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47 条记录 (耗时 0.027 秒)

    System and method for the deposition, detection and identification of threat agents using a fiber array spectral translator
    21.
    发明授权
    System and method for the deposition, detection and identification of threat agents using a fiber array spectral translator 有权
    使用光纤阵列光谱转换器的威胁剂的沉积，检测和鉴定的系统和方法

    公开(公告)号：US07480033B2

    公开(公告)日：2009-01-20

    申请号：US11351269

    申请日：2006-02-09

    申请人： Patrick J. Treado ,  Charles W. Gardner, Jr. ,  John S. Maier

    发明人： Patrick J. Treado ,  Charles W. Gardner, Jr. ,  John S. Maier

    IPC分类号： G01N21/00 ,  G01N21/65 ,  G01J3/44

    CPC分类号： G01J3/44 ,  G01N21/65

    摘要： A system and method for depositing a sample of a threat agent is deposited onto a substrate. A first optical collection device collects at least one of the following: elastic scattered light produced by the threat agent, and Raman scattered light produced by the threat agent. A second optical collection device collects Raman scattered light produced by the threat agent, wherein the second optical collection device comprises a two dimensional non-linear array of optical fibers drawn into a one dimensional fiber stack that converts a non-linear field of view into a linear field of view, wherein the one dimensional fiber stack is coupled to an entrance slit of a Raman imaging spectrometer. The threat agent deposited on the substrate is identified.

    摘要翻译： 将用于沉积威胁剂的样品的系统和方法沉积在基底上。 第一光学收集装置收集以下至少一种：由威胁剂产生的弹性散射光和由威胁剂产生的拉曼散射光。 第二光学收集装置收集由威胁剂产生的拉曼散射光，其中第二光学收集装置包括被拉入一维光纤堆叠的二维非线性光纤阵列，其将非线性视场转换为 线性视野，其中所述一维光纤堆叠被耦合到拉曼成像光谱仪的入口狭缝。 鉴定沉积在基底上的威胁剂。

    Method and apparatus for super montage large area spectroscopic imaging
    22.
    发明授权
    Method and apparatus for super montage large area spectroscopic imaging 有权
    超级蒙太奇大面积光谱成像方法与装置

    公开(公告)号：US07479966B2

    公开(公告)日：2009-01-20

    申请号：US11228382

    申请日：2005-09-19

    申请人： John S. Maier ,  Jason H. Neiss

    发明人： John S. Maier ,  Jason H. Neiss

    IPC分类号： G09G5/00 ,  G09G5/02 ,  G06K9/36 ,  G02B5/32 ,  G02B27/12 ,  G02F1/07 ,  G01J3/00 ,  G01J3/42 ,  G01J3/28 ,  G01N21/00 ,  G02F1/33 ,  G09G5/10

    CPC分类号： G06T5/006 ,  G01J2003/2826 ,  G06T5/50

    摘要： The disclosure relates to Method and Apparatus for Super Montage Large area Spectroscopic Imaging. In one embodiment of the disclosure, a method for producing a spectroscopic image of an object includes the steps of (a) irradiating the object with light to thereby produce from the object scattered and/or emitted light for each of a plurality of wavelengths; (b) producing separately for each of the plurality of wavelengths a plurality of substantially contiguous sub-images of the object; (c) compensating for spatial aberrations in ones of the sub-images for a select one of the plurality of wavelengths; (d) compensating for intensity aberrations between ones of the substantially contiguous sub-images for one of the plurality of wavelengths; and (e) combining the sub-images for the select one wavelength to thereby produce said spectroscopic image of the object.

    摘要翻译： 本公开涉及超级蒙太奇大面积光谱成像方法和装置。 在本公开的一个实施例中，一种用于产生物体的分光图像的方法包括以下步骤：（a）用光照射物体，从而从多个波长中的每一个的物体散射和/或发射光产生; （b）为所述多个波长中的每一个分别产生所述物体的多个基本相邻的子图像; （c）补偿所述多个波长中的选择一个的子图像中的空间像差; （d）补偿所述多个波长中的一个波长的所述基本连续的子图像中的一个的强度像差; 以及（e）组合所选择的一个波长的子图像，从而产生该对象的所述分光图像。

    Invasive chemometry
    23.
    发明授权
    Invasive chemometry 有权
    侵入性化学法

    公开(公告)号：US07330747B2

    公开(公告)日：2008-02-12

    申请号：US11267913

    申请日：2005-11-03

    申请人： John S. Maier

    发明人： John S. Maier

    IPC分类号： A61B5/00

    CPC分类号： G06F19/10 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/415 ,  A61B5/418 ,  A61B5/4519

    摘要： The invention relates to methods and devices for assessing one or more components of a selected tissue in an animal. The present invention permits non-invasive assessment of tissue components in a body structure containing multiple tissue types by assessing multiple regions of the animal's body for an optical characteristic of the tissue of interest and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the tissue component for one or more regions that exhibit the optical characteristic of the tissue of interest.

