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    Graphene reinforced concrete
    24.
    发明授权
    Graphene reinforced concrete 有权

    公开(公告)号：US11339093B2

    公开(公告)日：2022-05-24

    申请号：US16960988

    申请日：2019-03-12

    Applicant: University of Exeter

    Inventor： Monica Craciun ,  Dimitar Dimov ,  Saverio Russo

    IPC: C04B14/02 ,  C04B40/00

    Abstract: A reinforced concrete material is described comprising a cementitious material (22) in which graphene is substantially uniformly distributed. A method of production of concrete is also described comprising the steps of forming a substantially uniform suspension (20) of graphene with water, and mixing the suspension (20) with a cementitious material (22) to form a concrete material (28).

    CONSTRUCTION BLOCK WITH PHOTOVOLTAIC DEVICE
    25.
    发明申请
    CONSTRUCTION BLOCK WITH PHOTOVOLTAIC DEVICE 审中-公开

    公开(公告)号：US20200343851A1

    公开(公告)日：2020-10-29

    申请号：US16604823

    申请日：2018-04-04

    Applicant: University of Exeter

    Inventor： Hasan Baig ,  Tapas Mallick ,  James Morgan Williams

    IPC: H02S20/26 ,  E04C1/42 ,  H02S40/22

    Abstract: A construction block (10) is described, comprising an input wall (16) and an output wall (22) spaced apart from the input wall (16), a void (32) being formed between the input wall (16) and the output wall (22), wherein the input wall (16) has a plurality of projections (18) formed integrally therewith, the projections (18) extending toward but stopping short of the output wall (22) and serving to disrupt convection currents forming in the void (32), at least one of the projections (18) comprising a solar concentrator which has a photovoltaic device (28) mounted thereon.

    PROBE FOR OPTICAL SPECTROSCOPY
    26.
    发明申请
    PROBE FOR OPTICAL SPECTROSCOPY 审中-公开

    公开(公告)号：US20200015684A1

    公开(公告)日：2020-01-16

    申请号：US16495560

    申请日：2018-03-15

    Applicant: The University of Bristol ,  The University of Exeter ,  Gloucestershire Hospitals NHS Foundation Trust

    Inventor： Nicholas Stone ,  John Charles Clifford Day

    IPC: A61B5/00

    Abstract: A probe (10) comprising a body portion (70) and a tip portion (80). The body portion comprises: a first mounting portion (72) comprising a plurality of first carriers supporting elongate first waveguides, and disposed in an equiangular arrangement around a longitudinal axis (A) of the body portion; a body end fitting (74) at which first ends of the first waveguides are supported such that the first waveguides can transmit electromagnetic radiation signals from an energy source to the body end fitting and/or transmit electromagnetic radiation signals from the body end fitting to a receiver. The tip portion comprises: a second mounting portion (82) comprising a plurality of second carriers supporting elongate second waveguides, the second carriers being disposed in the equiangular arrangement around a longitudinal axis of the tip portion; and a tip end fitting (88) at which first ends of the second waveguides are supported in the equiangular arrangement around the longitudinal axis of the tip portion; and an elongate conduit (12) for piercing human tissue.

    VACCINE
    28.
    发明申请
    VACCINE 审中-公开
    疫苗

    公开(公告)号：US20170051023A1

    公开(公告)日：2017-02-23

    申请号：US15243409

    申请日：2016-08-22

    Applicant: University of Exeter

    Inventor： Richard W. Titball ,  Sergio Paulo Fernandes Da Costa ,  Claire Naylor ,  Ajit Basak

    IPC: C07K14/33 ,  C12N7/00

    CPC classification number: C07K14/33 ,  A61K39/08 ,  A61K2039/552 ,  A61K2039/575 ,  A61K2039/6006

    Abstract: There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID NO:3, the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by Clostridium perfringens.

    Abstract translation: 提供了包含SEQ ID NO：1的至少10个连续氨基酸的NetB表位多肽，并且与SEQ ID NO：3中的等同位置相比，在氨基酸130和297之间的至少一个位置具有突变，突变 优选地位于边缘结构域内，所述多肽能够结合与SEQ ID NO：1结合的抗体，并且与SEQ ID NO：1的毒性相比具有降低的毒性。 该多肽可用于使受试者免疫产气荚膜梭菌感染。

    Epsilon toxin epitopes from Clostridium perfringens with reduced toxicity
    29.
    发明授权
    Epsilon toxin epitopes from Clostridium perfringens with reduced toxicity 有权
    来自产气荚膜梭菌的Epsilon毒素表位具有降低的毒性

    公开(公告)号：US09573981B2

    公开(公告)日：2017-02-21

    申请号：US14387809

    申请日：2013-03-28

    Applicant: UNIVERSITY OF EXETER

    Inventor： Richard W. Titball ,  Monika Bokori-Brown ,  Claire Naylor

    IPC: A61K39/08 ,  C07K14/33 ,  C07K16/12 ,  A61K39/00

    CPC classification number: C07K14/33 ,  A61K39/00 ,  A61K39/08 ,  C07K16/1282

    Abstract: There is provided an epsilon toxin epitope polypeptide comprising a sequence of at least 10 contiguous amino acids from SEQ ID NO:3, the sequence comprising a mutation of at least one tyrosine residue compared to the equivalent sequence in SEQ ID NO:3, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:5 and having reduced toxicity compared with the toxicity of SEQ ID NO:5. The polypeptide is useful in a method of vaccinating a subject against developing a disease caused by clostridium perfringens and/or caused by (or associated with the presence of) active epsilon toxin.

    Abstract translation: 提供了包含SEQ ID NO：3的至少10个连续氨基酸的序列的ε-毒素表位多肽，所述序列包含与SEQ ID NO：3中的等同序列相比至少一个酪氨酸残基的突变，所述多肽 能够结合与SEQ ID NO：5结合的抗体，并且与SEQ ID NO：5的毒性相比具有降低的毒性。 该多肽可用于接种受试者以发展由产气荚膜梭菌引起的疾病和/或由活性ε毒素（或与其存在）引起的疾病接种的方法。

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