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公开(公告)号：US20090042294A1
公开(公告)日：2009-02-12
申请号：US12283661
申请日：2008-09-15
Applicant: Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
Inventor： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC classification number: C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
Abstract: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
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公开(公告)号：US08663230B2
公开(公告)日：2014-03-04
申请号：US13037998
申请日：2011-03-01
Applicant: Anthony Miniaci , Steven W. Ek
Inventor： Anthony Miniaci , Steven W. Ek
IPC: A61B17/56
CPC classification number: A61B17/1668 , A61B17/1677 , A61B17/1684 , A61B17/175 , A61F2/3603 , A61F2/4607 , A61F2/4618 , A61F2002/4007 , A61F2002/4636 , A61F2002/4677
Abstract: A method according to one embodiment may provide access to an articular surface of a bone. The method includes forming a passage through at least a portion of the bone. The passage provides an opening in the articular surface. The method further includes inserting a tether through the passage. The tether inserted through the passage can be coupled to at least one device from an insertion site remote from the articular surface. The tether can be withdrawn through the passage to convey the device to a location proximate the articular surface.
Abstract translation: 根据一个实施例的方法可以提供对骨的关节表面的接近。 该方法包括形成通过骨的至少一部分的通道。 通道在关节表面提供开口。 该方法还包括通过通道插入系绳。 穿过通道插入的系绳可以从远离关节表面的插入部位耦合到至少一个装置。 系绳可以通过通道被抽出以将装置传送到靠近关节表面的位置。
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公开(公告)号：US08556902B2
公开(公告)日：2013-10-15
申请号：US13043430
申请日：2011-03-08
Applicant: Steven W. Ek , Tim Brightman , Anthony Miniaci
Inventor： Steven W. Ek , Tim Brightman , Anthony Miniaci
IPC: A61B17/56
CPC classification number: A61F2/30756 , A61B17/1637 , A61B17/1684 , A61B17/17 , A61B17/1714 , A61B17/1735 , A61B17/175 , A61B17/1778 , A61F2/3601 , A61F2/4003 , A61F2002/30299 , A61F2002/30332 , A61F2002/3085 , A61F2002/4007 , A61F2002/4631 , A61F2220/0033 , A61F2230/0093
Abstract: A system and method may be used for accessing an articular surface and for preparing an implant site on the articular surface. The method may include locating a portion of the articular. An access passage may be drilled towards the articular surface though bone behind the articular surface. An implant site may be excised in the articular surface relative to an axis defined by the access passage.
Abstract translation: 可以使用系统和方法来访问关节表面并且用于在关节表面上准备植入部位。 该方法可以包括定位关节的一部分。 可以通过关节表面后面的骨头朝向关节表面钻取入通道。 可以在关节表面中相对于由进入通道限定的轴线切除植入部位。
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Patent Agency Ranking
24.发明授权Apparatus and method for sequentially anchoring multiple graft ligaments in a bone tunnel 有权将多个移植韧带顺序锚定在骨隧道中的装置和方法公开(公告)号：US08491652B2
公开(公告)日：2013-07-23
申请号：US12765444
申请日：2010-04-22
Applicant: Stephen D. Fening , Anthony Miniaci
Inventor： Stephen D. Fening , Anthony Miniaci
CPC classification number: A61F2/0811 , A61B2017/0425 , A61B2017/0438 , A61F2002/0835 , A61F2002/0852 , A61F2002/0858 , A61F2002/0882 , Y10T292/1099
Abstract: An apparatus for anchoring at least two graft ligaments within a longitudinal bone tunnel includes a longitudinal sleeve having at least two radially spaced ligament-contacting surfaces located in lateral opposition to a sleeve inner lumen. The sleeve is configured for at least partial insertion into the bone tunnel with each graft ligament positioned laterally adjacent a different ligament-contacting surface. The graft ligaments are at least partially located between the bone tunnel and the sleeve. An actuating member has longitudinally separated proximal and distal actuating member ends. An asymmetrically offset profile is defined by at least one of the sleeve and the actuating member. The asymmetrically offset profile has a plurality of longitudinally spaced engagement thresholds. The actuating member is inserted longitudinally into the sleeve to cause frictional engagement of each graft ligament with both the bone tunnel and at least one ligament-contacting surface. The frictional engagement of each graft ligament is temporally spaced apart from the frictional engagement of at least one other graft ligament. The temporal spacing is provided by the plurality of engagement thresholds. A method of anchoring at least two longitudinally extending graft ligaments within a bone tunnel is also provided.
