公开(公告)号：US20120107645A1

公开(公告)日：2012-05-03

申请号：US13339310

申请日：2011-12-28

申请人： Yi Zheng ,  Yimin Hsu ,  Wen-Chien David Hsiao ,  Ming Jiang ,  Aron Pentek ,  Sue Siyang Zhang ,  Edward Hin Pong Lee ,  Hung-Chin Guthrie ,  Ning Shi ,  Vladimir Nikitin ,  Prabodh Ratnaparkhi ,  Yinshi Liu

发明人： Yi Zheng ,  Yimin Hsu ,  Wen-Chien David Hsiao ,  Ming Jiang ,  Aron Pentek ,  Sue Siyang Zhang ,  Edward Hin Pong Lee ,  Hung-Chin Guthrie ,  Ning Shi ,  Vladimir Nikitin ,  Prabodh Ratnaparkhi ,  Yinshi Liu

IPC分类号： G11B5/33 ,  G11B5/127

CPC分类号： G11B5/3166 ,  G11B5/112 ,  G11B5/1278 ,  G11B5/3116 ,  G11B5/3146 ,  Y10T29/49043 ,  Y10T29/49044 ,  Y10T29/49046 ,  Y10T29/49048 ,  Y10T29/49052 ,  Y10T428/11 ,  Y10T428/1186

摘要： A method for manufacturing a magnetic write head for perpendicular magnetic recording. The method includes forming a write pole, and then depositing a refill layer. A mask structure can be formed over the writ pole and refill layer, the mask structure being configured to define a stitched pole. An ion milling or reactive ion milling can then be performed to remove portions of the refill layer that are not protected by the mask structure. Then a magnetic material can be deposited to form a stitched write pole that defines a secondary flare point. The stitched pole can also be self aligned with an electrical lapping guide in order to accurately locate the front edge of the secondary flare point relative to the air bearing surface of the write head.

摘要翻译： 一种用于制造用于垂直磁记录的磁写头的方法。 该方法包括形成写极，然后沉积补充层。 掩模结构可以形成在写极和再填充层上，掩模结构被配置为限定缝合极。 然后可以执行离子铣或反应离子研磨以去除未被掩模结构保护的部分填充层。 然后可以沉积磁性材料以形成限定二次闪光点的缝合写入极。 缝合的杆也可以与电动研磨引导件自对准，以便相对于写入头的空气轴承表面精确地定位二次扩张点的前边缘。

公开(公告)号：US08136228B2

公开(公告)日：2012-03-20

申请号：US12343713

申请日：2008-12-24

申请人： Aron Pentek ,  Sue Siyang Zhang ,  Yi Zheng

发明人： Aron Pentek ,  Sue Siyang Zhang ,  Yi Zheng

IPC分类号： G11B5/127 ,  H04R31/00

CPC分类号： G11B5/3163 ,  G11B5/112 ,  G11B5/1278 ,  G11B5/3116 ,  G11B5/3146 ,  G11B5/315 ,  Y10T29/49032 ,  Y10T29/49039 ,  Y10T29/49043 ,  Y10T29/49044 ,  Y10T29/49046 ,  Y10T29/49048 ,  Y10T29/49052

摘要： A method for manufacturing a magnetic write head that avoids the challenges associated with the formation of fence structures during write pole definition. A magnetic write pole material is deposited. A mask structure is deposited over the magnetic write pole material. The mask structure includes a first hard mask, a marker layer, a physically robust, inorganic RIEable image transfer layer, a second hard mask structure over the image transfer layer and a photoresist layer over the second hard mask. A reactive ion etching process can be used to transfer the image of the photoresist mask and second hard mask layer onto the image transfer layer. An ion milling is performed to define the write pole. A layer of non-magnetic material such as alumina is deposited. An ion milling is performed until the marker layer has been reached, and another reactive ion etching is performed to remove the remaining hard mask.

摘要翻译： 一种用于制造写磁头的磁头的方法，其避免了写磁极定义期间与栅栏结构的形成有关的挑战。 沉积磁性写入极材料。 掩模结构沉积在磁性写入极材料上。 掩模结构包括第一硬掩模，标记层，物理上坚固的无机RIEable图像转印层，图像转印层上方的第二硬掩模结构和在第二硬掩模上的光致抗蚀剂层。 可以使用反应离子蚀刻工艺将光致抗蚀剂掩模和第二硬掩模层的图像转印到图像转印层上。 执行离子铣削以限定写入极。 沉积一层非磁性材料如氧化铝。 进行离子研磨直到达到标记层，并执行另一反应离子蚀刻以除去剩余的硬掩模。