    摘要翻译： 本发明涉及用于评估动物中选定组织的一种或多种组分的方法和装置。 本发明允许通过评估动物身体的多个区域以获得感兴趣的组织的光学特征并单独评估一种或多种光学（例如拉曼或NIR），从而对包含多种组织类型的身体结构中的组织成分进行非侵入式评估。 表现出感兴趣组织的光学特性的一个或多个区域的组织组分的特征。

    Spectroscopic systems and methods for classifying and pharmaceutically treating cells
    25.
    发明授权
    Spectroscopic systems and methods for classifying and pharmaceutically treating cells 有权
    用于分类和药物治疗细胞的光谱系统和方法

    公开(公告)号：US08379197B2

    公开(公告)日：2013-02-19

    申请号：US12462350

    申请日：2009-08-03

    申请人： Janice Panza ,  John S. Maier ,  Jason Neiss

    发明人： Janice Panza ,  John S. Maier ,  Jason Neiss

    IPC分类号： G01J3/00 ,  G01J3/44

    CPC分类号： G01J3/44 ,  G01J3/10 ,  G01J3/36 ,  G01N15/1475 ,  G01N21/6458 ,  G01N21/65 ,  G01N2015/1006 ,  G01N2015/1488 ,  G02B21/0096

    摘要： A system and method to distinguish normal cells from cells having undergone a biochemical change. A pre-determined vector space is selected where the vector space mathematically describes a first plurality of reference spectral data sets for normal cells and a second plurality of reference spectral data sets for cells having undergone a biochemical change. A sample is irradiated to generate a target spectral data set based on photons absorbed, reflected, emitted, or scattered by the sample. The target spectral data set is transformed into a pre-determined vector space. A distribution of transformed data is analyzed in the pre-determined vector space. Based on the analysis, the sample is classified as containing normal cells, cells having undergone a biochemical change, and combinations thereof. The method includes treating the sample with a pharmaceutical agent prior to irradiating the sample and using the classification to assess the efficiency of the pharmaceutical agent.

    摘要翻译： 将正常细胞与经历生物化学变化的细胞区分开的系统和方法。 选择预定向量空间，其中矢量空间数学地描述正常小区的第一多个参考频谱数据集，以及经历生物化学变化的小区的第二多个参考频谱数据集。 照射样品以基于样品吸收，反射，发射或散射的光子产生目标光谱数据集。 将目标光谱数据集转换为预定向量空间。 在预定向量空间中分析变换数据的分布。 基于该分析，将样品分类为含有正常细胞，经历生物化学变化的细胞及其组合。 该方法包括在照射样品之前用药剂处理样品并使用分类来评估药剂的效率。

    Method and apparatus for super montage large area spectroscopic imaging
    26.
    发明授权
    Method and apparatus for super montage large area spectroscopic imaging 有权
    超级蒙太奇大面积光谱成像方法与装置

    公开(公告)号：US07705981B2

    公开(公告)日：2010-04-27

    申请号：US12180344

    申请日：2008-07-25

    申请人： John S. Maier ,  Jason H. Neiss

    发明人： John S. Maier ,  Jason H. Neiss

    IPC分类号： G01J3/44

    CPC分类号： G06T5/006 ,  G01J2003/2826 ,  G06T5/50

    摘要： The disclosure relates to Method and Apparatus for Super Montage Large area Spectroscopic Imaging. In one embodiment of the disclosure, a method for producing a spectroscopic image of an object includes the steps of (a) irradiating the object with light to thereby produce from the object scattered and/or emitted (interchangeably “scattered”) light for each of a plurality of wavelengths; (b) producing separately for each of the plurality of wavelengths a plurality of substantially contiguous sub-images of the object; (c) compensating for spatial aberrations in ones of the sub-images for a select one of the plurality of wavelengths; (d) compensating for intensity aberrations between ones of the substantially contiguous sub-images for one of the plurality of wavelengths; and (e) combining the sub-images for the select one wavelength to thereby produce said spectroscopic image of the object.

