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30 条记录 (耗时 0.02 秒)

    Apparatus and methods for optical stimulation of neural tissues
    24.
    发明授权
    Apparatus and methods for optical stimulation of neural tissues 有权
    用于光学刺激神经组织的装置和方法

    公开(公告)号：US08444683B2

    公开(公告)日：2013-05-21

    申请号：US11945649

    申请日：2007-11-27

    申请人： Anita Mahadevan-Jansen ,  Jonathon D. Wells ,  E. Duco Jansen

    发明人： Anita Mahadevan-Jansen ,  Jonathon D. Wells ,  E. Duco Jansen

    IPC分类号： A61N5/06

    CPC分类号： A61N5/0622 ,  A61N5/0618

    摘要： The present invention, in one aspect, relates to a method for stimulating neural tissue of a living subject. In one embodiment, the method has the steps of generating at least one beam of radiation; introducing at least one of one or more chromophores and one or more optical agents to a target neural tissue; and delivering the at least one beam of radiation to the target neural tissue, wherein the at least one beam of radiation is delivered with a radiant exposure that causes a thermal gradient in the target neural tissue, thereby stimulating the target neural tissue.

    摘要翻译： 本发明在一个方面涉及一种用于刺激活体的神经组织的方法。 在一个实施例中，该方法具有产生至少一个辐射束的步骤; 将一种或多种发色团和一种或多种光学剂中的至少一种引入靶神经组织; 以及将所述至少一束辐射递送到所述靶神经组织，其中所述至少一束辐射以辐射暴露递送，所述辐射暴露导致所述靶神经组织中的热梯度，从而刺激所述靶神经组织。

    METHOD AND APPARATUS OF PULSED INFRARED LIGHT FOR THE INHIBITION OF CENTRAL NERVOUS SYSTEM NEURONS
    25.
    发明申请
    METHOD AND APPARATUS OF PULSED INFRARED LIGHT FOR THE INHIBITION OF CENTRAL NERVOUS SYSTEM NEURONS 有权
    用于抑制中枢神经系统神经元的脉冲红外光的方法和装置

    公开(公告)号：US20130013030A1

    公开(公告)日：2013-01-10

    申请号：US13480012

    申请日：2012-05-24

    申请人： Anita Mahadevan-Jansen ,  Jonathan Cayce ,  Robert Friedman ,  Anna Roe ,  E. Duco Jansen ,  Mykyta Chernov ,  Peter E. Konrad

    发明人： Anita Mahadevan-Jansen ,  Jonathan Cayce ,  Robert Friedman ,  Anna Roe ,  E. Duco Jansen ,  Mykyta Chernov ,  Peter E. Konrad

    IPC分类号： A61N5/067

    CPC分类号： A61N5/0622 ,  A61N2005/063 ,  A61N2005/0659 ,  A61N2005/067

    摘要： Certain aspects of the present disclosure are directed to a method of applying infrared neural stimulation (INS) to the central nervous system (CNS) of a target. The methods includes applying a pulsed infrared laser at a stimulation site in the CNS; and evoking responses from a region of interest of the CNS that is at or adjacent to the stimulation site by the pulsed infrared laser. In the method, the pulsed infrared laser penetrates a predetermined penetration depth of the stimulation site. Certain aspects of the present disclosure are directed to an apparatus for applying INS to the CNS of a target. The apparatus includes a generator generating a pulsed infrared laser, which penetrates a predetermined penetration depth of a stimulation site to evoke a response from the CNS, and an optical medium adapted for delivering the pulsed infrared laser at the stimulation site of the CNS.

    摘要翻译： 本公开的某些方面涉及将红外神经刺激（INS）应用于靶的中枢神经系统（CNS）的方法。 所述方法包括在CNS的刺激部位应用脉冲红外激光; 并通过脉冲红外激光引起来自刺激部位处于或相邻的CNS的感兴趣区域的反应。 在该方法中，脉冲红外激光穿透刺激部位的预定穿透深度。 本公开的某些方面涉及用于将INS应用于目标的CNS的装置。 该装置包括产生脉冲红外激光器的发生器，其穿透刺激部位的预定穿透深度以引起来自CNS的响应，以及适于在CNS的刺激部位处递送脉冲红外激光的光学介质。

    COMMON DETECTOR FOR COMBINED RAMAN SPECTROSCOPY-OPTICAL COHERENCE TOMOGRAPHY
    26.
    发明申请
    COMMON DETECTOR FOR COMBINED RAMAN SPECTROSCOPY-OPTICAL COHERENCE TOMOGRAPHY 有权
    用于组合拉曼光谱光学相干光谱的通用检测器

