rate of the biological substance.