公开(公告)号：US20160305890A1

公开(公告)日：2016-10-20

申请号：US15038483

申请日：2014-11-18

Applicant: KEMIRA OYJ

Inventor： Lari Vähäsalo ,  Iiris Joensuu ,  Marjatta Piironen

IPC: G01N21/85 ,  G01N33/18 ,  G01N21/31 ,  G01N15/06 ,  G01N21/78 ,  B03B7/00 ,  G01N33/34 ,  G01N21/82 ,  G01N31/22 ,  C09B67/32 ,  D21H23/08 ,  G01N21/59 ,  G01N21/27

CPC classification number: G01N21/85 ,  B03B7/00 ,  C02F1/5209 ,  C09B21/00 ,  C09B67/0075 ,  D21H23/08 ,  D21H23/78 ,  G01N15/06 ,  G01N21/274 ,  G01N21/314 ,  G01N21/59 ,  G01N21/78 ,  G01N21/82 ,  G01N21/83 ,  G01N27/447 ,  G01N31/22 ,  G01N33/182 ,  G01N33/343 ,  G01N2015/0053 ,  G01N2015/0092 ,  G01N2015/0693 ,  G01N2021/3155 ,  G01N2021/7783 ,  G01N2021/8411 ,  G01N2021/8416 ,  G01N2021/8557 ,  G01N2201/127 ,  G01N2201/129

Abstract: The present invention concerns a method of optical measurement of an aqueous stream, and of processing the results of the measurement in order to determine the anionic charge of the stream, the method being carried out by measuring the light absorption of the stream and predicting the amount of anionic groups in the stream using a mathematical processing, such as mathematical calculations. Particularly, the method includes the steps of adding an amount of a cationic dye to the aqueous stream, measuring the light absorption spectra of the obtained dye-containing stream, and processing the obtained light absorption spectrum using said mathematical processing in order to obtain the anionic charge. The invention also concerns the use of the obtained spectrum in determining the turbidity of the stream, as well as a device suitable for use in carrying out the method.

Abstract translation: 本发明涉及一种光学测量水流的方法，并且处理测量结果以确定流的阴离子电荷，该方法通过测量流的光吸收和预测量的量来进行 的阴离子基团使用数学处理，如数学计算。 特别地，该方法包括以下步骤：向含水流中加入一定量的阳离子染料，测量所得含染料流的光吸收光谱，并使用所述数学处理处理所获得的光吸收光谱，以获得阴离子 收费。 本发明还涉及所获得的光谱在确定流的浊度中的用途，以及适用于实施该方法的装置。

公开(公告)号：US20160274027A1

公开(公告)日：2016-09-22

申请号：US14413376

申请日：2014-02-20

Applicant: HALLIBURTON ENERGY SERVICES, INC.

Inventor： David L. Perkins ,  Robert Paul Freese ,  Christopher Michael Jones ,  Richard Neal Gardner

IPC: G01N21/45 ,  G02B5/28

CPC classification number: G01N21/45 ,  G01N21/85 ,  G01N2201/061 ,  G01N2201/068 ,  G01N2201/12 ,  G01N2201/129 ,  G02B5/28 ,  G02B5/285

Abstract: Disclosed are improved integrated computational elements for use in optical computing devices. One integrated computational element includes an optical substrate, first and second pluralities of optical thin film layers alternatingly deposited on the optical substrate to form a thin film stack, wherein each optical thin film layer of the first plurality exhibits a first refractive index and each optical thin film layer of the second plurality exhibits a second refractive index different than the first refractive index, and at least one additional optical thin film layer arranged in or on the thin film stack and in optical communication with at least one of the optical thin film layers of the first and second pluralities, the at least one additional optical thin film layer exhibiting a third refractive index that is different than the first and second refractive indices.

