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    APPARATUS FOR INTRODUCING FLUID INTO MICROFLUIDIC CHIP BY USING CENTRIFUGAL FORCE, A SYSTEM INCLUDING THE APPARATUS, AND A METHOD OF USING THE APPARATUS
    21.
    发明申请
    APPARATUS FOR INTRODUCING FLUID INTO MICROFLUIDIC CHIP BY USING CENTRIFUGAL FORCE, A SYSTEM INCLUDING THE APPARATUS, AND A METHOD OF USING THE APPARATUS 有权
    通过使用离心力将流体引入微流化芯片的装置，包括装置的系统以及使用装置的方法

    公开(公告)号：US20080072994A1

    公开(公告)日：2008-03-27

    申请号：US11846794

    申请日：2007-08-29

    Applicant: Young-rok KIM ,  Jun-hong MIN ,  Kak NAMKOONG ,  Kwang-ho CHEONG ,  Chang-eun YOO ,  Ki-woong HAN ,  Ki-eun KIM

    Inventor： Young-rok KIM ,  Jun-hong MIN ,  Kak NAMKOONG ,  Kwang-ho CHEONG ,  Chang-eun YOO ,  Ki-woong HAN ,  Ki-eun KIM

    IPC: B65B1/14

    CPC classification number: B01L9/527 ,  B01L3/5021 ,  B01L3/5027 ,  B01L2200/027 ,  B01L2300/0832 ,  B01L2400/0409 ,  C12M23/16

    Abstract: An apparatus introducing a fluid using a centrifugal force includes an introduction member including a chip receiver and a fluid introduction reservoir, the chip receiver receiving a first part of a microfluidic chip, the first part including an inlet, the fluid introduction reservoir storing a fluid to be introduced to the microfluidic chip, the fluid introduction reservoir having an exit formed to correspond to the inlet of the microfluidic chip received in the chip receiver, and a support member supporting a second part of the microfluidic chip, wherein the microfluidic chip is disposed between the introduction member and the support member, the apparatus is rotatable in a state where the introduction member is closer to a center of rotation than the microfluidic chip, and the fluid is introducible from the fluid introduction reservoir through the inlet into the microfluidic chip due to a centrifugal force generated by rotation.

    Abstract translation: 使用离心力引入流体的装置包括引入构件，其包括芯片接收器和流体引入储存器，所述芯片接收器接收微流体芯片的第一部分，所述第一部分包括入口，所述流体引入储存器将流体存储到 引入到微流体芯片中，流体引入储存器具有形成为对应于接收在芯片接收器中的微流体芯片的入口的出口，以及支撑微流体芯片的第二部分的支撑构件，其中微流体芯片设置在 引导构件和支撑构件，该装置可以在导入构件比微流体芯片更靠近旋转中心的状态下旋转，并且流体可以从流体引入储存器通过入口引入到微流体芯片中，这是由于 由旋转产生的离心力。

    METHOD AND APPARATUS FOR CONCENTRATING AND AMPLIFYING NUCLEIC ACID IN SINGLE MICRO CHAMBER
    22.
    发明申请
    METHOD AND APPARATUS FOR CONCENTRATING AND AMPLIFYING NUCLEIC ACID IN SINGLE MICRO CHAMBER 有权
    在单个微室中浓缩和放大核酸的方法和装置

    公开(公告)号：US20070269819A1

    公开(公告)日：2007-11-22

    申请号：US11620961

    申请日：2007-01-08

    Applicant: Young-rok KIM ,  Jun-hong MIN ,  In-ho LEE ,  Young-sun LEE ,  Chang-eun YOO ,  Ki-woong HAN

    Inventor： Young-rok KIM ,  Jun-hong MIN ,  In-ho LEE ,  Young-sun LEE ,  Chang-eun YOO ,  Ki-woong HAN

    IPC: C12Q1/68 ,  C12M3/00

    CPC classification number: C12Q1/6806 ,  B01L3/5027 ,  B01L3/5088 ,  C12Q1/686 ,  C12Q2565/629 ,  C12Q2537/149 ,  C12Q2527/125

    Abstract: A method of sequentially performing concentration and amplification of nucleic acid in a single micro chamber includes: introducing a nucleic acid-containing sample and a solution including a kosmotropic salt to a micro chamber having a hydrophilic interior surface to concentrate the nucleic acid by binding the nucleic acid on the interior surface of the micro chamber; and performing a polymerase chain reaction (PCR) by adding a PCR mixture to the chamber. Since the nucleic acid is reversibly bound to the interior surface of the micro chamber, PCR yield is higher compared with a surface of aluminum oxide in which irreversible binding occurs. In addition, all processes are sequentially performed in a single micro chamber so that the number of samples, consumables, time, and labor for treatment and analysis can be reduced, detection sensitivity can be improved, and risk of sample cross contamination significantly reduced without sample loss by eliminating transporting of the sample. A complete automated system for concentration and amplification of nucleic acid is thus readily provided.

