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公开(公告)号:US08859725B2
公开(公告)日:2014-10-14
申请号:US13056434
申请日:2008-07-31
申请人: Luis F. Quintana Porras , Amanda Sole Gonzalez , Elisenda Bañón-Maneus , Josep M. Campistol , Pedro Rodriguez Cutillas
发明人: Luis F. Quintana Porras , Amanda Sole Gonzalez , Elisenda Bañón-Maneus , Josep M. Campistol , Pedro Rodriguez Cutillas
IPC分类号: A61K38/00 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C07K1/00 , C07K14/47 , C07K7/18 , C07K14/74 , G01N33/68
CPC分类号: G01N33/6893 , C07K7/18 , C07K14/47 , C07K14/70539 , G01N33/6851 , G01N2800/245 , G01N2800/347
摘要: The invention provides novel healthy kidney biomarkers useful in the monitoring of renal function and in the prognosis and diagnosis of renal dysfunctions, especially those related to graft rejection. The invention further relates to methods for aiding in the evaluation, and design of personalized therapies in transplantation nephrology.
摘要翻译: 本发明提供了可用于监测肾功能以及肾功能异常的预后和诊断的新型健康肾生物标志物,特别是与移植物排斥有关的那些。 本发明还涉及用于帮助评估和设计移植肾脏学中的个性化疗法的方法。
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公开(公告)号:US20140109679A1
公开(公告)日:2014-04-24
申请号:US14142407
申请日:2013-12-27
申请人: Pedro Rodriguez
发明人: Pedro Rodriguez
IPC分类号: G01H17/00
摘要: For identifying a fault in an electrical machine vibration is measured in a plurality of radial directions of the stator. On the basis of the vibration measurements a vibration frequency and a mode shape of the vibration at this frequency is determined. Characteristics of the vibration in terms of both the vibration frequency and the mode shape are used to identify a fault condition of the electrical machine.
摘要翻译: 为了识别电机中的故障,在定子的多个径向方向上测量振动。 基于振动测量,确定该频率下的振动频率和振动模式形状。 振动频率和振型的振动特性用于识别电机的故障状态。
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公开(公告)号:US07932639B2
公开(公告)日:2011-04-26
申请号:US11968056
申请日:2007-12-31
申请人: Hung-Piao Ma , Alon Naveh , Gil Schwarzband , Annabelle Pratt , Jorge Pedro Rodriguez , Joseph T. Dibene, II , Sean M. Welch , Kosta Luria , Edward R. Stanford
发明人: Hung-Piao Ma , Alon Naveh , Gil Schwarzband , Annabelle Pratt , Jorge Pedro Rodriguez , Joseph T. Dibene, II , Sean M. Welch , Kosta Luria , Edward R. Stanford
IPC分类号: H02J1/00
CPC分类号: H02J1/10 , G11C5/147 , H02J2001/008 , Y10T307/305 , Y10T307/658 , Y10T307/675
摘要: Methods and mechanisms to simultaneously regulate two or more supply voltages provided to an integrated circuit by a voltage regulator. In an embodiment of the invention, a voltage regulation message exchanged between the integrated circuit and the voltage regulator includes an identifier indicating two or more supply voltages selected from a plurality of supply voltages provided to the integrated circuit by the voltage regulator, where the voltage regulation message relates to the indicated two or more supply voltages. In another embodiment, the voltage regulation message indicates a desired supply voltage level to which the indicated two or more supply voltages are to transition.
