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1.发明授权Combined raman spectroscopy-optical coherence tomography (RS-OCT) system and applications of the same 有权联合拉曼光谱 - 光学相干断层扫描（RS-OCT）系统及其应用公开(公告)号：US07508524B2
公开(公告)日：2009-03-24
申请号：US11780793
申请日：2007-07-20
IPC分类号： G01B9/02
CPC分类号： G01N21/4795 , A61B5/0066 , A61B5/0075 , A61B5/444 , A61B5/445 , G01B9/0203 , G01B9/02089 , G01B9/02091 , G01B2290/35 , G01N21/65
摘要： An apparatus for evaluating a target of interest of a living subject. In one embodiment, the apparatus has a first light source for generating a broadband light, a second light source for generating a monochromatic light, a beamsplitter optically coupled to the first light source for receiving the broadband light and splitting it into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning it into the beamsplitter, and a probe having a working end placed proximal to a target of interest of a living subject, optically coupled to the beamsplitter and the second light source for receiving the sample light and the monochromatic light, delivering them from the working end to the target of interest, collecting from the working end a backscattering light and a Raman scattering light that are obtained from interaction of the sample light and the monochromatic light with the target of interest, respectively, and returning the backscattering light into the beamsplitter so as to generate an interference signal between the returned backscattering light and the returned reference light in the beamsplitter.
摘要翻译： 一种用于评估活体感兴趣的目标的装置。 在一个实施例中，该装置具有用于产生宽带光的第一光源，用于产生单色光的第二光源，光学耦合到第一光源的分束器，用于接收宽带光并将其分割为参考光和 样品光，参考臂，其光学耦合到分束器，用于接收参考光并将其返回到分束器中;以及探针，其具有放置在活体的感兴趣目标附近的工作端，光学耦合到分束器，第二 用于接收样品光和单色光的光源，将其从工作端传送到感兴趣的目标，从工作端收集从样品光和单色光的相互作用获得的后向散射光和拉曼散射光 分别与感兴趣的目标，并将后向散射光返回到分束器中以便发射 在分束器中消除返回的后向散射光与返回的参考光之间的干扰信号。
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2.发明授权Common detector for combined raman spectroscopy-optical coherence tomography 有权联合拉曼光谱 - 光学相干断层扫描的共同检测器公开(公告)号：US08553219B2
公开(公告)日：2013-10-08
申请号：US13012529
申请日：2011-01-24
申请人： Chetan A. Patil , Anita Mahadevan-Jansen , Antonius Gerardus Johannes Maria Van Leeuwen , Jeroen Kalkman
发明人： Chetan A. Patil , Anita Mahadevan-Jansen , Antonius Gerardus Johannes Maria Van Leeuwen , Jeroen Kalkman
CPC分类号： G01B9/02044 , A61B3/102 , A61B5/0066 , A61B5/0075 , A61B5/442 , A61B5/443 , G01B9/0203 , G01B9/02091 , G01J3/44 , G01J3/453 , G01N21/4795 , G01N21/65 , G01N2021/1787
摘要： An apparatus includes first and second light sources for respectively generating broadband and monochromatic lights, a beamsplitter optically coupled to the first light source for splitting the broadband light into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning the received reference light into the beamsplitter, a sample arm optically coupled to the beamsplitter and the second light source for combining the sample and monochromatic lights, delivering the combined light to the target of interest, collecting a backscattering light and a Raman scattering light generated from interaction of the combined light with the target of interest, returning the backscattering light into the beamsplitter so as to generate an interference signal between the returned backscattering light and the returned reference light in the beamsplitter, and directing the Raman scattering light in an output optical path.