公开(公告)号：US20110319756A1

公开(公告)日：2011-12-29

申请号：US13254227

申请日：2010-03-09

申请人： Yi Zheng ,  Aiping Yao ,  James F. Greenleaf ,  Shigao Chen ,  Matthew W. Urban

发明人： Yi Zheng ,  Aiping Yao ,  James F. Greenleaf ,  Shigao Chen ,  Matthew W. Urban

IPC分类号： A61B8/00

CPC分类号： G01S7/52036 ,  A61B8/485 ,  G01S7/52022 ,  G01S15/8952

摘要： A method for measuring a mechanical property of a subject includes using an ultrasound transducer to apply ultrasonic vibration pulses to a location in a subject in order to induce shear waves at multiple prescribed orthogonal frequencies in the subject. The ultrasound transducer is directed by an excitation signal that is composed of multiple orthogonal basis functions, each having a given frequency component corresponding to the prescribed orthogonal frequencies. The power level of each orthogonal basis function is independently adjustable. The excitation signal can be sparsely sampled, or portions of the excitation signal can be removed in order to improve tissue vibration and to provide for the interleaving ultrasonic vibration and detection pulses. Ultrasonic detection pulses are applied to at least one motion detection point, from which echo signals are received. From the received echo signals, a motion signal is determined, from which mechanical properties of the subject are calculated.

摘要翻译： 用于测量受试者的机械性质的方法包括使用超声波换能器将超声波振动脉冲施加到受试者中的位置，以便在受试者中以多个规定的正交频率诱发剪切波。 超声换能器由多个正交基函数组成的激励信号引导，每个正交基函数具有对应于规定正交频率的给定频率分量。 每个正交基函数的功率电平是独立可调的。 励磁信号可以被稀疏地采样，或者可以去除激励信号的部分，以便改善组织振动并提供交织超声波振动和检测脉冲。 超声波检测脉冲被施加到至少一个运动检测点，从该运动检测点接收回波信号。 从所接收的回波信号中，确定运动信号，从而计算被摄体的机械性质。

公开(公告)号：US20110261485A1

公开(公告)日：2011-10-27

申请号：US12766764

申请日：2010-04-23

申请人： Aron Pentek ,  Yi Zheng

发明人： Aron Pentek ,  Yi Zheng

IPC分类号： G11B5/187

CPC分类号： G11B5/3116 ,  G11B5/1278 ,  G11B5/23 ,  G11B5/3146 ,  G11B5/315 ,  G11B5/3163

摘要： A magnetic write head having a magnetic write pole with a wrap around magnetic trailing shield. The wrap around magnetic trailing shield is separated by a first non-magnetic side gap at a first side of the write pole and by a second non-magnetic side gap at a second side of the write pole. The first second non-magnetic side gap is larger than the first non-magnetic side gap and is preferably at least twice the thickness of the first non-magnetic side gap. This design provides additional protection adjacent track interference at one side of the write pole and additional protection against magnetic write field loss at the other side of the write pole.

摘要翻译： 一种具有磁性写磁极的磁性写头，其具有围绕磁性后屏蔽的环绕。 绕磁屏蔽的缠绕由写磁极的第一侧的第一非磁性侧隙和写极的第二侧的第二非磁性侧间隙分开。 第一第二非磁性侧间隙大于第一非磁性侧间隙，优选为第一非磁性侧间隙的厚度的至少两倍。 该设计提供了额外的保护，在写入极的一侧附近有跟踪干扰，并且在写入极的另一侧具有额外的防磁磁场损耗的保护。

公开(公告)号：US20110212898A1

公开(公告)日：2011-09-01

申请号：US13036964

申请日：2011-02-28

申请人： Yi Zheng ,  David A. Williams

发明人： Yi Zheng ,  David A. Williams

IPC分类号： A61K38/02 ,  C12N9/00 ,  C12N9/14 ,  C07K19/00 ,  A61P35/00

CPC分类号： C07K14/4706 ,  C07K2319/01 ,  C07K2319/02 ,  C07K2319/03 ,  C12N9/14 ,  C12Y306/05002

摘要： Chimeric peptides or fusion proteins are disclosed that include a RhoGAP activity domain and at least one specificity domain that targets a specific Rho protein. The fusion proteins can be used to inhibit any GTPase activity within a cell. The fusion proteins are particularly advantageous for the treatment of cancer. The present invention generally relates to chimeric peptides capable of regulating GTPases, and more particularly, to methods of targeting individual GTPases by using GTPase-activating proteins. Such proteins may be used for the treatment of cancers and other GTPase-related diseases. This invention relates to nucleic acid molecules and the encoded GTPase activating proteins, and variants thereof, and to the use of these molecules in the characterization, diagnosis, prevention, and treatment of cell signaling, immune, and cell proliferative disorders, particularly cancer. Disclosed herein are compounds and methods for regulating transcription of a selected gene.

