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公开(公告)号：US20160250165A1
公开(公告)日：2016-09-01
申请号：US15154539
申请日：2016-05-13
Applicant: DUKE UNIVERSITY
Inventor： Bruce A. Sullenger , Sabah Oney , Tung Suet Ruby Lam , Kam Leong
IPC: A61K31/164 , C12N15/115 , G01N33/53 , A61K31/14 , A61K31/132
CPC classification number: A61K31/164 , A61K31/00 , A61K31/132 , A61K31/14 , A61K38/00 , C07K14/46 , C12N15/111 , C12N15/115 , C12N2310/16 , C12N2320/50 , G01N33/5308 , G01N33/94 , G01N2500/00 , G01N2500/20
Abstract: The present invention relates, in general, to agents that modulate the pharmacological activity of nucleic acid molecules and, in particular, to agents that bind therapeutic or diagnostic nucleic acid molecules in a sequence independent manner and modulate (e.g., inhibit or reverse) their activity. The invention also relates to compositions comprising such agents and to methods of using same.
Abstract translation: 本发明一般涉及调节核酸分子的药理学活性的试剂，特别是涉及以不依赖序列的方式结合治疗或诊断核酸分子并调节（例如抑制或逆转）其活性的试剂 。 本发明还涉及包含这些试剂的组合物及其使用方法。
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公开(公告)号：US20160030332A1
公开(公告)日：2016-02-04
申请号：US14783717
申请日：2014-04-09
Applicant: DUKE UNIVERSITY
Inventor： Jaewoo Lee , Johannes Urban , Bruce A. Sullenger
IPC: A61K9/00 , A61K9/127 , A61K31/7115 , A61K39/00 , C12N15/117 , C12N15/115
CPC classification number: A61K9/0012 , A61K9/127 , A61K31/7115 , A61K39/0011 , C12N15/115 , C12N15/117 , C12N2310/16 , C12N2310/17 , C12N2310/31 , C12N2310/33 , C12N2310/335 , C12N2310/531 , C12N2320/31 , C12N2320/32 , C12N2310/322 , C12N2310/3533
Abstract: Methods of inhibiting the growth of cells or inducing cell death by contacting the cells with or introducing into the cells a composition including a 5′ triphosphate, 2′ fluoro-modified pyrimidine non-linear single stranded RNA at least 17 nucleotides long with a least 3 base pairings or a 5′ triphosphate, 2′ fluoro-modified double stranded RNA at least 17 base pairs long in an amount effective to inhibit cell growth, induce cell death or induce cytokine production by the cells. The methods also include administration of the compositions to a subject. The subject may have a proliferative disorder or infectious disease and administration of the compositions provided herein may treat the disorder or disease.
Abstract translation: 通过使细胞与细胞接触或引入细胞来抑制细胞生长或诱导细胞死亡的方法包括至少17个核苷酸长的5'三磷酸，2'氟修饰的嘧啶非线性单链RNA的组合物，具有至少3个 碱基配对或5'三磷酸，2'氟修饰的双链RNA，至少17碱基对长，有效抑制细胞生长，诱导细胞死亡或诱导细胞产生细胞因子。 所述方法还包括将组合物给予受试者。 受试者可能具有增殖性疾病或感染性疾病，并且本文提供的组合物的施用可以治疗疾病或疾病。
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公开(公告)号：US20240150772A1
公开(公告)日：2024-05-09
申请号：US18205390
申请日：2023-06-02
Applicant: Duke University
Inventor： Bruce A. Sullenger , Michael Goldstein , Elizabeth D. Pratico , Michael Kastan , Bethany Gray
IPC: C12N15/115 , A61P35/00
CPC classification number: C12N15/115 , A61P35/00 , C12N2310/16
Abstract: Provided herein are compositions including aptamers capable of binding to and/or inhibiting the activity of nucleolin. Methods of treating cancer in a subject by administering such compositions are also provided.