摘要翻译： 一种装置包括用于分别产生宽带和单色光的第一和第二光源，光耦合到第一光源的分束器，用于将宽带光分成参考光和采样光;参考臂，光耦合到分束器，用于接收 参考光并将接收到的参考光返回到分光器中，样品臂光耦合到分束器和第二光源，用于组合样品和单色光，将组合的光输送到感兴趣的目标，收集后向散射光和拉曼 由组合光与感兴趣的目标的相互作用产生的散射光，将后向散射光返回到分光器中，以便在分光器中产生返回的后向散射光与返回的参考光之间的干涉信号，并将拉曼散射光引导到 输出光路。
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3.发明申请COMMON DETECTOR FOR COMBINED RAMAN SPECTROSCOPY-OPTICAL COHERENCE TOMOGRAPHY 有权用于组合拉曼光谱光学相干光谱的通用检测器公开(公告)号：US20120188538A1
公开(公告)日：2012-07-26
申请号：US13012529
申请日：2011-01-24
申请人： Chetan A. Patil , Anita Mahadevan-Jansen , Antonius Gerardus Johannes Maria van Leeuwen , Jeroen Kalkman
发明人： Chetan A. Patil , Anita Mahadevan-Jansen , Antonius Gerardus Johannes Maria van Leeuwen , Jeroen Kalkman
CPC分类号： G01B9/02044 , A61B3/102 , A61B5/0066 , A61B5/0075 , A61B5/442 , A61B5/443 , G01B9/0203 , G01B9/02091 , G01J3/44 , G01J3/453 , G01N21/4795 , G01N21/65 , G01N2021/1787
摘要： In one aspect of the present invention, an apparatus includes a first light source for generating a broadband light, and a second light source for generating a monochromatic light, a beamsplitter optically coupled to the first light source for receiving the broadband light and splitting the received broadband light into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning the received reference light into the beamsplitter, and a sample arm optically coupled to the beamsplitter and the second light source for combining the sample light and the monochromatic light, delivering the combined sample and monochromatic light to the target of interest, collecting a backscattering light and a Raman scattering light that are generated from interaction of the sample light and the monochromatic light with the target of interest, respectively, returning the backscattering light into the beamsplitter so as to generate an interference signal between the returned backscattering light and the returned reference light in the beamsplitter, and directing the Raman scattering light in an output optical path, and a single detector optically coupled to the beamsplitter for collecting the interference signal.
摘要翻译： 在本发明的一个方面中，一种装置包括用于产生宽带光的第一光源和用于产生单色光的第二光源，光学耦合到第一光源的分束器，用于接收宽带光并分离所接收的 将宽带光转换为参考光和采样光，参考臂光耦合到分束器，用于接收参考光并将接收到的参考光返回到分光器中;以及样品臂，光学耦合到分束器和第二光源，用于组合 样品光和单色光，将组合的样品和单色光输送到感兴趣的目标，分别收集从样品光和单色光与感兴趣的目标的相互作用产生的后向散射光和拉曼散射光 ，将后向散射光返回到分束器中以产生 在分束器中返回的后向散射光和返回的参考光之间产生干涉信号，并将拉曼散射光引导到输出光路中，以及单个检测器，其光耦合到分束器以收集干扰信号。
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公开(公告)号：US20170046586A1
公开(公告)日：2017-02-16
申请号：US14822447
申请日：2015-08-10
CPC分类号： G06K9/3233 , A61B5/0071 , A61B5/0075 , A61B90/30 , A61B2090/366 , A61B2090/373 , A61B2505/05 , G06K9/2027 , G06K9/2054 , G06T7/0014 , G06T2207/30004 , H04N9/3185 , H04N9/3194
摘要： Devices and methods for producing a highlighted overlay of a region, including an illumination source configured to illuminate the region at a bandwidth containing a first wavelength at a working distance, an imager at a working distance configured to image the illuminated region at a bandwidth containing a second wavelength, where the first and second bandwidths and wavelengths are not visible, a visible light projector configured to illuminate the region and registered to the imager to produce alignment of imaged feature with projected features at the same location on the region, and a controller executing a program configured to filter acquired images from the imager to identify areas of the region of a predetermined light intensity, and control the projector to visibly highlight those areas on the region.