摘要翻译: 同时调节通过电压调节器提供给集成电路的两个或多个电源电压的方法和机制。 在本发明的一个实施例中,在集成电路和电压调节器之间交换的电压调节消息包括一个标识符,该标识符指示通过电压调节器从提供给集成电路的多个电源电压中选择的两个或多个电源电压,其中电压调节 消息涉及所指示的两个或更多个电源电压。 在另一个实施例中,电压调节消息指示所指示的两个或更多个电源电压要转换到的期望电源电压电平。
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公开(公告)号:US06545346B2
公开(公告)日:2003-04-08
申请号:US09816665
申请日:2001-03-23
IPC分类号: H01L2302
CPC分类号: H01L23/49822 , H01L23/642 , H01L2224/16 , H01L2224/16235 , H01L2924/00014 , H01L2924/15311 , H01L2924/3011 , H01L2224/0401
摘要: An apparatus includes a package having a first surface and a conductive contact exposed at the first surface. A capacitor is inside the package. The capacitor has a first conductive contact exposed at a first surface of the capacitor. The first conductive contact has a first portion spanning a width of the first surface of the capacitor. The first surface of the capacitor is substantially parallel to the first surface of the package. A conductive path connects the first portion of the first conductive contact of the capacitor to the first conductive contact proximate the first surface of the package.
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公开(公告)号:US06532143B2
公开(公告)日:2003-03-11
申请号:US09751612
申请日:2000-12-29
申请人: David G. Figueroa , Kishore K. Chakravorty , Huong T. Do , Larry Eugene Mosley , Jorge Pedro Rodriguez , Ken Brown
发明人: David G. Figueroa , Kishore K. Chakravorty , Huong T. Do , Larry Eugene Mosley , Jorge Pedro Rodriguez , Ken Brown
IPC分类号: H01G430
CPC分类号: H01G4/30 , H01L23/642 , H01L2224/16225 , H01L2924/00014 , H05K1/0298 , H05K1/162 , H01L2224/0401
摘要: A capacitor includes multiple tiers (302, 304, 306, 1210, 1212, 1310, 1312, 1380, FIGS. 3, 12, 13), which provide capacitance to a load at different inductance values. Each tier includes multiple layers (311-325, 1220, 1222, 1320, 1322, 1382, FIGS. 3, 12, 13) of patterned conductive material, which are separated by layers of dielectric material. In one embodiment, tiers are stacked in a vertical direction, and are electrically connected through vias (330, 332, 334, 1230, 1232, FIGS. 3, 12) that extend through some or all of the tiers. In another embodiment, one or more tiers (1310, 1312, FIG. 13) are located in a center region (1404, FIG. 14) of the capacitor, and one or more other tiers (1380, FIG. 13) are located in a peripheral region (1408, FIG. 14) of the capacitor. In that embodiment, the center tiers and peripheral tiers are electrically connected through one or more additional layers (1370, FIG. 13) of patterned conductive material. The capacitors of the various embodiments can be used as discrete devices, which are mountable on or embeddable within a housing (e.g., a package, interposer, socket or PC board), or they can be integrally fabricated within the housing.
摘要翻译: 电容器包括多层(302,304,306,1210,1212,1310,1312,1380,图3,12,13),其以不同的电感值向负载提供电容。 每个层包括被介电材料层隔开的图案化导电材料的多层(311-325,1220,1222,1320,1322,1382,图3,12,13)。 在一个实施例中,层是沿垂直方向堆叠的,并且通过延伸穿过一些或所有层的通孔(330,332,334,1230,1232,图3,12)电连接。 在另一个实施例中,一个或多个层(1310,1312,图13)位于电容器的中心区域(1404,图14)中,并且一个或多个其他层(图13中的1380)位于 电容器的外围区域(1408,图14)。 在该实施例中,中心层和外围层通过图案化导电材料的一个或多个附加层(1370,图13)电连接。 各种实施例的电容器可以用作可安装在壳体(例如,封装,插入件,插座或PC板)中或嵌入其中的分立器件,或者它们可以一体地制造在壳体内。
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公开(公告)号:US09110076B2
公开(公告)日:2015-08-18
申请号:US13259271
申请日:2010-04-16
CPC分类号: G01N33/6848 , G01N33/6842
摘要: The present invention provides a method for quantifying modified peptides in a sample, the method comprising: (a) obtaining peptides from the sample; (b) adding reference modified peptides to the peptides obtained in step (a) to produce a mixture of peptides and reference modified peptides; (c) carrying out mass spectrometry (MS) on said mixture of peptides and reference modified peptides to obtain data relating to the peptides in the sample; and (d) comparing the data relating to the peptides in the sample with data in a database of modified peptides using a computer program; wherein the database of modified peptides is compiled by a method comprising: (i) obtaining peptides from a sample; (ii) enriching modified peptides from the peptides obtained in step (i); (iii) carrying out liquid chromatography-tandem mass spectrometry (LC-MS/MS) on the enriched modified peptides obtained in step (ii); (iv) comparing the modified peptides detected in step (iii) to a known reference database in order to identify the modified peptides; and (v) compiling data relating to the modified peptides identified in step (iv) into a database.
