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21.发明申请BINDING INTERACTION OF PROANTHOCYANIDINS WITH BACTERIA AND BACTERIAL COMPONENTS 有权环孢菌素与细菌和细菌成分的结合相互作用公开(公告)号：US20080176933A1
公开(公告)日：2008-07-24
申请号：US11832852
申请日：2007-08-02
IPC分类号： A61K31/353 , A61P37/00
CPC分类号： A61K31/353 , A61K47/55 , A61K47/552 , C07D311/62 , C07H1/00 , C07H21/04 , G01N33/56911 , G01N2333/415 , G01N2400/50
摘要： A composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6. A method of administering to an immunosuppressed patient or a patient diagnosed with sepsis or septic shock a composition having a proanthocyanidin. A method of administering to a patient diagnosed with a gram negative bacterial infection a composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6.
摘要翻译： 具有至少约6的平均聚合度的原花青素化合物的组合物。向免疫抑制患者或诊断为败血症或败血性休克的患者施用具有原花色素的组合物的方法。 向诊断为革兰氏阴性细菌感染的患者施用具有平均聚合度至少约6的原花青素化合物的组合物的方法。
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22.发明申请APPLICATIONS OF THE BINDING INTERACTION OF PROANTHOCYANIDINS WITH BACTERIA AND BACTERIAL COMPONENTS 失效环丙沙星与细菌和细菌成分的结合相互作用的应用公开(公告)号：US20080064050A1
公开(公告)日：2008-03-13
申请号：US11832834
申请日：2007-08-02
IPC分类号： G01N33/554 , C07C53/00 , C07D311/00 , C07H1/00 , C07H21/04 , C07K14/00 , C12M1/00 , C12N7/00
CPC分类号： A61K31/353 , A61K47/55 , A61K47/552 , C07D311/62 , C07H1/00 , C07H21/04 , G01N33/56911 , G01N2333/415 , G01N2400/50
摘要： A composition having: a proanthocyanidin; and a macromolecule, an assembly of macromolecules, a semi-solid, or a solid surface to which the proanthocyanidini is immobilized.
摘要翻译： 具有：原花色素的组合物 和大分子，大分子，半固体或固体表面的组装，其中原花青素被固定到其上。
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公开(公告)号：US20150343691A1
公开(公告)日：2015-12-03
申请号：US14824635
申请日：2015-08-12
CPC分类号： B29C47/065 , B01L3/5027 , B01L3/502746 , B01L3/502776 , B01L2400/0487 , B01L2400/084 , B29C47/0014 , B29C47/0816 , B29C47/30 , G02B6/032 , Y10T29/49 , Y10T137/0318 , Y10T137/0324 , Y10T137/0329 , Y10T137/0335
摘要： A sheath flow system having a channel with at least one fluid transporting structure located in the top and bottom surfaces situated so as to transport the sheath fluid laterally across the channel to provide sheath fluid fully surrounding the core solution. At the point of introduction into the channel, the sheath fluid and core solutions flow side by side within the channel or the core solution may be bounded on either side by the sheath fluid. The system is functional over a broad channel size range and with liquids of high or low viscosity. The design can be readily incorporated into microfluidic chips without the need for special manufacturing protocols. Uses include extruding materials and/or fabricating structures.