Abstract translation: 公开了用于光学计算设备的改进的集成计算元件。 一个集成的计算元件包括光学基板，交替沉积在光学基板上以形成薄膜叠层的第一和第二多个光学薄膜层，其中第一多个的每个光学薄膜层呈现第一折射率，并且每个光学薄膜 第二多个薄膜层呈现与第一折射率不同的第二折射率，以及至少一个附加的光学薄膜层，其布置在薄膜叠层中或薄膜堆叠上，并且与至少一个光学薄膜层 第一和第二多个，至少一个额外的光学薄膜层具有不同于第一和第二折射率的第三折射率。

公开(公告)号：US09448165B2

公开(公告)日：2016-09-20

申请号：US15081465

申请日：2016-03-25

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  John L. Smith ,  William Van Antwerp

IPC: G01J5/02 ,  G01N21/359 ,  A61B5/145 ,  A61B5/1455 ,  G01N33/483

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, illumination is directed to the medium and corresponding radiation from the medium is collected. Spectral energy changes associated with fragment(s)/feature(s) obtained from the collected radiation are determined using collision computing. Such spectral energy changes generally represent analyte concentration. The collection of radiation and/or illumination is controlled either to target a particular volume of the medium or such that the spectral energy changes become directionally monotonic with respect to analyte concentration, or both. The collection parameters include: duration of collection, location and/or a size of a collection spot on the medium surface, and angle of a collector relative to the medium surface. The illuminated and/or collection spots may be treated to improve accuracy of analyte measurement.

Abstract translation: 在用于在诸如组织的培养基中检测/测量葡萄糖和其它分析物的非侵入性系统中，照射被引导到介质并收集来自培养基的相应辐射。 使用碰撞计算确定与从收集的辐射获得的片段/特征相关联的光谱能量变化。 这种光谱能量变化通常表示分析物浓度。 控制辐射和/或照明的收集以靶向介质的特定体积，或者使得光谱能量变化相对于分析物浓度变得朝向单调，或两者。 收集参数包括：介质表面上的收集点的持续时间，位置和/或收集点的大小以及收集器相对于介质表面的角度。 可以处理照明和/或收集点以提高分析物测量的准确度。

公开(公告)号：US20160231236A1

公开(公告)日：2016-08-11

申请号：US15081465

申请日：2016-03-25

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  John L. Smith ,  William Van Antwerp

IPC: G01N21/359 ,  A61B5/1455 ,  G01N33/483 ,  A61B5/145

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, illumination is directed to the medium and corresponding radiation from the medium is collected. Spectral energy changes associated with fragment(s)/feature(s) obtained from the collected radiation are determined using collision computing. Such spectral energy changes generally represent analyte concentration. The collection of radiation and/or illumination is controlled either to target a particular volume of the medium or such that the spectral energy changes become directionally monotonic with respect to analyte concentration, or both. The collection parameters include: duration of collection, location and/or a size of a collection spot on the medium surface, and angle of a collector relative to the medium surface. The illuminated and/or collection spots may be treated to improve accuracy of analyte measurement.

Abstract translation: 在用于在诸如组织的培养基中检测/测量葡萄糖和其它分析物的非侵入性系统中，照射被引导到介质并收集来自培养基的相应辐射。 使用碰撞计算确定与从收集的辐射获得的片段/特征相关联的光谱能量变化。 这种光谱能量变化通常表示分析物浓度。 控制辐射和/或照明的收集以靶向介质的特定体积，或者使得光谱能量变化相对于分析物浓度变得朝向单调，或两者。 收集参数包括：介质表面上的收集点的持续时间，位置和/或收集点的大小以及收集器相对于介质表面的角度。 可以处理照明和/或收集点以提高分析物测量的准确度。

公开(公告)号：US09395300B2

公开(公告)日：2016-07-19

申请号：US14233566

申请日：2012-07-16

Applicant: Karl Sass ,  Dirk Greis ,  Michael Noah ,  Christian Ueckermann

Inventor： Karl Sass ,  Dirk Greis ,  Michael Noah ,  Christian Ueckermann

IPC: G01N21/59 ,  G01N21/31 ,  G01N33/49

CPC classification number: G01N21/59 ,  G01N21/31 ,  G01N21/314 ,  G01N33/491 ,  G01N33/492 ,  G01N2021/3129 ,  G01N2021/3148 ,  G01N2201/129

Abstract: The invention relates to a method for the spectrophotometric determination of the concentration of multiple substances, preferably bilirubin, haemoglobin and lipids, in a sample of body fluid.