摘要翻译： 公开了嵌合肽或融合蛋白，其包括RhoGAP活性结构域和至少一个靶向特异性Rho蛋白的特异性结构域。 融合蛋白可用于抑制细胞内的任何GTP酶活性。 融合蛋白对癌症的治疗特别有利。 本发明一般涉及能够调节GTP酶的嵌合肽，更具体地，涉及通过使用GTP酶活化蛋白靶向各种GTP酶的方法。 这些蛋白质可用于治疗癌症和其它与GTP酶有关的疾病。 本发明涉及核酸分子和编码的GTP酶活化蛋白及其变体，以及这些分子在表征，诊断，预防和治疗细胞信号传导，免疫和细胞增殖性疾病，特别是癌症中的用途。 本文公开了用于调节所选基因转录的化合物和方法。

公开(公告)号：US20110151676A1

公开(公告)日：2011-06-23

申请号：US13039724

申请日：2011-03-03

申请人： Nitin K. Ingle ,  Jing Tang ,  Yi Zheng ,  Zheng Yuan ,  Zhenbin Ge ,  Xinliang Lu ,  Chien-Teh Kao ,  Vikash Banthia ,  William H. McClintock ,  Mei Chang

发明人： Nitin K. Ingle ,  Jing Tang ,  Yi Zheng ,  Zheng Yuan ,  Zhenbin Ge ,  Xinliang Lu ,  Chien-Teh Kao ,  Vikash Banthia ,  William H. McClintock ,  Mei Chang

IPC分类号： H01L21/31

CPC分类号： H01L21/67253 ,  H01L21/02164 ,  H01L21/0217 ,  H01L21/3105 ,  H01L21/31116 ,  H01L21/76232

摘要： A method for forming a semiconductor structure includes forming a plurality of features across a surface of a substrate, with at least one space being between two adjacent features. A first dielectric layer is formed on the features and within the at least one space. A portion of the first dielectric layer interacts with a reactant derived from a first precursor and a second precursor to form a first solid product. The first solid product is decomposed to substantially remove the portion of the first dielectric layer. A second dielectric layer is formed to substantially fill the at least one space.

摘要翻译： 一种用于形成半导体结构的方法包括跨越衬底的表面形成多个特征，其中至少一个空间位于两个相邻特征之间。 第一电介质层形成在特征上并且在至少一个空间内。 第一介电层的一部分与衍生自第一前体和第二前体的反应物相互作用以形成第一固体产物。 第一固体产物被分解以基本上除去第一介电层的部分。 形成第二电介质层以基本上填充至少一个空间。

公开(公告)号：US20110135962A1

公开(公告)日：2011-06-09

申请号：US12634480

申请日：2009-12-09

申请人： LIUBO HONG ,  Aron Pentek ,  Yi Zheng

发明人： LIUBO HONG ,  Aron Pentek ,  Yi Zheng

IPC分类号： G11B5/33

CPC分类号： G11B5/1278 ,  G11B5/23 ,  G11B5/3116 ,  G11B5/315 ,  G11B5/3163 ,  Y10T428/1171

摘要： Methods for fabrication of tapered magnetic poles with a non-magnetic front bump layer. A magnetic pole may have a tapered surface at or near and air bearing surface (ABS), wherein a thickness of the write pole increases in a direction away from the ABS. A non-magnetic front bump layer may be formed on the tapered surface of the magnetic pole and away from the ABS. The front bump layer may increase the separation distance between a shield layer and the magnetic pole near the tapered surface, thereby improving the performance of the write head.