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公开(公告)号：US20230330271A1
公开(公告)日：2023-10-19
申请号：US18086378
申请日：2022-12-21
Applicant: Duke University
Inventor： Bruce A. Sullenger , Kady-Ann C. Steen-Burrell , Bethany Powell Gray
IPC: A61K49/00 , C07H21/02 , C12N15/115
CPC classification number: A61K49/0002 , A61K49/0021 , A61K49/0032 , A61K49/0054 , C07H21/02 , C12N15/115 , C12N2310/113 , C12N2310/16 , C12N2310/317 , C12N2310/3517
Abstract: Provided herein are imaging agents, antidotes to the imaging agents and methods of using the same to image a thrombus or blood clot or thrombin including sites of thrombin accumulation and to diagnose and treat thrombosis. The imaging agents include an aptamer capable of binding the thrombus or thrombin in particular linked to a reporter moiety. The imaging agents may be used to label the thrombus or sites of thrombin accumulation. Antidotes capable of binding to the aptamer in the imaging agent are also provided. The antidotes may further be linked to a quencher capable of quenching the reporter moiety.
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公开(公告)号：US20190136416A1
公开(公告)日：2019-05-09
申请号：US16120988
申请日：2018-09-04
Applicant: DUKE UNIVERSITY
Inventor： Bruce A. Sullenger , Hemraj A. Juwarker , Kam W. Leong , Jennifer Gamboa Jackman
IPC: D01F6/22 , A61L27/54 , A61L15/24 , A61L15/44 , A61L27/16 , D06M15/61 , D06M15/00 , D06M15/59 , D01F6/42 , D01F6/36 , D01D5/00
CPC classification number: D01F6/22 , A61L15/24 , A61L15/44 , A61L15/46 , A61L27/16 , A61L27/54 , A61L2300/404 , A61L2300/41 , A61L2400/12 , B29C48/88 , D01D5/003 , D01F6/36 , D01F6/42 , D06M14/10 , D06M15/00 , D06M15/285 , D06M15/59 , D06M15/61 , D06M2101/20 , D06M2101/26 , D06M2400/01 , D10B2509/022
Abstract: Methods of making polycationic nanofibers by grafting cationic polymers onto electrospun neutral nanofibers and polycationic nanofibers produced by the methods are provided herein. In addition, methods of using the polycationic nanofibers to reduce inflammation, to adsorb anionic compounds such as heparin or nucleic acids, to inhibit the growth of microbes or inhibit the formation of a biofilm are also provided. The polycationic nanofibers may be in a mesh and may be included in a medical device, wound dressing, bandage, or as part of a graft.
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Patent Agency Ranking
公开(公告)号：US20180318454A1
公开(公告)日：2018-11-08
申请号：US15773765
申请日：2016-11-04
Applicant: Duke University
Inventor： Bruce A. Sullenger , Hemraj Juwarker , Angelo Moreno , Nelson Chao , Eda Holl
CPC classification number: A61K49/0054 , A61K31/195 , A61K31/785 , A61K47/60 , A61K49/0021 , A61K49/0052 , A61K2123/00 , A61P31/00 , A61P37/00 , A61P43/00 , G01N33/52
Abstract: Disclosed herein are polycationic polymers and methods of using the same. The polycationic polymer comprises a dendrimer or dendron, the dendrimer or the dendron comprising a focal point, a plurality of cationic termini, and a branched cationic polymer between the focal point and the plurality of cationic termini. Also disclosed polycationic polymers further comprising a detectable label; and a crosslinker, wherein the crosslinker links the detectable label and the focal point of the dendron. The resulting conjugated polycationic polymers may be used in tracking methods of methods of treating disease. Methods of using polycationic polymers to treat autoimmune diseases, infectious diseases and acute radiation syndrome are also disclosed.