    公开(公告)号：US20120188538A1

    公开(公告)日：2012-07-26

    申请号：US13012529

    申请日：2011-01-24

    申请人： Chetan A. Patil ,  Anita Mahadevan-Jansen ,  Antonius Gerardus Johannes Maria van Leeuwen ,  Jeroen Kalkman

    发明人： Chetan A. Patil ,  Anita Mahadevan-Jansen ,  Antonius Gerardus Johannes Maria van Leeuwen ,  Jeroen Kalkman

    IPC分类号： G01J3/44 ,  G01B9/02

    CPC分类号： G01B9/02044 ,  A61B3/102 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/442 ,  A61B5/443 ,  G01B9/0203 ,  G01B9/02091 ,  G01J3/44 ,  G01J3/453 ,  G01N21/4795 ,  G01N21/65 ,  G01N2021/1787

    摘要： In one aspect of the present invention, an apparatus includes a first light source for generating a broadband light, and a second light source for generating a monochromatic light, a beamsplitter optically coupled to the first light source for receiving the broadband light and splitting the received broadband light into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning the received reference light into the beamsplitter, and a sample arm optically coupled to the beamsplitter and the second light source for combining the sample light and the monochromatic light, delivering the combined sample and monochromatic light to the target of interest, collecting a backscattering light and a Raman scattering light that are generated from interaction of the sample light and the monochromatic light with the target of interest, respectively, returning the backscattering light into the beamsplitter so as to generate an interference signal between the returned backscattering light and the returned reference light in the beamsplitter, and directing the Raman scattering light in an output optical path, and a single detector optically coupled to the beamsplitter for collecting the interference signal.

    摘要翻译： 在本发明的一个方面中，一种装置包括用于产生宽带光的第一光源和用于产生单色光的第二光源，光学耦合到第一光源的分束器，用于接收宽带光并分离所接收的 将宽带光转换为参考光和采样光，参考臂光耦合到分束器，用于接收参考光并将接收到的参考光返回到分光器中;以及样品臂，光学耦合到分束器和第二光源，用于组合 样品光和单色光，将组合的样品和单色光输送到感兴趣的目标，分别收集从样品光和单色光与感兴趣的目标的相互作用产生的后向散射光和拉曼散射光 ，将后向散射光返回到分束器中以产生 在分束器中返回的后向散射光和返回的参考光之间产生干涉信号，并将拉曼散射光引导到输出光路中，以及单个检测器，其光耦合到分束器以收集干扰信号。

    Combined raman spectroscopy-optical coherence tomography (RS-OCT) system and applications of the same
    30.
    发明授权
    Combined raman spectroscopy-optical coherence tomography (RS-OCT) system and applications of the same 有权
    联合拉曼光谱 - 光学相干断层扫描（RS-OCT）系统及其应用

    公开(公告)号：US07508524B2

    公开(公告)日：2009-03-24

    申请号：US11780793

    申请日：2007-07-20

    申请人： Anita Mahadevan-Jansen ,  Ton Van Leeuwen ,  Chetan A. Patil

    发明人： Anita Mahadevan-Jansen ,  Ton Van Leeuwen ,  Chetan A. Patil

    IPC分类号： G01B9/02

    CPC分类号： G01N21/4795 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/444 ,  A61B5/445 ,  G01B9/0203 ,  G01B9/02089 ,  G01B9/02091 ,  G01B2290/35 ,  G01N21/65

    摘要： An apparatus for evaluating a target of interest of a living subject. In one embodiment, the apparatus has a first light source for generating a broadband light, a second light source for generating a monochromatic light, a beamsplitter optically coupled to the first light source for receiving the broadband light and splitting it into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning it into the beamsplitter, and a probe having a working end placed proximal to a target of interest of a living subject, optically coupled to the beamsplitter and the second light source for receiving the sample light and the monochromatic light, delivering them from the working end to the target of interest, collecting from the working end a backscattering light and a Raman scattering light that are obtained from interaction of the sample light and the monochromatic light with the target of interest, respectively, and returning the backscattering light into the beamsplitter so as to generate an interference signal between the returned backscattering light and the returned reference light in the beamsplitter.

    摘要翻译： 一种用于评估活体感兴趣的目标的装置。 在一个实施例中，该装置具有用于产生宽带光的第一光源，用于产生单色光的第二光源，光学耦合到第一光源的分束器，用于接收宽带光并将其分割为参考光和 样品光，参考臂，其光学耦合到分束器，用于接收参考光并将其返回到分束器中;以及探针，其具有放置在活体的感兴趣目标附近的工作端，光学耦合到分束器，第二 用于接收样品光和单色光的光源，将其从工作端传送到感兴趣的目标，从工作端收集从样品光和单色光的相互作用获得的后向散射光和拉曼散射光 分别与感兴趣的目标，并将后向散射光返回到分束器中以便发射 在分束器中消除返回的后向散射光与返回的参考光之间的干扰信号。