Antibodies to human vascular endothelial growth factor 2 and methods of using the same
    21.
    发明授权
    Antibodies to human vascular endothelial growth factor 2 and methods of using the same 失效
    人血管内皮生长因子2的抗体及其使用方法

    公开(公告)号:US07576189B2

    公开(公告)日:2009-08-18

    申请号:US11211724

    申请日:2005-08-26

    摘要: Disclosed is a human VEGF2 polypeptide and DNA(RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Also disclosed is a method of using such polypeptide for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antagonists to inhibit tumor growth, inflammation and to treat diabetic retinopathy, rheumatoid arthritis and psoriasis. Diagnostic methods for detecting mutations in the VEGF2 coding sequence and alterations in the concentration of VEGF2 protein in a sample derived from a host are also disclosed.

    摘要翻译: 公开了编码这种VEGF2多肽的人VEGF2多肽和DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还公开了使用这种多肽刺激伤口愈合和维持血管组织修复的方法。 还提供了使用拮抗剂抑制肿瘤生长,炎症和治疗糖尿病性视网膜病,类风湿性关节炎和牛皮癣的方法。 还公开了用于检测VEGF2编码序列中的突变和来自宿主的样品中VEGF2蛋白浓度变化的诊断方法。

    Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2
    24.
    发明授权
    Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2 失效
    通过施用血管内皮生长因子2刺激患者血管生成的方法

    公开(公告)号:US07186688B1

    公开(公告)日:2007-03-06

    申请号:US09107997

    申请日:1998-06-30

    摘要: Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA (RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.

    摘要翻译: 公开了人VEGF2多肽,生物活性,诊断学或治疗上有用的片段,类似物或衍生物,以及编码这种VEGF2多肽的DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。 还提供了使用抗体和拮抗剂抑制肿瘤血管发生,从而抑制肿瘤生长,炎症,糖尿病性视网膜病,类风湿性关节炎和牛皮癣的方法。

    Antibodies to human vascular endothelial growth factor 2
    25.
    发明授权
    Antibodies to human vascular endothelial growth factor 2 有权
    人血管内皮生长因子2的抗体

    公开(公告)号:US07109308B1

    公开(公告)日:2006-09-19

    申请号:US10023584

    申请日:2001-12-21

    IPC分类号: C12P21/08 C07K16/00

    摘要: Disclosed is a human VEGF2 polypeptide and DNA(RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Also disclosed is a method of using such polypeptide for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antagonists to inhibit tumor growth, inflammation and to treat diabetic retinopathy, rheumatoid arthritis and psoriasis. Diagnostic methods for detecting mutations in the VEGF2 coding sequence and alterations in the concentration of VEGF2 protein in a sample derived from a host are also disclosed.

    摘要翻译: 公开了编码这种VEGF2多肽的人VEGF2多肽和DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还公开了使用这种多肽刺激伤口愈合和维持血管组织修复的方法。 还提供了使用拮抗剂抑制肿瘤生长,炎症和治疗糖尿病性视网膜病,类风湿性关节炎和牛皮癣的方法。 还公开了用于检测VEGF2编码序列中的突变和来自宿主的样品中VEGF2蛋白浓度变化的诊断方法。

    Vascular endothelial growth factor 2
    28.
    发明授权
    Vascular endothelial growth factor 2 失效
    血管内皮生长因子2

    公开(公告)号:US5932540A

    公开(公告)日:1999-08-03

    申请号:US999811

    申请日:1997-12-24

    摘要: Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.

    摘要翻译: 公开了人VEGF2多肽,生物活性,诊断学或治疗上有用的片段,类似物或衍生物,以及编码这种VEGF2多肽的DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。 还提供了使用抗体和拮抗剂抑制肿瘤血管发生,从而抑制肿瘤生长,炎症,糖尿病性视网膜病,类风湿性关节炎和牛皮癣的方法。