    Abstract translation: 在单个微室中依次进行核酸的浓缩和扩增的方法包括：将含核酸的样品和包含可变性盐的溶液引入具有亲水性内表面的微室中，以通过结合核酸来浓缩核酸 酸在微室的内表面上; 并通过向该室加入PCR混合物进行聚合酶链式反应（PCR）。 由于核酸可逆地结合到微室的内表面，与其中发生不可逆结合的氧化铝的表面相比，PCR产率更高。 此外，所有过程都在单个微室中顺序进行，以便可以减少样品数量，消耗品，时间和处理和分析的劳动力，可以提高检测灵敏度，并且样品交叉污染的风险在没有样品时显着降低 通过消除样品的运输而损失。 因此容易提供用于浓缩和扩增核酸的完整的自动化系统。

    Cell lysis method by immobilized metal-ligand complex
    23.
    发明申请
    Cell lysis method by immobilized metal-ligand complex 失效
    固定化金属配体复合物的细胞裂解法

    公开(公告)号：US20060099711A1

    公开(公告)日：2006-05-11

    申请号：US11267005

    申请日：2005-11-04

    Applicant: Chang-eun Yoo ,  Joon-ho Kim ,  Kyu-youn Hwang ,  Hun-joo Lee ,  Hee-kyun Lim ,  Soo-min Ma ,  Nam Huh ,  Soo-suk Lee

    Inventor： Chang-eun Yoo ,  Joon-ho Kim ,  Kyu-youn Hwang ,  Hun-joo Lee ,  Hee-kyun Lim ,  Soo-min Ma ,  Nam Huh ,  Soo-suk Lee

    IPC: G01N1/00

    CPC classification number: C12Q1/6806 ,  Y10T436/25 ,  C12Q2523/308

    Abstract: Provided is a lysis method for cells or viruses, including: immobilizing a metal-ligand complex on a solid support; and mixing the complex immobilized on the support with a cell or virus solution. According to the lysis method, by immobilizing a chemical on a solid support to perform cell lysis, the dilution problem according to the addition of a cell lysis solution can be resolved and a separate process of removing the chemical is not required so as to reduce the steps upon LOC implementation. In addition, since a variety of solid supports, such as chips, beads, nanoparticles etc. can be used, cell lysis apparatuses of various forms can be fabricated.

    Abstract translation: 提供了一种细胞或病毒的裂解方法，包括：将固定支持物上的金属 - 配体复合物固定; 并将固定在载体上的复合物与细胞或病毒溶液混合。 根据裂解方法，通过将化学物质固定在固体支持体上以进行细胞裂解，可以解决根据细胞溶解溶液的添加的稀释问题，并且不需要单独的除去化学品的方法，以减少 LOC实施步骤。 此外，由于可以使用各种固体支持体，例如芯片，珠粒，纳米粒子等，因此可以制造各种形式的细胞裂解装置。

    Hybridization system using the control of pump and valves in closed system
    30.
    发明授权
    Hybridization system using the control of pump and valves in closed system 失效
    混合系统使用封闭系统中的泵和阀的控制

    公开(公告)号：US07732191B2

    公开(公告)日：2010-06-08

    申请号：US11295843

    申请日：2005-12-06

    Applicant: Soo-suk Lee ,  Sung-ouk Jung ,  Chang-eun Yoo ,  Hun-joo Lee ,  Christopher Hansung Ko ,  Nam Huh

    Inventor： Soo-suk Lee ,  Sung-ouk Jung ,  Chang-eun Yoo ,  Hun-joo Lee ,  Christopher Hansung Ko ,  Nam Huh

    IPC: C12M1/34 ,  C12M1/36

    CPC classification number: B01L7/00 ,  B01F13/0059 ,  B01F13/0222 ,  B01L3/5027 ,  B01L2200/0689 ,  B01L2300/0636 ,  B01L2300/14 ,  B01L2300/1822 ,  B01L2400/0487 ,  G01N2035/00544

    Abstract: Provided is a hybridization system for hybridizing a biochip including: a chamber device including at least a hybridization chamber including a support for a biochip and a first cover having a sample inlet; an agitation device including: two air channels connected to ends of the hybridization chamber; two valves disposed in the air channels; an integrated air channel to which the two air channels are connected; and an air pump disposed in the integrated air channel; and a washing and drying device including: a flow channel connected to one of the two air channels through a branched valve; a flow pump disposed in the flow channel; and a buffer inlet disposed opposite the flow channel.

    Abstract translation: 提供了一种用于杂交生物芯片的杂交系统，包括：至少包括一个包括用于生物芯片的支撑物的杂交室的腔室装置和具有样品入口的第一盖子; 一种搅拌装置，包括：两个连接到杂交室端部的空气通道; 设置在空气通道中的两个阀; 两个空气通道连接的集成空气通道; 以及设置在所述集成空气通道中的空气泵; 以及洗涤干燥装置，包括：流路，其通过分支阀连接到所述两个空气通道中的一个; 设置在流路中的流量泵; 以及与流动通道相对设置的缓冲器入口。

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