摘要翻译： 用于产生区域的突出覆盖的装置和方法，包括被配置为在工作距离处以包含第一波长的带宽照亮区域的照明源，工作距离处的成像器被配置成以包含 第二波长，其中第一和第二带宽和波长不可见，可见光投影器被配置为照亮该区域并被注册到成像器以产生成像特征与区域上相同位置处的投影特征的对准，以及控制器执行 程序，被配置为从所述成像器过滤所获取的图像，以识别所述区域的预定光强度的区域，并且控制所述投影仪以可视地突出显示所述区域上的那些区域。
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5.发明授权公开(公告)号：US08498699B2
公开(公告)日：2013-07-30
申请号：US13013816
申请日：2011-01-26
申请人： Jonathon D. Wells , Mark P. Bendett , James S. Webb , Charles A. Lemaire , Austin R. Duke , E. Duco Jansen , Peter E. Konrad , Anita Mahadevan-Jansen
发明人： Jonathon D. Wells , Mark P. Bendett , James S. Webb , Charles A. Lemaire , Austin R. Duke , E. Duco Jansen , Peter E. Konrad , Anita Mahadevan-Jansen
IPC分类号： A61N1/00
CPC分类号： A61N1/36017 , A61B2018/2025 , A61N1/36082 , A61N1/378 , A61N5/0601 , A61N5/0613 , A61N5/0622 , A61N2005/063 , A61N2005/0659
摘要： An apparatus and method for stimulating animal tissue (for example to trigger a nerve action potential (NAP) signal in a human patient) by application of both electrical and optical signals for treatment and diagnosis purposes. The application of an electrical signal before or simultaneously to the application of a NAP-triggering optical signal allows the use of a lower amount of optical power or energy than would otherwise be needed if an optical signal alone was used for the same purpose and effectiveness. The application of the electrical signal may precondition the nerve tissue such that a lower-power optical signal can be used to trigger the desired NAP, which otherwise would take a higher-power optical signal were the electric signal not applied. Some embodiments include an implanted nerve interface having a plurality of closely spaced electrodes placed transversely and/or longitudinally to the nerve and a plurality of optical emitters.
摘要翻译： 一种用于刺激动物组织（例如在人类患者中触发神经动作电位（NAP）信号）的装置和方法）通过应用电信号和光信号用于治疗和诊断目的。 在应用NAP触发光信号之前或同时应用电信号允许使用比如果单独使用光信号用于相同目的和有效性时所需要的更少量的光功率或能量。 电信号的应用可以预处理神经组织，使得可以使用较低功率的光信号来触发所需的NAP，否则将在不施加电信号的情况下采取更高功率的光信号。 一些实施例包括植入的神经界面，其具有横向和/或纵向设置于神经的多个紧密间隔的电极以及多个光发射器。
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6.发明授权System and method for differentiation of normal and malignant in vivo liver tissues 有权正常和恶性体内肝组织分化的系统和方法公开(公告)号：US07979107B2
公开(公告)日：2011-07-12
申请号：US12537008
申请日：2009-08-06
IPC分类号： A61B5/05
CPC分类号： A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/4244
摘要： A method for differentiating malignant in vivo liver tissues from normal in vivo liver tissues of a living subject includes the steps of: (a) illuminating a first area and a second area of in vivo liver tissues of the living subject with a first excitation light, (b) measuring an intensity of fluorescent light emitted from each of the first area and the second area of in vivo liver tissues in response to the first excitation light as a function of wavelength so as to obtain a first and a second fluorescent spectra, respectively, (c) illuminating the first area and the second area of in vivo liver tissues with a second excitation light, (d) measuring an intensity of diffuse light reflected by each of the first area and the second area of in vivo liver tissues in response to the second excitation light as a function of wavelength so as to obtain a first and a second diffused reflectance spectra, respectively, and (e) identifying one of the first area and the second area of in vivo liver tissues as malignant liver tissues and the other one of the first area and the second area of in vivo liver tissues as normal liver tissues, by comparing the first fluorescence spectrum and the second florescence spectrum, and comparing the first diffused reflection spectrum and the second diffused reflection spectrum.
