公开(公告)号：US08715214B2

公开(公告)日：2014-05-06

申请号：US12310137

申请日：2007-08-23

申请人： Pascal Kopperschmidt

发明人： Pascal Kopperschmidt

IPC分类号： A61M37/00

CPC分类号： A61M5/1452 ,  A61M1/3649 ,  A61M1/3672

摘要： A method is provided for the filling of a metering apparatus of a therapy device having an extracorporeal circuit with which the metering apparatus is in communication such that an agent can be infused into the extracorporeal circuit during the operation of the therapy device by means of the metering device. The method includes a step of diluting a concentrate located in the metering apparatus by taking up a diluting agent from the extracorporeal circuit.

摘要翻译： 提供了一种用于填充具有体外回路的治疗装置的计量装置的方法，所述计量装置与计量装置连通，使得在治疗装置的操作期间可以通过计量将药剂输入到体外回路中 设备。 该方法包括通过从体外回路吸收稀释剂来稀释位于计量装置中的浓缩物的步骤。

公开(公告)号：US20140098359A1

公开(公告)日：2014-04-10

申请号：US14111248

申请日：2012-04-10

申请人： Malte Gross ,  Pascal Kopperschmidt ,  Andreas Malerhofer ,  Alfred Gagel

发明人： Malte Gross ,  Pascal Kopperschmidt ,  Andreas Malerhofer ,  Alfred Gagel

IPC分类号： A61B5/00 ,  G01N21/65 ,  G01N21/64

CPC分类号： A61B5/0082 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14546 ,  A61B5/14557 ,  A61M1/367 ,  G01N21/6486 ,  G01N21/65

摘要： The present invention pertains to a method for monitoring a treatment of a patient, preferably for monitoring hemodialysis, hemodiafiltration and/or peritoneal dialysis, the method comprising the steps of irradiating a sample of a dialysis liquid used in the treatment with irradiation light of at least a first irradiation wavelength, detecting light emitted by the irradiated sample in at least a first detection wavelength, the detection wavelength being different from the first irradiation wavelength, and determining the presence and/or concentration of at least one analyte in the sample on the basis of the detected light.

摘要翻译： 本发明涉及一种用于监测患者治疗的方法，优选用于监测血液透析，血液透析滤过和/或腹膜透析，所述方法包括以下步骤：将用于治疗的透析液样品至少照射至少 第一照射波长，检测由至少第一检测波长的被照射样品发射的光，检测波长与第一照射波长不同，并且基于该基准确定样品中至少一种分析物的存在和/或浓度 的检测光。

公开(公告)号：US08617093B2

公开(公告)日：2013-12-31

申请号：US13376650

申请日：2010-06-01

申请人： Pascal Kopperschmidt ,  Thomas Nuernberger

发明人： Pascal Kopperschmidt ,  Thomas Nuernberger

IPC分类号： A61M37/00

CPC分类号： A61M1/3627 ,  A61M1/3624 ,  A61M1/3639 ,  A61M1/3641 ,  A61M2205/18 ,  A61M2205/707

摘要： The present invention relates to a method and a device for monitoring a fluid system of an extracorporeal blood treatment device. In the method according to the present invention and the device according to the present invention, the pressure in a ventilation line branching off the venous drip chamber in the venous blood line is measured, a hydrophobic filter being disposed in the ventilation line. A fault in the fluid system is determined in the absence of pressure variations in the segment of the ventilation line remote from the venous drip chamber. The pressure variations in the ventilation line can be generated downstream of the hydrophobic filter by alternately ventilating the ventilation line that is closed downstream of the hydrophobic filter during blood treatment.

摘要翻译： 本发明涉及用于监测体外血液处理装置的流体系统的方法和装置。 在根据本发明的方法和根据本发明的装置中，测量在静脉血液管线中分流出静脉滴注室的通气管路中的压力，在通气管线中设置疏水性过滤器。 在远离静脉滴注腔的通气管段的压力变化不存在的情况下，确定流体系统中的故障。 在血液处理期间，通过在疏水性过滤器下游关闭的通气管交替通风，可以在疏水性过滤器的下游产生通气管路的压力变化。

公开(公告)号：US08460552B2

公开(公告)日：2013-06-11

申请号：US10580869

申请日：2004-09-11

申请人： Pascal Kopperschmidt ,  Malte Gross

发明人： Pascal Kopperschmidt ,  Malte Gross

IPC分类号： B01D11/00 ,  B01D35/00

CPC分类号： A61M1/3441 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3609 ,  A61M1/3639 ,  A61M2230/207

摘要： A method and device that identify impairments of the blood flow in an extra-corporeal blood circuit during extracorporeal treatment of the blood using an extracorporeal haemodialysis device, where the phase angle of at least one harmonic oscillation of an oscillating pressure signal that propagates in the extracorporeal blood circuit is determined. Impairments of the blood flow are detected in the extracorporeal blood circuit based on a characteristic modification of the phase angle of at least one harmonic oscillation of the pressure signal. A temporal modification of the phase angle may be compared with a predefined threshold value and an impairment is detected if the value of the modification of the phase angle is greater than the predefined threshold value. The method and device permit an early identification of a coagulation of the blood that flows through the haemodialysis unit, so that countermeasures can be initiated promptly.