摘要翻译: 本发明提供了一种量化样品中修饰肽的方法,所述方法包括:(a)从样品中获得肽; (b)将参考修饰的肽加入到步骤(a)中获得的肽中以产生肽和参考修饰肽的混合物; (c)在所述肽和参考修饰肽混合物上进行质谱(MS)以获得与样品中肽相关的数据; 和(d)使用计算机程序将与样品中肽相关的数据与修饰肽数据库中的数据进行比较; 其中所述修饰肽的数据库通过以下方法进行编译,所述方法包括:(i)从样品获得肽; (ii)从步骤(i)中获得的肽富集修饰的肽; (iii)对步骤(ii)中获得的富集的修饰肽进行液相色谱 - 串联质谱(LC-MS / MS); (iv)将步骤(iii)中检测到的修饰肽与已知参考数据库进行比较,以鉴定修饰的肽; 和(v)将与步骤(iv)中鉴定的修饰肽相关的数据编入数据库。
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公开(公告)号:US20140015250A1
公开(公告)日:2014-01-16
申请号:US13884796
申请日:2011-11-08
CPC分类号: G01R19/16533 , F03D7/00 , F03D7/0284 , F03D7/042 , F03D9/255 , F03D9/257 , F05B2270/337 , G01R19/10 , H02J3/26 , H02J3/386 , H02J2003/001 , H02K7/183 , H02P9/04 , Y02E10/723 , Y02E10/725 , Y02E10/763 , Y02E40/50
摘要: A wind turbine includes a grid side converter coupled to a grid via a power line. The method includes determining a first active power reference and a first reactive power reference indicating a requested amount of active power and reactive power, respectively, depending on at least a wind turbine operation strategy; determining a positive and negative sequence components of a grid voltage; determining indications of an actual amount of active power and reactive power to be supplied by the grid side converter to the grid, respectively; generating a parameters defining a proportion of positive sequence current component and negative sequence current component to be injected by the grid side converter in order to supply active power and reactive power; and supplying, with the grid side converter, active and reactive power to the power line based on the current reference.
摘要翻译: 风力涡轮机包括通过电力线耦合到电网的电网侧转换器。 该方法包括至少根据风力涡轮机操作策略确定第一有功功率基准和第一无功功率参考,所述第一无功功率参考分别表示所请求的有功功率和无功功率量; 确定电网电压的正序和负序分量; 确定由电网侧转换器提供给电网的有效功率和无功功率的实际量的指示; 产生定义电网侧转换器要注入的正序电流分量和负序电流分量比例的参数,以提供有功功率和无功功率; 并且基于电流参考,与电网侧转换器一起向电力线提供有功和无功功率。
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公开(公告)号:US20130303386A1
公开(公告)日:2013-11-14
申请号:US13880447
申请日:2011-10-18
CPC分类号: G06F19/18 , C12Q1/48 , C12Q1/485 , G01N33/6842
摘要: The present invention provides a method for identifying differential activation of a bisubstrate protein modifying enzyme between samples, comprising: (i) incubating a first sample with x different concentrations of the non-protein substrate of said enzyme, wherein x is 2 or greater than 2; (ii) quantifying modification of a polypeptide in said sample at each of the x different concentrations of the non-protein substrate; (iii) determining the affinity of said enzyme for said non-protein substrate; (iv) repeating steps (i) to (iii) for a second or subsequent sample; and (v) comparing the affinity of said enzyme for said non-protein substrate between said samples; wherein a difference in affinity of said enzyme for said non-protein substrate between samples is indicative of differential activation of said enzyme between samples. The present invention also provides a method for identifying an in vivo substrate of a bisubstrate protein modifying enzyme.