Abstract translation: 用于将至少两个移植韧带锚固在纵向骨隧道内的装置包括纵向套管，其具有位于与套管内腔侧向对置的至少两个径向隔开的韧带接触表面。 套筒构造成用于至少部分地插入到骨隧道中，其中每个移植韧带横向邻近于不同的韧带接触表面。 移植韧带至少部分地位于骨隧道和套管之间。 致动构件具有纵向分离的近端和远端致动构件端部。 不对称偏移轮廓由套筒和致动构件中的至少一个限定。 非对称偏移轮廓具有多个纵向间隔的接合阈值。 致动构件纵向插入套筒中，以使每个移植韧带与骨隧道和至少一个韧带接触表面摩擦接合。 每个移植韧带的摩擦接合在时间上与至少一个其他移植韧带的摩擦接合间隔开。 时间间隔由多个接合阈值提供。 还提供了在骨隧道内锚定至少两个纵向延伸的移植韧带的方法。
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25.发明申请APPARATUS AND METHOD FOR SEQUENTIALLY ANCHORING MULTIPLE GRAFT LIGAMENTS IN A BONE TUNNEL 有权一种用于在骨隧道中顺序锚定多条绞股烟的装置和方法公开(公告)号：US20100274356A1
公开(公告)日：2010-10-28
申请号：US12765444
申请日：2010-04-22
Applicant: Stephen D. Fening , Anthony Miniaci
Inventor： Stephen D. Fening , Anthony Miniaci
IPC: A61F2/08
CPC classification number: A61F2/0811 , A61B2017/0425 , A61B2017/0438 , A61F2002/0835 , A61F2002/0852 , A61F2002/0858 , A61F2002/0882 , Y10T292/1099
Abstract: An apparatus for anchoring at least two graft ligaments within a longitudinal bone tunnel includes a longitudinal sleeve having at least two radially spaced ligament-contacting surfaces located in lateral opposition to a sleeve inner lumen. The sleeve is configured for at least partial insertion into the bone tunnel with each graft ligament positioned laterally adjacent a different ligament-contacting surface. The graft ligaments are at least partially located between the bone tunnel and the sleeve. An actuating member has longitudinally separated proximal and distal actuating member ends. An asymmetrically offset profile is defined by at least one of the sleeve and the actuating member. The asymmetrically offset profile has a plurality of longitudinally spaced engagement thresholds. The actuating member is inserted longitudinally into the sleeve to cause frictional engagement of each graft ligament with both the bone tunnel and at least one ligament-contacting surface. The frictional engagement of each graft ligament is temporally spaced apart from the frictional engagement of at least one other graft ligament. The temporal spacing is provided by the plurality of engagement thresholds. A method of anchoring at least two longitudinally extending graft ligaments within a bone tunnel is also provided.