摘要翻译： 用非磁性前凸块层制造锥形磁极的方法。 磁极可以在空气轴承表面（ABS）处或附近具有锥形表面，其中写入极的厚度在远离ABS的方向上增加。 可以在磁极的锥形表面上远离ABS形成非磁性前凸块层。 前凸块层可以增加在锥形表面附近的屏蔽层和磁极之间的间隔距离，从而提高写入头的性能。

公开(公告)号：US20110120878A1

公开(公告)日：2011-05-26

申请号：US12623206

申请日：2009-11-20

申请人： Liubo Hong ,  Wen-Chien D. Hsiao ,  Yimin Hsu ,  Yi Zheng

发明人： Liubo Hong ,  Wen-Chien D. Hsiao ,  Yimin Hsu ,  Yi Zheng

IPC分类号： C23C14/34 ,  C25D5/34

CPC分类号： G11B5/1278 ,  G11B5/3116 ,  G11B5/3143 ,  G11B5/315 ,  G11B5/3163 ,  Y10T29/49048

摘要： A method for manufacturing a magnetic write head having a write pole and a trailing wrap around magnetic shield, and having a non-magnetic step layer and a non-magnetic bump to provide additional spacing between the write pole and the trailing wrap around shield at a location removed from the air bearing surface. A magnetic write pole material is deposited on a substrate and a non-magnetic step layer is deposited over the write pole. A reactive ion milling can he used to pattern the non-magnetic step layer to have a front edge that is located a desired distance from an air hearing surface. A patterning and ion milling process is then performed to define a write pole, and then a layer of alumina is deposited and ion milled to from a tapered, non-magnetic bump at the front the non-magnetic step layer.

摘要翻译： 一种用于制造磁性写入头的方法，该写入磁头在磁屏蔽周围具有写入磁极和尾部缠绕，并且具有非磁性阶跃层和非磁性凸起，以在写入磁极和屏蔽之间的后续缠绕在一个 位置从空气轴承表面移除。 磁性写入极材料沉积在衬底上，非磁性步骤层沉积在写入极上。 他可以使用反应离子研磨来对非磁性阶梯层进行图案化以具有位于距离空气听力表面所需距离的前边缘。 然后进行图形化和离子研磨处理以限定写入极，然后沉积氧化铝层，并从非磁性阶梯层前面的锥形非磁性凸块离子研磨。

公开(公告)号：US20110063950A1

公开(公告)日：2011-03-17

申请号：US12992228

申请日：2009-05-15

申请人： James F. Greenleaf ,  Shigao Chen ,  Yi Zheng ,  Aiping Yao

发明人： James F. Greenleaf ,  Shigao Chen ,  Yi Zheng ,  Aiping Yao

IPC分类号： G01S15/88

CPC分类号： A61B8/485 ,  G01S7/52038

摘要： A method for measuring a mechanical property of a subject includes using an ultrasonic transducer to apply ultrasonic vibration pulses to a vibration origin in the subject in an on-off time sequence in order to impart a harmonic motion at a prescribed frequency to the subject, and when the vibration pulses are off, preferably using the same transducer to apply ultrasonic detection pulses to a motion detection point and to receive echo signals therefrom in order to sense the harmonic motion on the subject at the motion detection point The ultrasonic detection pulses are interspersed with the vibration pulses and can be applied in a non-uniform manner From the received ultrasonic echo signals, a harmonic signal is detected and a characteristic such as amplitude or phase of the detected harmonic signal is calculated using a Kalman filter or interpolation.

摘要翻译： 用于测量受试者的机械性质的方法包括使用超声波换能器以开关时间顺序将超声波振动脉冲施加到被检体中的振动起点，以向受检者施加规定频率的谐波运动，以及 当振动脉冲关闭时，优选地使用相同的换能器将超声波检测脉冲施加到运动检测点并从其接收回波信号，以便感测在运动检测点处的对象上的谐波运动。超声波检测脉冲分布在 可以以不均匀的方式施加振动脉冲从接收到的超声波回波信号中，检测出谐波信号，并且使用卡尔曼滤波器或内插来计算检测到的谐波信号的振幅或相位的特性。

公开(公告)号：US07826982B2

公开(公告)日：2010-11-02

申请号：US11496959

申请日：2006-07-31

申请人： Yi Zheng ,  Nicolas Nassar ,  Karlheinz R. Skowronek

发明人： Yi Zheng ,  Nicolas Nassar ,  Karlheinz R. Skowronek

IPC分类号： G01N31/00 ,  G06G7/58

CPC分类号： C12N9/16 ,  A61K31/506 ,  C07K2299/00 ,  Y02A90/26

摘要： The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools.

摘要翻译： 优选的实施方案通常涉及影响Rho家族GTP酶，优选Rac（Rac1，Rac2和/或Rac3）成员的GTP-结合活性的方法和组合物，所述组合物包括调节GTP / GDP交换活性的化合物 用于化合物的用途，包括筛选识别Rac GTP酶的化合物，以及治疗与Rho家族GTP酶（包括Rac）相关或相关的病理状况的方法。 优选实施方案还涉及使用这些化合物或其衍生物的方法，例如在治疗学，诊断学和研究工具中。