A METHOD AND SYSTEM FOR DETERMINING A QUANTITATIVE COMPOSITION RATIO OF A MICROBIAL STRAIN MIXTURE FOR USE IN A FERMENTATION PROCESS

    公开(公告)号:US20240368666A1

    公开(公告)日:2024-11-07

    申请号:US18291626

    申请日:2022-07-26

    Abstract: A method of determining a quantitative composition ratio of a microbial strain mixture for use in a fermentation process. The method includes repeatedly performing method cycles, each method cycle comprising the steps of: selecting a set of plurality of microbial strain mixtures having different quantitative composition ratios; concurrently performing fermentation processes for each selected microbial strain mixture; determining, for each of the fermentation processes, at least one performance indicator of the microbial strain mixture; and providing the at least one performance indicator for each of the fermentation processes to a statistical model which is configured to optimize a predefined objective function, wherein the statistical model is configured to determine, based on said determined performance indicators, a subsequent set of plurality of microbial strain mixtures with different quantitative composition ratios for selection in a next cycle.

    FERMENTATION SYSTEM, FEED CONTROLLER, AND RELATED METHODS

    公开(公告)号:US20240327777A1

    公开(公告)日:2024-10-03

    申请号:US18709000

    申请日:2022-11-10

    CPC classification number: C12M41/48 C12M41/32 C12M41/36

    Abstract: A feed control system and related methods for a heterologous product, such as a human milk oligosaccharide, fermentation system are disclosed. The feed control system comprises a feed controller. The feed controller comprises a processor and an interface. The processor is configured to obtain a biomass content in a fermentation broth. The processor is configured to determine a carbon input parameter based on the biomass content. The processor is configured to control a carbon input to the fermentation broth according to the carbon input parameter.

Patent Agency Ranking