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公开(公告)号：US4807676A
公开(公告)日：1989-02-28
申请号：US705578
申请日：1985-02-26
CPC分类号： A61M1/029
摘要： A workstation for use in processing units of blood into components includes hangers for supporting the primary and transfer containers usable to store and transport the blood components, an optical sensor for sensing the outflow of red blood cells from the primary container, electrically actuated solenoid clamps for selectively opening and closing flow lines from an additive container and flow lines to the transfer containers. Electrically controlled radiant energy sources can be used to provide sterile flow connections where sterile connectors are joined together to form the blood component transfer set.
摘要翻译： 用于将血液处理单元用于部件的工作站包括用于支撑用于存储和运输血液成分的初级和转运容器的悬挂件，用于感测红细胞从主容器流出的光学传感器，用于 选择性地打开和关闭来自添加剂容器和流动管线到流动容器的流动管线。 可以使用电控辐射能源来提供无菌流动连接，其中无菌连接器连接在一起以形成血液成分转移组。
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22.发明授权
公开(公告)号：US4389206A
公开(公告)日：1983-06-21
申请号：US243981
申请日：1981-03-16
CPC分类号： B04B5/0442 , B04B2005/045 , B04B2005/0492
摘要： A rotatable processing bowl-type apparatus for separating blood components where a plurality of flexible umbilical tubes are positioned to establish communication with a processing bowl at one end thereof. Certain segments of each of the cables are stiffer than other segments of the same cables for improved life and performance. Also, outer portions of portions of the cables are impregnated with silicone oil.
摘要翻译： 一种用于分离血液成分的可旋转处理碗式装置，其中定位有多个柔性脐带管，以在其一端与加工碗建立连通。 每条电缆的某些部分比相同电缆的其他部分更硬，以提高寿命和性能。 此外，电缆的部分的外部部分用硅油浸渍。
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公开(公告)号：US07938454B2
公开(公告)日：2011-05-10
申请号：US11739433
申请日：2007-04-24
IPC分类号： F16L33/00
CPC分类号： F16L47/02 , A61M39/18 , A61M2039/167 , B29C65/1412 , B29C65/1435 , B29C65/1441 , B29C65/1445 , B29C65/1467 , B29C65/148 , B29C65/16 , B29C65/7473 , B29C66/0242 , B29C66/1142 , B29C66/1162 , B29C66/5221 , B29C66/5223 , B29C66/52293 , B29C66/52296 , B29C66/52297 , B29C66/52298 , B29C66/534 , B29C66/54 , B29C66/71 , B29C66/73921 , B29C66/857 , B29L2023/007 , F16L13/0236 , F16L47/06 , F16L47/20 , F16L2201/44 , Y10S604/905 , B29K2069/00 , B29K2033/12 , B29K2033/08 , B29K2027/16 , B29K2027/12
摘要： A system for forming a fluid connection includes a first connector and a second connector. Both connectors include a tubular body having a membrane mounted on a distal end thereof. A support member facilitates the coupling of the connectors together so that the membranes are abutted together. Radiant energy is applied to the abutted membranes so as to first sterilize the membranes and then melt the membranes so that a passage is formed therethrough.
摘要翻译： 用于形成流体连接的系统包括第一连接器和第二连接器。 两个连接器包括具有安装在其远端上的膜的管状体。 支撑构件便于将连接器耦合在一起，使得膜抵靠在一起。 将辐射能量施加到邻接的膜上，以便首先对膜进行灭菌，然后熔化膜，使得通过其形成通道。
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公开(公告)号：US5993949A
公开(公告)日：1999-11-30
申请号：US975602
申请日：1997-11-21
申请人： Larry Rosenbaum , Steven Giovanetto , Sidney T. Smith , David V. Bacehowski , Gregg Nebgen , Varsha Kalyankar
发明人： Larry Rosenbaum , Steven Giovanetto , Sidney T. Smith , David V. Bacehowski , Gregg Nebgen , Varsha Kalyankar
IPC分类号： B32B27/28 , B32B27/08 , B32B27/30 , B32B27/32 , C08L23/08 , C08L23/10 , C08L25/04 , C08L53/00 , C08L53/02 , C08L77/00
CPC分类号： B32B27/08 , B29C47/0021 , B29C47/061 , C08L23/08 , C08L23/10 , C08L2203/02 , C08L23/0815 , C08L23/0846 , C08L23/0853 , C08L23/0869 , C08L25/04 , C08L53/00 , C08L53/02 , C08L77/00 , Y10T428/1341 , Y10T428/2495 , Y10T428/2878 , Y10T428/2883 , Y10T428/31743 , Y10T428/31746 , Y10T428/31909 , Y10T428/31913 , Y10T428/31917 , Y10T428/31928 , Y10T428/31931 , Y10T428/31935
摘要： A multiple layer structure comprising a skin layer, a barrier layer, a radio frequency susceptible layer having a first polyolefin in an amount within a range of 30-60% by weight, a second polyolefin in an amount within the range of 25-50% by weight, a radio frequency susceptible polymer in an amount within the range of 3-40% by weight, a styrene and hydrocarbon block copolymer in an amount within the range of 5-40% by weight of the sealant layer.
