-
公开(公告)号：US08986988B2
公开(公告)日：2015-03-24
申请号：US12680249
申请日：2008-09-29
申请人： Rohit Nandkumar Karnik , Seungpyo Hong , Ying Mei , Daniel Griffith Anderson , Jeffrey Michael Karp , Robert S. Langer , Suman Bose
发明人： Rohit Nandkumar Karnik , Seungpyo Hong , Ying Mei , Daniel Griffith Anderson , Jeffrey Michael Karp , Robert S. Langer , Suman Bose
IPC分类号： C12N5/07 , C12N5/00 , C12N5/0735 , C12N5/078 , C12M1/00
CPC分类号： C12N5/0068 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2300/0877 , B01L2300/16 , C12M23/16 , C12M47/02 , C12N5/0062 , C12N2501/58 , C12N2501/585 , C12N2533/50 , C12N2533/52 , C12N2535/10
摘要： The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and edges are disclosed.
摘要翻译： 本发明提供了基于在细胞粘附分子包被的区域的边缘上的表面上的细胞滚动的细胞分离系统。 公开了涂覆区域和边缘的各种设计。
-
公开(公告)号：US08969353B2
公开(公告)日：2015-03-03
申请号：US13128020
申请日：2009-11-06
申请人： Kerry Peter Mahon , Kevin Thomas Love , Christopher G. Levins , Kathryn Ann Whitehead , Robert S. Langer , Daniel Griffith Anderson
发明人： Kerry Peter Mahon , Kevin Thomas Love , Christopher G. Levins , Kathryn Ann Whitehead , Robert S. Langer , Daniel Griffith Anderson
IPC分类号： A61K31/495 , C07D241/04 , A61K9/127 , A61K47/16 , C07C215/14 , C12N15/11 , C07C217/08 , A61K9/51 , C12N15/88 , C07D295/13 , A61K48/00
CPC分类号： C07D295/13 , A61K9/107 , A61K9/1271 , A61K9/5123 , A61K31/7088 , A61K38/02 , A61K47/16 , A61K47/54 , A61K47/545 , A61K48/0025 , B01J2531/0252 , B01J2531/845 , C07C215/14 , C07C217/08 , C12N15/111 , C12N15/1137 , C12N15/88 , C12N2310/14 , C12N2310/3515 , C12N2320/32
摘要： Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
摘要翻译： 氨基醇类固醇通过使胺与环氧化物封端的化合物反应来制备。 还提供了从市售的原料制备氨基醇类固醇的方法。 氨基醇类固醇可以由外消旋或立体化学纯环氧化物制备。 氨基醇类固醇或其盐形式优选是可生物降解的和生物相容的并且可以用于各种药物递送系统中。 鉴于这些氨基醇类脂质化合物的氨基部分，它们特别适用于递送多核苷酸。 已经制备了含有本发明的类脂和多核苷酸的复合物，胶束，脂质体或颗粒。 本发明的类脂质也可用于制备用于药物递送的微粒。 考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。
-
公开(公告)号：US08551463B2
公开(公告)日：2013-10-08
申请号：US12797141
申请日：2010-06-09
申请人： Daniel Griffith Anderson , Amir Nashat , Mitchell John DeRosa , David Thomas Puerta , Ronald P. McLaughlin , Bryan Scott Akcasu , Susan Alice Williams , Richard Matthew Ramirez
发明人： Daniel Griffith Anderson , Amir Nashat , Mitchell John DeRosa , David Thomas Puerta , Ronald P. McLaughlin , Bryan Scott Akcasu , Susan Alice Williams , Richard Matthew Ramirez
摘要： The present invention provides compositions, kits and methods for treating scalp hair. The compositions include fluorinated (but not perfluorinated), non-polymeric compounds in a suitable excipient to provide beneficial effects on hair.