    摘要翻译： 本公开涉及超级蒙太奇大面积光谱成像方法和装置。 在本公开的一个实施例中，用于产生物体的分光图像的方法包括以下步骤：（a）用光照射物体，从而从物体散射和/或发射（互换地“散射”）的光中产生 多个波长; （b）为所述多个波长中的每一个分别产生所述物体的多个基本相邻的子图像; （c）补偿所述多个波长中的选择一个的子图像中的空间像差; （d）补偿所述多个波长中的一个波长的所述基本连续的子图像中的一个的强度像差; 和（e）组合所选择的一个波长的子图像，从而产生该对象的所述分光图像。

    SYSTEM AND METHOD FOR THE DEPOSITION, IMAGING, DETECTION AND IDENTIFICATION OF THREAT AGENTS
    27.
    发明申请
    SYSTEM AND METHOD FOR THE DEPOSITION, IMAGING, DETECTION AND IDENTIFICATION OF THREAT AGENTS 有权
    沉积物成像，成像，检测和鉴定的系统和方法

    公开(公告)号：US20080316468A1

    公开(公告)日：2008-12-25

    申请号：US11351329

    申请日：2006-02-09

    申请人： Patrick J. Treado ,  Charles W. Gardner, JR. ,  John S. Maier

    发明人： Patrick J. Treado ,  Charles W. Gardner, JR. ,  John S. Maier

    IPC分类号： G01N21/47 ,  G01J3/44 ,  G01N21/65

    CPC分类号： G01J3/44 ,  G01N21/65

    摘要： A system and method for depositing a sample of a threat agent onto a substrate. The deposition of the threat agent onto the substrate is visually observed by analyzing the elastic scattered photons produced by the threat agent using elastic scatter imaging to form an image of the threat agent on the substrate, wherein depositing of the threat agent is substantially coincident in time with visually observing of the deposition of the threat agent.A system and method for depositing a sample of a threat agent onto a substrate. A single illumination source illuminates the threat agent on the substrate with a plurality of photons to thereby produce elastic scattered photons. Deposition of the threat agent onto the substrate is visually observed by analyzing the elastic scattered photons produced by the threat agent using elastic scatter imaging to form an image of the threat agent on the substrate.

    摘要翻译： 一种用于将威胁剂样品沉积到基底上的系统和方法。 通过使用弹性散射成像分析由威胁剂产生的弹性散射光子以形成威胁剂在基材上的图像，目视观察威胁剂沉积在基材上，其中威胁剂的沉积在时间上基本一致 在视觉上观察威胁剂的沉积。 一种用于将威胁剂样品沉积到基底上的系统和方法。 单个照明源用多个光子照射基板上的威胁剂，从而产生弹性散射的光子。 通过使用弹性散射成像分析由威胁剂产生的弹性散射光子以在基底上形成威胁剂的图像，目视观察威胁剂在基材上的沉积。

    System and method for dynamic chemical imaging
    28.
    发明授权
    System and method for dynamic chemical imaging 有权
    动态化学成像系统和方法

    公开(公告)号：US07317526B2

    公开(公告)日：2008-01-08

    申请号：US11399032

    申请日：2006-04-06

    申请人： Thomas C. Voigt ,  David Tuschel ,  John S. Maier

    发明人： Thomas C. Voigt ,  David Tuschel ,  John S. Maier

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01N21/6456 ,  G01J3/12 ,  G01J3/1256 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/44 ,  G01J2003/1269 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/65

    摘要： A system and method for detecting dynamic changes that occur in a sample between a first time interval and a second time interval using a series of at least first and second sequential chemical images of the sample. During the first time interval: (i) the sample is illuminated with a plurality of photons to thereby produce photons scattered or emitted by the sample; (ii) a two-dimensional array of detection elements is used to simultaneously detect scattered or emitted photons in a first predetermined wavelength band from different locations on or within the sample; and (iii) the two-dimensional array of detection elements is thereafter used one or more further times to simultaneously detect scattered or emitted photons in one or more further predetermined wavelength band(s) from different locations on or within the sample. The outputs of the two-dimensional array of detection elements during the first time interval are then combined to generate the first chemical image of the sample. The process is repeated during the second time interval to generate the second chemical image of the sample. Dynamic changes occurring in the sample between the first time interval and the second time interval are detected based on one or more differences between the first and second chemical images.

    摘要翻译： 一种系统和方法，用于使用所述样本的至少第一和第二顺序化学图像的一系列来检测在第一时间间隔和第二时间间隔之间在样本中发生的动态变化。 在第一时间间隔期间：（i）样品用多个光子照射，从而产生样品散射或发射的光子; （ii）检测元件的二维阵列用于同时从样品上或样品内的不同位置检测来自第一预定波长带的散射或发射的光子; 然后，（iii）检测元件的二维阵列此后再被使用一次或多次，以同时检测来自样品上或样品内的不同位置的一个或多个另外的预定波长带中的散射或发射的光子。 然后组合在第一时间间隔期间检测元件的二维阵列的输出以产生样本的第一化学图像。 该过程在第二时间间隔期间重复以产生样品的第二化学图像。 基于第一和第二化学图像之间的一个或多个差异来检测在第一时间间隔和第二时间间隔之间在样本中发生的动态变化。