摘要翻译： 一种多层结构，包括表皮层，阻挡层，具有30-60重量％范围内的第一聚烯烃的射频敏感层，第二聚烯烃的量为25-50重量％ ，3-70重量％范围内的无线电频率敏感聚合物，密封剂层重量5-40重量％范围内的苯乙烯和烃嵌段共聚物。
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公开(公告)号：US5759147A
公开(公告)日：1998-06-02
申请号：US472671
申请日：1995-06-07
CPC分类号： F04B43/10 , B04B1/00 , B04B5/0428 , B04B5/0442 , C07K16/30 , F04B9/02 , B04B2005/045 , B04B2005/0464
摘要： A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer circumferential wall plus an inner circumferential wall, spaced from the outer wall, to define a circumferential slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.
摘要翻译： 血液成分分离装置包括适于在离心机中围绕其轴旋转的离心机碗。 碗限定外周壁加上与外壁间隔开的内周壁，以限定适于接收血液成分的圆周槽。 接入管适用于与槽连通。 优选地，在狭槽中设置细长的，柔性的可折叠内衬。 单独的进入管也可以与细长的可收缩容器的端部之间的细长的容器内部连通。 此外，槽的一部分可以限定向外延伸的螺旋的形状，以在流体沿着狭槽移动时为其中的流体提供增加的重力场。
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公开(公告)号：US4937194A
公开(公告)日：1990-06-26
申请号：US303188
申请日：1989-01-30
申请人： Martha C. Pattillo , David V. Bacehowski , Arnold C. Bilstad , Herbert M. Cullis , T. Michael Dennehey , James W. Yang , William C. Brown
发明人： Martha C. Pattillo , David V. Bacehowski , Arnold C. Bilstad , Herbert M. Cullis , T. Michael Dennehey , James W. Yang , William C. Brown
CPC分类号： C12M23/14 , C12M33/07 , Y10S435/80
摘要： A system for metering nutrient media to cell culture containers includes a media flow conduit which defines at one end means for substantially aseptic communication with the source of the media. In a preferred embodiment, sterile connectors may be used for essentially sterile conditions. A branch conduit extends from the flow conduit at a location spaced from the ends. The branch conduit communicates with means for receiving a predetermined-volume aliquot of media through the media flow conduit from said one end. The flow conduit also defines a portion downstream from the branch conduit, which communicates with at least one cell culture container, each container being a flexible bag. At least part of the flexible bag is made of a material capable of providing at least 2 times the oxygen diffusion and at least 2 times the carbon dioxide diffusion between the bag interior and exterior, compared with an identically-sized, sealed bag having polyethylene walls 0.013 inch thick.
摘要翻译： 用于向细胞培养容器计量营养培养基的系统包括介质流动管道，其在一端限定用于与介质源实质上无菌的通信。 在优选的实施方案中，无菌连接器可用于基本上无菌的条件。 分支导管在与端部间隔开的位置处从流动管道延伸。 分支管道与用于从所述一端通过介质流动管道接收预定体积等分的介质的装置连通。 流动导管还限定了与至少一个细胞培养容器连通的分支导管下游的部分，每个容器是柔性袋。 与具有聚乙烯壁的相同尺寸的密封袋相比，柔性袋的至少一部分由能够提供至少2倍的氧扩散和袋内部和外部之间的二氧化碳扩散的材料制成。 0.013英寸厚
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公开(公告)号：US4910147A
公开(公告)日：1990-03-20
申请号：US247463
申请日：1988-09-21
申请人： David V. Bacehowski , Arnold C. Bilstad , David Fisher , Robert Gliniecki , Michael R. Keilman , Sidney T. Smith
发明人： David V. Bacehowski , Arnold C. Bilstad , David Fisher , Robert Gliniecki , Michael R. Keilman , Sidney T. Smith
摘要： A cell culture media container is provided. The container comprises a body constructed from flexible film and defining a containment area for containing the cell culture media, the body including a front face and a back face, the front and back face being sealed to each other along at least three sides thereof. The container includes a fill port for filling the containment area with cell culture media, the port being sealed to a face of the body and being so constructed and arranged that it extends from the face normal thereto. The container is constructed from a high barrier, optically clear, radiation sterilizable film.