摘要翻译： 本发明提供用于治疗头皮头发的组合物，试剂盒和方法。 组合物包括在合适的赋形剂中的氟化（但不是全氟化的）非聚合物，以提供对头发的有益作用。
-
公开(公告)号：US20120251560A1
公开(公告)日：2012-10-04
申请号：US13428695
申请日：2012-03-23
申请人： James E. Dahlman , Avraham D. Schroeder , Daniel Griffith Anderson , Robert S. Langer , Christopher G. Levins
发明人： James E. Dahlman , Avraham D. Schroeder , Daniel Griffith Anderson , Robert S. Langer , Christopher G. Levins
IPC分类号： A61K31/133 , C07D257/02 , C07D267/00 , A61K8/41 , A61K38/02 , A61K39/00 , A61P37/04 , A61P35/00 , C07C215/14 , A61K31/7088
CPC分类号： A61K47/22 , A61K9/0019 , A61K9/1272 , A61K47/34 , A61K47/543 , A61K47/59 , A61K47/6907 , A61K47/6911 , A61K47/6921 , C07D257/02 , C07D273/00 , C07D273/08 , C07D295/084 , C08G73/10 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/32
摘要： The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as “conjugated lipomers” or “lipomers”) containing one or more groups of the formula (iii): wherein R3 and R4 are as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.
摘要翻译： 本发明提供含有一个或多个式（ⅲ）的基团的本发明的共轭聚乙烯亚胺（PEI）聚合物和共轭氮杂 - 大环化合物（统称为共轭脂族或脂肪族），其中R 3和R 4如本文所定义。 还提供了包含本发明的共轭脂族物的组合物，以及制备和使用方法。
-
公开(公告)号：US07785575B2
公开(公告)日：2010-08-31
申请号：US12404193
申请日：2009-03-13
申请人： Daniel Griffith Anderson , Amir Nashat , Mitchell John DeRosa , David Thomas Puerta , Ronald P. McLaughlin , Bryan Scott Akcasu , Susan Alice Williams , Richard Matthew Ramirez
发明人： Daniel Griffith Anderson , Amir Nashat , Mitchell John DeRosa , David Thomas Puerta , Ronald P. McLaughlin , Bryan Scott Akcasu , Susan Alice Williams , Richard Matthew Ramirez
CPC分类号： A61K8/37 , A61K8/8152 , A61Q5/06 , A61Q5/12 , A61Q9/02
摘要： The present invention provides kits and methods for treating hair on the scalp comprising non-toxic compositions providing beneficial effects on hair without employing high temperatures, free radical initiators or rinsing hair after applying the compositions.
-
公开(公告)号：US20100178267A1
公开(公告)日：2010-07-15
申请号：US12354697
申请日：2009-01-15
IPC分类号： A61K8/72 , A61Q5/02 , A61Q5/06 , A61Q5/12 , C08F118/02
摘要： Hair treatment compositions are disclosed comprising a β-amino ester compound in a cosmetically acceptable vehicle, such as a spray or cream. In embodiments, the compounds include a polybutadiene moiety. Methods of treating hair with the compositions to impart volume, texture and definition are also disclosed.
摘要翻译： 公开的美发处理组合物包括化妆品可接受的载体如喷雾剂或霜剂中的“ - 氨基酯化合物”。 在实施方案中，化合物包括聚丁二烯部分。 还公开了用组合物处理头发以赋予体积，质地和定义的方法。
-
公开(公告)号：US08450298B2
公开(公告)日：2013-05-28
申请号：US12716732
申请日：2010-03-03
申请人： Kerry Peter Mahon , Kevin Thomas Love , Christopher G. Levins , Kathryn Ann Whitehead , Robert S. Langer , Daniel Griffith Anderson
发明人： Kerry Peter Mahon , Kevin Thomas Love , Christopher G. Levins , Kathryn Ann Whitehead , Robert S. Langer , Daniel Griffith Anderson
IPC分类号： A61K38/00
CPC分类号： C07D295/13 , A61K9/107 , A61K9/1271 , A61K9/5123 , A61K31/7088 , A61K38/02 , A61K47/16 , A61K47/54 , A61K47/545 , A61K48/0025 , B01J2531/0252 , B01J2531/845 , C07C215/14 , C07C217/08 , C12N15/111 , C12N15/1137 , C12N15/88 , C12N2310/14 , C12N2310/3515 , C12N2320/32
摘要： Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
-
公开(公告)号：USRE43612E1
公开(公告)日：2012-08-28
申请号：US12568481
申请日：2009-09-28
IPC分类号： A61K31/765 , C08G69/44 , C08G63/44 , C07C327/00
CPC分类号： C12N15/88 , A61K9/1641 , A61K9/5146 , A61K47/59 , A61K47/593 , A61K47/6935 , B82Y5/00 , C08G73/02 , C08G73/06 , C08G73/0611 , C08G73/0616 , C08G73/0627
摘要： Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. A system for preparing and screening polymers in parallel using semi-automated robotic fluid delivery systems is also provided.