Abstract translation: 本发明涉及分光光度法测定体液样品中多种物质，优选胆红素，血红蛋白和脂质的浓度的方法。

公开(公告)号：US20160139043A1

公开(公告)日：2016-05-19

申请号：US14993905

申请日：2016-01-12

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William Van Antwerp ,  John L. Smith

IPC: G01N21/3577 ,  G01N33/49 ,  G01N21/359

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: A synthetic projection system determines analyte concentration, such as blood glucose concentration, from a spectral-energy change associated with an uncharacterized instance of a medium in which the analyte is likely present. The projection system is factory calibrated for different instances of the medium, without needing instance-specific training or calibration. The projection system includes a set of projector curves, each relating spectral-energy change values obtained by analyzing reference medium samples to analyte concentrations in those samples. Each projector curve also corresponds to a respective range of energy-change gradients, determined using a group of surrogate media characterized according to analyte concentrations measured using a reference system. A spectral-energy-change gradient for the uncharacterized medium may be computed to select one of the projectors curves. Analyte concentration in the uncharacterized medium can be reliably computed at a specified high level of accuracy using the spectral-energy change associated therewith and the selected curve.

Abstract translation: 合成投影系统从与可能存在分析物的介质的非特征实例相关联的光谱能量变化来确定分析物浓度，例如血糖浓度。 投影系统在不同实例的介质下进行出厂校准，无需实例特定的训练或校准。 投影系统包括一组投影仪曲线，每个投影仪曲线都将通过分析参考介质样品获得的光谱能量变化值与这些样品中的分析物浓度相关联。 每个投影仪曲线也对应于能量变化梯度的相应范围，使用一组代用介质，其特征在于使用参考系统测量的分析物浓度。 可以计算未表征介质的光谱能量变化梯度以选择投影仪曲线之一。 使用与其相关联的光谱能量变化和所选择的曲线，可以以指定的高精确度可靠地计算未表征介质中的分析物浓度。

公开(公告)号：US20160139042A1

公开(公告)日：2016-05-19

申请号：US14993885

申请日：2016-01-12

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti

IPC: G01N21/3577 ,  G01N33/49 ,  G01N21/359

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: A synthesizer synthesizes Zyotons, waveforms that without a collision can travel substantially unperturbed in a propagation medium over a specified distance, for extracting via collision computing properties of interest of signals, such as the occurrence/absence of events and presence or concentrations of substances such as blood glucose, toxic chemicals, etc., obtained from high noise/clutter environments. The Zyotons are synthesized using base waveform families/generator functions unrelated to the signal environment. The Zyotons and corresponding carrier kernels include component(s) adapted to correspond to a signal property of interest and other component(s) adapted to correspond to other properties, such as noise and clutter. The number of each type of component(s) may be determined using a representative signal obtained from the environment that is optionally transformed via derivitization, addition of noise and/or another representative signal, etc. A base waveform family/generator function can be selected according to the representative signal morphology.

Abstract translation: 合成器合成Zyotons，没有碰撞的波形可以在传播介质中在特定距离内基本上不受干扰地传播，用于通过诸如事件的发生/不存在以及物质的存在或浓度（例如， 血糖，有毒化学物质等，从高噪声/杂波环境中获得。 Zyotons使用与信号环境无关的基本波形族/发生器功能合成。 Zyotons和相应的载体内核包括适于对应于感兴趣的信号特性的组件和适于对应于诸如噪声和杂波的其他性质的其它组件的组件。 可以使用从环境获得的代表信号来确定每种类型的组件的数量，所述代表性信号可选地通过衍生化，噪声的添加和/或其他代表性信号进行变换。可以选择基本波形族/发生器功能 根据代表信号的形态。

公开(公告)号：US20160139041A1

公开(公告)日：2016-05-19

申请号：US14993830

申请日：2016-01-12

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William Van Antwerp ,  John L. Smith

IPC: G01N21/3577 ,  G01N33/49 ,  G01N21/359

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: A collision-computing system detects and amplifies the energy associated with a feature signal to determine occurrences or absence of events, such as ultrasonic and/or geophysical events, or to determine presence and/or concentrations of substances such as blood glucose, toxic chemicals, etc., in a noisy, high-clutter environment or sample. To this end, a conditioned feature, obtained by modulating a carrier kernel with a feature signal, is collided with a Zyoton—a waveform that without a collision can travel substantially unperturbed in a propagation medium over a specified distance. The conditioned feature and the Zyoton are particularly constructed to be co-dependent in terms of their respective dispersion velocities and the divergence of a waveform resulting from the collision. The collision operation can transfer at least a portion of the feature energy to the resulting waveform, and the transferred energy can be amplified in successive collisions for detecting/measuring events/substances.

