公开(公告)号：US10035769B2

公开(公告)日：2018-07-31

申请号：US15366590

申请日：2016-12-01

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Scott C. Virgil ,  David E. White ,  Taiga Yurino ,  Yiyang Liu ,  Douglas C. Behenna ,  Douglas Duquette ,  Christian Eidamshaus

IPC: C07D207/27 ,  C07D207/277 ,  C07D211/76 ,  C07D211/78 ,  C07D211/90 ,  C07D211/96 ,  C07D223/10 ,  C07D265/32

CPC classification number: C07D211/78 ,  C07D207/06 ,  C07D207/08 ,  C07D207/10 ,  C07D207/16 ,  C07D207/26 ,  C07D207/263 ,  C07D207/267 ,  C07D207/27 ,  C07D207/273 ,  C07D207/277 ,  C07D207/46 ,  C07D211/16 ,  C07D211/18 ,  C07D211/22 ,  C07D211/34 ,  C07D211/38 ,  C07D211/60 ,  C07D211/76 ,  C07D211/88 ,  C07D211/90 ,  C07D211/94 ,  C07D211/96 ,  C07D223/04 ,  C07D223/10 ,  C07D241/04 ,  C07D241/08 ,  C07D241/52 ,  C07D265/30 ,  C07D265/32 ,  C07D309/04 ,  C07D309/30

Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.

公开(公告)号：US09809607B2

公开(公告)日：2017-11-07

申请号：US14818417

申请日：2015-08-05

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Anton Toutov ,  Kerry Betz ,  Alexey Fedorov ,  Brian M. Stoltz ,  Wenbo Liu ,  Robert H. Grubbs

IPC: C08G75/00 ,  C07F7/08 ,  C07D209/12

CPC classification number: C07F7/0801 ,  C07D209/12 ,  C07F7/0827 ,  C07F7/0832

Abstract: The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system or method comprising or consisting essentially of a mixture of (a) at least one organosilane and (b) at least one strong base, the definition of strong base now also including KOH, said system being preferably, but not necessarily substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.

公开(公告)号：US12259343B2

公开(公告)日：2025-03-25

申请号：US17762232

申请日：2020-09-10

Applicant: The Regents of the University of California ,  California Institute of Technology

Inventor： Hosea M. Nelson ,  Jose A. Rodriguez ,  Brian M. Stoltz ,  Tamir Gonen ,  Michael Martynowycz

IPC: G01N1/42 ,  G01N23/2055

Abstract: The present disclosure provides methods of collecting electron diffraction patterns from nanocrystals to obtain a three-dimensional structural model of a compound, as well as methods of identifying compounds and methods of determining polymorphic forms. In addition, the present disclosure provides methods of characterizing a first compound from a sample, as well as methods of screening compounds from a sample. The present disclosure also provides systems for characterizing a compound from a sample, which systems include modules for high-performance liquid chromatography, dispensing, and electron microscopy.

公开(公告)号：US11845770B2

公开(公告)日：2023-12-19

申请号：US17971194

申请日：2022-10-21

Applicant: California Institute of Technology ,  Holoclara, Inc.

Inventor： Brian M. Stoltz ,  Corey M. Reeves ,  Eduardo J. Martinez ,  Simon Bailey

IPC: C07H15/18 ,  A61P29/00 ,  C07H15/04 ,  C07H15/10 ,  C07H15/26

CPC classification number: C07H15/18 ,  A61P29/00 ,  C07H15/04 ,  C07H15/10 ,  C07H15/26

Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. For example, the present invention provides methods of treating immune and/or inflammatory disorders by administering a composition comprising a compound having the structure of Formula (I).

公开(公告)号：US11753421B2

公开(公告)日：2023-09-12

申请号：US17688122

申请日：2022-03-07

Applicant: California Institute of Technology

Inventor： Anton Toutov ,  Kerry Betz ,  Alexey Fedorov ,  Brian M. Stoltz ,  Wenbo Liu ,  Robert H. Grubbs

IPC: C07F7/08 ,  C07D209/12

CPC classification number: C07F7/0801 ,  C07D209/12 ,  C07F7/0827 ,  C07F7/0832

Abstract: The present disclosure describes methods for silylating aromatic derivatives, comprising the use of hydrosilanes and potassium hydroxide.

公开(公告)号：US11214568B2

公开(公告)日：2022-01-04

申请号：US16657672

申请日：2019-10-18

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Alexander W. Sun ,  Stephan N. Hess ,  Carina I. Jette ,  Irina Geibel ,  Shoshana Bachman ,  Masaki Hayashi ,  Hideki Shimizu ,  Jeremy B. Morgan ,  Shunya Sakurai ,  Zachary P. Sercel

IPC: C07D243/08 ,  C07D413/14 ,  C07D207/26 ,  C07D239/06 ,  C07D507/00 ,  C07D241/08

Abstract: Described here are transition metal-catalyzed enantioselective arylation and vinylation reactions of α-substituted lactams, such as γ-lactams. The use of various electrophiles and ligands are described, and result in the construction of α-quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee).

公开(公告)号：US10995049B2

公开(公告)日：2021-05-04

申请号：US16922290

申请日：2020-07-07

Applicant: California Institute of Technology

Inventor： Jiaming Li ,  Chen Xu ,  Tonia S Ahmed ,  Robert H Grubbs ,  Brian M. Stoltz

IPC: C07C45/29 ,  C07C29/00 ,  C07C49/557 ,  C07C49/577

Abstract: The present disclosure is directed to methods of preparing prostaglandin J natural products by stereoretentive metatheses reactions and intermediates used in the synthesis of these natural products, including the use of intermediates of Formula (I-A), where R1 is defined in the specification

公开(公告)号：US20210047348A1

公开(公告)日：2021-02-18

申请号：US17074717

申请日：2020-10-20

Applicant: California Institute of Technology

Inventor： Anton Toutov ,  Kerry Betz ,  Alexey Fedorov ,  Brian M. Stoltz ,  Wenbo Liu ,  Robert H. Grubbs

IPC: C07F7/08 ,  C07D209/12

Abstract: The present disclosure describes methods for silylating aromatic derivatives, comprising the use of hydrosilanes and potassium hydroxide.

公开(公告)号：US20210017111A1

公开(公告)日：2021-01-21

申请号：US16922290

申请日：2020-07-07

Applicant: California Institute of Technology

Inventor： Jiaming Li ,  Chen Xu ,  Tonia S. Ahmed ,  Robert H. Grubbs ,  Brian M. Stoltz

IPC: C07C45/29 ,  C07C49/577 ,  C07C49/557

Abstract: The present disclosure is directed to methods of preparing prostaglandin J natural products by stereoretentive metatheses reactions and intermediates used in the synthesis of these natural products, including the use of intermediates of Formula (I-A), where R1 is defined in the specification

公开(公告)号：US20190077796A1

公开(公告)日：2019-03-14

申请号：US16055559

申请日：2018-08-06

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Masaki Hayashi ,  Satoshi Hashimoto

IPC: C07D409/06 ,  C07D207/277 ,  C07D207/27 ,  C07D207/273

Abstract: This disclosure provides methods for intermolecular enantioselective C-acylation of lactams with quaternary stereogenic centers by applying a chiral Ni catalyst. The methods comprise treating a lactam with a chiral Ni catalyst, an aryl nitrile, and an aryl halide.