摘要翻译： 用于区分恶性体内肝组织与活体受试者的正常体内肝组织的方法包括以下步骤：（a）用第一激发光照射活体的肝脏组织的第一区域和第二区域， （b）响应于作为波长的函数的第一激发光，测量从体内肝组织的第一区域和第二区域发射的荧光的强度，以分别获得第一和第二荧光光谱 （c）用第二激发光照射体内肝组织的第一区域和第二区域，（d）响应于测量由体内肝组织的第一区域和第二区域反映的漫射光的强度 作为波长的函数的第二激发光，以分别获得第一和第二扩散反射光谱，（e）识别体内肝脏的第一区域和第二区域之一 通过比较第一荧光光谱和第二荧光光谱，比较第一扩散反射光谱和第二扩散反应谱图，将组织作为恶性肝组织，将体内肝组织的第一区域和第二区域作为正常肝组织 反射光谱。
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7.发明申请Methods and Apparatus for Optical Spectroscopic Detection of Cell and Tissue Death 有权光学检测细胞和组织死亡的方法和装置公开(公告)号：US20090292211A1
公开(公告)日：2009-11-26
申请号：US12537008
申请日：2009-08-06
IPC分类号： A61B6/00
CPC分类号： A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/4244
摘要： A method for detecting death process of a cell or tissue of a living subject. In one embodiment, the method includes the steps of illuminating the cell or tissue of the living subject with a coherent light, collecting fluorescent light returned from the illuminated cell or tissue of the living subject, identifying a NAD(P)H peak of a spectrum of the collected fluorescent light with a wavelength, λpeak, and obtaining the intensity of the NAD(P)H peak of the spectrum of the collected fluorescent light substantially corresponding to the wavelength λpeak. These steps are repeated at sequential stages until the intensity of the NAD(P)H peak of the spectrum at a current stage is less than the intensity of the NAD(P)H peak of the spectrum at an earlier stage immediately prior to the current stage so as to detect death process of the cell of the living subject at the current stage using the intensity of the NAD(P)H peak of the spectrum.
摘要翻译： 一种用于检测活体受试者的细胞或组织的死亡过程的方法。 在一个实施例中，该方法包括以相干光照射活体的细胞或组织的步骤，收集从活体受试者的照射细胞或组织返回的荧光，识别光谱的NAD（P）H峰 所收集的荧光的波长为lambdapeak，并且获得基本上对应于波长兰帕达克的所收集的荧光的光谱的NAD（P）H峰的强度。 这些步骤在连续阶段重复，直到当前阶段的光谱的NAD（P）H峰的强度小于在电流之前的较早阶段的光谱的NAD（P）H峰的强度 使用光谱的NAD（P）H峰的强度来检测当前阶段的活体的细胞的死亡过程。
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公开(公告)号：US06921413B2
公开(公告)日：2005-07-26
申请号：US10333700
申请日：2001-08-15
CPC分类号： A61N5/0622 , A61B5/0048 , A61N5/0601 , A61N5/0613 , A61N5/0619 , A61N2005/063 , A61N2005/0659 , A61N2005/0665 , A61N2005/067
摘要： The present invention provides methods of directly stimulating neural tissue with optical energy. By stimulating neural tissue at wavelengths, laser pulses, and spot sizes disclosed herein, nerve stimulation may be used to uniquely stimulate neural tissue in way not afforded by other means of stimulation. It can allow basic scientists to study the properties of individual neurons or populations of neurons without piercing tissue with fragile microelectrodes. Furthermore, responses of neural tissue can be studied in a pure fashion without contamination by electrical artifact commonly seen with electrical stimulation. With respect to clinical uses, optical stimulation can be used to map function in subsections of peripheral nerves as an aid to operative repair. Finally, stimulation with optical energy does not require physical contact with the nerve which may be an advantage clinically when physical manipulation of neural tissue is not desired.