Abstract translation: 用于将至少两个移植韧带锚固在纵向骨隧道内的装置包括纵向套管，其具有位于与套管内腔侧向对置的至少两个径向隔开的韧带接触表面。 套筒构造成用于至少部分地插入到骨隧道中，其中每个移植韧带横向邻近于不同的韧带接触表面。 移植韧带至少部分地位于骨隧道和套管之间。 致动构件具有纵向分离的近端和远端致动构件端部。 不对称偏移轮廓由套筒和致动构件中的至少一个限定。 非对称偏移轮廓具有多个纵向间隔的接合阈值。 致动构件纵向插入套筒中，以使每个移植韧带与骨隧道和至少一个韧带接触表面摩擦接合。 每个移植韧带的摩擦接合在时间上与至少一个其他移植韧带的摩擦接合间隔开。 时间间隔由多个接合阈值提供。 还提供了在骨隧道内锚定至少两个纵向延伸的移植韧带的方法。
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26.发明授权公开(公告)号：US07465766B2
公开(公告)日：2008-12-16
申请号：US11176544
申请日：2005-07-07
Applicant: Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
Inventor： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC classification number: C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
Abstract: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
Abstract translation: 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络，特别是提供用于各种组织类型的合成的，可植入的组织基质材料。 特别地，描述人造或合成软骨，声带材料，玻璃体材料，软组织材料和二尖瓣材料。 在一个实施方案中，网络由酪胺取代和交联的透明质酸分子组成，其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的，一致的透明质酸基水凝胶。
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27.发明申请公开(公告)号：US20060084759A1
公开(公告)日：2006-04-20
申请号：US11176544
申请日：2005-07-07
Applicant: Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq Darr , Kiyotaka Fukamachi , Richard Gross , David Haynes , Keiji Kamohara , Daniel Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
Inventor： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq Darr , Kiyotaka Fukamachi , Richard Gross , David Haynes , Keiji Kamohara , Daniel Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC classification number: C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
Abstract: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
Abstract translation: 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络，特别是提供用于各种组织类型的合成的，可植入的组织基质材料。 特别地，描述人造或合成软骨，声带材料，玻璃体材料，软组织材料和二尖瓣材料。 在一个实施方案中，网络由酪胺取代和交联的透明质酸分子组成，其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的，一致的透明质酸基水凝胶。
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28.发明申请Method and instruments for positioning humeral component during shoulder arthroplasty 有权肩关节成形术中定位肱骨组件的方法和仪器公开(公告)号：US20050085919A1
公开(公告)日：2005-04-21
申请号：US10740154
申请日：2003-12-18
Applicant: Anitra Durand-Allen , Roy Wiley , Louis Bigliani , Evan Flatow , Ian Kelly , George McCluskey , Anthony Miniaci , Gregory Nicholson , Michael Pearl , Ken Yamaguchi
Inventor： Anitra Durand-Allen , Roy Wiley , Louis Bigliani , Evan Flatow , Ian Kelly , George McCluskey , Anthony Miniaci , Gregory Nicholson , Michael Pearl , Ken Yamaguchi
CPC classification number: A61B17/862 , A61B17/1778 , A61B17/8883 , A61F2/30734 , A61F2/40 , A61F2/4059 , A61F2/4612 , A61F2/4657 , A61F2/4684 , A61F2002/30616 , A61F2002/30617 , A61F2002/30708 , A61F2002/30713 , A61F2002/30884 , A61F2002/30896 , A61F2002/4018 , A61F2002/4033 , A61F2002/4051 , A61F2002/4062 , A61F2002/4631 , A61F2002/4658 , A61F2002/4687 , A61F2250/0084 , A61F2250/0087 , A61F2250/0097
Abstract: The present invention relates to a set of tools and accessories used for properly positioning a stemmed humeral component, and/or a humeral stem provisional, within a canal in the humerus. The set of tools and accessories includes one or more fin clamps that are configured to be temporarily attached to a fin on the humeral component or the provisional; a ruler that is configured to be attached to the arm of the fin clamp, a fixation pin and pin driver configured to be used with the other tools for marking a position on the humerus; and one or more sleeves that are configured to slide over the stem of the humeral stem provisional to maintain it in the desired position.
Abstract translation: 本发明涉及一种用于在肱骨的管道内适当地定位肱骨头部件和/或肱骨静脉的工具和附件。 一组工具和附件包括一个或多个翅片夹，其被配置为临时附接到肱骨部件上的翅片或临时的; 被配置为附接到所述翅片夹的臂的标尺，固定销和销驱动器，其被配置为与用于标记所述肱骨上的位置的其它工具一起使用; 以及构造成在肱骨柄的杆上滑动以临时使其保持在期望位置的一个或多个套筒。
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