公开(公告)号：US20110126913A1

公开(公告)日：2011-06-02

申请号：US12954519

申请日：2010-11-24

Applicant: Debjyoti Banerjee ,  Konrad Faulstich ,  Aldrich N. K. Lau ,  Umberto Ulmanella ,  Jun Xie

Inventor： Debjyoti Banerjee ,  Konrad Faulstich ,  Aldrich N. K. Lau ,  Umberto Ulmanella ,  Jun Xie

IPC: F16K31/64 ,  F16K51/00

CPC classification number: F16K99/0001 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2400/0661 ,  B01L2400/0677 ,  B01L2400/0683 ,  B01L2400/082 ,  B01L2400/084 ,  B01L2400/086 ,  F16K99/003 ,  F16K99/0036 ,  F16K99/0057 ,  F16K2099/0084 ,  Y10S422/901 ,  Y10T137/0318 ,  Y10T137/0324 ,  Y10T137/1624 ,  Y10T137/1812 ,  Y10T137/2191 ,  Y10T137/8376 ,  Y10T137/8593 ,  Y10T137/85978 ,  Y10T436/143333 ,  Y10T436/2575

Abstract: A diagnostic device is provided that includes a plurality of retainment regions, with the retainment regions that are separated by at least one dissolvable barrier. The retainment regions can be interconnected through at least one fluid processing passageway. A retainment region can include a container such as a retainment region, well, chamber, or other receptacle, or a retainment region such as a surface on which the material is retained. The retainment regions can include a reaction retainment region, one or more reagent retainment regions, each containing unreacted reagents, and a sample retainment region. A pressure-actuated valve can be positioned in each fluid processing passageway interconnecting the one or more reagent retainment regions with the respective intermediate retainment regions interposed between each of the one or more reagent retainment regions and the reaction retainment region. The dissolvable barrier can be a fluid flow modulator in the at least one fluid processing passageway.

Abstract translation: 提供了一种诊断装置，其包括多个保持区域，其中保留区域被至少一个可溶解的屏障隔开。 保持区域可以通过至少一个流体处理通道相互连接。 保持区域可以包括诸如保持区域，孔，腔室或其它容器的容器，或诸如保持材料的表面的保持区域。 保留区域可以包括反应保留区域，一个或多个试剂保留区域，每个含有未反应的试剂和样品保留区域。 压力致动阀可以定位在每个流体处理通道中，其将一个或多个试剂保留区域与插入在一个或多个试剂保留区域中的每一个和反应保留区域之间的各个中间保留区域互连。 可溶解屏障可以是至少一个流体处理通道中的流体流动调节器。

公开(公告)号：US20110083964A1

公开(公告)日：2011-04-14

申请号：US12793548

申请日：2010-06-03

Applicant: Umberto ULMANELLA

Inventor： Umberto ULMANELLA

IPC: C25B9/00

CPC classification number: F16K99/0042 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/0673 ,  B01L2300/0861 ,  B01L2400/0427 ,  F16K99/0001 ,  F16K99/0017 ,  F16K99/0019 ,  F16K2099/0084 ,  G05D7/0694 ,  Y10T137/0391 ,  Y10T137/212 ,  Y10T137/2931 ,  Y10T137/8593 ,  Y10T137/86493

Abstract: The present teachings relate to microfluidic valves and pumping systems, which may be suitable for controlling and facilitating liquid flow. Electrodes are disposed proximately to volumes containing a liquid. The liquid flow can be facilitated by electrowetting forces. Processes for controlling the flow of liquids, as well as for pumping liquids, are also disclosed.

Abstract translation: 本教导涉及微流体阀和泵送系统，其可适用于控制和促进液体流动。 电极靠近容纳液体的体积放置。 可以通过电润湿力促进液体流动。 还公开了用于控制液体流动以及泵送液体的方法。

公开(公告)号：US20110020179A1

公开(公告)日：2011-01-27

申请号：US12789363

申请日：2010-05-27

Applicant: Min Yue ,  David M. Liu ,  Yuh-Min Chiang ,  Joon-Mo Yang ,  Dennis Lehto ,  Charles S. Vann ,  Nigel P. Beard ,  Ian A. Harding ,  John Van Camp ,  Alexander Dromaretsky ,  Sergey V. Ermakov ,  Mark F. Oldham ,  Joy Roy ,  Maryam Shariati ,  Umberto Ulmanella

Inventor： Min Yue ,  David M. Liu ,  Yuh-Min Chiang ,  Joon-Mo Yang ,  Dennis Lehto ,  Charles S. Vann ,  Nigel P. Beard ,  Ian A. Harding ,  John Van Camp ,  Alexander Dromaretsky ,  Sergey V. Ermakov ,  Mark F. Oldham ,  Joy Roy ,  Maryam Shariati ,  Umberto Ulmanella

IPC: G01N33/00

CPC classification number: C12Q1/6806 ,  B01J2219/00317 ,  B01J2219/00722 ,  B01L3/502707 ,  B01L3/502723 ,  B01L3/50853 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/16 ,  B01L2300/041 ,  B01L2300/048 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2400/0694 ,  G01N35/028 ,  Y10T436/2575

Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.

Abstract translation: 用于多个分析物检测的系统和方法包括用于分配包括基底的生物样品的系统，其中所述基底包括多个样品室，用于每个样品室的样品引入通道和用于每个样品室的排气通道。 该系统可以进一步包括包含在每个样品室中并被配置用于进入基底的生物样品的核酸分析的预加载试剂和被配置为与基底接触以密封每个样品室以便基本上防止 每个样品室中包含的样品从每个样品室流出。 底物可以由检测相容和测定相容的材料构成。

公开(公告)号：US20060228734A1

公开(公告)日：2006-10-12

申请号：US11378559

申请日：2006-03-17

Applicant: Charles Vann ,  Umberto Ulmanella

Inventor： Charles Vann ,  Umberto Ulmanella

IPC: C12Q1/68 ,  C12M1/34

CPC classification number: G01N21/6428 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/502761 ,  B01L3/50851 ,  B01L2200/0642 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2400/0677 ,  G01N21/6452 ,  G01N33/54386 ,  G01N2021/0325 ,  G01N2021/6482

Abstract: A fluid processing device, method and system are provided. The fluid processing device can comprise: a substrate; a plurality of reaction regions disposed in or on the substrate; at least one channel interconnecting the plurality of reaction regions, the at least one channel having a cross-sectional area that includes a maximum dimension; and a plurality of reagent-releasing beads. Each reagent-releasing bead can be positioned in a respective one of the reaction regions. Each bead can comprise one or more reaction components for an assay. Each of the reagent-releasing beads can have a minimum dimension that is greater than the maximum dimension of the channel cross-section.

Abstract translation: 提供流体处理装置，方法和系统。 流体处理装置可以包括：基板; 设置在所述基板中或所述基板上的多个反应区域; 至少一个通道，其互连所述多个反应区域，所述至少一个通道具有包括最大尺寸的横截面积; 和多个试剂释放珠。 每个试剂释放珠可以位于相应的一个反应区域中。 每个珠可以包含用于测定的一种或多种反应成分。 每个试剂释放珠可以具有大于通道横截面的最大尺寸的最小尺寸。