摘要翻译： 本发明提供了用光能直接刺激神经组织的方法。 通过刺激本文公开的波长，激光脉冲和斑点尺寸的神经组织，可以使用神经刺激来以不能被其他刺激方式提供的方式唯一地刺激神经组织。 它可以允许基础科学家研究单个神经元或神经元群体的性质，而不刺穿脆弱的微电极组织。 此外，可以以纯粹的方式研究神经组织的反应，而不会通过电刺激常见的电赝像而被污染。 关于临床用途，可以使用光学刺激来将外周神经的子部分中的功能作为辅助手术修复。 最后，用光学能量刺激不需要与神经的物理接触，这在神经组织的物理操作是不希望的时候临床可能是有利的。
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公开(公告)号：US20140024902A1
公开(公告)日：2014-01-23
申请号：US13117850
申请日：2011-05-27
申请人： Anita Mahadevan-Jansen , Jonathon D. Wells , E. Duco Jansen , Peter E. Konrad , Changquing C. Kao
发明人： Anita Mahadevan-Jansen , Jonathon D. Wells , E. Duco Jansen , Peter E. Konrad , Changquing C. Kao
IPC分类号： A61B5/00
CPC分类号： A61N5/0622 , A61B5/0048 , A61N5/0601 , A61N5/0613 , A61N5/0619 , A61N2005/063 , A61N2005/0659 , A61N2005/0665 , A61N2005/067
摘要： The present invention, in one aspect, relates to a system for stimulating neural tissue of a living subject. The system comprises an energy source capable of generating optical energy, a connector having a first end and a second end capable of transmitting optical energy, and a probe operably coupled to the second end of the connector and having an end portion for delivering optical energy to a target neural tissue. In one embodiment, the energy source comprises a tunable laser.
摘要翻译： 本发明在一个方面涉及一种用于刺激活体的神经组织的系统。 该系统包括能够产生光能的能量源，具有第一端和能够透射光能的第二端的连接器，以及可操作地耦合到连接器的第二端的探针，并具有用于将光能传递到 目标神经组织。 在一个实施例中，能量源包括可调激光器。
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10.发明申请Apparatus and method for radio frequency ablation of a liver tumor in liver tissues 审中-公开肝组织肝肿瘤射频消融的装置和方法公开(公告)号：US20110295125A1
公开(公告)日：2011-12-01
申请号：US13116994
申请日：2011-05-26
CPC分类号： A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/4244
摘要： A method for detecting death process of a cell or tissue of a living subject. In one embodiment, the method includes the steps of illuminating the cell or tissue of the living subject with a coherent light, collecting fluorescent light returned from the illuminated cell or tissue of the living subject, identifying a NAD(P)H peak of a spectrum of the collected fluorescent light with a wavelength, λpeak, and obtaining the intensity of the NAD(P)H peak of the spectrum of the collected fluorescent light substantially corresponding to the wavelength λpeak. These steps are repeated at sequential stages until the intensity of the NAD(P)H peak of the spectrum at a current stage is less than the intensity of the NAD(P)H peak of the spectrum at an earlier stage immediately prior to the current stage so as to detect death process of the cell of the living subject at the current stage using the intensity of the NAD(P)H peak of the spectrum.
摘要翻译： 一种用于检测活体受试者的细胞或组织的死亡过程的方法。 在一个实施例中，该方法包括以相干光照射活体的细胞或组织的步骤，收集从活体受试者的照射细胞或组织返回的荧光，识别光谱的NAD（P）H峰 的收集的荧光的波长λpeak，并且获得基本上对应于波长λpeak的所收集的荧光的光谱的NAD（P）H峰的强度。 这些步骤在连续阶段重复，直到当前阶段的光谱的NAD（P）H峰的强度小于在电流之前的较早阶段的光谱的NAD（P）H峰的强度 使用光谱的NAD（P）H峰的强度来检测当前阶段的活体的细胞的死亡过程。
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