摘要翻译： 一种方法和装置，其使用体外血液透析装置来识别血液体外处理期间体外血液回路中的血流的损伤，其中振荡压力信号的至少一次谐波振荡在体外传播的相位角 确定血液回路。 基于对压力信号的至少一次谐波振荡的相位角的特征修改，在体外血液回路中检测出血流的损伤。 可以将相位角的时间修改与预定义的阈值进行比较，并且如果相位角的修改值大于预定阈值，则检测损伤。 该方法和装置允许早期鉴定血液透析装置中血液的凝结，从而可以及时启动对策。

公开(公告)号：US20120083726A1

公开(公告)日：2012-04-05

申请号：US13376650

申请日：2010-06-01

申请人： Pascal Kopperschmidt ,  Thomas Nüenberger

发明人： Pascal Kopperschmidt ,  Thomas Nüenberger

IPC分类号： A61M1/34

CPC分类号： A61M1/3627 ,  A61M1/3624 ,  A61M1/3639 ,  A61M1/3641 ,  A61M2205/18 ,  A61M2205/707

摘要： The present invention relates to a method and a device for monitoring a fluid system of an extracorporeal blood treatment device. In the method according to the present invention and the device according to the present invention, the pressure in a ventilation line branching off the venous drip chamber in the venous blood line is measured, a hydrophobic filter being disposed in the ventilation line. A fault in the fluid system is determined in the absence of pressure variations in the segment of the ventilation line remote from the venous drip chamber. The pressure variations in the ventilation line can be generated downstream of the hydrophobic filter by alternately ventilating the ventilation line that is closed downstream of the hydrophobic filter during blood treatment.

摘要翻译： 本发明涉及用于监测体外血液处理装置的流体系统的方法和装置。 在根据本发明的方法和根据本发明的装置中，测量在静脉血液管线中分流出静脉滴注室的通气管路中的压力，在通气管线中设置疏水性过滤器。 在远离静脉滴注腔的通气管段的压力变化不存在的情况下，确定流体系统中的故障。 在血液处理期间，通过在疏水性过滤器下游关闭的通气管交替通风，可以在疏水性过滤器的下游产生通气管路的压力变化。

公开(公告)号：US20110230814A1

公开(公告)日：2011-09-22

申请号：US13059249

申请日：2009-08-14

申请人： Pascal Kopperschmidt ,  Reiner Spickermann

发明人： Pascal Kopperschmidt ,  Reiner Spickermann

IPC分类号： A61M1/14 ,  G01N27/00

CPC分类号： F04B43/12 ,  A61M1/1006 ,  A61M1/1037 ,  A61M1/1039 ,  A61M1/1086 ,  A61M1/16 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3607 ,  A61M2205/3331 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/702 ,  F04B43/0081 ,  F04B2201/1203

摘要： The invention further relates to an apparatus and method for monitoring a peristaltic hose pump, in particular a peristaltic hose pump of an extracorporeal blood treatment device. The power consumed by the pump and/or the pressure in the tubing segment upstream or downstream of the pump is/are measured during operation of the pump and test signals I1(t), I2(t) which are associated with the individual displacement members are determined. The power or pressure signals associated with the individual displacement members significantly differ from each other during abnormal operation of the hose pump, but no significant differences can be recognized during normal operation of the pump.

摘要翻译： 本发明还涉及用于监测蠕动软管泵的装置和方法，特别是体外血液处理装置的蠕动软管泵。 在泵的运行期间测量泵所消耗的功率和/或泵上游或下游的管段中的压力，并且与各个位移构件相关联的测试信号I1（t），I2（t） 确定。 与各个位移构件相关联的动力或压力信号在软管泵的异常操作期间彼此显着不同，但是在泵的正常操作期间不能识别出明显的差异。

公开(公告)号：US20110178452A1

公开(公告)日：2011-07-21

申请号：US13122220

申请日：2009-09-29

申请人： Pascal Kopperschmidt

发明人： Pascal Kopperschmidt

IPC分类号： A61M1/00

CPC分类号： A61M1/30 ,  A61M1/1006 ,  A61M1/1039 ,  A61M1/1086 ,  A61M1/302 ,  A61M1/308 ,  A61M1/3603 ,  A61M2205/3334

摘要： A device for the extracorporal blood treatment in a single-needle operating mode includes means for delivering blood into, and means for delivering blood out of means for collecting blood, and a controller for setting the respective delivery rates of the means for the delivery of blood. The operating mode of the means for delivering blood is continually switched between an arterial and a venous phase by the controller, wherein during the arterial phase the delivery rate Qb of the means for delivering blood is greater than the delivery rate Qsn of the means for delivering blood such that blood may be withdrawn from the patient during the arterial phase, and during the venous phase the delivery rate Qb is smaller than the delivery rate Qsn such that blood may be administered to the patient during the venous phase.

