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    Method of increasing the molecular weight in the manufacture of polysuccinimide
    22.
    发明授权
    Method of increasing the molecular weight in the manufacture of polysuccinimide 失效
    在多糖制剂中增加分子量的方法

    公开(公告)号：US5142062A

    公开(公告)日：1992-08-25

    申请号：US726337

    申请日：1991-07-05

    申请人： Joachim Knebel ,  Klaus Lehmann

    发明人： Joachim Knebel ,  Klaus Lehmann

    IPC分类号： C08G73/10

    CPC分类号： C08G73/1092

    摘要： A method of manufacturing polysuccinimides with molecular weights in the range 100,000 to about 200,000 by polycondensation of aspartic acid, with phosphoric acids as condensation agents, in at least two process stages, at temperatures of 100.degree.-250.degree. C. and under reduced pressure, where in the second stage the mixture containing aspartic acid and phosphoric acid undergoes subsequent condensation following comminution.

    摘要翻译： 通过天冬氨酸与磷酸作为缩合剂的缩聚制备分子量在100,000至约200,000范围内的聚琥珀酰亚胺的方法，在至少两个工艺步骤中，在100-250℃的温度和减压下， 在第二阶段中，含有天冬氨酸和磷酸的混合物在粉碎后经历随后的冷凝。

    Protective breathing aid device for diving or other operation under pressure
    23.
    发明授权
    Protective breathing aid device for diving or other operation under pressure 失效
    用于在压力下进行潜水或其他作业的防护呼吸辅助装置

    公开(公告)号：US4567889A

    公开(公告)日：1986-02-04

    申请号：US518355

    申请日：1983-07-29

    申请人： Klaus Lehmann

    发明人： Klaus Lehmann

    IPC分类号： A61M16/22 ,  A61M16/00 ,  A62B7/02 ,  A62B7/04 ,  A62B9/02 ,  A62B18/08 ,  A62B19/00 ,  B63C11/24

    CPC分类号： B63C11/24 ,  A61M16/00 ,  A62B18/08 ,  A62B19/00 ,  A62B7/02 ,  A61M16/0075

    摘要： A protective exhaling device of the circulating path type with exhaling protection, with its exhaling duct connected, in the circulating path through a CO.sub.2 absorber and a gas volume equalizing chamber containing a variable volume of gas, to an inhaling duct to which there is connected a reservoir of compressed gas supplying oxygen for breathing, has a cylinder and piston unit connected to the pressure bottle pressure or to an intermediate regulator pressure for pneumatically producing a force applied to the variable volume chamber. That assures that the force determining the overpressure level is always exerted at the same magnitude independently of the amplitude of the content of the equalizing chamber of variable volume. There is an automatic switchover from overpressure operation to normal underpressure operation in the case of a major leakage. For this purpose the cylinder and piston unit is provided with an outlet valve that opens when the piston goes beyond a predetermined stroke position, so that the overpressure diminishes through the piston and at the same time the supply of pressurized gas is blocked. Thus, in the case of major leakage there is no risk that the compressed gas supply will empty quickly without the user of the apparatus noticing it. After elimination of the leak overpressure can be reinstated manually or automatically. The equipment is suitable both for diving and for compressed air breathing protection equipment generally.

    摘要翻译： 具有排气保护的循环路径类型的保护性呼出装置，其排出管连接在通过CO 2吸收器的循环路径和容纳可变体积气体的气体容积平衡室中，连接到吸入管 为呼吸提供氧气的压缩气体储存器具有连接到压力瓶压力的气缸和活塞单元或用于气动地产生施加到可变容积室的力的中间调节器压力。 这确保了确定超压水平的力总是以与可变容积的均衡室的内容的振幅无关地以相同的大小施加。 在主要泄漏的情况下，超压运行到正常负压运行都有自动切换。 为此，气缸和活塞单元设置有当活塞超过预定行程位置时打开的出口阀，使得过压通过活塞减小，同时加压气体的供应被阻挡。 因此，在主要泄漏的情况下，没有设备使用者注意到压缩气体供应就不会有快速清空的风险。 消除泄漏超压后可手动或自动恢复。 该设备一般适用于潜水和压缩空气呼吸保护设备。

    Electric Heating Device for Heating Fluids
    25.
    发明申请
    Electric Heating Device for Heating Fluids 有权
    加热流体电加热装置

    公开(公告)号：US20140086566A1

    公开(公告)日：2014-03-27

    申请号：US13629252

    申请日：2012-09-27

    申请人： Ralph Waechter ,  Michael Stoerzinger ,  Bernd Halbrock ,  Alexander Dauth ,  Klaus Lehmann

    发明人： Ralph Waechter ,  Michael Stoerzinger ,  Bernd Halbrock ,  Alexander Dauth ,  Klaus Lehmann

    IPC分类号： F24H9/00

    CPC分类号： F24H9/0005 ,  B60H1/2221 ,  B60H2001/2278 ,  F24H1/009 ,  F24H1/102 ,  F24H9/0015 ,  H05B3/42 ,  H05B2203/021

    摘要： The invention relates to an electric heating device for heating fluids, comprising at least one heating rod, which has at least one heating element, a housing, which encloses the heating rod and has an inlet opening and an outlet opening, wherein the inlet opening and the outlet opening are interconnected by a winding flow channel. According to the invention, the flow channel forms a helix that has a longitudinal axis, wherein the heating rod is disposed next to the longitudinal axis of the helix and extends through a helically winding wall of the flow channel at a plurality of points.

