-
公开(公告)号:US12139456B2
公开(公告)日:2024-11-12
申请号:US17801681
申请日:2021-02-16
Applicant: DSM IP Assets B.V.
Inventor: Werner Bonrath , Rolf Kuenzi
IPC: C07C67/293 , C07C46/06 , C07C50/14
Abstract: The present invention relates to a new process of production of menaquinone 4, which is also known as vitamin K2.
-
公开(公告)号:US20240368666A1
公开(公告)日:2024-11-07
申请号:US18291626
申请日:2022-07-26
Applicant: DSM IP Assets B.V.
Inventor: Willi GOTTSTEIN , Paul KLAASSEN , Paulus Petrus DE WAAL
Abstract: A method of determining a quantitative composition ratio of a microbial strain mixture for use in a fermentation process. The method includes repeatedly performing method cycles, each method cycle comprising the steps of: selecting a set of plurality of microbial strain mixtures having different quantitative composition ratios; concurrently performing fermentation processes for each selected microbial strain mixture; determining, for each of the fermentation processes, at least one performance indicator of the microbial strain mixture; and providing the at least one performance indicator for each of the fermentation processes to a statistical model which is configured to optimize a predefined objective function, wherein the statistical model is configured to determine, based on said determined performance indicators, a subsequent set of plurality of microbial strain mixtures with different quantitative composition ratios for selection in a next cycle.
-
公开(公告)号:US20240365838A1
公开(公告)日:2024-11-07
申请号:US18684736
申请日:2022-10-07
Applicant: DSM IP ASSETS B.V.
Inventor: Patricia DRYJA , Kai URBAN , Tony STEINEBRUNNER , Christian SCHAEFER , Rudolf HOLER
IPC: A23P10/25 , B29C48/00 , B29C48/04 , B29C48/88 , B29K105/00
Abstract: The invention relates to an extrusion apparatus for the continuous production of solid food supplements, feed additives or pharmaceutical preparations, which comprise nutritional or pharmaceutical actives homogeneously dispersed in a carrier material matrix. The invention also relates to a method for the production of such preparations by extrusion.
-
公开(公告)号:US12128158B2
公开(公告)日:2024-10-29
申请号:US18108038
申请日:2023-02-10
Applicant: DSM IP Assets B.V.
Inventor: Noel L. Davison , Henricus Johannes Arts , Aylvin Jorge Angelo Athanasius Dias , Anne Marie Persson , Ruud Jozef Regina Wilhelmus Peters
IPC: A61L31/08 , A61L17/04 , A61L17/14 , A61L27/18 , A61L27/32 , A61L27/34 , A61L31/06 , A61L31/10 , C08L75/04
CPC classification number: A61L31/086 , A61L17/04 , A61L17/145 , A61L27/18 , A61L27/32 , A61L27/34 , A61L31/06 , A61L31/10 , C08L75/04 , A61L2420/02 , A61L2430/02 , A61L2430/38
Abstract: The disclosure relates to a method of making a bioceramic coating on a fibrous article for use in a medical implant, comprising steps of providing an article comprising fibers made from a biocompatible, non-biodegradable polymer; coating at least the fibers that will be in contact with bone upon use as an implant with a solution of a coating polymer to result in coated fibers having a coating polymer layer; treating the coated fibers with a dispersion of bioactive ceramic particles 0.01-10 μm in a treating solvent comprising a solvent for the coating polymer in at least one step; and substantially removing the treating solvent; to result in the particles being partly embedded in the coating polymer layer of the coated fibers.
-
公开(公告)号:US20240352236A1
公开(公告)日:2024-10-24
申请号:US18682570
申请日:2023-08-09
Inventor: Rudan YA , Fei ZHANG , Zhoupin LIU , Jie ZHAO , Chienkuo YUAN
CPC classification number: C08L5/00 , B01J13/046 , C08L2205/02
Abstract: The present invention relates to a compound thickener comprising rhamsan gum and gellan gum. In the compound thickener, rhamsan gum accounts for 50%-95% of the total weight of rhamsan gum and gellan gum. The combination of rhamsan gum and gellan gum in the compound thickener produces a synergistic effect, and its viscosity is remarkably improved. The compound thickener can be applied to products such as foods, beverages, pharmaceutical products, and personal care products, and when the compound thickener is applied as a gelling agent in soft capsule shells, the shell strength and the shell elasticity are better.