摘要翻译： 鞘流系统具有通道，其具有位于顶表面和底表面中的至少一个流体输送结构，所述流体输送结构位于所述顶表面和底表面中，以便将护套流体横向流过通道以提供完全围绕芯溶液的护套流体。 在引入通道时，鞘液和芯溶液在通道内并排流动，或者芯溶液可以通过护套液两侧界定。 该系统在宽通道尺寸范围内以及具有高或低粘度液体的功能。 该设计可以容易地并入到微流控芯片中，而不需要特殊的制造协议。 用途包括挤压材料和/或制造结构。
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公开(公告)号：US20150328636A1
公开(公告)日：2015-11-19
申请号：US14789440
申请日：2015-07-01
CPC分类号： C12N5/0697 , A61F2240/001 , B01J19/0093 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0093 , B01J2219/00936 , B01L3/502707 , B01L3/502746 , B01L3/502776 , B01L2200/0636 , B01L2200/10 , B01L2200/12 , B01L2300/0838 , B01L2300/0887 , B01L2300/12 , B01L2300/16 , B01L2400/0487 , B01L2400/084 , B29D99/0078 , B29K2995/0056 , B29K2995/006 , B29L2009/00 , B29L2023/00 , C12M21/08 , C12M25/10 , C12M25/12 , C12M25/14 , C12N5/0602 , G02B6/032 , G02B2006/0325
摘要： A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
摘要翻译： 纤维包括围绕中心腔的一层或多层聚合物，以及设置在内腔内和/或在一层或多层中的至少一层内的活动动物细胞，其中纤维的外径为5至8000微米， 其中每个单独的聚合物层具有0.1至250微米的厚度。 还公开了包括这种纤维的模型组织，以及制造这种纤维的方法。 纤维可以用作合成血管，导管或神经。
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公开(公告)号：US20150322408A1
公开(公告)日：2015-11-12
申请号：US14789269
申请日：2015-07-01
IPC分类号： C12N5/071
CPC分类号： C12N5/0697 , A61F2240/001 , B01J19/0093 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0093 , B01J2219/00936 , B01L3/502707 , B01L3/502746 , B01L3/502776 , B01L2200/0636 , B01L2200/10 , B01L2200/12 , B01L2300/0838 , B01L2300/0887 , B01L2300/12 , B01L2300/16 , B01L2400/0487 , B01L2400/084 , B29D99/0078 , B29K2995/0056 , B29K2995/006 , B29L2009/00 , B29L2023/00 , C12M21/08 , C12M25/10 , C12M25/12 , C12M25/14 , C12N5/0602 , G02B6/032 , G02B2006/0325
摘要： A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
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公开(公告)号：US20090011430A1
公开(公告)日：2009-01-08
申请号：US12118028
申请日：2008-05-09
CPC分类号： G01N27/3276
摘要： A device having: a laminar flow channel for liquids; two or more electrodes; a confining fluid inlet; a sample inlet; and a meter for measuring the impedance of any fluid between the electrodes. The device may have one or more specific binding sites, or it may have sheathing and unsheathing fluid transporting structures. A method of: providing the device; flowing a confining fluid and a conductive liquid that may contain cells or particles through the channel as described herein; and measuring the impedance between the electrodes.
摘要翻译： 一种具有：用于液体的层流通道的装置; 两个或多个电极; 限流流体入口; 样品入口 以及用于测量电极之间的任何流体的阻抗的仪表。 该装置可以具有一个或多个特异性结合位点，或者其可以具有护套和未固化的流体输送结构。 一种提供装置的方法; 使包含细胞或颗粒的限制流体和导电液体流过本文所述的通道; 并测量电极之间的阻抗。
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27.发明授权Method for surface modification to create regions resistant to adsorption of biomolecules 失效用于表面改性以产生耐吸附生物分子的区域的方法
公开(公告)号：US5965305A
公开(公告)日：1999-10-12
申请号：US367888
申请日：1995-01-03
申请人： Frances S. Ligler , Suresh Bhatia , Lisa C. Shriver-Lake , Jacque Georger , Jeff Calvert , Charles Dulcey
发明人： Frances S. Ligler , Suresh Bhatia , Lisa C. Shriver-Lake , Jacque Georger , Jeff Calvert , Charles Dulcey
IPC分类号： C12N5/00 , C12N11/06 , C12N11/14 , C40B60/14 , G03F7/00 , G03F7/004 , G03F7/24 , G06N3/00 , G03C3/00
CPC分类号： C12N5/0068 , B82Y10/00 , B82Y30/00 , B82Y40/00 , B82Y5/00 , C12N11/06 , C12N11/14 , G03F7/00 , G03F7/004 , G03F7/24 , G06N3/002 , B01J2219/00432 , B01J2219/00603 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00659 , B01J2219/00711 , C12N2535/10 , C40B60/14 , Y10S430/128 , Y10S436/905
摘要： Irradiating, with ultraviolet light, surfaces which contain thiol groups, epoxy groups, or vicinal diol groups, results in surfaces which exhibit a reduced adsorption of biomolecules. In the case of surfaces having thiol groups such irradiation also results in a reduced capacity for the bonding of heterobifunctional crosslinking reagents. Such irradiation may be carried out in a patternwise fashion to obtain patterned surfaces.
