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    System and method for dynamic chemical imaging
    1.
    发明授权
    System and method for dynamic chemical imaging 有权
    动态化学成像系统和方法

    公开(公告)号：US07317526B2

    公开(公告)日：2008-01-08

    申请号：US11399032

    申请日：2006-04-06

    申请人： Thomas C. Voigt ,  David Tuschel ,  John S. Maier

    发明人： Thomas C. Voigt ,  David Tuschel ,  John S. Maier

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01N21/6456 ,  G01J3/12 ,  G01J3/1256 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/44 ,  G01J2003/1269 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/65

    摘要： A system and method for detecting dynamic changes that occur in a sample between a first time interval and a second time interval using a series of at least first and second sequential chemical images of the sample. During the first time interval: (i) the sample is illuminated with a plurality of photons to thereby produce photons scattered or emitted by the sample; (ii) a two-dimensional array of detection elements is used to simultaneously detect scattered or emitted photons in a first predetermined wavelength band from different locations on or within the sample; and (iii) the two-dimensional array of detection elements is thereafter used one or more further times to simultaneously detect scattered or emitted photons in one or more further predetermined wavelength band(s) from different locations on or within the sample. The outputs of the two-dimensional array of detection elements during the first time interval are then combined to generate the first chemical image of the sample. The process is repeated during the second time interval to generate the second chemical image of the sample. Dynamic changes occurring in the sample between the first time interval and the second time interval are detected based on one or more differences between the first and second chemical images.

    摘要翻译： 一种系统和方法，用于使用所述样本的至少第一和第二顺序化学图像的一系列来检测在第一时间间隔和第二时间间隔之间在样本中发生的动态变化。 在第一时间间隔期间：（i）样品用多个光子照射，从而产生样品散射或发射的光子; （ii）检测元件的二维阵列用于同时从样品上或样品内的不同位置检测来自第一预定波长带的散射或发射的光子; 然后，（iii）检测元件的二维阵列此后再被使用一次或多次，以同时检测来自样品上或样品内的不同位置的一个或多个另外的预定波长带中的散射或发射的光子。 然后组合在第一时间间隔期间检测元件的二维阵列的输出以产生样本的第一化学图像。 该过程在第二时间间隔期间重复以产生样品的第二化学图像。 基于第一和第二化学图像之间的一个或多个差异来检测在第一时间间隔和第二时间间隔之间在样本中发生的动态变化。

    Dynamic imaging of biological cells and other subjects
    2.
    发明授权
    Dynamic imaging of biological cells and other subjects 有权
    生物细胞和其他科目的动态成像

    公开(公告)号：US07564546B2

    公开(公告)日：2009-07-21

    申请号：US10556038

    申请日：2005-06-30

    申请人： John S. Maier ,  Patrick J. Treado ,  David Tuschel ,  Thomas C. Voigt

    发明人： John S. Maier ,  Patrick J. Treado ,  David Tuschel ,  Thomas C. Voigt

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01N21/6456 ,  G01J3/2803 ,  G01J3/32 ,  G01J3/36 ,  G01J3/44 ,  G01N21/359 ,  G01N21/6486 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/656

    摘要： The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.

    摘要翻译： 本发明涉及动态化学成像方法，包括细胞成像方法。 该方法包括以基本上单色的光照亮电池的至少一部分，并且在多个离散时间评估从照射部分散射的拉曼偏移光。 可以在每个离散时间处以多个拉曼位移（RS）值评估拉曼移位的光，并且可以将每个离散时间的RS值选择为预选择的分量的特征。 如此获得的图像的拉曼光谱特征的多变量分析可以产生视场中部件的位置和化学特性。 该信息可以与从视野获得的其他光谱数据（例如，可见显微镜图像）组合或覆盖。

    Invasive chemometry
    5.
    发明授权
    Invasive chemometry 有权
    侵入性化学法

    公开(公告)号：US08532726B2

    公开(公告)日：2013-09-10

    申请号：US12069546

    申请日：2008-02-11

    申请人： John S. Maier

    发明人： John S. Maier

    IPC分类号： A61B5/1455

    CPC分类号： G06F19/10 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/415 ,  A61B5/418 ,  A61B5/4519

    摘要： The invention relates to methods and devices for assessing one or more components of a selected tissue in an animal. The present invention permits non-invasive assessment of tissue components in a body structure containing multiple tissue types by assessing multiple regions of the animal's body for an optical characteristic of the tissue of interest and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the tissue component for one or more regions that exhibit the optical characteristic of the tissue of interest.