Abstract translation: 碰撞计算系统检测和放大与特征信号相关联的能量，以确定诸如超声波和/或地球物理事件之类的事件的出现或不存在，或者确定物质的存在和/或浓度，例如血糖，有毒化学物质， 等等，在嘈杂，高杂乱的环境或样品中。 为此，通过调制具有特征信号的载体核获得的调节特征与Zyoton-a波形相撞，其中没有碰撞可以在传播介质中在特定距离上基本上不受干扰地行进。 调节特征和Zyoton特别构造为在它们各自的分散速度和由碰撞产生的波形的发散度方面是共同依赖的。 碰撞操作可以将特征能量的至少一部分转移到所得到的波形，并且传送的能量可以在连续的碰撞中被放大以用于检测/测量事件/物质。

公开(公告)号：US20160132617A1

公开(公告)日：2016-05-12

申请号：US14538699

申请日：2014-11-11

Applicant: SpectraSensors, Inc.

Inventor： Xiang Liu ,  Alfred Feitisch ,  Keith Benjamin Helbley ,  James Tedesco

IPC: G06F17/50 ,  G06F17/10 ,  G01N21/3504 ,  G01N21/65 ,  G01N21/39

CPC classification number: G06F17/5009 ,  G01J1/0433 ,  G01J3/0294 ,  G01J3/28 ,  G01J3/42 ,  G01J3/44 ,  G01N21/3504 ,  G01N21/39 ,  G01N21/65 ,  G01N2021/3545 ,  G01N2021/399 ,  G01N2201/0612 ,  G01N2201/129 ,  G06F17/10

Abstract: Background composition concentration data representative of an actual background composition of a sample gas can be used to model absorption spectroscopy measurement data obtained for a gas sample and to correct an analysis of the absorption spectroscopy data (e.g. for structural interference and collisional broadening) based on the modeling.

Abstract translation: 可以使用代表样品气体的实际背景组成的背景组合物浓度数据来模拟对于气体样品获得的吸收光谱测量数据，并且基于该样品气体的吸收光谱数据（例如，用于结构干扰和碰撞展宽）进行分析 造型。

公开(公告)号：US20160097716A1

公开(公告)日：2016-04-07

申请号：US14869550

申请日：2015-09-29

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William V. Antwerp ,  John L. Smith

IPC: G01N21/47 ,  A61B5/024 ,  G01N33/49 ,  G01N21/49 ,  G01N21/359

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, spectra from the medium are deconstructed into features. Conditioned features, which contain frequency components specific to glucose or the other analytes, are derived from one or more features by modulating a carrier kernel with the feature. The conditioned features are computationally collided with one or more Zyotons that are co-dependent with the conditioned features. One or more collisions amplify a property of the analyte e.g., energy absorbed by glucose in tissue from radiation directed to the skin. A gradient of several values of the amplified property, each value corresponding to a particular radiation pattern according to a spectroscopic tomographic sequence, is used to select a suitable projector curve, with which a representative amplified value is projected to an accurate estimate of the concentration of glucose or the other analytes, without needing personalized calibration.

Abstract translation: 在用于在诸如组织的培养基中检测/测量葡萄糖和其它分析物的非侵入性系统中，来自培养基的光谱被解构为特征。 包含特定于葡萄糖或其他分析物的频率分量的条件特征通过调制具有该特征的载体核心从一个或多个特征导出。 条件特征与一个或多个与条件特征相关的Zyotons计算相撞。 一个或多个碰撞放大分析物的性质，例如组织中由葡萄糖吸收的能量，辐射被引导到皮肤。 使用放大性能的几个值的梯度，每个值对应于根据光谱断层扫描序列的特定辐射图，其值被选择合适的投影仪曲线，其中代表性的放大值被预测为准确地估计浓度 葡萄糖或其他分析物，不需要个性化校准。