-
公开(公告)号:US20240350390A1
公开(公告)日:2024-10-24
申请号:US18683029
申请日:2022-08-23
Applicant: DSM IP ASSETS B.V.
Inventor: Lise Anne KOHLER , Pascal Christian SIEBER
CPC classification number: A61K8/608 , A61K8/442 , A61Q19/005 , A61Q19/10 , A61K2800/30
Abstract: The present invention relates to sulfate-free cleansing compositions comprising at least one zwitterionic surfactant and at least one human milk oligosaccharide as well as to a method of increasing the foaming properties of cleansing compositions comprising at least one surfactant by incorporation of one or more human milk oligosaccharides into said cleansing composition.
-
公开(公告)号:US20240342095A1
公开(公告)日:2024-10-17
申请号:US18753538
申请日:2024-06-25
Applicant: DSM IP Assets B.V.
Inventor: Dominik BRUNNER , Laure CLASADONTE , Emmanuel HEINRICH , Roland SCHUEPFER
CPC classification number: A61K9/2063 , A61K9/2009 , A61K9/2031 , A61K9/2095 , A61K9/288 , A61K31/04
Abstract: Compositions are formed of a compressed mixture which includes a powderous formulation of a carrier and 3-nitrooxypropanol or derivatives thereof as an active ingredient, and a gluten. The composition remains intact in water after 24 hours.
-
28.
公开(公告)号:US20240327886A1
公开(公告)日:2024-10-03
申请号:US18561233
申请日:2022-05-17
Applicant: DSM IP Assets B.V.
Inventor: Manos PAPADAKIS , Ted JOHANSON , Peter BECKER
CPC classification number: C12P19/04 , C07K14/245 , C12N1/20 , C12N9/1051 , C12N15/52 , C12P19/18 , C12R2001/19 , C12Y204/01062 , C12Y204/01069 , C12Y204/01222
Abstract: This invention relates to a method of producing mixtures of various human milk oligosaccharides (HMOs) with unique HMO blend profiles, consisting predominantly of LNFP-I and LNT and of other HMOs in less significant amounts. The less abundant HMOs might be 2′-FL, LNT-II or DFL. The strategies for achieving specific HMO blends include strain engineering and fermentation methods.
-
公开(公告)号:US20240327777A1
公开(公告)日:2024-10-03
申请号:US18709000
申请日:2022-11-10
Applicant: DSM IP ASSETS B.V.
Inventor: Natalia CHRAPKOVA , Peter BECKER , Ted JOHANSON , Mikael JANSEN
Abstract: A feed control system and related methods for a heterologous product, such as a human milk oligosaccharide, fermentation system are disclosed. The feed control system comprises a feed controller. The feed controller comprises a processor and an interface. The processor is configured to obtain a biomass content in a fermentation broth. The processor is configured to determine a carbon input parameter based on the biomass content. The processor is configured to control a carbon input to the fermentation broth according to the carbon input parameter.
-
公开(公告)号:US12104139B2
公开(公告)日:2024-10-01
申请号:US16563260
申请日:2019-09-06
Applicant: DSM IP ASSETS B.V.
Inventor: Neil Francis Leininger , Ginger Shank , Xiao Dong , Joseph William Pfeifer, III , Vidya Pai
IPC: C11B1/02 , C07C51/42 , C07C51/487 , C11B3/00
CPC classification number: C11B1/02 , C07C51/42 , C07C51/487 , C11B1/025 , C11B3/001 , C07C51/487 , C07C57/03 , C07C51/42 , C07C57/03
Abstract: Disclosed herein are processes for obtaining a microbial oil comprising one or more polyunsaturated fatty acids (PUFAs) from one or more microbial cells by lysing the cells to form a lysed cell composition, treating the lysed cell composition to form an oil-containing emulsion and then recovering the oil from the oil-containing emulsion. Further disclosed herein is microbial oil comprising one or more PUFAs that is recovered from microbial cells by at least one process described herein.
-
-
-
-
-
-
-
-
-