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公开(公告)号：US20180318337A1
公开(公告)日：2018-11-08
申请号：US15773933
申请日：2016-11-04
Applicant: Duke University
Inventor： Bruce A. Sullenger , Ibtehaj Naqvi , Ruwan Gunaratne , Rebekah White
IPC: A61K31/785 , A61K9/00 , A61P35/04 , C12Q1/6886
CPC classification number: A61K31/785 , A61K9/0012 , A61K31/724 , A61K31/80 , A61P35/04 , C08L57/12 , C08L2203/02 , C12Q1/68 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178
Abstract: Methods of treating cancer in a subject by administering a therapeutically effective amount of a polycationic polymer to the subject are provided. Methods of treating cancer in a subject by contacting a bodily fluid from a subject with a polycationic polymer are also provided. Methods of detecting cancer or metastasis of cancer by obtaining a sample from a subject and determining the level of circulating free DNA (cfDNA), cfRNA, inorganic polyphosphates or the number of exosomes or nucleosomes in the sample are also provided.
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公开(公告)号：US09970014B2
公开(公告)日：2018-05-15
申请号：US15620143
申请日：2017-06-12
Applicant: Duke University
Inventor： Erin Soule , Bruce A. Sullenger
IPC: C07H21/02 , C07H21/04 , C12N15/115 , C12N15/113 , C12N5/00
CPC classification number: C12N15/115 , C12N15/113 , C12N2310/113 , C12N2310/16 , C12N2310/321 , C12N2310/322 , C12N2310/3517 , C12N2310/3521 , C12N2310/3533 , C12N2310/531 , C12N2320/30 , C12N2320/50
Abstract: Provided herein are Factor V/Factor Va-targeting aptamer compositions and antidote compositions targeting such aptamer compositions. Methods for preventing blood clots using such compositions are also provided.
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公开(公告)号：US20170355992A1
公开(公告)日：2017-12-14
申请号：US15620143
申请日：2017-06-12
Applicant: Duke University
Inventor： Erin Soule , Bruce A. Sullenger
IPC: C12N15/115 , C12N15/113
CPC classification number: C12N15/115 , C12N15/113 , C12N2310/113 , C12N2310/16 , C12N2310/321 , C12N2310/322 , C12N2310/3517 , C12N2310/3521 , C12N2310/3533 , C12N2310/531 , C12N2320/30 , C12N2320/50
Abstract: Provided herein are Factor V/Factor Va-targeting aptamer compositions and antidote compositions targeting such aptamer compositions. Methods for preventing blood clots using such compositions are also provided.
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30.发明申请公开(公告)号：US20170037544A1
公开(公告)日：2017-02-09
申请号：US15304416
申请日：2015-04-16
Applicant: DUKE UNIVERSITY
Inventor： Bruce A. Sullenger , Hemraj A. Juwarker , Kam W. Leong , Jennifer M. Gamboa Jackman
CPC classification number: D01F6/22 , A61L15/24 , A61L15/44 , A61L27/16 , A61L27/54 , B29C47/88 , D01D5/003 , D01F6/36 , D01F6/42 , D06M15/00 , D06M15/59 , D06M15/61 , D06M2101/26 , D10B2509/022
Abstract: Methods of making polycationic nanofibers by grafting cationic polymers onto electrospun neutral nanofibers and polycationic nanofibers produced by the methods are provided herein. In addition, methods of using the polycationic nanofibers to reduce inflammation, to adsorb anionic compounds such as heparin or nucleic acids, to inhibit the growth of microbes or inhibit the formation of a biofilm are also provided. The polycationic nanofibers may be in a mesh and may be included in a medical device, wound dressing, bandage, or as part of a graft.
Abstract translation: 本文提供了通过将阳离子聚合物接枝到通过该方法生产的电纺中性纳米纤维和聚阳离子纳米纤维上制备聚阳离子纳米纤维的方法。 此外，还提供了使用聚阳离子纳米纤维减少炎症，吸附阴离子化合物如肝素或核酸以抑制微生物生长或抑制生物膜形成的方法。 聚阳离子纳米纤维可以是网状物，并且可以包括在医疗装置，伤口敷料，绷带中或作为移植物的一部分。
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