摘要翻译: 本发明提供了一种用于鉴定样品之间双底物蛋白质修饰酶的差异激活的方法,其包括:(i)将第一样品与所述酶的非蛋白质底物的x个不同浓度的温育,其中x为2或大于2 ; (ii)在x蛋白底物的x个不同浓度的每一个上定量所述样品中多肽的修饰; (iii)确定所述酶对所述非蛋白质底物的亲和力; (iv)对第二个或随后的样品重复步骤(i)至(iii); 和(v)比较所述酶在所述样品之间对所述非蛋白质底物的亲和力; 其中所述酶对样品之间的所述非蛋白质底物的亲和力差异表示所述酶在样品之间的差异激活。 本发明还提供了鉴定双底物蛋白质修饰酶的体内底物的方法。
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公开(公告)号:US08067932B2
公开(公告)日:2011-11-29
申请号:US12513531
申请日:2007-11-06
申请人: Remus Teodorescu , Pedro Rodriguez
发明人: Remus Teodorescu , Pedro Rodriguez
IPC分类号: G01R19/25
CPC分类号: G01R19/2513
摘要: This invention deals with an advanced Real-time Grid Monitoring System (RTGMS) suitable for both single-phase and three-phase electric power systems. This invention provides an essential signal processing block to be used as a part of complex systems either focused on supervising and diagnosing power systems or devoted to control power processors interacting with the grid. This invention is based on a new algorithm very suitable for real-time characterization of the grid variables under distorted and unbalanced grid conditions. The main characteristic of this invention is the usage of a frequency-locked loop, based on detecting the grid frequency, for synchronizing to the grid variables. It results in a very robust system response in relation to existing technique based on the phase-angle detection since grid frequency is much more stable variable than the grid voltage/current phase-angle, mainly during grid faults. Moreover, the algorithm supporting this invention is very efficient and can be implemented in regular industrial microprocessors. These features make the RTGMS object of this invention ideal to be applied in the control of distributed generation systems (DGS), flexible AC transmission systems (FACTS), power quality conditioners (PQC) and uninterruptible power supplies (UPS). In all these systems, the fast and precise real time detection of the voltage and/or current sequence components under grid fault conditions is a crucial matter.
摘要翻译: 本发明涉及适用于单相和三相电力系统的高级实时电网监控系统(RTGMS)。 本发明提供了一种基本的信号处理模块,用作复杂系统的一部分,其重点在于监督和诊断电力系统,或专门用于控制与电网相互作用的功率处理器。 本发明基于一种非常适合在失真和不平衡电网条件下对电网变量进行实时表征的新算法。 本发明的主要特征是基于检测电网频率来使频率锁定环与网格变量同步的使用。 由于电网频率比电网电压/电流相位角更为稳定,主要是在电网故障期间,因此相对于基于相位角检测的现有技术,可以获得非常强大的系统响应。 此外,支持本发明的算法非常有效,并且可以在常规工业微处理器中实现。 这些特征使得本发明的RTGMS对象理想地应用于分布式发电系统(DGS),灵活交流传输系统(FACTS),电力质量调节器(PQC)和不间断电源(UPS)的控制中。 在所有这些系统中,在电网故障条件下电压和/或电流序列组件的快速和精确的实时检测是至关重要的。
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公开(公告)号:USD625673S1
公开(公告)日:2010-10-19
申请号:US29343000
申请日:2009-09-03
申请人: Pedro Rodriguez
设计人: Pedro Rodriguez
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