摘要翻译： 用紫外线照射含有硫醇基团，环氧基团或连二醇基团的表面，导致表现出生物分子吸附减少的表面。 在具有硫醇基的表面的情况下，这种照射也导致异双功能交联试剂的结合的能力降低。 这种照射可以以图案方式进行以获得图案化表面。
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公开(公告)号：USH1775H
公开(公告)日：1999-01-05
申请号：US422103
申请日：1995-04-14
IPC分类号： G01N33/569 , G01N33/554
CPC分类号： G01N33/569 , G01N2400/50
摘要： The presently claimed invention is an apparatus and method for the detection of endotoxin via a competitive assay.
摘要翻译： 本发明是通过竞争性测定法检测内毒素的装置和方法。
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公开(公告)号：US5354654A
公开(公告)日：1994-10-11
申请号：US92518
申请日：1993-07-16
申请人： Frances S. Ligler , James P. Whelan
发明人： Frances S. Ligler , James P. Whelan
IPC分类号： G01N33/532 , G01N33/536 , G01N33/58 , G01N33/543 , G01N33/566 , G01N33/569
CPC分类号： G01N33/532 , G01N33/536 , G01N33/58 , Y10S435/963
摘要： A dry reagent prepared by lyophilizing a labelled ligand-immobilized receptor complex or a labelled receptor-immobilized ligand complex is, on rehydration, useful for detecting analytes in samples in a variety of displacement assays.
摘要翻译： 通过冻结标记的配位体固定化受体复合物或标记的受体固定的配体复合物制备的干试剂在再水化时可用于在各种置换测定中检测样品中的分析物。
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公开(公告)号：US09573311B2
公开(公告)日：2017-02-21
申请号：US13728651
申请日：2012-12-27
CPC分类号： B29C47/065 , B01L3/5027 , B01L3/502746 , B01L3/502776 , B01L2400/0487 , B01L2400/084 , B29C47/0014 , B29C47/0816 , B29C47/30 , G02B6/032 , Y10T29/49 , Y10T137/0318 , Y10T137/0324 , Y10T137/0329 , Y10T137/0335
摘要： A sheath flow system having a channel with first and second fluid transporting structures located on opposing surfaces facing one another across the channel in the top and bottom surfaces of the channel situated so as to transport the sheath fluid laterally across the channel to provide sheath fluid fully surrounding the core solution. At the point of introduction into the channel, the sheath fluid and core solutions flow side by side within the channel or the core solution may be bounded on either side by the sheath fluid. The system is functional over a broad channel size range and with liquids of high or low viscosity. The design can be readily incorporated into microfluidic chips without the need for special manufacturing protocols.
摘要翻译： 一种护套流动系统，其具有通道，该第一和第二流体输送结构位于相对的表面上，所述第一和第二流体输送结构跨过所述通道的顶表面和底表面中的通道相互面对，以便将护套流体横向跨过通道输送以提供鞘液 围绕核心解决方案。 在引入通道时，鞘液和芯溶液在通道内并排流动，或者芯溶液可以通过护套液两侧界定。 该系统在宽通道尺寸范围内以及具有高或低粘度液体的功能。 该设计可以容易地并入到微流控芯片中，而不需要特殊的制造协议。
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