摘要翻译： 提供细胞培养基容器。 容器包括由柔性膜构成的主体并且限定用于容纳细胞培养基的容纳区域，所述容器包括前表面和后表面，所述前表面和后表面沿着其至少三个侧面被彼此密封。 容器包括用于用容纳细胞培养基填充容纳区域的填充口，该孔口被密封到主体的表面，并被构造和布置成使得其从正面与其正面延伸。 容器由高屏障，光学透明的辐射灭菌膜构成。
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公开(公告)号：US4900321A
公开(公告)日：1990-02-13
申请号：US288522
申请日：1988-12-22
申请人： Stephen B. Kaufman , Robert Patterson , David V. Bacehowski , Arnold C. Bilstad , Patrick N. Huehls
发明人： Stephen B. Kaufman , Robert Patterson , David V. Bacehowski , Arnold C. Bilstad , Patrick N. Huehls
摘要： A fluid delivery system has a container with an integrally attached sample cell. A selected fluid can be accumulated in the container. The sample cell can be filled with part of the fluid in the container and then isolated from the container by heat or dielectric sealing. The fluid in the sample cell can be brought into contact with selected test reagents. The test reagents can provide a visual indicia of the presence of selected characteristics in the fluid.
摘要翻译： 流体输送系统具有带有整体连接的样品池的容器。 所选择的流体可以积聚在容器中。 样品池可以在容器中填充一部分流体，然后通过加热或电介质密封与容器隔离。 样品池中的流体可以与选定的试剂接触。 测试试剂可以提供在流体中存在所选特征的视觉标记。
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公开(公告)号：US4786286A
公开(公告)日：1988-11-22
申请号：US868202
申请日：1986-03-23
CPC分类号： B29C66/857 , A61M1/0209 , A61M39/143 , B29C65/1435 , B29C65/1483 , B29C65/7473 , B29C65/7802 , B29C66/5221 , B29C66/52293 , B29C66/52297 , B29C66/52298 , B29C66/534 , B29C66/54 , B29C66/73921 , A61M2039/1027 , B29C65/1403 , B29C65/1406 , B29C65/1409 , B29C65/1412 , B29C66/5224 , B29C66/73365 , B29C66/73774 , B29K2995/0025 , B29K2995/0027 , Y10S604/905
摘要： A fluid collection system includes an input unit having a hollow needle coupled through a section of flexible conduit to an anticoagulant reservoir which is in turn coupled via a second section of hollow conduit to a first sterile connector. A collection container, which can be a dry, flexible, plastic bag, is coupled by a plastic conduit to second and third sterile connectors. The first and second connectors can be joined together and sealed to form a sterile system. A transfer container includes a flexible plastic container coupled via a hollow plastic conduit to a fourth sterile connector. The fourth sterile connector is joinable with the third sterile connector to form a sterile two container system. Fluids collected in the primary container can then be transferred to the secondary container.
摘要翻译： 流体收集系统包括输入单元，该输入单元具有通过柔性导管的一部分连接到抗凝血储存器的中空针，所述抗凝剂储存器又通过中空导管的第二部分耦合到第一无菌连接器。 可以是干燥，柔性的塑料袋的收集容器通过塑料导管连接到第二和第三无菌连接器。 第一和第二连接器可以连接在一起并密封以形成无菌系统。 转移容器包括通过中空塑料导管连接到第四无菌连接器的柔性塑料容器。 第四无菌连接器可与第三无菌连接器连接以形成无菌的两个容器系统。 收集在主容器中的流体然后可以被转移到次级容器。
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公开(公告)号：US4253458A
公开(公告)日：1981-03-03
申请号：US18499
申请日：1979-03-08
CPC分类号： A61J1/10 , A61M1/0209 , A61M1/0236 , A61M1/0272 , B65B69/0058 , A61J1/12
摘要： Blood plasma is frozen in a sealed, flexible, collapsible container which defines an inlet at one end and a shoulder portion surrounding the inlet. The container tapers from the shoulder portion to a generally flat configuration at its end opposite the one end. After the freezing step, the shoulder portion is cut away from the container to define a cut end. Thereafter, the frozen plasma may be removed from the container in frozen form by squeezing the wall of the tapered container to expel the frozen plasma out of the cut end of the container.
摘要翻译： 将血浆冷冻在密封的，柔性的，可折叠的容器中，其在一端限定入口和围绕入口的肩部。 容器从肩部逐渐变细到与其一端相对的端部处的大致平坦的构型。 在冷冻步骤之后，将肩部从容器上切下以限定切割端。 此后，可以通过挤压锥形容器的壁将冻结的等离子体从冷冻形式的容器中移出，以将冷冻的等离子体从容器的切割端排出。
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