    摘要翻译： 本发明涉及用于评估动物中选定组织的一种或多种组分的方法和装置。 本发明允许通过评估动物身体的多个区域以获得感兴趣的组织的光学特征并单独评估一种或多种光学（例如拉曼或NIR），从而对包含多种组织类型的身体结构中的组织成分进行非侵入性评估。 表现出感兴趣组织的光学特性的一个或多个区域的组织组分的特征。

    Raman Characterization of Transplant Tissue
    7.
    发明申请
    Raman Characterization of Transplant Tissue 有权
    移植组织的拉曼表征

    公开(公告)号：US20100034743A1

    公开(公告)日：2010-02-11

    申请号：US12537513

    申请日：2009-08-07

    申请人： Jeffrey Cohen ,  John S. Maier ,  Shona Stewart

    发明人： Jeffrey Cohen ,  John S. Maier ,  Shona Stewart

    IPC分类号： A61K49/00 ,  G01J3/44 ,  G01N21/65 ,  A61P43/00

    CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/44 ,  G01N2021/656

    摘要： A system and method for determining a disease state and clinical outcome of a sample. A sample is illuminated to produce Raman scattered photons, the Raman scattered photons are assessed to generate a Raman spectroscopic data set representative of the sample, wherein said Raman spectroscopic data set comprises at least one of: a Raman spectra of the sample and a spatially accurate wavelength resolved Raman image of the sample; the Raman spectroscopic data set is evaluated using a chemometric technique to classify the disease state of the sample as: acute, chronic, incipient, or none. In one embodiment, the chemontric technique is principle component analysis. In another embodiment, the sample is obtained prior to transplantation and analysis can determine the likelihood of rejection by a host.

    摘要翻译： 用于确定样品的疾病状态和临床结果的系统和方法。 照射样品以产生拉曼散射光子，评估拉曼散射光子以产生代表样品的拉曼光谱数据集，其中所述拉曼光谱数据集包括以下至少一个：样品的拉曼光谱和空间准确的 样品的波长分辨拉曼图像; 使用化学计量技术评估拉曼光谱数据集，以将样品的疾病状态分类为急性，慢性，初期或无。 在一个实施方案中，化学方法是主要成分分析。 在另一个实施方案中，在移植之前获得样品，并且分析可以确定宿主排斥的可能性。

    Method for Correlating Spectroscopic Measurements with Digital Images of Contrast Enhanced Tissue
    8.
    发明申请
    Method for Correlating Spectroscopic Measurements with Digital Images of Contrast Enhanced Tissue 有权
    将光谱测量与对比增强组织的数字图像相关联的方法

    公开(公告)号：US20090086203A1

    公开(公告)日：2009-04-02

    申请号：US12329688

    申请日：2008-12-08

    申请人： Jeffrey Cohen ,  John S. Maier

    发明人： Jeffrey Cohen ,  John S. Maier

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01J3/02 ,  G01J3/0264 ,  G01J3/0289 ,  G01J3/0291 ,  G01N21/6458 ,  G01N21/6486 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/6417 ,  G01N2021/6423 ,  G01N2021/656

    摘要： A system and method of correlating Raman measurements with digital images of a sample so to classify the sample's disease state. A spectroscopic data set is obtained for the sample positioned in the field of view of a spectroscopic device. With the sample removed from the field of view, the sample is treated with a contrast enhancing agent. The treated sample is repositioned in the spectroscopic device's field of view and a digital image of the treated sample is obtained. The spectroscopic data set is linked with the digital image by defining a transformation to map the image spatial coordinates of the digital image to the spectral spatial coordinates of the spectroscopic data. For the spectroscopic data set of the sample, the database is searched to identify a spectroscopic data set, of a known sample having well characterized pathology, which matches the sample's spectroscopic data set.

    摘要翻译： 将拉曼测量与样本的数字图像相关联的系统和方法，以对样本的疾病状态进行分类。 对于位于分光装置的视野中的样品获得光谱数据集。 从样品中取出样品后，用对比度增强剂处理样品。 经处理的样品在分光装置的视野中重新定位，并获得处理过的样品的数字图像。 通过定义将数字图像的图像空间坐标映射到光谱数据的光谱空间坐标的变换，光谱数据集与数字图像相关联。 对于样本的光谱数据集，搜索数据库以识别具有良好表征的病理学的已知样品的光谱数据集，其与样品的光谱数据集相匹配。