摘要翻译： 用于以单针操作模式进行体外血液处理的装置包括用于将血液输送到用于收集血液的装置中的装置和用于输送血液的装置，以及用于设定用于输送血液的装置的各自输送速率的控制器 。 用于输送血液的装置的操作模式由控制器在动脉和静脉期之间连续切换，其中在动脉期期间，用于输送血液的装置的输送速率Qb大于用于输送的装置的输送速率Qsn 血液，使得血液可以在动脉期期间从患者中取出，并且在静脉期期间，输送速率Qb小于输送速率Qsn，使得可以在静脉期期间向患者施用血液。

公开(公告)号：US20100004579A1

公开(公告)日：2010-01-07

申请号：US12310137

申请日：2007-08-23

申请人： Pascal Kopperschmidt

发明人： Pascal Kopperschmidt

IPC分类号： A61M1/14

CPC分类号： A61M5/1452 ,  A61M1/3649 ,  A61M1/3672

摘要： The invention relates to a method for the filling of a metering apparatus of a therapy device having an extracorporeal circuit with which the metering apparatus is in communication such that an agent can be infused into the extracorporeal circuit during the operation of the therapy device by means of the metering device, with the method comprising the step of the dilution of a concentrate located in the metering apparatus, wherein the dilution of the concentrate located in the metering apparatus takes place in that the metering apparatus takes up the diluting agent from the extracorporeal circuit in the condition connected to the extracorporeal circuit.

摘要翻译： 本发明涉及一种用于填充具有体外回路的治疗装置的计量装置的方法，所述计量装置与所述计量装置连通，使得在治疗装置的操作期间可以通过以下方式将试剂注入体外回路中： 计量装置，其方法包括稀释位于计量装置中的浓缩物的步骤，其中位于计量装置中的浓缩物的稀释发生在于计量装置从体外循环中吸收稀释剂 条件连接到体外电路。

公开(公告)号：US11376353B2

公开(公告)日：2022-07-05

申请号：US13512133

申请日：2010-11-16

申请人： Pascal Kopperschmidt ,  Alfred Gagel

发明人： Pascal Kopperschmidt ,  Alfred Gagel

IPC分类号： B01D61/32 ,  B01D61/28 ,  B01D61/24 ,  A61M1/16 ,  A61M1/36 ,  A61M1/34

摘要： The present invention relates to a method for regulating supply of substituate in an extracorporeal blood treatment with an extracorporeal blood treatment apparatus comprising a dialyzer divided by a semipermeable membrane into a blood chamber and a dialyzing fluid chamber and a device for supplying substituate. Moreover, the present invention relates to an extracorporeal blood treatment apparatus having a device for regulating supply of substituate. Regulation of supply of substituate in the extracorporeal blood treatment takes place as a function of the rheological loading of the dialyzer. To regulate supply of substituate during extracorporeal blood treatment, rheological loading of the dialyzer is determined from transmembrane pressure on the dialyzer and flow resistance of the dialyzer and substituate rate is increased or reduced according to the loading. The selection of dialyzer parameters or blood parameters is therefore no longer necessary and the distinction between pre-dilution and post-dilution is also made obsolete.

公开(公告)号：US09233341B2

公开(公告)日：2016-01-12

申请号：US13500930

申请日：2010-10-01

申请人： Pascal Kopperschmidt ,  Christoph Bocklet

发明人： Pascal Kopperschmidt ,  Christoph Bocklet

IPC分类号： B01D61/00 ,  B01D35/00 ,  G01N15/08 ,  B01D65/10 ,  A61M1/16 ,  B01D61/22

CPC分类号： B01D65/102 ,  A61M1/1656 ,  A61M1/1672 ,  A61M2205/3317 ,  A61M2205/705 ,  B01D61/22 ,  B01D65/10 ,  B01D65/104 ,  B01D2311/243

摘要： The present invention relates to devices and methods for inspecting filters for extracorporeal blood treatment devices, e.g., filters for filtering dialysis fluid. The inspection of the filter according to the present invention is based on the measurement of the flow potential before and after changing the fluid flow of an electrolytic fluid between a transversal flow through the semi-permeable membrane of the filter and a longitudinal flow along the semi-permeable membrane of the filter, or vice versa. Changing the flow direction of the electrolytic fluid results in a change to the conductivity proceeding from a base value P to a higher value P2 or a lower value P1, wherein the conductivity readjusts to the base value P after a certain time interval T1, T2. An improper state of the filter is determined on the basis of the change in conductivity after changing the flow direction of the electrolytic fluid.

摘要翻译： 本发明涉及用于检查用于体外血液处理装置的过滤器的装置和方法，例如用于过滤透析液的过滤器。 根据本发明的过滤器的检查是基于在通过过滤器的半透膜的横向流动和沿半过滤器的纵向流动改变电解液的流体流动之前和之后的流量的测量 过滤器的不透水膜，反之亦然。 改变电解液的流动方向导致从基值P向较高值P2或较低值P1开始的电导率的变化，其中在一定时间间隔T1，T2之后，电导率重新调整到基值P. 基于改变电解液流动方向后的电导率变化来确定过滤器的不正确状态。