摘要翻译： 描述了从双（仲胺）或伯胺向双（丙烯酸酯）共轭加成制备的聚（＆（bgr。 - 氨基酯））。 还提供了从市售的原料制备这些聚合物的方法。 这些含叔胺的聚合物优选是可生物降解的和生物相容的并且可以用于各种药物递送系统中。 鉴于这些聚合物的聚（胺）性质，它们特别适用于递送多核苷酸。 已经制备了含有聚合物/多核苷酸复合物的纳米颗粒。 本发明的聚合物也可以用于包封待递送的其它试剂。 考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。 还提供了使用半自动机器人流体输送系统并行制备和筛选聚合物的系统。
-
公开(公告)号：US20120164095A1
公开(公告)日：2012-06-28
申请号：US13414407
申请日：2012-03-07
IPC分类号： A61K8/81 , C08F236/06 , A61Q5/02 , A61Q5/06 , A61Q5/12
摘要： Hair treatment compositions are disclosed comprising a β-amino ester compound in a cosmetically acceptable vehicle, such as a spray or cream. In embodiments, the compounds include a polybutadiene moiety. Methods of treating hair with the compositions to impart volume, texture and definition are also disclosed.
摘要翻译： 公开的美发处理组合物包括化妆品可接受的载体如喷雾剂或霜剂中的“ - 氨基酯化合物”。 在实施方案中，化合物包括聚丁二烯部分。 还公开了用组合物处理头发以赋予体积，质地和定义的方法。
-
公开(公告)号：US20090068255A1
公开(公告)日：2009-03-12
申请号：US12112374
申请日：2008-04-30
申请人： Betty Yu , Amir Nashat , Daniel Griffith Anderson , David Thomas Puerta , Benjamin Adams , Scott Clark , Yushan Kim , Eric George Spengler , Ronald P. McLaughlin , Susan Eilidh Bedford , Zhi Li
发明人： Betty Yu , Amir Nashat , Daniel Griffith Anderson , David Thomas Puerta , Benjamin Adams , Scott Clark , Yushan Kim , Eric George Spengler , Ronald P. McLaughlin , Susan Eilidh Bedford , Zhi Li
IPC分类号： A61K8/14 , A61K8/49 , A61K31/351 , A61Q19/08 , A61Q17/04 , A61P17/02 , A61P35/00 , A61P17/00 , A61Q19/00 , A61K31/4412 , A61K9/127
CPC分类号： A61K8/062 , A61K8/0212 , A61K8/0229 , A61K8/064 , A61K8/14 , A61K8/498 , A61K2800/31 , A61K2800/782 , A61Q17/04 , A61Q19/00 , A61Q19/005 , A61Q19/08
摘要： The application of matrix metalloproteinase (MMP) inhibitors to the skin inhibits the degradation of proteins found in the skin including collagen, elastin, and other basement membrane and extracellular matrix protein. MMP inhibitors may be used in both cosmetic compositions and pharmaceutical compositions for application to skin. MMP inhibitors are formulated with a cosmetically suitable vehicle or pharmaceutically acceptable excipient for application to the skin as creams, lotions, ointments, solutions, face masks, etc. As cosmetics, the inventive MMP inhibitor compositions are applied to the skin to prevent or reduce the appearance of wrinkles, pigmentation changes, loss of elasticity, or other effects associated with aging or sun damage. As pharmaceuticals, the inventive MMP inhibitor compositions may also be applied to the skin to treat or prevent a skin disease (e.g., proliferative disease, inflammatory disease).
摘要翻译： 基质金属蛋白酶（MMP）抑制剂对皮肤的应用抑制皮肤中发现的蛋白质的降解，包括胶原蛋白，弹性蛋白，以及其他基底膜和细胞外基质蛋白质。 MMP抑制剂可用于化妆品组合物和用于皮肤应用的药物组合物中。 MMP抑制剂与美容上合适的载体或药学上可接受的赋形剂一起配制，用于作为乳膏，洗剂，软膏，溶液，面罩等应用于皮肤。作为化妆品，将本发明的MMP抑制剂组合物施用于皮肤以防止或减少 皱纹的出现，色素沉着变化，丧失弹性或与老化或太阳损伤有关的其他影响。 作为药物，本发明的MMP抑制剂组合物也可以施用于皮肤以治疗或预防皮肤疾病（例如增殖性疾病，炎性疾病）。
-
-
-
-
-
-
-
-
-
搜索结果
44 条记录 (耗时 0.031 秒)