    摘要翻译： 本发明涉及一种用于加热流体的电加热装置，其包括至少一个加热棒，该加热棒具有至少一个加热元件，壳体包围加热棒并具有入口和出口，其中入口开口和 出口开口通过缠绕流动通道相互连接。 根据本发明，流动通道形成具有纵向轴线的螺旋，其中加热棒设置在螺旋线的纵向轴线旁边，并且在多个点处延伸穿过流动通道的螺旋缠绕的壁。

    Acrylic enteric coating compositions
    26.
    发明授权
    Acrylic enteric coating compositions 有权
    丙烯酸肠溶组合物

    公开(公告)号：US06420473B1

    公开(公告)日：2002-07-16

    申请号：US09501866

    申请日：2000-02-10

    申请人： Ramireddy Chittamuru ,  George Reyes ,  Thomas P. Farrell ,  Charles F. Vesey ,  Dev K. Mehra ,  Hans-Ulrich Petereit ,  Klaus Lehmann

    发明人： Ramireddy Chittamuru ,  George Reyes ,  Thomas P. Farrell ,  Charles F. Vesey ,  Dev K. Mehra ,  Hans-Ulrich Petereit ,  Klaus Lehmann

    IPC分类号： C08J312

    CPC分类号： A61K9/2893 ,  A61K9/2813 ,  A61K9/2846 ,  A61K47/02

    摘要： A non-toxic, edible, enteric film coating, dry powder composition for use in making an aqueous enteric suspension which may be used in coating pharmaceutical tablets comprises a) an acrylic resin, said resin comprising i) from 20 to 85 percent by weight of at least one alkyl acrylate or alkyl methacrylate moiety, ii) from 80 to 15 percent by weight of at least one vinyl or vinylidene moiety having a carboxylic acid group capable of salt formation, and iii) from 0 to 30 percent by weight of at least one other vinyl or vinylidene moiety copolymerizable with i) and ii), b) an alkalizing agent capable of reacting with the acrylic resin such that, after reaction, 0.1 to 10 mole percent of the acidic groups in 1a-ii) are present in the salt form, and c) a detackifier.

    摘要翻译： 可用于制备可用于包衣药物片剂的水性肠溶悬浮液的无毒，可食用的肠溶薄膜包衣干粉组合物包括a）丙烯酸树脂，所述树脂包含i）20至85重量％ 至少一种丙烯酸烷基酯或甲基丙烯酸烷基酯部分，ii）80至15重量％的至少一个具有能够形成盐的羧酸基团的乙烯基或亚乙烯基部分，和iii）至少0至30重量％ 可与i）和ii）共聚的另一个乙烯基或亚乙烯基部分，b）能够与丙烯酸类树脂反应的碱化剂，使得反应后，1a-ii）中的0.1〜10摩尔％的酸性基团存在于 盐形式，和c）防粘剂。

    Method for making carrier systems for biologically active materials
    29.
    发明授权
    Method for making carrier systems for biologically active materials 失效
    制备生物活性物质载体体系的方法

    公开(公告)号：US5342646A

    公开(公告)日：1994-08-30

    申请号：US979425

    申请日：1992-11-19

    申请人： Wolfgang Kleese ,  Dieter Kraemer ,  Hans-Ulrich Petereit ,  Klaus Lehmann ,  Werner Siol

    发明人： Wolfgang Kleese ,  Dieter Kraemer ,  Hans-Ulrich Petereit ,  Klaus Lehmann ,  Werner Siol

    IPC分类号： C07K17/08 ,  C12N11/08 ,  G01N33/545 ,  B05D7/00 ,  A61K9/16 ,  B05D1/12

    CPC分类号： G01N33/545 ,  C07K17/08 ,  C12N11/08

    摘要： What is disclosed is a method for preparing carrier systems, adaptable to the covalent bonding thereto of biologically active materials, consisting of a known solid support material having a surface coated with a polymer containing functional groups suitable for covalent bonding, by coating the support material with a film-forming polymer dispersion and a non-film-forming polymer dispersion, suitably in admixture, at least one of the two polymer dispersions containing a polymer having functional groups suitable for covalent bonding with a biologically active material.

    摘要翻译： 公开的是一种制备载体系统的方法，其适用于生物活性材料的共价键合，其由已知的固体支持材料组成，所述固体支持材料具有涂覆有包含适于共价键合的官能团的聚合物的表面，通过用 一种成膜聚合物分散体和一种非成膜聚合物分散体，适当地混合两种聚合物分散体中的至少一种，其含有具有适于与生物活性材料共价键合的官能团的聚合物。

    Method for coating pharmaceutical formulations
    30.
    发明授权
    Method for coating pharmaceutical formulations 失效
    药物制剂的涂敷方法

    公开(公告)号：US4705695A

    公开(公告)日：1987-11-10

    申请号：US744330

    申请日：1985-06-13

    申请人： Klaus Lehmann ,  Dieter Dreher ,  Harry Goetz

    发明人： Klaus Lehmann ,  Dieter Dreher ,  Harry Goetz

    IPC分类号： A61K47/32 ,  A61K9/28 ,  A61K9/32 ,  A61K9/50

    CPC分类号： A61K9/2846 ,  A61K9/5026

    摘要： A method for coating solid pharmaceutical formulations, comprising coating said solid formulation with an aqueous fluid, film forming coating medium comprising a dissolved polymer prepared from acrylic and/or methacrylic monomers having a side group containing a tertiary amine substituent, wherein the amine nitrogen atom is converted to the ammonium salt form; and then drying said coated film.

    摘要翻译： 一种用于涂覆固体药物制剂的方法，包括用水性流体包衣所述固体制剂，成膜包衣介质，其包含由具有含叔胺取代基的侧基的丙烯酸和/或甲基丙烯酸单体制备的溶解聚合物，其中胺氮原子为 转化为铵盐形式; 然后干燥所述涂膜。